Find hotels near Big Bend Regional Medical Center, Alpine from $68

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Our top choices for Big Bend Regional Medical Center hotels

Egyptian cotton sheets, premium bedding, memory foam beds
Alpine Bed and Breakfast

Alpine Bed and Breakfast

Alpine Bed and Breakfast
4.0 star property
0.2 mi from Big Bend Regional Medical Center
10.0 out of 10, Exceptional, (90)
"Awesome place to stay! "
United States
Isabel
$191 nightly
The price is $216
Dec 17 - Dec 18
Total with taxes and fees
Alpine Bed and Breakfast
Restaurant
Hampton Inn Alpine

Hampton Inn Alpine

Hampton Inn Alpine
2.5 star property
1.5 mi from Big Bend Regional Medical Center
9.2 out of 10, Wonderful, (1003)
"Very friendly staff, comfortable bed "
United States
Omar
$111 nightly
The price is $126
Jan 5 - Jan 6, 2026
Total with taxes and fees
Hampton Inn Alpine
Interior
The Holland Hotel

The Holland Hotel

The Holland Hotel
3.0 star property
< 0.1 mi from Big Bend Regional Medical Center
8.6 out of 10, Excellent, (546)
"Everything --- absolutely excellent. "
United States
Tarai
$112 nightly
The price is $126
Dec 16 - Dec 17
Total with taxes and fees
The Holland Hotel
Free buffet breakfast
Holiday Inn Express & Suites Alpine Southeast by IHG

Holiday Inn Express & Suites Alpine Southeast by IHG

Holiday Inn Express & Suites Alpine Southeast by IHG
2.5 star property
1.4 mi from Big Bend Regional Medical Center
9.0 out of 10, Wonderful, (999)
"Clean room staff friendly breakfast usual 😋 parking ok"
United States
Lawrence
$108 nightly
The price is $122
Dec 21 - Dec 22
Total with taxes and fees
Holiday Inn Express & Suites Alpine Southeast by IHG
Signature Room | Individually decorated, free WiFi, bed sheets
Alpine City Place

Alpine City Place

Alpine City Place
3.0 star property
< 0.1 mi from Big Bend Regional Medical Center
8.0 out of 10, Very Good, (79)
"Nice spot in town to stay at. Room was clean and comfortable. The noise from the band below didn't bother me and was over around 11pm. Would stay here again. "
United States
Sheldon
$89 nightly
The price is $101
Dec 16 - Dec 17
Total with taxes and fees
Alpine City Place
Double Room | Free WiFi, bed sheets
Antelope Lodge

Antelope Lodge

Antelope Lodge
3.5 star property
1.5 mi from Big Bend Regional Medical Center
8.6 out of 10, Excellent, (584)
"We loved our stay here. "
United States
Candace
$127 nightly
The price is $143
Dec 16 - Dec 17
Total with taxes and fees
Antelope Lodge
Property grounds
The Maverick Inn

The Maverick Inn

The Maverick Inn
3.0 star property
0.8 mi from Big Bend Regional Medical Center
8.2 out of 10, Very Good, (449)
"Looks a little dated, but the rooms are comfortable and well furnished "
United States
steve
$96 nightly
The price is $108
Dec 16 - Dec 17
Total with taxes and fees
The Maverick Inn
Coffee service
Quality Inn Alpine

Quality Inn Alpine

Quality Inn Alpine
2.5 star property
1.5 mi from Big Bend Regional Medical Center
8.4 out of 10, Very Good, (848)
"Staff was friendly and helpful. The rooms were clean and beds comfortable. "
United States
Ryan
$116 nightly
The price is $131
Jan 9 - Jan 10, 2026
Total with taxes and fees
Quality Inn Alpine
Restaurant
Americas Best Value Inn Alpine

Americas Best Value Inn Alpine

Americas Best Value Inn Alpine
2.5 star property
1.4 mi from Big Bend Regional Medical Center
7.4 out of 10, Good, (570)
"Lighting is dim and the are no charging outlets for phones. Staff should have more knowledge of local restaurants."
United States
Nancy
$120 nightly
The price is $136
Dec 16 - Dec 17
Total with taxes and fees
Americas Best Value Inn Alpine
Standard Room, 2 Double Beds, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks
Value Lodge

Value Lodge

Value Lodge
2.0 star property
1.4 mi from Big Bend Regional Medical Center
7.4 out of 10, Good, (353)
"Staff was great and it’s a nice place to stay. "
United States
Orlando
$78 nightly
The price is $88
Dec 18 - Dec 19
Total with taxes and fees
Value Lodge
Desk, iron/ironing board, free cribs/infant beds, free WiFi
Travelodge by Wyndham Alpine

Travelodge by Wyndham Alpine

Travelodge by Wyndham Alpine
2.0 star property
1.9 mi from Big Bend Regional Medical Center
6.6 out of 10, (603)
"Need lots of improvement "
United States
Ashish
$120 nightly
The price is $136
Jan 9 - Jan 10, 2026
Total with taxes and fees
Travelodge by Wyndham Alpine
Lobby
OYO Alpine TX near Big Bend National Park

OYO Alpine TX near Big Bend National Park

OYO Alpine TX near Big Bend National Park
2.5 star property
0.5 mi from Big Bend Regional Medical Center
4.8 out of 10, (489)
"had a fantastic stay at this property. The hospitality, cleanliness, and overall service quality were exceptional. The staff ensured a smooth and comfortable experience from check-in to check-out. Highly satisfied and would definitely recommend this hotel to others"
United States
Amber
$61 nightly
The price is $68
Dec 16 - Dec 17
Total with taxes and fees
OYO Alpine TX near Big Bend National Park
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Big Bend Regional Medical Center Hotel Reviews

The Cowboy House - Rustic charm

The Cowboy House - Rustic charm

10/10 Excellent
"This was a great accommodation! Good amenities, easy communication with the host."
Elizabeth F. 3-night trip
Posted 2 days ago
The Cowboy House - Rustic charm

Hotels near other Big Bend Regional Medical Center attractions

Kiowa Gallery

3.8/5 (19 reviews)
You can spend an afternoon studying the exhibits at Kiowa Gallery during your travels in Alpine. Wander around the parks or enjoy the area's restaurants.
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Museum of the Big Bend

4.5/5 (95 reviews)
You can spend an afternoon exploring the galleries in Museum of the Big Bend during your trip to Alpine. Wander around the parks or enjoy the area's restaurants.
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Frequently asked questions

What's the area like around Big Bend Regional Medical Center?
Big Bend Regional Medical Center is located in Alpine. Travelers like the surrounding area for its parks. If you're looking for a convenient place to stay, check out the 56 hotels and other accommodations you'll find within a mile.
What's the best hotel to stay near Big Bend Regional Medical Center?
Adjacent to Big Bend Regional Medical Center, The Holland Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers free parking and free WiFi. Other good options within a short distance include OYO Alpine TX near Big Bend National Park and Alpine City Place.
How many hotels are there near Big Bend Regional Medical Center?
Expedia has 56 hotels and other accommodations within a mile from Big Bend Regional Medical Center.
If I need to cancel the hotel reservation for my stay near Big Bend Regional Medical Center, will I receive a refund?
Yes, you'll find most hotel bookings are refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to view the best options available near Big Bend Regional Medical Center.
Where can I learn more about changing or cancelling my trip in the area near Big Bend Regional Medical Center?
To access more information about changing or cancelling your stay near Big Bend Regional Medical Center, head over to our customer service page.
What can I see and do near Big Bend Regional Medical Center?
You might spend a leisurely day outdoors at Kokernot Municipal Park and Shipman Park. Attractions like Kiowa Gallery and Museum of the Big Bend highlight the local culture. You might plan a visit to Kokernot Field or Alpine Municipal Pool while you're in the area.