Top 10 Hotels in Clarksdale, MO (from $81) 2026 - Competitive Prices

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Our top choices for Clarksdale hotels

A lobby with a seating area, a reception desk, and a chandelier.

A hotel room with a kitchenette, a sofa, a bench, a lamp, and a framed picture on the wall.

A Drury Inn & Suites hotel with a modern architectural design, featuring a covered entrance and a parking lot.

A hotel lobby with a reception desk, seating area, and a refrigerator.

1. Drury Inn & Suites St Joseph

St. Joseph

Luis

$110 nightly

$127 total

Oct 4 - Oct 5

Total with taxes and fees

An indoor swimming pool with clear lane markings, a lifeguard chair, and a pool ladder.

A Hampton Inn by Hilton building with a modern facade, large windows, and a well-lit entrance.

A reception desk with a clock, a framed picture, and a wall with a 'smile' sign.

A neatly made bed with white linens and a headboard.

2. Hampton Inn St. Joseph

St. Joseph

Gary

$89 nightly

$103 total

Oct 4 - Oct 5

Total with taxes and fees

A pool area with a rock formation backdrop, a wooden post, and a sign indicating a clinic.

A hotel with a stone facade, a covered entrance, and a landscaped area with a small pond.

A cozy log cabin interior with a fireplace, wooden furniture, and a television.

A hotel room with a large bed, a fireplace, a TV, and a jacuzzi.

3. Stoney Creek Hotel St. Joseph

St. Joseph

Bobby

$130 nightly

$151 total

Oct 25 - Oct 26

Total with taxes and fees

A modern living room with a blue sofa, a fireplace, and a stone accent wall.

An indoor swimming pool with clear water, a lifeguard chair, and a pool ladder.

A modern hotel lobby with a stone fireplace, blue sofas, a round table, and large windows offering a view of the parking lot.

A Fairfield Inn & Suites Marriott hotel entrance with a modern design, including a prominent overhang and a stone pillar.

4. Fairfield Inn & Suites by Marriott St. Joseph

St. Joseph

William

$105 nightly

$122 total

Oct 18 - Oct 19

Total with taxes and fees

A hotel room with a sofa, two beds, a patterned ottoman, a wall art piece, and a window with a view.

A modern hotel building with a prominent 'HOME 2' sign, multiple floors, and a covered entrance area.

An outdoor seating area with a fire feature, a pool, and a view of the building.

5. Home2 Suites By Hilton St. Joseph

St. Joseph

Stacey

$114 nightly

$132 total

Oct 4 - Oct 5

Total with taxes and fees

A hotel room with a bed, a sofa, a small table, a microwave, and a TV.

A coffee station with two coffee machines, a coffee press, and various coffee pods and cups.

A coffee station with two coffee machines and a sign that reads 'MUST. HAVE. COFFEE.'

A swimming pool with a clear blue water surface, surrounded by wooden lounge chairs and a tiled deck.

6. Holiday Inn Express Hotel & Suites St. Joseph by IHG

St. Joseph

Teresa

$114 nightly

$132 total

Oct 18 - Oct 19

Total with taxes and fees

A multi-story hotel with a 'My Place' sign, featuring a stone facade and a covered entrance.

A hotel room with a bed, a desk, a chair, a kitchenette, and a framed picture on the wall.

7. My Place Hotel St Joseph MO

St. Joseph

Marcella

$84 nightly

$98 total

Oct 4 - Oct 5

Total with taxes and fees

A swimming pool with a hot tub, a ladder, and a slide.

A reception area with a coffee station, a potted plant, and a banner promoting breakfast.

A hotel room with a large bed, two bedside tables with lamps, a desk, and a chair.

A reception area with a reception desk, a plant, a coffee station, and a sign for breakfast.

8. Quality Inn Cameron

Cameron

Mary Ashleigh

$115 nightly

$127 total

Oct 27 - Oct 28

Total with taxes and fees

A hotel room with two beds, a desk, a television, and a bathroom visible through an open door.

A cozy room with a coffee machine, a clock, and a potted plant.

A hotel with a covered outdoor area, a brick building, and a sign for a nearby Subway.

A modern kitchen with granite countertops, wooden cabinets, and a central island.

9. SureStay Hotel by Best Western Cameron

Cameron

Marvin

$78 nightly

$86 total

Oct 4 - Oct 5

Total with taxes and fees

A Red Roof Inn with a parking lot, handicap accessible parking, and a building with multiple windows and air conditioning units.

A coffee station with a coffee machine, creamer dispensers, and a juice dispenser.

A hotel reception area with a reception desk, a telephone, and a sign indicating free Wi-Fi in all rooms.

A hotel room with a large bed, a desk, a chair, and a TV.

10. Red Roof Inn Cameron

Cameron

Kevin

$86 nightly

$95 total

Oct 4 - Oct 5

Total with taxes and fees

A hotel room with two beds, a desk, a chair, and a television.

A building with a 'welcome' sign, a number '6' on the door, and a covered entrance area.

A hallway with a 7UP vending machine, white doors, and a brown mat.

A hotel reception area with a wooden counter, a coffee machine, a phone, and a television.

11. Motel 6 Saint Joseph, MO

St. Joseph

Tina

$70 nightly

$81 total

Oct 4 - Oct 5

Total with taxes and fees

A hotel room with a large bed, a red wall, and a cityscape painting above the bed.

A reception desk with a clock, decorative wall art, and American flags.

A hotel room with a television, a lamp, a microwave, and a desk with a chair.

12. AmeriStay Inn

St. Joseph

Paul

$73 nightly

$85 total

Oct 18 - Oct 19

Total with taxes and fees

A hotel bathroom with a wooden bathtub, a desk with a lamp, a chair, a television, and a microwave.

An indoor swimming pool with clear water, surrounded by white plastic chairs and tables, and a lifeguard sign on the wall.

A reception area with a marble counter, a fish tank, a welcome sign, and a 'Super 8' sign.

A two-story building with a covered parking area and a brick facade.

13. Super 8 by Wyndham Cameron

Cameron

Bianca

$88 nightly

$97 total

Oct 25 - Oct 26

Total with taxes and fees

A large, historic brick building with a prominent tower and a grand entrance.

A traditional interior with a fireplace, wooden furniture, and a chandelier.

A brick building with a covered porch and a large bush of white flowers.

A traditional room with a fireplace, ornate chandelier, and classic furniture.

14. Vineyard Mansion & Carriage House Bed & Breakfast

St. Joseph

Stephanie

$147 nightly

$157 total

Sep 28 - Sep 29

Total with taxes and fees

A large brick building with multiple windows and a covered porch area.

A traditional interior with a fireplace, a wooden staircase, and a patterned floor.

A covered porch with columns, potted plants, and a brick wall.

A grand entrance with a stained glass window, a red upholstered sofa, and a wooden chair.

15. Whiskey Mansion

St. Joseph

Lana

$142 nightly

$164 total

Oct 2 - Oct 3

Total with taxes and fees

A modern living area with a sofa, coffee table, and a dining table with chairs.

A multi-story hotel with a stone facade, multiple windows, and a parking lot.

A laundry facility with multiple washing machines and dryers, a table, and a door leading to another room.

A hotel room with two beds, a desk, a chair, a television, and a window with blinds.

16. Woodspring Suites St. Joseph

St. Joseph

$99 nightly

$115 total

Oct 5 - Oct 6

Total with taxes and fees

A gazebo with a metal roof and wooden benches.

A living room with a leather sofa, a glass coffee table, and various potted plants.

A lobby with a fireplace, a table with four chairs, and a patterned carpet.

A hotel room with two beds, a nightstand with a lamp, a small table, a mirror, and a window.

17. Econo Lodge Cameron

Cameron

Jeff

$76 nightly

$83 total

Oct 11 - Oct 12

Total with taxes and fees

A reception desk with a "WELCOME" sign, a clock, and a mirror.

A kitchenette with a coffee machine, a trash can, and a sign indicating coffee service hours.

A compact refrigerator with a microwave on top, an air conditioner, and a power outlet on the wall.

A compact kitchenette with a microwave, sink, and small refrigerator.

18. Motel 6 Cameron, MO

Cameron

Mark

$75 nightly

$82 total

Sep 29 - Sep 30

Total with taxes and fees

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Top Clarksdale Hotel Reviews

Drury Inn & Suites St Joseph

8/10 Good

"Only thing was all week I worked out the fitness area was never cleaned and it was dirty."

Stoney Creek Hotel St. Joseph

8/10 Good

"The beds and pillows in the rooms should be replaced"

Vineyard Mansion & Carriage House Bed & Breakfast

8/10 Good

"This was a nice place to stop in St Joseph’s. Communication was great. Received several emails explaining checkin and other details about staying here. My biggest complaint was the bed was not comfortable. It had a dip right in the middle that I kept rolling into. Also would have liked to have a bathroom attached instead of the detached version that we had."

My Place Hotel St Joseph MO

10/10 Excellent

"Everything was fabulous except for no way to use the kitchenette. Absolutely nothing was provided, which doesn't make any sense for people who are traveling from other states."

Quality Inn Cameron

8/10 Good

"Cleanliness is top of mind for the employees. Th The breakfast was excellent. The beds were uncomfortable."

SureStay Hotel by Best Western Cameron

8/10 Good

"good breakfast and easy parking"

Super 8 by Wyndham Cameron

8/10 Good

"For a quick overnight stay, it was perfect."

Red Roof Inn Cameron

8/10 Good

"For the price, I thought this was a great choice. My biggest complaint is somebody should always be behind the counter greeting people or letting us know their presence. The world is becoming a place where people are less involved and I think if you’re in any type of business, customer skills is a very important decision in the choices I make."

Hampton Inn St. Joseph

8/10 Good

"Fine"

More cheap stays in Clarksdale

AmeriStay Inn

4502 SE US HWY 169 St. Joseph MO

$73 nightly

$85 total

Oct 18 - Oct 19

Total with taxes and fees

5.4/10 (770 reviews)

SureStay Hotel by Best Western Cameron

2210 US Highway 36 Cameron MO

$78 nightly

$86 total

Oct 4 - Oct 5

Total with taxes and fees

8.2/10 Very Good! (1,003 reviews)