Clarksdale Vacation Rentals

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Vacation Rentals in Clarksdale

Ant’s Waterfront 2 Bdrm Cabin w/ Best Sunset View!

Saint Joseph
9.0 out of 10, Wonderful, (22)
"Really was relaxing stay cabin was just what we needed thank you so much "
United States
Alan T.
$145 nightly
The price is $161
Dec 15 - Dec 16
Total with taxes and fees
Ant’s Waterfront 2 Bdrm Cabin w/ Best Sunset View!

Penthouse w/ Boho Loft, Jacuzzi, + Balcony -3 bdrm

Saint Joseph
9.2 out of 10, Wonderful, (15)
"Perfect place to stay while visiting family in town!"
United States
Cristy S.
$161 nightly
The price is $179
Dec 15 - Dec 16
Total with taxes and fees
Penthouse w/ Boho Loft, Jacuzzi, + Balcony -3 bdrm

1BR Retreat Prime Location Stay in Historic Charm

Saint Joseph
8.0 out of 10, Very Good, (3)
"Wonderful stay! Alexander was very helpful and responded very promptly. Clean quaint place. "
United States
Jodi W.
1BR Retreat Prime Location Stay in Historic Charm

Immersion Experience Into a Fictional Magical World

Saint Joseph
10.0 out of 10, Exceptional, (53)
"Great place to stay. Recommended with 2 thumbs up"
United States
Crystal R.
Immersion Experience Into a Fictional Magical World

French Quarters

Saint Joseph
9.2 out of 10, Wonderful, (22)
"That's a beautiful antique very well kept felt safe in the neighborhood and we you have no problem"
United States
Bruce B.
French Quarters

Cozy Colors Hideaway

Saint Joseph
9.4 out of 10, Exceptional, (12)
"The home was great and the hosts amazing! "
United States
randy w.
$303 nightly
The price is $317
Dec 9 - Dec 10
Total with taxes and fees
Cozy Colors Hideaway

Cozy Cactus Retreat-Family Friendly 4 bed/2bath near St. Joseph/Savannah, MO

2.0 star property
Saint Joseph
10.0 out of 10, Exceptional, (19)
"Very clean and spacious Would definitely stay there again"
United States
Jerry B.
$241 nightly
The price is $241
Dec 9 - Dec 10
Total with taxes and fees
Cozy Cactus Retreat-Family Friendly 4 bed/2bath near St. Joseph/Savannah, MO

1BR Getaway – Historic Charm in Prime Location

Saint Joseph
10.0 out of 10, Exceptional, (1)
"Clean, easily accessible, and simple made for an enjoyable stay. "
United States
Patricia W.
$131 nightly
The price is $131
Dec 11 - Dec 12
Total with taxes and fees
1BR Getaway – Historic Charm in Prime Location

Unique, Two-story 3bdr Apt w/ Spiral Staircase in Museum Hill

Saint Joseph
Unique, Two-story 3bdr Apt w/ Spiral Staircase in Museum Hill

Waterfront Sunset Cabin w/ Patio & Firepit- 2 bdrm

Saint Joseph
8.8 out of 10, Excellent, (25)
"I have stayed ay most of the units in this area, owned by this host. Every visit has been wonderful and I will continue to book at this host sites whenever I am in St. Joe"
United States
Duane C.
$145 nightly
The price is $161
Dec 14 - Dec 15
Total with taxes and fees
Waterfront Sunset Cabin w/ Patio & Firepit- 2 bdrm

Riverfront 2 bdrm Jacuzzi Cabin w/ Sunset Balcony

Saint Joseph
8.6 out of 10, Excellent, (12)
"We have stayed at other properties with the same manager. Everyone of them have been clean and ready to go when we got there. "
United States
Yancey C.
$155 nightly
The price is $173
Jan 5 - Jan 6, 2026
Total with taxes and fees
Riverfront 2 bdrm Jacuzzi Cabin w/ Sunset Balcony

Waterfront Rock Shower Suite w/ Sunset View Room!

Saint Joseph
$161 nightly
The price is $179
Dec 15 - Dec 16
Total with taxes and fees
Waterfront Rock Shower Suite w/ Sunset View Room!

Waterfront 3bd House w/ Sunset View & Fenced Yard

Saint Joseph
10.0 out of 10, Exceptional, (4)
"Nice, clean, comfortable. Very relaxing view of the river."
United States
rb24rb
$167 nightly
The price is $185
Dec 15 - Dec 16
Total with taxes and fees
Waterfront 3bd House w/ Sunset View & Fenced Yard

Welcome to Casa de Campo!

Saint Joseph
10.0 out of 10, Exceptional, (18)
"I stayed here with my mother & we loved it! So homey & cozy. Everything about it was great. Definitely recommend!"
United States
Rachel S.
$169 nightly
The price is $188
Jan 7 - Jan 8, 2026
Total with taxes and fees
Welcome to Casa de Campo!

Home Away From Home! Clean & Comfy 2-bedroom Home

St Joseph
10.0 out of 10, Exceptional, (33)
"It was great!"
United States
Jen W.
Home Away From Home! Clean & Comfy 2-bedroom Home

Secluded cabin on farmland with fire pit, pond, a/c & treehouse

2.0 star property
Maysville
9.8 out of 10, Exceptional, (10)
"Fantastic, secluded get away. The host was very easy to connect with and the cabin was well stocked. "
United States
Marcy
Secluded cabin on farmland with fire pit, pond, a/c & treehouse

"The Edmond" an 1887 Arts & Crafts gem! - 1 King - 1 Queen

Saint Joseph
10.0 out of 10, Exceptional, (17)
"We had a great stay! The property was lovely and well maintained. "
United States
Mary
$186 nightly
The price is $200
Dec 9 - Dec 10
Total with taxes and fees
"The Edmond" an 1887 Arts & Crafts gem! - 1 King - 1 Queen

Ant’s Riverfront Studio Cabin w/ Best View & Yard!

Saint Joseph
9.0 out of 10, Wonderful, (25)
"Easy check-in, good place to park, and the VRBO had all the necessities for an enjoyable weekend. Great place to bring your furry baby. The BEST is the VIEW of the Missouri River. The location is also very close to the Remington Nature Center, which was wonderful to explore. "
United States
Trana M.
$128 nightly
The price is $142
Dec 16 - Dec 17
Total with taxes and fees
Ant’s Riverfront Studio Cabin w/ Best View & Yard!

Comfortable & Clean 2-bdrm Home W/Great Amenities

Saint Joseph
10.0 out of 10, Exceptional, (22)
"Owner was great to work with, the property was in a nice location and beds were comfy. We would definitely stay there again."
United States
Amy W.
Comfortable & Clean 2-bdrm Home W/Great Amenities

My Fairleighdy is a 3-bedroom house, perfectly located in historic Saint Joseph.

Saint Joseph
10.0 out of 10, Exceptional, (1)
"Great size and quiet neighborhood. We were very happy with our stay!!"
United States
Dawn S.
$255 nightly
The price is $255
Dec 16 - Dec 17
Total with taxes and fees
My Fairleighdy is a 3-bedroom house, perfectly located in historic Saint Joseph.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Clarksdale Hotel Reviews

Find out more about Clarksdale

Everything you need to know about Clarksdale vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Clarksdale vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Clarksdale vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Clarksdale vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Clarksdale. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Clarksdale in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $131 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Clarksdale rentals

At Expedia, we put the best Clarksdale vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Clarksdale rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Clarksdale vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Clarksdale. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find a vacation rental in Clarksdale?

Yes, we offer vacation rentals close to the most popular local attractions in Clarksdale, or you can choose a more remote option if you're looking for a relaxing stay.

What are some of the best vacation rentals that Clarksdale has to offer?

Immersion Experience Into a Fictional Magical World: This vacation home rental near Clarksdale is located in the city center and has a garden, a selection of games, and a barbecue grill to put you at ease in your new surroundings. It has 5 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

What can I see and do in Clarksdale?

While exploring the area, visit family-friendly sights like Cool Crest Garden Golf, or get outside and enjoy nature at Civic Center Park. Glore Psychiatric Museum and Krug Park are a couple of places you'll find in the larger area.

What are vacation rentals like in Clarksdale?

Vacation rentals are privately owned accommodations you can reserve for several days or longer in Clarksdale. Vacation rentals offer extras such as kitchens and laundry facilities so you'll have all the comforts of home. If you're concerned about a clean environment, vacation rentals can offer a sense of security away from shared hotel elevators and busy front desks while still allowing you the experience of travel. You'll also have more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive option for a small group gathering.