Cayos Los Grullos Vacations from $603
Book a Hotel + Flight or Car together to unlock savings
Better together
Save up to $1,045 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
The Latest Cayos Los Grullos vacation packages
Price found within the past 48 hours. Click for updated prices.
Central Hotel Panama Casco Viejo
Casco Viejo
per person
Aug 7 - Aug 10
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (918 reviews)
My room was spacious, clean and comfortable. The Hotel staff were very friendly and helpful and made my first visit to Panama a very memorable one.
Reviewed on Jun 24, 2025
Don't see what you're looking for?
See all available trips from Columbus to Cayos Los Grullos
View all tripsDiscover the most popular places to visit in Cayos Los Grullos
Museum of the Kuna Nation
You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Masargantupo. Stroll along the seaside or experience the area's festivals.
Porvenir Museum
You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.
What to do in Cayos Los Grullos
San Blas Money Heist Island Day tour - Visit 3-islands + Natural Pool
$76
per adult
Overnight in San Blas - Private Room + Meals + Boat Tour
$160
per adult
Discover the San Blas Islands in one day (3 islands)
$71
per adult
Cayos Los Grullos Hotel Deals
San Blas Private Over-the-Water Cabin
Nusatupo, Narganá, Guna Yala
"I liked the modern payment system that was used for booking the trip, the food was great, the location was as described. I disliked the communication with the reseller this booking goes through. They dropped the ball on communicating pickup time and itinerary confirmation, even when i tried calling ..."
Reviewed on Oct 27, 2022
Cabanas Narasgandub - Naranjo Chico
Kuna Yala, Narganá, Guna Yala
Beautiful scenery and an amazing community
"Our stay at Cabanas Narasgandub was everything you would expect from a remote and rustic location. You will rise when the rooster crows at the crack of dawn and likely be sleepy shortly after the sun goes down. The cabins are extremely rustic and this location is not for someone expecting a 5 star ..."
Reviewed on Sep 27, 2019
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Cayos Los Grullos Vacation Packages
More vacations you might like
Frequently asked questions
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.