Top 10 Hotels in Clarksdale, MO (from $76) 2026 - Competitive Prices

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Our top choices for Clarksdale hotels

A lobby with a seating area, a reception desk, and a chandelier.

A hotel room with a kitchenette, a sofa, a bench, a lamp, and a framed picture on the wall.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

A Drury Inn & Suites hotel with a modern architectural design, featuring a covered entrance and a parking lot.

1. Drury Inn & Suites St Joseph

St. Joseph

Luis

$110 nightly

$127 total

Sep 20 - Sep 21

Total with taxes and fees

An indoor swimming pool with clear lane markings, a lifeguard chair, and a pool ladder.

A neatly made bed with white linens and a headboard.

A snack and beverage vending area with various snack options and refrigerated beverage dispensers.

A reception desk with a clock, a framed picture, and a wall with a 'smile' sign.

2. Hampton Inn St. Joseph

St. Joseph

Gary

$89 nightly

$103 total

Sep 27 - Sep 28

Total with taxes and fees

A hotel room with a bed, a sofa, a small table, a microwave, and a TV.

A Holiday Inn Express & Suites sign with a building in the background.

A coffee station with two coffee machines, a coffee press, and various coffee pods and cups.

A hotel reception area with two reception desks, a wall-mounted sign, and a patterned carpet.

3. Holiday Inn Express Hotel & Suites St. Joseph by IHG

St. Joseph

April

$114 nightly

$132 total

Oct 4 - Oct 5

Total with taxes and fees

A pool area with a rock formation backdrop, a wooden post, and a sign indicating a clinic.

A hotel room with a large bed, a fireplace, a TV, and a jacuzzi.

A hotel with a stone facade, a covered entrance, and a landscaped area with a small pond.

A wooden reception desk with a moose mural, a mounted cow head, and a framed map on the wall.

4. Stoney Creek Hotel St. Joseph

St. Joseph

Carmen

$134 nightly

$155 total

Sep 20 - Sep 21

Total with taxes and fees

A hotel room with two beds, a desk, a television, and a bathroom visible through an open door.

A 8 ft. clearance hotel entrance with a SureStay sign, brick exterior, and potted plants.

A modern kitchen with granite countertops, wooden cabinets, and a central island.

A hotel with a covered outdoor area, a brick building, and a sign for a nearby Subway.

5. SureStay Hotel by Best Western Cameron

Cameron

John

$78 nightly

$86 total

Sep 20 - Sep 21

Total with taxes and fees

A modern living room with a blue sofa, a fireplace, and a stone accent wall.

A Fairfield Inn & Suites Marriott hotel entrance with a modern design, including a prominent overhang and a stone pillar.

An indoor swimming pool with clear water, a lifeguard chair, and a pool ladder.

A modern hotel lobby with a stone fireplace, blue sofas, a round table, and large windows offering a view of the parking lot.

6. Fairfield Inn & Suites by Marriott St. Joseph

St. Joseph

William

$114 nightly

$132 total

Oct 4 - Oct 5

Total with taxes and fees

A hotel room with a bed, a desk, a chair, a kitchenette, and a framed picture on the wall.

A modern restaurant with a bar area, seating arrangements, and a kitchen in the background.

7. My Place Hotel St Joseph MO

St. Joseph

Marcella

$89 nightly

$103 total

Sep 20 - Sep 21

Total with taxes and fees

A hotel room with a sofa, two beds, a patterned ottoman, a wall art piece, and a window with a view.

8. Home2 Suites By Hilton St. Joseph

St. Joseph

Stacey

$114 nightly

$132 total

Oct 4 - Oct 5

Total with taxes and fees

A hotel room with a large bed, two bedside tables, a nightstand, a red wall, and a framed picture on the wall.

A kitchen with wooden cabinets, a toaster, a fruit bowl, and a waffle maker.

A Red Roof Inn with a covered entrance, air conditioning units, and a parking lot with marked spaces.

A hotel reception area with a reception desk, a telephone, and a sign indicating free Wi-Fi in all rooms.

9. Red Roof Inn Cameron

Cameron

Kevin

$86 nightly

$95 total

Oct 1 - Oct 2

Total with taxes and fees

A swimming pool with a hot tub, a ladder, and a slide.

A reception area with a coffee station, a potted plant, and a banner promoting breakfast.

A reception area with a reception desk, a plant, a coffee station, and a sign for breakfast.

A hotel room with a large bed, two bedside tables with lamps, a desk, and a chair.

10. Quality Inn Cameron

Cameron

Mary Ashleigh

$117 nightly

$130 total

Sep 27 - Sep 28

Total with taxes and fees

A hotel room with a large bed, a red wall, and a cityscape painting above the bed.

A reception desk with a clock, decorative wall art, and American flags.

A hotel room with a television, a lamp, a microwave, and a desk with a chair.

11. AmeriStay Inn

St. Joseph

Debbie

$72 nightly

$83 total

Sep 30 - Oct 1

Total with taxes and fees

A hotel bathroom with a wooden bathtub, a desk with a lamp, a chair, a television, and a microwave.

An indoor swimming pool with clear water, surrounded by white plastic chairs and tables, and a lifeguard sign on the wall.

A two-story building with a covered parking area and a brick facade.

A reception area with a marble counter, a fish tank, a welcome sign, and a 'Super 8' sign.

12. Super 8 by Wyndham Cameron

Cameron

Bianca

$88 nightly

$96 total

Oct 11 - Oct 12

Total with taxes and fees

A hotel room with two beds, a desk, a chair, and a television.

A vending machine with snacks and a 7UP machine in a hallway with a staircase.

A hallway with a 7UP vending machine, white doors, and a brown mat.

A hotel reception area with a wooden counter, a coffee machine, a phone, and a television.

13. Motel 6 Saint Joseph, MO

St. Joseph

Dennis

$70 nightly

$81 total

Oct 4 - Oct 5

Total with taxes and fees

A large, historic brick building with a prominent tower and a grand entrance.

A traditional interior with a fireplace, wooden furniture, and a chandelier.

A traditional room with a fireplace, ornate chandelier, and classic furniture.

A brick building with a covered porch and a large bush of white flowers.

14. Vineyard Mansion & Carriage House Bed & Breakfast

St. Joseph

Stephanie

$147 nightly

$157 total

Sep 20 - Sep 21

Total with taxes and fees

A large brick building with multiple windows and a covered porch area.

A grand entrance with a stained glass window, a red upholstered sofa, and a wooden chair.

A red brick building with a garden in front.

A traditional interior with a fireplace, a wooden staircase, and a patterned floor.

15. Whiskey Mansion

St. Joseph

Sydney M

$156 nightly

$181 total

Sep 14 - Sep 15

Total with taxes and fees

A gazebo with a metal roof and wooden benches.

A hotel room with a wooden desk, two red chairs, a TV mounted on the wall, a mirror, and a wardrobe.

A living room with a leather sofa, a glass coffee table, and various potted plants.

A lobby with a fireplace, a table with four chairs, and a patterned carpet.

16. Econo Lodge Cameron

Cameron

Jeff

$75 nightly

$82 total

Oct 11 - Oct 12

Total with taxes and fees

A reception desk with a "WELCOME" sign, a clock, and a mirror.

A compact kitchenette with a microwave, sink, and small refrigerator.

A park bench with metal supports and a wooden seat, surrounded by trees and a gravel path.

A building with a covered entrance, brick walls, and a white roof.

17. Motel 6 Cameron, MO

Cameron

Brian

$70 nightly

$76 total

Sep 14 - Sep 15

Total with taxes and fees

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Top Clarksdale Hotel Reviews

Holiday Inn Express Hotel & Suites St. Joseph by IHG

10/10 Excellent

"The staff was great and the breakfast was delicious!"

Super 8 by Wyndham Cameron

10/10 Excellent

"Everything was perfect especially all staff thank you"

Whiskey Mansion

10/10 Excellent

"Beautiful restored home, beds were so comfortable. Quick drive to st Joe museums and downtown. Owner is super nice guy. We had a mix up with Expedia over the nights planned and he fixed it quickly."

SureStay Hotel by Best Western Cameron

8/10 Good

"Y"

Hampton Inn St. Joseph

8/10 Good

"Clean rooms,staff was very helpful. Pet friendy."

Vineyard Mansion & Carriage House Bed & Breakfast

10/10 Excellent

"Marcena was so welcoming and took great care of me. If I come back to St. Jo, I'd.love to stay there again. Thank you!"

My Place Hotel St Joseph MO

10/10 Excellent

"Never stayed at one. It was awesome. Very clean room with tons of amenities. Staff was wonderful and the parking was great. Kitchen was very useful."

Motel 6 Saint Joseph, MO

8/10 Good

"Yes. Air was nice and cool! No pets with me."

AmeriStay Inn

8/10 Good

"It’s an older property, worn linens and towels. However, the unit was clean and smelled GOOD (not your usual hotel musk), staff was helpful and kind."