Top 10 Hotels in Clarksdale, MO (from $81) 2026 - Competitive Prices

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Our top choices for Clarksdale hotels

A lobby with a seating area, a reception desk, and a chandelier.

A hotel room with a kitchenette, a sofa, a bench, a lamp, and a framed picture on the wall.

A Drury Inn & Suites hotel with a modern architectural design, featuring a covered entrance and a parking lot.

A hotel lobby with a reception desk, seating area, and a refrigerator.

1. Drury Inn & Suites St Joseph

St. Joseph

Luis

$110 nightly

$127 total

Sep 27 - Sep 28

Total with taxes and fees

An indoor swimming pool with clear lane markings, a lifeguard chair, and a pool ladder.

A snack and beverage vending area with various snack options and refrigerated beverage dispensers.

A reception desk with a clock, a framed picture, and a wall with a 'smile' sign.

A Hampton Inn by Hilton building with a modern facade, large windows, and a well-lit entrance.

2. Hampton Inn St. Joseph

St. Joseph

Gary

$89 nightly

$103 total

Oct 4 - Oct 5

Total with taxes and fees

A pool area with a rock formation backdrop, a wooden post, and a sign indicating a clinic.

A hotel with a stone facade, a covered entrance, and a landscaped area with a small pond.

A hotel room with a large bed, a fireplace, a TV, and a jacuzzi.

A wooden reception desk with a moose mural, a mounted cow head, and a framed map on the wall.

3. Stoney Creek Hotel St. Joseph

St. Joseph

Carmen

$134 nightly

$155 total

Sep 20 - Sep 21

Total with taxes and fees

A hotel room with a bed, a sofa, a small table, a microwave, and a TV.

A hotel reception area with two reception desks, a wall-mounted sign, and a patterned carpet.

A coffee station with two coffee machines, a coffee press, and various coffee pods and cups.

A coffee station with two espresso machines, a sign reading "MUST HAVE COFFEE", and a display of coffee-related products.

4. Holiday Inn Express Hotel & Suites St. Joseph by IHG

St. Joseph

Teresa

$115 nightly

$133 total

Oct 18 - Oct 19

Total with taxes and fees

A modern living room with a blue sofa, a fireplace, and a stone accent wall.

A modern hotel lobby with a stone fireplace, blue sofas, a round table, and large windows offering a view of the parking lot.

An indoor swimming pool with clear water, a lifeguard chair, and a pool ladder.

A Fairfield Inn & Suites Marriott hotel entrance with a modern design, including a prominent overhang and a stone pillar.

5. Fairfield Inn & Suites by Marriott St. Joseph

St. Joseph

William

$105 nightly

$122 total

Oct 18 - Oct 19

Total with taxes and fees

A hotel room with a sofa, two beds, a patterned ottoman, a wall art piece, and a window with a view.

6. Home2 Suites By Hilton St. Joseph

St. Joseph

Stacey

$114 nightly

$132 total

Oct 11 - Oct 12

Total with taxes and fees

A swimming pool with a hot tub, a ladder, and a slide.

A reception area with a reception desk, a plant, a coffee station, and a sign for breakfast.

A hotel room with a large bed, two bedside tables with lamps, a desk, and a chair.

A hotel room with a brown sofa, a wooden coffee table, a desk with a chair, and a lamp. There are three framed pictures on the wall, a window with curtains, and a radiator.

7. Quality Inn Cameron

Cameron

Mary Ashleigh

$113 nightly

$126 total

Oct 18 - Oct 19

Total with taxes and fees

A hotel room with a large bed, two bedside tables, a nightstand, a red wall, and a framed picture on the wall.

A hotel room with a bed, a desk, a chair, a television, and an air conditioning unit.

A kitchen with wooden cabinets, a toaster, a fruit bowl, and a waffle maker.

A hotel reception area with a reception desk, a telephone, and a sign indicating free Wi-Fi in all rooms.

8. Red Roof Inn Cameron

Cameron

Kevin

$86 nightly

$95 total

Oct 1 - Oct 2

Total with taxes and fees

A hotel room with two beds, a desk, a television, and a bathroom visible through an open door.

A cozy room with a coffee machine, a clock, and a potted plant.

A 8 ft. clearance hotel entrance with a SureStay sign, brick exterior, and potted plants.

A hotel with a covered outdoor area, a brick building, and a sign for a nearby Subway.

9. SureStay Hotel by Best Western Cameron

Cameron

John

$78 nightly

$86 total

Sep 24 - Sep 25

Total with taxes and fees

A multi-story hotel with a 'My Place' sign, featuring a stone facade and a covered entrance.

A modern restaurant with a bar area, seating arrangements, and a kitchen in the background.

A hotel room with a bed, a desk, a chair, a kitchenette, and a framed picture on the wall.

10. My Place Hotel St Joseph MO

St. Joseph

Marcella

$90 nightly

$104 total

Oct 18 - Oct 19

Total with taxes and fees

A hotel bathroom with a wooden bathtub, a desk with a lamp, a chair, a television, and a microwave.

A hotel room with a bed, a desk with a computer, a chair, a TV, and a window with a view.

A reception area with a marble counter, a fish tank, a welcome sign, and a 'Super 8' sign.

An indoor swimming pool with clear water, surrounded by white plastic chairs and tables, and a lifeguard sign on the wall.

11. Super 8 by Wyndham Cameron

Cameron

Bianca

$90 nightly

$99 total

Oct 1 - Oct 2

Total with taxes and fees

A hotel room with a large bed, a red wall, and a cityscape painting above the bed.

A reception desk with a clock, decorative wall art, and American flags.

A restaurant with green tables and red chairs, a counter with a coffee machine, and a painting on the wall.

A hotel room with a television, a lamp, a microwave, and a desk with a chair.

12. AmeriStay Inn

St. Joseph

Paul

$72 nightly

$84 total

Oct 12 - Oct 13

Total with taxes and fees

A large, historic brick building with a prominent tower and a grand entrance.

A traditional room with a fireplace, ornate chandelier, and classic furniture.

A traditional interior with a fireplace, wooden furniture, and a chandelier.

A grand room with a red patterned carpet, a large potted plant, a wooden staircase, and a chandelier.

13. Vineyard Mansion & Carriage House Bed & Breakfast

St. Joseph

Stephanie

$147 nightly

$157 total

Sep 18 - Sep 19

Total with taxes and fees

A hotel room with two beds, a desk, a chair, and a television.

A hotel reception area with a wooden counter, a coffee machine, a phone, and a television.

A vending machine with snacks and a 7UP machine in a hallway with a staircase.

A hallway with a 7UP vending machine, white doors, and a brown mat.

14. Motel 6 Saint Joseph, MO

St. Joseph

Tina

$70 nightly

$81 total

Oct 4 - Oct 5

Total with taxes and fees

A large brick building with multiple windows and a covered porch area.

A red brick building with a garden in front.

A covered porch with columns, potted plants, and a brick wall.

A traditional interior with a fireplace, a wooden staircase, and a patterned floor.

15. Whiskey Mansion

St. Joseph

Sydney M

$139 nightly

$161 total

Oct 17 - Oct 18

Total with taxes and fees

A living room with a dark sofa, two cushions, a small side table with a plant, and a floral wall decal with the text 'Stay a while'.

A room with a pool table, a projector displaying a Roku interface, and a basketball hoop.

A wooden wall with a bed, a wall-mounted light fixture, and a power outlet.

A single bed with a wooden frame and black bedding, a brick wall, a window with a view, and a black door.

16. Firefly Lofts

Cameron

Jailayia

$255 nightly

$279 total

Oct 16 - Oct 17

Total with taxes and fees

A bedroom with a curved ceiling, a large window with a view of Earth, a bed with a grey duvet, and a small table with a lamp.

A room with a table and a stool, a window with shutters, and a door with a mirror.

A single-story house with a dark exterior, a front door, a small porch, and a number '620' sign.

17. Dragon's Den Lodging

Cameron

James

$96 nightly

$105 total

Oct 16 - Oct 17

Total with taxes and fees

A modern living room with a grey sofa, a blue ottoman, a black chair, a floor lamp, and a patterned rug.

A modern hotel room with a kitchenette, a blue ottoman, and a patterned rug.

A reception desk with a green wall, a wooden counter, and a sign indicating check-in/out times.

A compact kitchen with a refrigerator, microwave, sink, and wooden cabinets.

18. Woodspring Suites St. Joseph

St. Joseph

$99 nightly

$115 total

Oct 15 - Oct 16

Total with taxes and fees

A gazebo with a metal roof and wooden benches.

A hotel room with two beds, a nightstand with a lamp, a small table, a mirror, and a window.

A hotel room with a wooden desk, two red chairs, a TV mounted on the wall, a mirror, and a wardrobe.

A living room with a leather sofa, a glass coffee table, and various potted plants.

19. Econo Lodge Cameron

Cameron

Jeff

$76 nightly

$84 total

Sep 30 - Oct 1

Total with taxes and fees

A reception desk with a "WELCOME" sign, a clock, and a mirror.

A hotel room with two beds, a desk with a chair, a microwave, a TV, and a small shelf with toiletries.

A compact kitchenette with a microwave, sink, and small refrigerator.

A park bench with metal supports and a wooden seat, surrounded by trees and a gravel path.

20. Motel 6 Cameron, MO

Cameron

Mark

$75 nightly

$82 total

Sep 19 - Sep 20

Total with taxes and fees

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Top Clarksdale Hotel Reviews

Drury Inn & Suites St Joseph

10/10 Excellent

"A comfortable and quiet stay - Great food for Supper and Breakfast"

Red Roof Inn Cameron

10/10 Excellent

"Godd"

My Place Hotel St Joseph MO

10/10 Excellent

"No thanks"

Vineyard Mansion & Carriage House Bed & Breakfast

8/10 Good

"I stayed four nights in the Crown Room while in town for my daughter’s birthday. The room was clean, the bed was comfortable, and there was coffee ready every morning, which I appreciated. A few things stood out as less positive. When I first walked in and was looking around, I stepped in dog feces. That was an unpleasant welcome. I also regularly heard someone walking around on what seemed to be the third floor above me, which woke me up at times during the night. The website describes this as an “alternative bed and breakfast” and invites guests to help themselves to items in the pantry and fridge. In practice there was no clear separation between host food and guest food, which felt confusing. Designated guest areas or clearer labeling would help. I only saw the on-site host twice. She lives at the property. I’m fairly shy, and she came across as somewhat unfriendly, so interactions felt a bit awkward. Overall the space itself was fine and the bed and coffee were positives, but the cleanliness issue on arrival, the nighttime noise from above, the unclear shared kitchen setup, and limited host interaction left me with mixed feelings."

Hampton Inn St. Joseph

10/10 Excellent

"I thought it was clean, quiet, well attended, breakfast was great!"

SureStay Hotel by Best Western Cameron

10/10 Excellent

"Clean, comfortable room and grounds and dog friendly. Decent breakfast and helpful staff. I always stay here with my dog when I am going through the area."

Super 8 by Wyndham Cameron

10/10 Excellent

"Everything was perfect especially all staff thank you"

Whiskey Mansion

10/10 Excellent

"Beautiful restored home, beds were so comfortable. Quick drive to st Joe museums and downtown. Owner is super nice guy. We had a mix up with Expedia over the nights planned and he fixed it quickly."

Motel 6 Saint Joseph, MO

8/10 Good

"Yes. Air was nice and cool! No pets with me."

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