Top 10 Hotels in Clarksdale, MO (from $76) 2026 - Competitive Prices

Go beyond your typical stay in Clarksdale

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Our top choices for Clarksdale hotels

A lobby with a seating area, a reception desk, and a chandelier.

A hotel lobby with a reception desk, seating area, and a refrigerator.

A Drury Inn & Suites hotel with a modern architectural design, featuring a covered entrance and a parking lot.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

1. Drury Inn & Suites St Joseph

St. Joseph

Anthony

$110 nightly

$127 total

Aug 30 - Aug 31

Total with taxes and fees

An indoor swimming pool with clear lane markings, a lifeguard chair, and a pool ladder.

A reception desk with a clock, a framed picture, and a wall with a 'smile' sign.

A Hampton Inn by Hilton building with a modern facade, large windows, and a well-lit entrance.

A snack and beverage vending area with various snack options and refrigerated beverage dispensers.

2. Hampton Inn St. Joseph

St. Joseph

Dagmar

$98 nightly

$113 total

Sep 7 - Sep 8

Total with taxes and fees

A buffet with labeled food stations including omelets and cheese.

A hotel lobby with a green sofa, yellow armchairs, a patterned carpet, and a reception desk.

A hotel room with a bed, a sofa, a small table, a microwave, and a TV.

A swimming pool with a no diving sign, wooden chairs, and windows with views.

3. Holiday Inn Express Hotel & Suites St. Joseph by IHG

St. Joseph

April

$105 nightly

$121 total

Aug 30 - Aug 31

Total with taxes and fees

A hotel room with a sofa, two beds, a patterned ottoman, a wall art piece, and a window with a view.

4. Home2 Suites By Hilton St. Joseph

St. Joseph

Stacey

$102 nightly

$118 total

Sep 6 - Sep 7

Total with taxes and fees

A modern living room with a blue sofa, a fireplace, and a stone accent wall.

An indoor swimming pool with clear water, a lifeguard chair, and a pool ladder.

A restaurant with a long wooden table, chairs, and a bar area.

A Fairfield Inn & Suites Marriott hotel entrance with a modern design, including a prominent overhang and a stone pillar.

5. Fairfield Inn & Suites by Marriott St. Joseph

St. Joseph

William

$114 nightly

$132 total

Sep 6 - Sep 7

Total with taxes and fees

A pool area with a rock formation backdrop, a wooden post, and a sign indicating a clinic.

A wooden reception desk with a moose mural, a mounted cow head, and a framed map on the wall.

A cozy log cabin interior with a fireplace, wooden furniture, and a television.

A hotel with a stone facade, a covered entrance, and a landscaped area with a small pond.

6. Stoney Creek Hotel St. Joseph

St. Joseph

Arnold

$129 nightly

$149 total

Sep 24 - Sep 25

Total with taxes and fees

A hotel room with two beds, a desk, a television, and a bathroom visible through an open door.

A modern kitchen with granite countertops, wooden cabinets, and a central island.

A hotel with a covered outdoor area, a brick building, and a sign for a nearby Subway.

A 8 ft. clearance hotel entrance with a SureStay sign, brick exterior, and potted plants.

7. SureStay Hotel by Best Western Cameron

Cameron

John

$78 nightly

$86 total

Aug 30 - Aug 31

Total with taxes and fees

A hotel room with a large bed, a red wall, and a cityscape painting above the bed.

A hotel room with a television, a lamp, a microwave, and a desk with a chair.

A restaurant with green tables and red chairs, a counter with a coffee machine, and a painting on the wall.

8. AmeriStay Inn

St. Joseph

Debbie

$72 nightly

$83 total

Sep 13 - Sep 14

Total with taxes and fees

A hotel room with a bed, a desk, a chair, a kitchenette, and a framed picture on the wall.

A modern restaurant with a bar area, seating arrangements, and a kitchen in the background.

A multi-story hotel with a 'My Place' sign, featuring a stone facade and a covered entrance.

9. My Place Hotel St Joseph MO

St. Joseph

Marcella

$89 nightly

$103 total

Sep 6 - Sep 7

Total with taxes and fees

A hotel room with a large bed, a desk, a chair, and a TV on the wall.

A hotel room with a bed, a desk, a chair, a TV mounted on the wall, and an air conditioning unit.

10. Red Roof Inn Cameron

Cameron

Gloria

$89 nightly

$98 total

Sep 1 - Sep 2

Total with taxes and fees

A hotel bathroom with a wooden bathtub, a desk with a lamp, a chair, a television, and a microwave.

A two-story building with a covered parking area and a brick facade.

A hotel room with a bed, a desk with a computer, a chair, a TV, and a window with a view.

A reception area with a marble counter, a fish tank, a welcome sign, and a 'Super 8' sign.

11. Super 8 by Wyndham Cameron

Cameron

James

$84 nightly

$93 total

Sep 12 - Sep 13

Total with taxes and fees

A swimming pool with a hot tub, a ladder, and a slide.

A reception area with a coffee station, a potted plant, and a banner promoting breakfast.

A reception area with a reception desk, a plant, a coffee station, and a sign for breakfast.

A hotel room with a brown sofa, a wooden coffee table, a desk with a chair, and a lamp. There are three framed pictures on the wall, a window with curtains, and a radiator.

12. Quality Inn Cameron

Cameron

Peggy

$114 nightly

$127 total

Sep 23 - Sep 24

Total with taxes and fees

A hotel room with two beds, a desk, a chair, and a television.

A vending machine with snacks and a 7UP machine in a hallway with a staircase.

A hotel reception area with a wooden counter, a coffee machine, a phone, and a television.

A hallway with a 7UP vending machine, white doors, and a brown mat.

13. Motel 6 Saint Joseph, MO

St. Joseph

Dennis

$69 nightly

$80 total

Aug 28 - Aug 29

Total with taxes and fees

A large brick building with multiple windows and a covered porch area.

A covered porch with columns, potted plants, and a brick wall.

A red brick building with a garden in front.

A grand entrance with a stained glass window, a red upholstered sofa, and a wooden chair.

14. Whiskey Mansion

St. Joseph

Gwen

$142 nightly

$164 total

Aug 26 - Aug 27

Total with taxes and fees

A large, historic brick building with a prominent tower and a grand entrance.

A grand room with a red patterned carpet, a large potted plant, a wooden staircase, and a chandelier.

A traditional room with a fireplace, ornate chandelier, and classic furniture.

A brick building with a covered porch and a large bush of white flowers.

15. Vineyard Mansion & Carriage House Bed & Breakfast

St. Joseph

Cathie

$147 nightly

$157 total

Aug 27 - Aug 28

Total with taxes and fees

A gazebo with a metal roof and wooden benches.

A lobby with a fireplace, a table with four chairs, and a patterned carpet.

A living room with a leather sofa, a glass coffee table, and various potted plants.

A hotel room with two beds, a nightstand with a lamp, a small table, a mirror, and a window.

16. Econo Lodge Cameron

Cameron

Jeff

$75 nightly

$82 total

Sep 7 - Sep 8

Total with taxes and fees

A living room with a dark sofa, two cushions, a small side table with a plant, and a floral wall decal with the text 'Stay a while'.

A kitchen with a bar area, black and red bar stools, a refrigerator, and a trash bin.

A wooden wall with a bed, a wall-mounted light fixture, and a power outlet.

A room with a pool table, a projector displaying a Roku interface, and a basketball hoop.

17. Firefly Lofts

Cameron

Jailayia

$288 nightly

$316 total

Sep 4 - Sep 5

Total with taxes and fees

A reception desk with a "WELCOME" sign, a clock, and a mirror.

A kitchenette with a coffee machine, a trash bin, and a coffee sign on the wall.

A living room with a sofa, coffee table, and side tables.

A compact kitchenette with a microwave, sink, and small refrigerator.

18. Motel 6 Cameron, MO

Cameron

Brian

$70 nightly

$76 total

Aug 25 - Aug 26

Total with taxes and fees

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Top Clarksdale Hotel Reviews

Super 8 by Wyndham Cameron

8/10 Good

"The room was clean. There was no hangers in the room or a place to hang anything except 3 pegs on the wall. The vanity was in the room, not in the same room as the shower and toilet. The beds were comfortable but the pillows were very soft and lumpy."

My Place Hotel St Joseph MO

10/10 Excellent

"Newer hotel. Clean with surprising room amenities. Must be designed for traveling construction workers. Room has full size refrigerator with ice maker, 2 burner stove, microwave and flat screen TV. From what I could tell, they only offer rooms with 2 Queen beds. Quiet location near many restaurants. Shopping area and Theatre close by."

Stoney Creek Hotel St. Joseph

10/10 Excellent

"Room was clean and bed was super comfortable. Great water pressure in the shower. All the staff was very friendly and helpful. Overall great stay."

Drury Inn & Suites St Joseph

10/10 Excellent

"Clean room and hotel. Food options and coffee were great. Staff was friendly."

Red Roof Inn Cameron

10/10 Excellent

"Nice room spacious location was good as well."

Quality Inn Cameron

10/10 Excellent

"Very efficient stay. Easy in and out. Clean and safe"

Holiday Inn Express Hotel & Suites St. Joseph by IHG

8/10 Good

"Enjoyable stay. This was a business trip. Convenient location."

Hampton Inn St. Joseph

8/10 Good

"they need to give a ty guide option on the tv paging through channels one at a time is a real hassle especcially when you want to relax and have to spend an hour trying to find something to watch. wont come back even cheaper hotels give tv guide info"

Whiskey Mansion

10/10 Excellent

"Olin is a great proprietor, and Holly and Sharon could not have been more helpful and kind in getting us going every morning with a hearty breakfast and wonderful cheer. I was with three kids and we all loved it. Will be back again."

More cheap stays in Clarksdale

SureStay Hotel by Best Western Cameron

2210 US Highway 36 Cameron MO

$78 nightly

$86 total

Aug 30 - Aug 31

Total with taxes and fees

8.2/10 Very Good! (1,002 reviews)