Find 5 Star Hotels in St. Charles, MO from $149
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Compare St. Charles 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Our top choices for St. Charles 5-star hotels

The Ritz-Carlton, St. Louis
The Ritz-Carlton, St. Louis

Four Seasons Hotel St Louis
Four Seasons Hotel St Louis
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Renaissance St. Louis Airport Hotel
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Explore St. Charles: its history, live music, bars, and more!

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Find out more about St. Charles
Find out more about St. Charles
Why not demand the best of accommodations during your holiday to St. Charles? After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made St. Charles so popular in the last year. There's no reason to delay a getaway to St. Charles any longer. We should also mention, the hotels in this area are known for guest services, so you know you'll be looked after during your getaway. Reserve one of our 5-star hotels in St. Charles and indulge in the finer things in life for a while. Don't wait any longer!
Get a Great Deal on 5-Star Hotels in St. Charles
Don't be afraid to request the best service from your hotel, along with pristine rooms. Spa treatments, delicious meals, and attentive guest service are all waiting for you. You're sure to find exactly the accommodation you need. Additionally, the hotels in this area receive high marks for customer satisfaction, so you know you'll be well cared for during your getaway. What creature comforts do you want in your lodging? A full-body massage to help your cares fall away? A concierge to help you suggest the next attraction to visit? Plush carpeting, delectable chocolate desserts, and even space for your family pet in some cases...these hotels will astonish you. Want to see for yourself? Then explore the 353 reviews various guests have left on Expedia and get to know these places.
But you aren't going to spend your entire vacation in your room, of course. We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in St. Charles are the perfect place to rest up after an exciting day.
Your Getaway Starts Today
The results are in, and St. Charles 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Expedia can help you land a great deal on accommodation. Your great getaway is just a mouse-click away. Opt for one of our St. Charles 5-star hotels today and relax in luxe surroundings tomorrow.
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Explore a world of travel with Expedia
- 5 Star Hotels in St. Charles Historic District
- 4 Star Hotels in St. Charles Historic District
- Hotels near Lindenwood University
- Hotels near St. Charles Historic District
- Luxury Hotels in St. Charles Historic District
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- St. Charles County Hotels
- Hotels near Jaycee Park
- Hotels near Historic Main Street
- Hotels near First Missouri State Capitol Historic Site
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- Hotels near Katy Trail
- Hotels near Lewis & Clark Boathouse and Nature Center
- Hotels near Ameristar Casino St. Charles
- Hotels near Fast Lane Classic Cars
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- Lindenwood University
- Visit St. Charles Historic District
- Jaycee Park
- Historic Main Street
- Lewis & Clark Boathouse and Nature Center
- Katy Trail
- St Charles Convention Center
- Ameristar Casino St. Charles
- Fast Lane Classic Cars
- Visit Earth City
- Earth City Vacations
- Hollywood Casino
- Centene Community Ice Center
- Family Arena
- Hollywood Casino Amphitheatre
- Kokomo Joe's Family Fun Center
- SSM Health Rehabilitation Hospital
- St. Louis Mills Mall
- Historic Aircraft Restoration Museum
- Car rentals near Lindenwood University
- Car rentals near St Charles Convention Center
- Car rentals near Ameristar Casino St. Charles
- Car rentals near Fast Lane Classic Cars
- Car rentals near Earth City
- Enterprise Rental Cars in Earth City
- Hertz Rental Cars in Earth City
- Car rentals near Hollywood Casino
- Car rentals near Centene Community Ice Center
- Car rentals near Hollywood Casino Amphitheatre
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- Car rentals near SSM Health Rehabilitation Hospital
- Car rentals near Bridgeton
- Enterprise Rental Cars in Bridgeton