A street with houses, a water tower, and a banana tree.

Find 5 Star Hotels in Des Peres, MO from $130

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Des Peres 5 Star Hotels

Next weekend
Nov 13 - Nov 15
In two weeks
Nov 20 - Nov 22

Our top choices for Des Peres 5-star hotels

A modern hotel lobby with a glass facade, seating area, and a staircase.

1. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1,000 reviews)
"Exactly what you would expect from a four seasons hotel. Fantastic, all the way around!"
United States
JEFFREY
$375 nightly
The price is $438
Nov 9 - Nov 10
Total with taxes and fees
Four Seasons Hotel St Louis
An indoor dining area with a long table, chairs, hanging plants, and a view of a brick building through large windows.

2. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (587 reviews)
"Incredible stay! Loved the room, the staff were great, and the amenities were amazing! Definitely recommend staying here!"
United States
Kennedy
$549 nightly
The price is $641
Nov 27 - Nov 28
Total with taxes and fees
The Ritz-Carlton, St. Louis
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Des Peres.
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO
$113 nightly
The price is $133 total per night from Nov 27 to Nov 28
$133 total
Nov 27 - Nov 28
Total with taxes and fees
8.6/10 Excellent! (4,399 reviews)
Still don't see what you're looking for?
See all properties in Des Peres.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Des Peres

Just minutes from St. Louis, this charming suburb offers family-friendly recreation at Sugar Creek Park with playgrounds and walking trails. Spend an afternoon exploring the fascinating Museum of Transportation where vintage trains and automobiles bring America's transit history to life.

See all hotels in Des Peres
A museum exhibit with vintage vehicles including a 1934 Ford Phalet car and a fire truck.

Top Des Peres Hotel Reviews

Find out more about Des Peres

Pamper yourself on your impending escape. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Des Peres so popular in the last year. There's no reason to delay a getaway to Des Peres any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Book one of Expedia's luxurious 5-star hotels in Des Peres and get ready to enjoy the getaway of a lifetime. Don't wait any longer!

5-Star Hotels in Des Peres

You'll have a wonderful time at one of these 5-star hotels. Spa treatments, delicious meals, and personalized service are all waiting for you. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. What creature comforts do you want in your lodging? A reflexology treatment that will leave you feeling great? 24-hour room service, so you can order that filet mignon in the wee hours of the morning? A rejuvenating facial treatment to help your cares fall away?

Can't wait to get outside? You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Des Peres are the perfect place to relax after an exciting day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.

Make Your Escape

The results are in, and Des Peres 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. It's time to plan your next great escape -- Expedia can help you land a great deal on accommodation. Decide on one of Expedia's Des Peres 5-star hotels today and settle down in total tranquility tomorrow.

Frequently asked questions

What are the best 5-star hotels in Des Peres?
Boasting first-rate amenities and services, Expedia customers rate The Ritz-Carlton, St. Louis as one of the best 5-star hotels in Des Peres. You'll be immersed in a world of luxury from the moment you step into the lobby.
How much does it cost to stay in a 5-star hotel in Des Peres?
There are many different pricing options for a 5-star hotel in Des Peres on Expedia. How much you'll pay will depend on your travel dates, trip length and other factors. Compare all of the available properties for your chosen dates and use our pricing and other filters to discover the perfect luxury stay.

  • Search for the lowest price per night from $130

What makes a hotel 5 stars in Des Peres?
In Des Peres, a hotel needs to offer a certain number of high-end amenities to be rated 5 stars. These can include on-site gyms, gourmet restaurants, saunas and spas, premium bedding, luxury bathroom products and more. What also sets 5-star hotels apart is their guest-centric standard of service. You'll enjoy things like in-room massages, nightly turn-down services and concierge services. Some may also offer additional touches such as a welcome gift.

Explore a world of travel with Expedia