Title: Top 10 Hotels in Clarksdale, MO from $66 - Competitive Prices | Expedia.com [Vacation Rentals in Clarksdale](https://expedia.com/Clarksdale-Vacation-Rentals.d553248634983445286.Travel-Guide-VacationRentals)[Car Rentals in Clarksdale](https://expedia.com/Car-Rentals-In-Clarksdale.d553248634983445286.Car-Rental-Guide)[Clarksdale Vacation Packages](https://expedia.com/Clarksdale.d553248634983445286.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Clarksdale Pet-friendly [](https://www.expedia.com/Hotel-Search?destination=Clarksdale%2C+Missouri%2C+United+States+of+America®ionId=553248634983445286&latLong=39.813608%2C-94.550512&adults=2&startDate=2026-03-17&d1=2026-03-17&endDate=2026-03-19&d2=2026-03-19&amenities=PETS) Pool [](https://www.expedia.com/Hotel-Search?destination=Clarksdale%2C+Missouri%2C+United+States+of+America®ionId=553248634983445286&latLong=39.813608%2C-94.550512&adults=2&startDate=2026-03-17&d1=2026-03-17&endDate=2026-03-19&d2=2026-03-19&amenities=POOL) Great for families [](https://www.expedia.com/Hotel-Search?destination=Clarksdale%2C+Missouri%2C+United+States+of+America®ionId=553248634983445286&latLong=39.813608%2C-94.550512&adults=2&startDate=2026-03-17&d1=2026-03-17&endDate=2026-03-19&d2=2026-03-19&travelerType=family_friendly) Hot tub [](https://www.expedia.com/Hotel-Search?destination=Clarksdale%2C+Missouri%2C+United+States+of+America®ionId=553248634983445286&latLong=39.813608%2C-94.550512&adults=2&startDate=2026-03-17&d1=2026-03-17&endDate=2026-03-19&d2=2026-03-19&amenities=HOT_TUB) Apart­ment [](https://www.expedia.com/Hotel-Search?destination=Clarksdale%2C+Missouri%2C+United+States+of+America®ionId=553248634983445286&latLong=39.813608%2C-94.550512&adults=2&startDate=2026-03-17&d1=2026-03-17&endDate=2026-03-19&d2=2026-03-19&lodging=APARTMENT) ## Check prices for these dates Tonight [Mar 3 - Mar 4](https://www.expedia.com/Hotel-Search?regionId=553248634983445286&startDate=2026-03-03&endDate=2026-03-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 4 - Mar 5](https://www.expedia.com/Hotel-Search?regionId=553248634983445286&startDate=2026-03-04&endDate=2026-03-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=553248634983445286&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=553248634983445286&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Clarksdale hotels ![Front of property](https://images.trvl-media.com/lodging/19000000/18840000/18838600/18838527/86578d4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/19000000/18840000/18838600/18838527/8fa32ef0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/19000000/18840000/18838600/18838527/f76ef679.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/19000000/18840000/18838600/18838527/e03c581b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vineyard Mansion & Carriage House Bed & Breakfast [](https://www.expedia.com/St-Joseph-Hotels-Vineyard-Mansion-Carriage-House-Bed-Breakfast.h18838527.Hotel-Information) St. Joseph 9.0/10 Wonderful (200 reviews) "Enjoyed our stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vincent $147 nightly $157 total Mar 4 - Mar 5 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Vineyard-Mansion-Carriage-House-Bed-Breakfast.h18838527.Hotel-Information) ![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/aa4717a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/da4c15cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/33a09121.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/29a35617.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### My Place Hotel St Joseph MO [](https://www.expedia.com/St-Joseph-Hotels-My-Place-Hotel-St-Joesph-MO.h109463264.Hotel-Information) St. Joseph 9.2/10 Wonderful (220 reviews) "It was a clean place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ayden $74 nightly $85 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-My-Place-Hotel-St-Joesph-MO.h109463264.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/5000000/4220000/4214600/4214555/bd099a64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Miscellaneous](https://images.trvl-media.com/lodging/5000000/4220000/4214600/4214555/c9cd0093.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/5000000/4220000/4214600/4214555/cffb314f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/5000000/4220000/4214600/4214555/w1000h963x0y0-b16dd7a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Whiskey Mansion [](https://www.expedia.com/St-Joseph-Hotels-Whiskey-Mansion.h4214555.Hotel-Information) St. Joseph 9.2/10 Wonderful (589 reviews) "Bueatiful home, clean, quiet and fantastic service and food!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ellie $143 nightly $165 total Mar 28 - Mar 29 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Whiskey-Mansion.h4214555.Hotel-Information) ![Premium bedding, iron/ironing board, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/9d51d430.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/10d352cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/b3fa2b58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/6328c1ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AmeriStay Inn [](https://www.expedia.com/St-Joseph-Hotels-AmeriStay-Inn.h41477.Hotel-Information) St. Joseph 5.4/10 (712 reviews) "Always friendly staff and clean quiet rooms" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jacob $71 nightly $82 total Mar 9 - Mar 10 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-AmeriStay-Inn.h41477.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/47ec36cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/8955ad72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/55bf67a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/d40daa76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites St. Joseph by IHG [](https://www.expedia.com/St-Joseph-Hotels-Holiday-Inn-Express-Hotel-Suites-St-Joseph.h6846757.Hotel-Information) St. Joseph 9.2/10 Wonderful (810 reviews) "Breakfast was good, nice selection of food, Front desk staff were courteous and helpful, cleaning ladies were helpful, room was adequate, nice location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kim $101 nightly $117 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Holiday-Inn-Express-Hotel-Suites-St-Joseph.h6846757.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/115000000/114260000/114252400/114252394/574523e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi](https://images.trvl-media.com/lodging/115000000/114260000/114252400/114252394/30b33635.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Home2 Suites By Hilton St. Joseph [](https://www.expedia.com/St-Joseph-Hotels-Home2-Suites-By-Hilton-St-Joseph.h114252394.Hotel-Information) St. Joseph 9.4/10 Exceptional (103 reviews) "Great stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marcella M $106 nightly $122 total Mar 15 - Mar 16 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Home2-Suites-By-Hilton-St-Joseph.h114252394.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/2000000/1140000/1140000/1139931/82c1711e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Theme Suite with Whirlpool | Premium bedding, pillowtop beds, desk, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1140000/1140000/1139931/a2c57571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1140000/1140000/1139931/2de574ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1140000/1140000/1139931/f4de68bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stoney Creek Hotel St. Joseph [](https://www.expedia.com/St-Joseph-Hotels-Stoney-Creek-Hotel-St-Joseph.h1139931.Hotel-Information) St. Joseph 9.0/10 Wonderful (1,607 reviews) "Always enjoy staying here . Staff was awesome 👍" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) evvamae $124 nightly $143 total Mar 4 - Mar 5 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Stoney-Creek-Hotel-St-Joseph.h1139931.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/19000000/18180000/18179000/18178902/b42a1684.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/19000000/18180000/18179000/18178902/f5217c79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18180000/18179000/18178902/7977062c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/19000000/18180000/18179000/18178902/2dbfeb6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott St. Joseph [](https://www.expedia.com/St-Joseph-Hotels-Fairfield-Inn-Suites-By-Marriott-St-Joseph.h18178902.Hotel-Information) St. Joseph 9.6/10 Exceptional (480 reviews) "Clean room and friendly staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jerome $96 nightly $112 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Fairfield-Inn-Suites-By-Marriott-St-Joseph.h18178902.Hotel-Information) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/56e589c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/d7bb37bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/f99f9ca0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/8fa6ae99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Saint Joseph, MO [](https://www.expedia.com/St-Joseph-Hotels-Motel-6-Saint-Joseph.h49581.Hotel-Information) St. Joseph 4.6/10 (1,004 reviews) "Staff was very nice, very clean, pet friendly. Will definitely stay here again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amanda $72 nightly $83 total Mar 17 - Mar 18 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Motel-6-Saint-Joseph.h49581.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/110000/103100/103092/8e39c5c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/1000000/110000/103100/103092/d2e48a08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/110000/103100/103092/b90af532.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/110000/103100/103092/923f99c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn St. Joseph [](https://www.expedia.com/St-Joseph-Hotels-Hampton-Inn-St-Joseph.h103092.Hotel-Information) St. Joseph 8.2/10 Very Good (669 reviews) "A great place to stay-clean and friendly staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jason $79 nightly $92 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Hampton-Inn-St-Joseph.h103092.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/40000/40000/39991/917e85d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 Queen Bed, Accessible (Smoke Free) | Desk, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/40000/40000/39991/65cb8e48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/40000/40000/39991/dc26a342.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Queen Beds (Smoke Free) | Desk, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/40000/40000/39991/538cff90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Cameron [](https://www.expedia.com/St-Joseph-Hotels-Red-Roof-Inn-Cameron.h39991.Hotel-Information) Cameron 8.8/10 Excellent (1,003 reviews) "Clean room and friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica $82 nightly $91 total Mar 4 - Mar 5 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Red-Roof-Inn-Cameron.h39991.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4200/4180/d2b9e218.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4200/4180/15777d71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Accessible (Sofa Sleeper, Roll-in Shower, 2 Rooms) | Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/10000/4200/4180/97fa97c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/4200/4180/ce15b185.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites St Joseph [](https://www.expedia.com/St-Joseph-Hotels-Drury-Inn-Suites-St-Joseph.h4180.Hotel-Information) St. Joseph 9.4/10 Exceptional (1,002 reviews) "Amazing friendly staff, clean rooms, bathroom was spotless. Enjoyed my stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Aaron $100 nightly $116 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Drury-Inn-Suites-St-Joseph.h4180.Hotel-Information) ![Desk, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/10500/10417/ea88e07b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/10500/10417/a2399256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free breakfast](https://images.trvl-media.com/lodging/1000000/20000/10500/10417/60106125.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/10500/10417/80e80506.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SureStay Hotel by Best Western Cameron [](https://www.expedia.com/Cameron-Hotels-SureStay-Hotel-By-Best-Western-Cameron.h10417.Hotel-Information) Cameron 8.2/10 Very Good (1,002 reviews) "Good one night stay experience " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) LIQIANG $70 nightly $77 total Mar 11 - Mar 12 Total with taxes and fees [](https://www.expedia.com/Cameron-Hotels-SureStay-Hotel-By-Best-Western-Cameron.h10417.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42165/cdd2480a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/50000/42200/42165/eea04022.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42165/w3000h2001x0y1-908111e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42200/42165/602776a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Cameron [](https://www.expedia.com/St-Joseph-Hotels-Days-Inn-By-Wyndham-Cameron.h42165.Hotel-Information) Cameron 7.6/10 Good (842 reviews) "Easy to locate, quiet, room was clean, breakfast was OK" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vicki $66 nightly $73 total Apr 1 - Apr 2 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Days-Inn-By-Wyndham-Cameron.h42165.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/1000000/50000/42200/42192/85cb1016.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42192/a59c6aa9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/42200/42192/965f4dc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/42200/42192/27251199.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cameron [](https://www.expedia.com/St-Joseph-Hotels-Quality-Inn-Cameron.h42192.Hotel-Information) Cameron 8.4/10 Very Good (635 reviews) "Surprisingly quite next to the interstate. Older hotel, but still has some charm. Breakfast, customer service and the rooms were nice. My family and I enjoyed our stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimberly $103 nightly $115 total Apr 3 - Apr 4 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Quality-Inn-Cameron.h42192.Hotel-Information) ![Room, 1 King Bed, Hot Tub | Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/860000/855500/855452/fbe988e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855500/855452/d3b97e86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/860000/855500/855452/3d5ca308.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/860000/855500/855452/fd3d7861.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Cameron [](https://www.expedia.com/St-Joseph-Hotels-Super-8-By-Wyndham-Cameron.h855452.Hotel-Information) Cameron 8.4/10 Very Good (648 reviews) "Very clean and friendly staff. Nice place!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dean $75 nightly $82 total Mar 27 - Mar 28 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Super-8-By-Wyndham-Cameron.h855452.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/180000/171700/171630/683baa8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/180000/171700/171630/d13708b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/180000/171700/171630/7ac0c126.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Smoking, Ground Floor | Free cribs/infant beds, rollaway beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/180000/171700/171630/65898125.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Cameron [](https://www.expedia.com/St-Joseph-Hotels-Econo-Lodge-Cameron.h171630.Hotel-Information) Cameron 6.2/10 (162 reviews) "Lovely staff. Very helpful" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Colleen $68 nightly $75 total Mar 17 - Mar 18 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Econo-Lodge-Cameron.h171630.Hotel-Information) ![Deluxe Apartment, 3 Bedrooms, Park View | Park view](https://images.trvl-media.com/lodging/75000000/74710000/74704700/74704690/f105b4ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Apartment, 3 Bedrooms, Park View | 3 bedrooms, individually decorated, desk, laptop workspace](https://images.trvl-media.com/lodging/75000000/74710000/74704700/74704690/f2b04a15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Apartment, 3 Bedrooms, Park View | 3 bedrooms, individually decorated, desk, laptop workspace](https://images.trvl-media.com/lodging/75000000/74710000/74704700/74704690/w4032h2718x0y306-05e60f43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Apartment, 3 Bedrooms, Park View | Living area | 100-inch Smart TV with digital channels, TV, Netflix](https://images.trvl-media.com/lodging/75000000/74710000/74704700/74704690/e4bcc2ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cameron Suites [](https://www.expedia.com/Cameron-Hotels-Cameron-Suites.h74704690.Hotel-Information) Cameron $201 nightly $220 total Mar 4 - Mar 5 Total with taxes and fees [](https://www.expedia.com/Cameron-Hotels-Cameron-Suites.h74704690.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/10000000/10000000/9992800/9992788/c6efac2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/10000000/10000000/9992800/9992788/873f6f3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee and/or coffee maker](https://images.trvl-media.com/lodging/10000000/10000000/9992800/9992788/96bdd18f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/10000000/9992800/9992788/3cfc730e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Cameron, MO [](https://www.expedia.com/Cameron-Hotels-Motel-6-Cameron.h9992788.Hotel-Information) Cameron 7.0/10 Good (296 reviews) "Very clean and comfortable. Great staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joseph $59 nightly $66 total Mar 4 - Mar 5 Total with taxes and fees [](https://www.expedia.com/Cameron-Hotels-Motel-6-Cameron.h9992788.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-17&endDate=2026-03-18®ionId=553248634983445286&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=HTG_SPRING_PROMO_553248634983445286) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FClarksdale-Hotels.d553248634983445286.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FClarksdale-Hotels.d553248634983445286.Travel-Guide-Hotels) ## Top Clarksdale Hotel Reviews ![SureStay Hotel by Best Western Cameron](https://images.trvl-media.com/lodging/1000000/20000/10500/10417/b317db33_y.jpg) ### SureStay Hotel by Best Western Cameron 8/10 Good "Adequate clean room in an older motel." [](https://expedia.com/Cameron-Hotels-SureStay-Hotel-By-Best-Western-Cameron.h10417.Hotel-Information) ![Motel 6 Saint Joseph, MO](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/56e589c7_y.jpg) ### Motel 6 Saint Joseph, MO 2/10 Terrible "Dirty room. Bodily hair in sheets on bed, bathroom was dirty. Dust everywhere. Smoke alarm was beeping." [](https://expedia.com/St-Joseph-Hotels-Motel-6-Saint-Joseph.h49581.Hotel-Information) ![Fairfield Inn & Suites by Marriott St. Joseph](https://images.trvl-media.com/lodging/19000000/18180000/18179000/18178902/b42a1684_y.jpg) ### Fairfield Inn & Suites by Marriott St. Joseph 10/10 Excellent "I am hard to please and have high expectations and this Fairfield hit all the marks. It was clean, my room was well arranged, comfortable bed, spacious bathroom with room to lay out my personal items, a nice coffee station, desk, and more. The room is more spacious than the pictures would lead you to believe. I don’t eat breakfast but everything looked good and others seemed to be enjoying. I will definitely stay here again when back in St Joseph. " [](https://expedia.com/St-Joseph-Hotels-Fairfield-Inn-Suites-By-Marriott-St-Joseph.h18178902.Hotel-Information) ![Stoney Creek Hotel St. Joseph](https://images.trvl-media.com/lodging/2000000/1140000/1140000/1139931/82c1711e_y.jpg) ### Stoney Creek Hotel St. Joseph 10/10 Excellent "Clean, wonderful, great amminities !! Perfect and affordable" [](https://expedia.com/St-Joseph-Hotels-Stoney-Creek-Hotel-St-Joseph.h1139931.Hotel-Information) ![Holiday Inn Express Hotel & Suites St. Joseph by IHG](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/47ec36cb_y.jpg) ### Holiday Inn Express Hotel & Suites St. Joseph by IHG 10/10 Excellent "Very nice, clean and updated/new hotel. Great costumer service and complementary treats is a pleasant addition." [](https://expedia.com/St-Joseph-Hotels-Holiday-Inn-Express-Hotel-Suites-St-Joseph.h6846757.Hotel-Information) ![AmeriStay Inn](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/9d51d430_y.jpg) ### AmeriStay Inn 8/10 Good "Room was clean" [](https://expedia.com/St-Joseph-Hotels-AmeriStay-Inn.h41477.Hotel-Information) ![Quality Inn Cameron](https://images.trvl-media.com/lodging/1000000/50000/42200/42192/5baaa282_y.jpg) ### Quality Inn Cameron 10/10 Excellent "Room was very clean, hotel quiet and staff friendly and helpful. Comfortable bed too." [](https://expedia.com/St-Joseph-Hotels-Quality-Inn-Cameron.h42192.Hotel-Information) ![Drury Inn & Suites St Joseph](https://images.trvl-media.com/lodging/1000000/10000/4200/4180/d2b9e218_y.jpg) ### Drury Inn & Suites St Joseph 8/10 Good "We love the evening meal The rooms are dated and could use upgrading. We noticed when we stayed this last time it was kind of run down" [](https://expedia.com/St-Joseph-Hotels-Drury-Inn-Suites-St-Joseph.h4180.Hotel-Information) ![Super 8 by Wyndham Cameron](https://images.trvl-media.com/lodging/1000000/860000/855500/855452/fbe988e4_y.jpg) ### Super 8 by Wyndham Cameron 10/10 Excellent "The room was very clean, beds were very comfortable . Staff were friendly and helpful. It was almost like staying with family." [](https://expedia.com/St-Joseph-Hotels-Super-8-By-Wyndham-Cameron.h855452.Hotel-Information) ## More cheap stays in Clarksdale ![AmeriStay Inn](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/9d51d430_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### AmeriStay Inn 4502 SE US HWY 169 St. Joseph MO $71 nightly $82 total Mar 9 - Mar 10 Total with taxes and fees 5.4/10 (712 reviews) [](https://expedia.com/St-Joseph-Hotels-AmeriStay-Inn.h41477.Hotel-Information) ![Motel 6 Saint Joseph, MO](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/56e589c7_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Motel 6 Saint Joseph, MO 4021 Frederick Ave St. Joseph MO $72 nightly $83 total Mar 17 - Mar 18 Total with taxes and fees 4.6/10 (1,004 reviews) [](https://expedia.com/St-Joseph-Hotels-Motel-6-Saint-Joseph.h49581.Hotel-Information) ![My Place Hotel St Joseph MO](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/aa4717a0_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### My Place Hotel St Joseph MO 3621 N Village Dr St. Joseph MO $74 nightly $85 total Mar 22 - Mar 23 Total with taxes and fees 9.2/10 Wonderful! (220 reviews) [](https://expedia.com/St-Joseph-Hotels-My-Place-Hotel-St-Joesph-MO.h109463264.Hotel-Information) ![Red Roof Inn Cameron](https://images.trvl-media.com/lodging/1000000/40000/40000/39991/917e85d1_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Red Roof Inn Cameron 501 Northland Drive Cameron MO $82 nightly $91 total Mar 4 - Mar 5 Total with taxes and fees 8.8/10 Excellent! (1,003 reviews) [](https://expedia.com/St-Joseph-Hotels-Red-Roof-Inn-Cameron.h39991.Hotel-Information) ![Hampton Inn St. Joseph](https://images.trvl-media.com/lodging/1000000/110000/103100/103092/8e39c5c8_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn St. Joseph 3928 Frederick Ave St. Joseph MO $79 nightly $92 total Mar 8 - Mar 9 Total with taxes and fees [](https://expedia.com/St-Joseph-Hotels-Hampton-Inn-St-Joseph.h103092.Hotel-Information) ![Holiday Inn Express Hotel & Suites St. Joseph by IHG](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/47ec36cb_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express Hotel & Suites St. Joseph by IHG 3600 N. Village Dr. St. Joseph MO $101 nightly $117 total Mar 8 - Mar 9 Total with taxes and fees 9.2/10 Wonderful! (810 reviews) [](https://expedia.com/St-Joseph-Hotels-Holiday-Inn-Express-Hotel-Suites-St-Joseph.h6846757.Hotel-Information) ## Hotels in Clarksdale with star-rating ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 6 properties [](https://expedia.com/3Star-Clarksdale-Hotels.s30-0-d553248634983445286.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 27 properties [](https://expedia.com/2Star-Clarksdale-Hotels.s20-0-d553248634983445286.Travel-Guide-Filter-Hotels) ## Frequently asked questions ### What is the best area to stay in Clarksdale? > This central area is the heart of Clarksdale's blues music scene and is very walkable. You'll find a high concentration of blues clubs, juke joints, and historic markers. The Delta Blues Museum is also located downtown, offering a deep dive into the region's musical heritage. Many of the city's unique restaurants and shops are clustered here, making it convenient for exploring on foot. > > > Solo travelers and couples often find this area ideal due to its lively evenings and the ease of accessing various entertainment options. ### When is the best time to go to Clarksdale? > Spring brings mild temperatures, typically ranging from the 60s to 70s Fahrenheit, with blooming wildflowers and lush greenery. It's an excellent time for couples who enjoy outdoor activities like hiking or picnicking in nearby parks without the intense summer heat. The comfortable climate makes strolling through the small town center enjoyable. > > > Fall also provides agreeable temperatures, usually in the 60s, along with the scenic beauty of changing leaves. This period is ideal for solo travelers or those seeking a quiet retreat. The cooler weather is superb for visiting local antique shops, exploring historical sites, or simply enjoying a warm drink at a local coffee shop. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Clarksdale hotel booking with Expedia? > \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo. ### How much is the nightly rate at a Clarksdale hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Helena Hotels ](https://www.expedia.com/Helena-Hotels.d6179513.Travel-Guide-Hotels) - [Maysville Hotels ](https://www.expedia.com/Maysville-Hotels.d3000445233.Travel-Guide-Hotels) - [Osborn Hotels ](https://www.expedia.com/Osborn-Hotels.d3000349489.Travel-Guide-Hotels) - [5 Star Hotels in Maysville ](https://www.expedia.com/5Star-Maysville-Hotels.s50-0-d3000445233.Travel-Guide-Filter-Hotels) - [B&B in Osborn ](https://www.expedia.com/Osborn-Bed-And-Breakfast.d3000349489-aaBedAndBreakfast.Travel-Guide-Accommodation) - [5 Star Hotels in Osborn ](https://www.expedia.com/5Star-Osborn-Hotels.s50-0-d3000349489.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Osborn ](https://www.expedia.com/3Star-Osborn-Hotels.s30-0-d3000349489.Travel-Guide-Filter-Hotels) - 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