Title: Visit Clayton: 2026 Travel Guide for Clayton, Illinois | Expedia.com [Hotels in Clayton](https://expedia.com/Clayton-Hotels.d6124463.Travel-Guide-Hotels)[Vacation Rentals in Clayton](https://expedia.com/Clayton-Vacation-Rentals.d6124463.Travel-Guide-VacationRentals)[Flights to Clayton](https://expedia.com/Cheap-Flights-To-Clayton.d6124463.Travel-Guide-Flights)[Car Rentals in Clayton](https://expedia.com/Car-Rentals-In-Clayton.d6124463.Car-Rental-Guide)[Clayton Vacation Packages](https://expedia.com/Clayton.d6124463.Destination-Travel-Guides) # Clayton, IL ## Travel Guide ## Visit Clayton - Clayton Hotel Deals - Vacation Rentals in Clayton ![Cozy 1-bedroom apartment located right outside of Quincy, IL.](https://images.trvl-media.com/lodging/113000000/112910000/112904900/112904875/065edef0_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Cozy 1-bedroom apartment located right outside of Quincy, IL. Quincy IL Stay at this apartment in Quincy. Enjoy laundry facilities, patios, and an in-room coffeemaker. Popular attractions Westview Golf Course and Quincy Mall are ... 10/10 Exceptional! (16 reviews) Great place to stay and it’s pet friendly Reviewed on Mar 12, 2026 [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F10%2F2026&endDate=4%2F11%2F2026&selected=112904875&PinnedHotelID=112904875&HadPinnedHotel=true®ionId=6124463) [](https://expedia.com/Hotel-Search?startDate=4%2F10%2F2026&endDate=4%2F11%2F2026&selected=112904875&PinnedHotelID=112904875&HadPinnedHotel=true®ionId=6124463) ![Your home away from home in the Country](https://images.trvl-media.com/lodging/88000000/87930000/87926600/87926552/1ccd489d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Your home away from home in the Country Coatsburg IL $151 nightly $160 total Mar 30 - Mar 31 Total with taxes and fees Stay at this cottage in Adams County. Enjoy a garden, laundry facilities, and in-room jetted tubs. 10/10 Exceptional! (35 reviews) Nice house and great host to work with Reviewed on Jan 19, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F30%2F2026&endDate=3%2F31%2F2026&selected=87926552&PinnedHotelID=87926552&HadPinnedHotel=true®ionId=6124463) ![Tranquil La Prairie Retreat w/ Patio & Fireplace!](https://images.trvl-media.com/lodging/99000000/98560000/98557800/98557745/813a6724_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Tranquil La Prairie Retreat w/ Patio & Fireplace! La Prairie IL Stay at this cottage in La Prairie. Enjoy free parking, patios, and in-room fireplaces. [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F10%2F2026&endDate=4%2F11%2F2026&selected=98557745&PinnedHotelID=98557745&HadPinnedHotel=true®ionId=6124463) [](https://expedia.com/Hotel-Search?startDate=4%2F10%2F2026&endDate=4%2F11%2F2026&selected=98557745&PinnedHotelID=98557745&HadPinnedHotel=true®ionId=6124463) [See all 17 properties in Clayton](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F28%2F2026&endDate=3%2F29%2F2026®ionId=6124463) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Cozy 1-bedroom apartment located right outside of Quincy, IL.](https://images.trvl-media.com/lodging/113000000/112910000/112904900/112904875/065edef0_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Cozy 1-bedroom apartment located right outside of Quincy, IL. Quincy IL Stay at this apartment in Quincy. Enjoy laundry facilities, patios, and an in-room coffeemaker. Popular attractions Westview Golf Course and Quincy Mall are ... 10/10 Exceptional! (16 reviews) Great place to stay and it’s pet friendly Reviewed on Mar 12, 2026 [](https://expedia.com/Quincy-Hotels-Cozy-1-Bedroom-Apartment-Located-Right-Outside-Of-Quincy.h112904875.Hotel-Information) ![Your home away from home in the Country](https://images.trvl-media.com/lodging/88000000/87930000/87926600/87926552/1ccd489d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Your home away from home in the Country Coatsburg IL Stay at this cottage in Adams County. Enjoy a garden, laundry facilities, and in-room jetted tubs. 10/10 Exceptional! (35 reviews) Nice house and great host to work with Reviewed on Jan 19, 2026 [](https://expedia.com/Your-Home-Away-From-Home-In-The-Country.h87926552.Hotel-Information) ![Tranquil La Prairie Retreat w/ Patio & Fireplace!](https://images.trvl-media.com/lodging/99000000/98560000/98557800/98557745/813a6724_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Tranquil La Prairie Retreat w/ Patio & Fireplace! La Prairie IL Stay at this cottage in La Prairie. Enjoy free parking, patios, and in-room fireplaces. [](https://expedia.com/Tranquil-La-Prairie-Retreat-W-Patio-Fireplace.h98557745.Hotel-Information) [See all properties in Clayton](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6124463&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Clayton hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6124463&startDate=2026-03-27&endDate=2026-03-28)[Mar 27 - Mar 28](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6124463&startDate=2026-03-27&endDate=2026-03-28) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6124463&startDate=2026-03-28&endDate=2026-03-29)[Mar 28 - Mar 29](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6124463&startDate=2026-03-28&endDate=2026-03-29) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6124463&startDate=3%2F27%2F2026&endDate=3%2F29%2F2026)[Mar 27 - Mar 29](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6124463&startDate=3%2F27%2F2026&endDate=3%2F29%2F2026) ## Cities near Clayton ![Boston Quincy Marchet and Custom House tower](https://images.trvl-media.com/place/3622/3cdc0cdf-5fd1-4898-8330-39bf5d3131ca.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Quincy ![Aerial view of the city of Hannibal in Missouri from Lovers Leap overlook with Mississippi River and cruise boat](https://images.trvl-media.com/place/6068/0745fe01-80e8-4dd7-979d-f7342ba3c9e4.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Hannibal ![Aerial view of the Mark Twain Memorial highway river bridge between Hannibal Missouri and Illinois](https://images.trvl-media.com/place/183494/0a9be0ca-9f39-459b-b79c-ff4e273c1365.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Canton ![Old courthouse in Macomb](https://images.trvl-media.com/place/8802/b0675473-5b71-4cba-b130-a069d8ad23b0.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Macomb - Cities near Clayton - Places of interest [Quincy](https://expedia.com/Quincy.dx3622)[Hannibal](https://expedia.com/Hannibal.dx6068)[Canton](https://expedia.com/Canton.dx7238)[Macomb](https://expedia.com/Macomb.dx8802)[Pittsfield](https://expedia.com/Pittsfield.dx146411)[Beardstown](https://expedia.com/Beardstown.dx183176)[Palmyra](https://expedia.com/Palmyra.dx183484)[Camp Point](https://expedia.com/Camp-Point.dx6050535)[Colchester](https://expedia.com/Colchester.dx6124460)[La Grange](https://expedia.com/La-Grange.dx6354592)[Arenzville](https://expedia.com/Arenzville.dx3000346095)[Baylis](https://expedia.com/Baylis.dx3000346117)[Elvaston](https://expedia.com/Elvaston.dx3000346245)[Griggsville](https://expedia.com/Griggsville.dx3000346304)[La Prairie](https://expedia.com/La-Prairie.dx3000346370)[Meredosia](https://expedia.com/Meredosia.dx3000346427)[Paloma](https://expedia.com/Paloma.dx3000346493)[Astoria](https://expedia.com/Astoria.dx3000420825)[Barry](https://expedia.com/Barry.dx3000433380)[Carthage](https://expedia.com/Carthage.dx3000433687)[Lima](https://expedia.com/Lima.dx3000434463)[Rockport](https://expedia.com/Rockport.dx3000435152)[Warsaw](https://expedia.com/Warsaw.dx3000435638)[Winchester](https://expedia.com/Winchester.dx3000435714)[New London](https://expedia.com/New-London.dx3000445314) - [Siloam Springs State Park ](https://expedia.com/Siloam-Springs-State-Park-Illinois.d6124716.Vacation-Attraction)