Title: Car Rental Santa Fé - Expedia.com [Santa Fé Travel Guide](https://expedia.com/Guarani-Das-Missoes-Santa-Fe.dx553248635318393892)[Hotels in Santa Fé](https://expedia.com/Santa-Fe-Guarani-Das-Missoes-Hotels.0-n553248635318393892-0.Travel-Guide-Filter-Hotels)[Flights to Guarani das Missões](https://expedia.com/Cheap-Flights-To-Guarani-Das-Missoes.d553248634664609476.Travel-Guide-Flights)[Santa Fé Vacations](https://expedia.com/Santa-Fe.d553248635318393892.Destination-Travel-Guides) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_car.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # Car Rental Santa Fé ## Search and Compare from Car Companies in Santa Fé ## Featured car rental suppliers Compare from agencies ![car suppliers logo](https://forever.travel-assets.com/flex/flexmanager/images/2022/02/16/car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car rentals - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself One Key members save 10% or more on over 1 million car rentals [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers and package your flight, hotel, and car to save ## Top Car Deals in Santa Fé \* Price found within the past 6 days. Click for updated prices. ### Economy Chevrolet Spark or similar - 4 people Guarani das Missões, Rio Grande do Sul, BRA ![Chevrolet Spark](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_EC.png) [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20F%C3%A9,%20Guarani%20das%20Miss%C3%B5es,%20Rio%20Grande%20do%20Sul,%20Brazil&dpln=553248635318393892&date1=3/5/2026&date2=3/7/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22economy%22]) ### Compact Ford Focus or similar - 4 people Guarani das Missões, Rio Grande do Sul, BRA ![Ford Focus](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_CC.png) [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20F%C3%A9,%20Guarani%20das%20Miss%C3%B5es,%20Rio%20Grande%20do%20Sul,%20Brazil&dpln=553248635318393892&date1=3/5/2026&date2=3/7/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22compact%22]) ### Midsize Toyota Corolla or similar - 5 people Guarani das Missões, Rio Grande do Sul, BRA ![Toyota Corolla](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_IC.png) [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20F%C3%A9,%20Guarani%20das%20Miss%C3%B5es,%20Rio%20Grande%20do%20Sul,%20Brazil&dpln=553248635318393892&date1=3/5/2026&date2=3/7/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22midsize%22]) ### SUV Jeep Compass or similar - 5 people Guarani das Missões, Rio Grande do Sul, BRA ![Jeep Compass](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_SF.png) [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20F%C3%A9,%20Guarani%20das%20Miss%C3%B5es,%20Rio%20Grande%20do%20Sul,%20Brazil&dpln=553248635318393892&date1=3/5/2026&date2=3/7/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22suv%22]) ### Don't see what you're looking for? See all car rentals in Santa Fé [View all cars](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20F%C3%A9,%20Guarani%20das%20Miss%C3%B5es,%20Rio%20Grande%20do%20Sul,%20Brazil&dpln=553248635318393892&date1=3/5/2026&date2=3/7/2026&crfrr=defaultFlex&SearchType=Place) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=CTG_SPRING_PROMO_553248635318393892) ## Frequently asked questions ### How much is a rental car per day in Santa Fé? ### What happens if I need to cancel my Santa Fé car reservation? ### Where can I go on a road trip from Santa Fé? > - Head to Santa Maria for a fun-filled sightseeing experience. Around 120 miles from Santa Fé, it has numerous amazing attractions, including Royal Plaza Shopping. > - Roughly 95 miles away, São Borja is also popular with travelers. Make time to take in Joao Goulart Museum while you're here. It's one of the reasons people love this city. > - Spend time in nature and breathe in some fresh air at Itaipu Dam. It's approximately 190 miles from Santa Fé. ### How do I find the best car rental deals in Santa Fé with Expedia? ### How old do you have to be to rent a car in Santa Fé? ### What do you need to rent a car in Santa Fé? ### What side of the road do you drive on in Santa Fé? ### What is the cheapest car rental in Santa Fé? ### Can I rent a car for a month or longer in Santa Fé? ### Where can I find a Santa Fé car rental if I am younger than 25? ### What insurance should I choose for my car rental in Santa Fé? ### Can I drive in Santa Fé with my current driver's license? > - Age restrictions: You need to be 25 or older in most countries to rent a car. If you're younger than that, it may still be possible to rent a car but you'll have to pay a Young Driver's Surcharge. Additional restrictions may also apply to what kinds of cars you can rent. > - Driving limitations: Make sure you read the fine print before sliding behind the wheel. Usually, you can't cross country borders, drive onto ferries or on certain types of rugged terrain with a rental vehicle. ## Car Rental Information | Popular car types | [SUV](https://www.expedia.com/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.com/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.com/lp/b/car-rental/economy?rfrr=car.table.Economy) | | ------------------------------------------------ | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available | | | Our best deal of the day | | | Our second best deal of the day | | | Our third best deal of the day | | | From the airport to your hotel | [Airport Transportation](https://www.expedia.com/ground-transfers?rfrr=car.table.AirportTransportation) | | From popular domestic and international airports | [Airport Car Rentals](https://www.expedia.com/lp/b/car-rental/airport) | ## Explore a world of travel with Expedia - 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