Title: Top 10 Hotels in Clarksdale, MO from $66 - Competitive Prices | Expedia.com [Vacation Rentals in Clarksdale](https://expedia.com/Clarksdale-Vacation-Rentals.d553248634983445286.Travel-Guide-VacationRentals)[Car Rentals in Clarksdale](https://expedia.com/Car-Rentals-In-Clarksdale.d553248634983445286.Car-Rental-Guide)[Clarksdale Vacation Packages](https://expedia.com/Clarksdale.d553248634983445286.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Clarksdale Pet-friendly [](https://www.expedia.com/Hotel-Search?destination=Clarksdale%2C+Missouri%2C+United+States+of+America®ionId=553248634983445286&latLong=39.813608%2C-94.550512&adults=2&startDate=2026-03-18&d1=2026-03-18&endDate=2026-03-20&d2=2026-03-20&amenities=PETS) Pool [](https://www.expedia.com/Hotel-Search?destination=Clarksdale%2C+Missouri%2C+United+States+of+America®ionId=553248634983445286&latLong=39.813608%2C-94.550512&adults=2&startDate=2026-03-18&d1=2026-03-18&endDate=2026-03-20&d2=2026-03-20&amenities=POOL) Great for families [](https://www.expedia.com/Hotel-Search?destination=Clarksdale%2C+Missouri%2C+United+States+of+America®ionId=553248634983445286&latLong=39.813608%2C-94.550512&adults=2&startDate=2026-03-18&d1=2026-03-18&endDate=2026-03-20&d2=2026-03-20&travelerType=family_friendly) Hot tub [](https://www.expedia.com/Hotel-Search?destination=Clarksdale%2C+Missouri%2C+United+States+of+America®ionId=553248634983445286&latLong=39.813608%2C-94.550512&adults=2&startDate=2026-03-18&d1=2026-03-18&endDate=2026-03-20&d2=2026-03-20&amenities=HOT_TUB) Apart­ment [](https://www.expedia.com/Hotel-Search?destination=Clarksdale%2C+Missouri%2C+United+States+of+America®ionId=553248634983445286&latLong=39.813608%2C-94.550512&adults=2&startDate=2026-03-18&d1=2026-03-18&endDate=2026-03-20&d2=2026-03-20&lodging=APARTMENT) ## Check prices for these dates Tonight [Mar 4 - Mar 5](https://www.expedia.com/Hotel-Search?regionId=553248634983445286&startDate=2026-03-04&endDate=2026-03-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 5 - Mar 6](https://www.expedia.com/Hotel-Search?regionId=553248634983445286&startDate=2026-03-05&endDate=2026-03-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=553248634983445286&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=553248634983445286&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Clarksdale hotels ![Front of property](https://images.trvl-media.com/lodging/19000000/18840000/18838600/18838527/86578d4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/19000000/18840000/18838600/18838527/8fa32ef0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/19000000/18840000/18838600/18838527/f76ef679.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/19000000/18840000/18838600/18838527/f4c6728d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vineyard Mansion & Carriage House Bed & Breakfast [](https://www.expedia.com/St-Joseph-Hotels-Vineyard-Mansion-Carriage-House-Bed-Breakfast.h18838527.Hotel-Information) St. Joseph 9.0/10 Wonderful (200 reviews) "Enjoyed our stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vincent $147 nightly $157 total Mar 5 - Mar 6 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Vineyard-Mansion-Carriage-House-Bed-Breakfast.h18838527.Hotel-Information) ![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/aa4717a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/da4c15cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/w3000h1897x0y3-644920c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/33a09121.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### My Place Hotel St Joseph MO [](https://www.expedia.com/St-Joseph-Hotels-My-Place-Hotel-St-Joesph-MO.h109463264.Hotel-Information) St. Joseph 9.2/10 Wonderful (223 reviews) "It was a clean place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ayden $74 nightly $85 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-My-Place-Hotel-St-Joesph-MO.h109463264.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/5000000/4220000/4214600/4214555/bd099a64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Miscellaneous](https://images.trvl-media.com/lodging/5000000/4220000/4214600/4214555/c9cd0093.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/5000000/4220000/4214600/4214555/cffb314f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/5000000/4220000/4214600/4214555/w1000h963x0y0-b16dd7a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Whiskey Mansion [](https://www.expedia.com/St-Joseph-Hotels-Whiskey-Mansion.h4214555.Hotel-Information) St. Joseph 9.2/10 Wonderful (589 reviews) "Bueatiful home, clean, quiet and fantastic service and food!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ellie $137 nightly $159 total Apr 4 - Apr 5 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Whiskey-Mansion.h4214555.Hotel-Information) ![Premium bedding, iron/ironing board, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/9d51d430.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/b3fa2b58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/10d352cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/6685816e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AmeriStay Inn [](https://www.expedia.com/St-Joseph-Hotels-AmeriStay-Inn.h41477.Hotel-Information) St. Joseph 5.4/10 (712 reviews) "Always friendly staff and clean quiet rooms" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jacob $71 nightly $82 total Mar 9 - Mar 10 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-AmeriStay-Inn.h41477.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/47ec36cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/71deeec7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/8955ad72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/d40daa76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites St. Joseph by IHG [](https://www.expedia.com/St-Joseph-Hotels-Holiday-Inn-Express-Hotel-Suites-St-Joseph.h6846757.Hotel-Information) St. Joseph 9.2/10 Wonderful (810 reviews) "Breakfast was good, nice selection of food, Front desk staff were courteous and helpful, cleaning ladies were helpful, room was adequate, nice location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kim $101 nightly $117 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Holiday-Inn-Express-Hotel-Suites-St-Joseph.h6846757.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/115000000/114260000/114252400/114252394/574523e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi](https://images.trvl-media.com/lodging/115000000/114260000/114252400/114252394/30b33635.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Home2 Suites By Hilton St. Joseph [](https://www.expedia.com/St-Joseph-Hotels-Home2-Suites-By-Hilton-St-Joseph.h114252394.Hotel-Information) St. Joseph 9.4/10 Exceptional (103 reviews) "Great stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marcella M $98 nightly $113 total Mar 15 - Mar 16 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Home2-Suites-By-Hilton-St-Joseph.h114252394.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/2000000/1140000/1140000/1139931/82c1711e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1140000/1140000/1139931/64e61c4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1140000/1140000/1139931/2de574ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Theme Suite with Whirlpool | Premium bedding, pillowtop beds, desk, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1140000/1140000/1139931/a2c57571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stoney Creek Hotel St. Joseph [](https://www.expedia.com/St-Joseph-Hotels-Stoney-Creek-Hotel-St-Joseph.h1139931.Hotel-Information) St. Joseph 9.0/10 Wonderful (1,607 reviews) "Always enjoy staying here . Staff was awesome 👍" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) evvamae $123 nightly $142 total Mar 13 - Mar 14 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Stoney-Creek-Hotel-St-Joseph.h1139931.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/19000000/18180000/18179000/18178902/b42a1684.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/19000000/18180000/18179000/18178902/e0d9868d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18180000/18179000/18178902/7977062c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/19000000/18180000/18179000/18178902/f5217c79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott St. Joseph [](https://www.expedia.com/St-Joseph-Hotels-Fairfield-Inn-Suites-By-Marriott-St-Joseph.h18178902.Hotel-Information) St. Joseph 9.6/10 Exceptional (480 reviews) "Clean room and friendly staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jerome $96 nightly $112 total Mar 15 - Mar 16 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Fairfield-Inn-Suites-By-Marriott-St-Joseph.h18178902.Hotel-Information) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/56e589c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/f99f9ca0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/eb107eed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/d7bb37bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Saint Joseph, MO [](https://www.expedia.com/St-Joseph-Hotels-Motel-6-Saint-Joseph.h49581.Hotel-Information) St. Joseph 4.6/10 (1,005 reviews) "Staff was very nice, very clean, pet friendly. Will definitely stay here again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amanda $75 nightly $87 total Mar 5 - Mar 6 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Motel-6-Saint-Joseph.h49581.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/110000/103100/103092/8e39c5c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/110000/103100/103092/923f99c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/110000/103100/103092/b90af532.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/110000/103100/103092/8254b815.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn St. Joseph [](https://www.expedia.com/St-Joseph-Hotels-Hampton-Inn-St-Joseph.h103092.Hotel-Information) St. Joseph 8.2/10 Very Good (670 reviews) "A great place to stay-clean and friendly staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jason $79 nightly $92 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Hampton-Inn-St-Joseph.h103092.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/40000/40000/39991/917e85d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Queen Beds (Smoke Free) | Desk, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/40000/40000/39991/538cff90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/40000/39991/cc53b139.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 Queen Bed, Accessible (Smoke Free) | Desk, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/40000/40000/39991/65cb8e48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Cameron [](https://www.expedia.com/St-Joseph-Hotels-Red-Roof-Inn-Cameron.h39991.Hotel-Information) Cameron 8.8/10 Excellent (1,003 reviews) "Clean room and friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica $82 nightly $91 total Mar 5 - Mar 6 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Red-Roof-Inn-Cameron.h39991.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4200/4180/d2b9e218.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4200/4180/15777d71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4200/4180/2dd83c29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Accessible (Sofa Sleeper, Roll-in Shower, 2 Rooms) | Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/10000/4200/4180/97fa97c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites St Joseph [](https://www.expedia.com/St-Joseph-Hotels-Drury-Inn-Suites-St-Joseph.h4180.Hotel-Information) St. Joseph 9.4/10 Exceptional (1,003 reviews) "Amazing friendly staff, clean rooms, bathroom was spotless. Enjoyed my stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Aaron $100 nightly $116 total Mar 15 - Mar 16 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Drury-Inn-Suites-St-Joseph.h4180.Hotel-Information) ![Desk, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/10500/10417/ea88e07b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free breakfast](https://images.trvl-media.com/lodging/1000000/20000/10500/10417/60106125.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/10500/10417/33a59e94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/10500/10417/a2399256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SureStay Hotel by Best Western Cameron [](https://www.expedia.com/Cameron-Hotels-SureStay-Hotel-By-Best-Western-Cameron.h10417.Hotel-Information) Cameron 8.2/10 Very Good (1,004 reviews) "Good one night stay experience " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) LIQIANG $70 nightly $77 total Mar 12 - Mar 13 Total with taxes and fees [](https://www.expedia.com/Cameron-Hotels-SureStay-Hotel-By-Best-Western-Cameron.h10417.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42165/cdd2480a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42200/42165/602776a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking | In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42200/42165/9fa0a9ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42165/w3000h2001x0y1-908111e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Cameron [](https://www.expedia.com/St-Joseph-Hotels-Days-Inn-By-Wyndham-Cameron.h42165.Hotel-Information) Cameron 7.6/10 Good (842 reviews) "Easy to locate, quiet, room was clean, breakfast was OK" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vicki $66 nightly $73 total Apr 1 - Apr 2 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Days-Inn-By-Wyndham-Cameron.h42165.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/1000000/50000/42200/42192/85cb1016.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/42200/42192/27251199.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/42200/42192/965f4dc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking | In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/42200/42192/28b1385b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cameron [](https://www.expedia.com/St-Joseph-Hotels-Quality-Inn-Cameron.h42192.Hotel-Information) Cameron 8.4/10 Very Good (636 reviews) "Surprisingly quite next to the interstate. Older hotel, but still has some charm. Breakfast, customer service and the rooms were nice. My family and I enjoyed our stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimberly $103 nightly $114 total Apr 3 - Apr 4 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Quality-Inn-Cameron.h42192.Hotel-Information) ![Room, 1 King Bed, Hot Tub | Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/860000/855500/855452/fbe988e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855500/855452/2c2d2265.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/860000/855500/855452/fd3d7861.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855500/855452/d3b97e86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Cameron [](https://www.expedia.com/St-Joseph-Hotels-Super-8-By-Wyndham-Cameron.h855452.Hotel-Information) Cameron 8.4/10 Very Good (648 reviews) "Very clean and friendly staff. Nice place!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dean $75 nightly $82 total Mar 27 - Mar 28 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Super-8-By-Wyndham-Cameron.h855452.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/180000/171700/171630/683baa8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Smoking, Ground Floor | Free cribs/infant beds, rollaway beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/180000/171700/171630/65898125.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free cribs/infant beds, rollaway beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/180000/171700/171630/f60992f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/180000/171700/171630/7ac0c126.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Cameron [](https://www.expedia.com/St-Joseph-Hotels-Econo-Lodge-Cameron.h171630.Hotel-Information) Cameron 6.2/10 (162 reviews) "Lovely staff. Very helpful" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Colleen $67 nightly $74 total Mar 15 - Mar 16 Total with taxes and fees [](https://www.expedia.com/St-Joseph-Hotels-Econo-Lodge-Cameron.h171630.Hotel-Information) ![Deluxe Apartment, 3 Bedrooms, Park View | Park view](https://images.trvl-media.com/lodging/75000000/74710000/74704700/74704690/f105b4ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Apartment, 3 Bedrooms, Park View | Living area | 100-inch Smart TV with digital channels, TV, Netflix](https://images.trvl-media.com/lodging/75000000/74710000/74704700/74704690/e4bcc2ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Apartment, 3 Bedrooms, Park View | 3 bedrooms, individually decorated, desk, laptop workspace](https://images.trvl-media.com/lodging/75000000/74710000/74704700/74704690/w4032h2718x0y306-05e60f43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Apartment, 3 Bedrooms, Park View | In-room dining](https://images.trvl-media.com/lodging/75000000/74710000/74704700/74704690/9ed1ca1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cameron Suites [](https://www.expedia.com/Cameron-Hotels-Cameron-Suites.h74704690.Hotel-Information) Cameron $201 nightly $220 total Mar 5 - Mar 6 Total with taxes and fees [](https://www.expedia.com/Cameron-Hotels-Cameron-Suites.h74704690.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/10000000/10000000/9992800/9992788/c6efac2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/10000000/10000000/9992800/9992788/79d2554d_edited_dfdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/10000000/10000000/9992800/9992788/873f6f3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee and/or coffee maker](https://images.trvl-media.com/lodging/10000000/10000000/9992800/9992788/96bdd18f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Cameron, MO [](https://www.expedia.com/Cameron-Hotels-Motel-6-Cameron.h9992788.Hotel-Information) Cameron 7.0/10 Good (296 reviews) "Very clean and comfortable. Great staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joseph $59 nightly $66 total Mar 5 - Mar 6 Total with taxes and fees [](https://www.expedia.com/Cameron-Hotels-Motel-6-Cameron.h9992788.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-18&endDate=2026-03-19®ionId=553248634983445286&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=HTG_SPRING_PROMO_553248634983445286) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FClarksdale-Hotels.d553248634983445286.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FClarksdale-Hotels.d553248634983445286.Travel-Guide-Hotels) ## Top Clarksdale Hotel Reviews ![SureStay Hotel by Best Western Cameron](https://images.trvl-media.com/lodging/1000000/20000/10500/10417/b317db33_y.jpg) ### SureStay Hotel by Best Western Cameron 8/10 Good "Very nice " [](https://expedia.com/Cameron-Hotels-SureStay-Hotel-By-Best-Western-Cameron.h10417.Hotel-Information) ![Quality Inn Cameron](https://images.trvl-media.com/lodging/1000000/50000/42200/42192/5baaa282_y.jpg) ### Quality Inn Cameron 8/10 Good "The staff was nice, but often there was no one at the front desk. The breakfast was barely okay - there was NO butter, only margarine and not a great variety of other items either. But the worst was the treadmill - that is something that we specifically look for - this one was about half the size of a normal treadmill - it felt like using a child's toy and for that reason was not really useable - this is a total misrepresentation and totally unacceptable." [](https://expedia.com/St-Joseph-Hotels-Quality-Inn-Cameron.h42192.Hotel-Information) ![Motel 6 Saint Joseph, MO](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/56e589c7_y.jpg) ### Motel 6 Saint Joseph, MO 4/10 Poor " It's not a good shape. I got a room and it was on the 1st floor and I went in and the smoke alarm was chirping. So I went to the front desk and I told them, and they just gave me a different room which is fine and I moved over a couple of rooms, and I went in there and that place looked like it was under construction. there's no shower curtain, the shower bars, just leaned in the corner. It's really not clean that well. But I was like, I just drove 14 hours. I'm just gonna crash. Get up and leave the next day in the morning. Because I gotta do another 10 hours of driving. So I'm watching TV for a minute and I look down and there's water all over the floor. the building flooded. a line broke somewheres. I don't know wear and it flooded basically flooded that building coming out both sides, you know, because a hotel's built-in a rectangle, it's got rooms on both sides, right? Then they gave me another room in a different building. On the 2nd floor and I had to move all my stuff and I a travel nurse, so I had a lot of stuff that I had to move that I already moved it in, so I had to move it out of where I was and back into the truck and then upstairs and then into a room and I look around and the TV's already on says, no signal on it, the remote is gone. It didn't have a refrigerator or microwave and it past midnight at this point. Red lobster right there so i got a good dinner. The staff were very nice. The building not well maintined. Can't recommend this place. " [](https://expedia.com/St-Joseph-Hotels-Motel-6-Saint-Joseph.h49581.Hotel-Information) ![My Place Hotel St Joseph MO](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/aa4717a0_y.jpg) ### My Place Hotel St Joseph MO 10/10 Excellent "Spotless room and friendly staff." [](https://expedia.com/St-Joseph-Hotels-My-Place-Hotel-St-Joesph-MO.h109463264.Hotel-Information) ![Drury Inn & Suites St Joseph](https://images.trvl-media.com/lodging/1000000/10000/4200/4180/2dd83c29_y.jpg) ### Drury Inn & Suites St Joseph 10/10 Excellent "Restaurants conveniently located and right nest door to a couple gas options, easy to get around, and an all together fabulous experience at thia location. Staff were all friendly and helpful!!!" [](https://expedia.com/St-Joseph-Hotels-Drury-Inn-Suites-St-Joseph.h4180.Hotel-Information) ![Fairfield Inn & Suites by Marriott St. Joseph](https://images.trvl-media.com/lodging/19000000/18180000/18179000/18178902/b42a1684_y.jpg) ### Fairfield Inn & Suites by Marriott St. Joseph 10/10 Excellent "I am hard to please and have high expectations and this Fairfield hit all the marks. It was clean, my room was well arranged, comfortable bed, spacious bathroom with room to lay out my personal items, a nice coffee station, desk, and more. The room is more spacious than the pictures would lead you to believe. I don’t eat breakfast but everything looked good and others seemed to be enjoying. I will definitely stay here again when back in St Joseph. " [](https://expedia.com/St-Joseph-Hotels-Fairfield-Inn-Suites-By-Marriott-St-Joseph.h18178902.Hotel-Information) ![Stoney Creek Hotel St. Joseph](https://images.trvl-media.com/lodging/2000000/1140000/1140000/1139931/342fa799_y.jpg) ### Stoney Creek Hotel St. Joseph 10/10 Excellent "Clean, wonderful, great amminities !! Perfect and affordable" [](https://expedia.com/St-Joseph-Hotels-Stoney-Creek-Hotel-St-Joseph.h1139931.Hotel-Information) ![Holiday Inn Express Hotel & Suites St. Joseph by IHG](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/47ec36cb_y.jpg) ### Holiday Inn Express Hotel & Suites St. Joseph by IHG 10/10 Excellent "Very nice, clean and updated/new hotel. Great costumer service and complementary treats is a pleasant addition." [](https://expedia.com/St-Joseph-Hotels-Holiday-Inn-Express-Hotel-Suites-St-Joseph.h6846757.Hotel-Information) ![AmeriStay Inn](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/9d51d430_y.jpg) ### AmeriStay Inn 8/10 Good "Room was clean" [](https://expedia.com/St-Joseph-Hotels-AmeriStay-Inn.h41477.Hotel-Information) ## More cheap stays in Clarksdale ![AmeriStay Inn](https://images.trvl-media.com/lodging/1000000/50000/41500/41477/9d51d430_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### AmeriStay Inn 4502 SE US HWY 169 St. Joseph MO $71 nightly $82 total Mar 9 - Mar 10 Total with taxes and fees 5.4/10 (712 reviews) [](https://expedia.com/St-Joseph-Hotels-AmeriStay-Inn.h41477.Hotel-Information) ![My Place Hotel St Joseph MO](https://images.trvl-media.com/lodging/110000000/109470000/109463300/109463264/aa4717a0_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### My Place Hotel St Joseph MO 3621 N Village Dr St. Joseph MO $74 nightly $85 total Mar 22 - Mar 23 Total with taxes and fees 9.2/10 Wonderful! (223 reviews) [](https://expedia.com/St-Joseph-Hotels-My-Place-Hotel-St-Joesph-MO.h109463264.Hotel-Information) ![Motel 6 Saint Joseph, MO](https://images.trvl-media.com/lodging/1000000/50000/49600/49581/56e589c7_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Motel 6 Saint Joseph, MO 4021 Frederick Ave St. Joseph MO $75 nightly $87 total Mar 5 - Mar 6 Total with taxes and fees 4.6/10 (1,005 reviews) [](https://expedia.com/St-Joseph-Hotels-Motel-6-Saint-Joseph.h49581.Hotel-Information) ![Red Roof Inn Cameron](https://images.trvl-media.com/lodging/1000000/40000/40000/39991/917e85d1_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Red Roof Inn Cameron 501 Northland Drive Cameron MO $82 nightly $91 total Mar 5 - Mar 6 Total with taxes and fees 8.8/10 Excellent! (1,003 reviews) [](https://expedia.com/St-Joseph-Hotels-Red-Roof-Inn-Cameron.h39991.Hotel-Information) ![Hampton Inn St. Joseph](https://images.trvl-media.com/lodging/1000000/110000/103100/103092/8e39c5c8_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn St. Joseph 3928 Frederick Ave St. Joseph MO $79 nightly $92 total Mar 22 - Mar 23 Total with taxes and fees [](https://expedia.com/St-Joseph-Hotels-Hampton-Inn-St-Joseph.h103092.Hotel-Information) ![Holiday Inn Express Hotel & Suites St. Joseph by IHG](https://images.trvl-media.com/lodging/7000000/6850000/6846800/6846757/47ec36cb_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express Hotel & Suites St. Joseph by IHG 3600 N. Village Dr. St. Joseph MO $101 nightly $117 total Mar 22 - Mar 23 Total with taxes and fees 9.2/10 Wonderful! (810 reviews) [](https://expedia.com/St-Joseph-Hotels-Holiday-Inn-Express-Hotel-Suites-St-Joseph.h6846757.Hotel-Information) ## Hotels in Clarksdale with star-rating ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 6 properties [](https://expedia.com/3Star-Clarksdale-Hotels.s30-0-d553248634983445286.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 27 properties [](https://expedia.com/2Star-Clarksdale-Hotels.s20-0-d553248634983445286.Travel-Guide-Filter-Hotels) ## Frequently asked questions ### What is the best area to stay in Clarksdale? > This central area is the heart of Clarksdale's blues music scene and is very walkable. You'll find a high concentration of blues clubs, juke joints, and historic markers. The Delta Blues Museum is also located downtown, offering a deep dive into the region's musical heritage. Many of the city's unique restaurants and shops are clustered here, making it convenient for exploring on foot. > > > Solo travelers and couples often find this area ideal due to its lively evenings and the ease of accessing various entertainment options. ### When is the best time to go to Clarksdale? > Spring brings mild temperatures, typically ranging from the 60s to 70s Fahrenheit, with blooming wildflowers and lush greenery. It's an excellent time for couples who enjoy outdoor activities like hiking or picnicking in nearby parks without the intense summer heat. The comfortable climate makes strolling through the small town center enjoyable. > > > Fall also provides agreeable temperatures, usually in the 60s, along with the scenic beauty of changing leaves. This period is ideal for solo travelers or those seeking a quiet retreat. The cooler weather is superb for visiting local antique shops, exploring historical sites, or simply enjoying a warm drink at a local coffee shop. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Clarksdale hotel booking with Expedia? > \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo. ### How much is the nightly rate at a Clarksdale hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Helena Hotels ](https://www.expedia.com/Helena-Hotels.d6179513.Travel-Guide-Hotels) - [Maysville Hotels ](https://www.expedia.com/Maysville-Hotels.d3000445233.Travel-Guide-Hotels) - [Osborn Hotels ](https://www.expedia.com/Osborn-Hotels.d3000349489.Travel-Guide-Hotels) - [5 Star Hotels in Maysville ](https://www.expedia.com/5Star-Maysville-Hotels.s50-0-d3000445233.Travel-Guide-Filter-Hotels) - [B&B in Osborn ](https://www.expedia.com/Osborn-Bed-And-Breakfast.d3000349489-aaBedAndBreakfast.Travel-Guide-Accommodation) - [5 Star Hotels in Osborn ](https://www.expedia.com/5Star-Osborn-Hotels.s50-0-d3000349489.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Osborn ](https://www.expedia.com/3Star-Osborn-Hotels.s30-0-d3000349489.Travel-Guide-Filter-Hotels) - 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