$143 Cheap Flights from Tucson (TUS) to Des Moines (DSM)

View $143 flight on Tue, Jul 15, 2025Opens in a new window

Popular airlines from Tucson International Airport (TUS) to Des Moines International Airport (DSM)

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Cheap Flights from Tucson to Des Moines (TUS-DSM)

Prices were available within the past 7 days and start at $143 for one-way flights and $280 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Jun 18 - Wed, Jul 2
TUS
Tucson
DSM
Des Moines
$280 Roundtrip, found 2 days ago
$280
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jun 18 from Tucson to Des Moines, returning Wed, Jul 2, priced at $280 found 2 days ago
United
Tue, Jul 15 - Tue, Jul 22
TUS
Tucson
DSM
Des Moines
$285 Roundtrip, just found
$285
Roundtrip
just found
Select United flight, departing Tue, Jul 15 from Tucson to Des Moines, returning Tue, Jul 22, priced at $285 just found
Delta
Tue, Jul 15 - Tue, Jul 22
TUS
Tucson
DSM
Des Moines
$285 Roundtrip, just found
$285
Roundtrip
just found
Select Delta flight, departing Tue, Jul 15 from Tucson to Des Moines, returning Tue, Jul 22, priced at $285 just found
American Airlines
Tue, Jul 15 - Tue, Jul 22
TUS
Tucson
DSM
Des Moines
$285 Roundtrip, just found
$285
Roundtrip
just found
Select American Airlines flight, departing Tue, Jul 15 from Tucson to Des Moines, returning Tue, Jul 22, priced at $285 just found
American Airlines
Tue, Jul 15 - Tue, Jul 22
TUS
Tucson
DSM
Des Moines
$289 Roundtrip, just found
$289
Roundtrip
just found
Select American Airlines flight, departing Tue, Jul 15 from Tucson to Des Moines, returning Tue, Jul 22, priced at $289 just found
Delta
Wed, Jul 30 - Tue, Aug 5
TUS
Tucson
DSM
Des Moines
$290 Roundtrip, found 18 hours ago
$290
Roundtrip
found 18 hours ago
Select Delta flight, departing Wed, Jul 30 from Tucson to Des Moines, returning Tue, Aug 5, priced at $290 found 18 hours ago
Delta
Tue, Jun 10 - Tue, Jun 17
TUS
Tucson
DSM
Des Moines
$295 Roundtrip, found 1 day ago
$295
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Jun 10 from Tucson to Des Moines, returning Tue, Jun 17, priced at $295 found 1 day ago
United
Mon, Jun 2 - Tue, Jun 3
TUS
Tucson
DSM
Des Moines
$297 Roundtrip, found 4 days ago
$297
Roundtrip
found 4 days ago
Select United flight, departing Mon, Jun 2 from Tucson to Des Moines, returning Tue, Jun 3, priced at $297 found 4 days ago
United
Tue, Jul 15 - Tue, Jul 22
TUS
Tucson
DSM
Des Moines
$299 Roundtrip, just found
$299
Roundtrip
just found
Select United flight, departing Tue, Jul 15 from Tucson to Des Moines, returning Tue, Jul 22, priced at $299 just found
Southwest Airlines
Tue, Jul 15 - Tue, Jul 22
TUS
Tucson
DSM
Des Moines
$301 Roundtrip, just found
$301
Roundtrip
just found
Select Southwest Airlines flight, departing Tue, Jul 15 from Tucson to Des Moines, returning Tue, Jul 22, priced at $301 just found
Flights from Tucson (TUS) to Des Moines (DSM)
Origin airport
Tucson Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$280
Distance
1152 mi

Tucson to Des Moines Flights

The cheapest times to fly from Tucson to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Tucson to Des Moines are during the month of June. You can find some of the cheapest flights from Tucson to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Tucson to Des Moines

Sunday is one of the best days to book for cheap flights from Tucson to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Tucson to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Tucson to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $143 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Tucson to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Tucson to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tucson Intl. Airport (TUS) to Des Moines Intl. Airport (DSM) cost?
Discover the latest flight deals from TUS to DSM by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from TUS to DSM?
The cheapest flights from TUS to DSM are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from TUS to DSM?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from TUS to DSM. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Tucson Intl. Airport (TUS) to Des Moines Intl. Airport (DSM)?
You’ll have to take a flight with a layover when traveling from Tucson Intl. Airport (TUS) to Des Moines Intl. Airport (DSM). There are no daily direct flights on this route. However, simply filter your search to include one or more stops to discover the best option for your trip.
What day of the week has the most flights from TUS to DSM?
You’ll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tucson Intl. Airport (TUS) to Des Moines Intl. Airport (DSM)?
Select a flight from Tucson Intl. Airport (TUS) to Des Moines Intl. Airport (DSM) that takes off before 3 PM to reduce the likelihood of delays and cancellations. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Tucson Intl. Airport (TUS) to Des Moines Intl. Airport (DSM) last-minute?
Waiting until just before your departure to book a flight from TUS to DSM generally means paying more. While you might find some last-minute deals, they’re not always guaranteed. Allow some flexibility in your schedule for the best chance of scoring a bargain.
Is it cheaper to book a TUS to DSM flight and hotel package?
Compared with arranging flights and hotels separately, booking a TUS to DSM flight and hotel package with Expedia could lead to significant savings. What’s more, having everything in one place will take the hassle out of planning your trip. Simply secure your flights and select from our extensive range of stays, then tailor your trip with extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Tucson Intl. Airport (TUS) to Des Moines Intl. Airport (DSM)?
If you reserved your TUS to DSM flight within the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you’d like more information.

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*Available to One Key members.