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Our top choices for Defiance hotels

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.4 out of 10, Exceptional, (24)
"Very nice place. Clean room. Staff was excellent. "
United States
Richard
$76 nightly
The price is $88
Dec 25 - Dec 26
Total with taxes and fees
WoodSpring Suites St Peters-OFallon

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (847)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
$110 nightly
The price is $132
Jan 3 - Jan 4, 2026
Total with taxes and fees
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very Good, (1001)
"Clean room and friendly staff "
United States
Summer Dawn
$89 nightly
The price is $103
Jan 1 - Jan 2, 2026
Total with taxes and fees
Hampton Inn St. Charles St. Peters

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1606)
"Great place!"
United States
Biju
$92 nightly
The price is $108
Jan 8 - Jan 9, 2026
Total with taxes and fees
The Wildwood Hotel

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1000)
"Wonderful stay. Checkin was easy and host was very accommodating. "
United States
Teresa
$78 nightly
The price is $92
Jan 15 - Jan 16, 2026
Total with taxes and fees
Sleep Inn & Suites O'Fallon MO - Technology Drive

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (182)
"Clean room, nice staff, great food, and great service "
United States
Thuy
$101 nightly
The price is $117
Dec 27 - Dec 28
Total with taxes and fees
Best Western Plus Fenton

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very Good, (910)
"Very good experience, clean, and friendly staff."
United States
Lijing
$78 nightly
The price is $88
Jan 11 - Jan 12, 2026
Total with taxes and fees
Quality Inn Foristell

Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO
3.0 star property
O'Fallon
8.8 out of 10, Excellent, (719)
"Clean room, quiet"
United States
Laura
$94 nightly
The price is $111
Jan 23 - Jan 24, 2026
Total with taxes and fees
Hilton Garden Inn St. Louis/O'Fallon MO

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very Good, (1051)
"Everything was clean and friendly staff overall good experience "
United States
dennis
$85 nightly
The price is $98
Dec 28 - Dec 29
Total with taxes and fees
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1002)
"The room was clean. The beds were comfortable. The lady at the front desk had a smile and was nice. Hot coffee available 24 hours a day. Well lighted property, I’m traveling with my two dachshunds. I would stay here again if I came through here. "
United States
Cindy Laine
$78 nightly
The price is $92
Jan 8 - Jan 9, 2026
Total with taxes and fees
Comfort Inn & Suites St. Louis - O'Fallon

Super 8 by Wyndham Eureka/Six Flags Nearby

Super 8 by Wyndham Eureka/Six Flags Nearby
2.0 star property
Eureka
7.0 out of 10, Good, (1003)
"A much needed comfortable bed and hot shower, staff was lovely. "
United States
Rachel
$60 nightly
The price is $70
Jan 11 - Jan 12, 2026
Total with taxes and fees
Super 8 by Wyndham Eureka/Six Flags Nearby

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (844)
"A very nice stay with very pleasant staff"
United States
Clifford
$91 nightly
The price is $107
Jan 4 - Jan 5, 2026
Total with taxes and fees
Holiday Inn Express St. Louis West - O'Fallon by IHG

Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport
2.5 star property
Maryland Heights
8.0 out of 10, Very Good, (1035)
"The room was great and the bed was very comfortable "
United States
Joyce
$84 nightly
The price is $98
Dec 25 - Dec 26
Total with taxes and fees
Best Western Plus St. Louis West-Westport

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1123)
"Room was clean, air worked good, staff was super nice."
United States
Jessica
$79 nightly
The price is $91
Dec 28 - Dec 29
Total with taxes and fees
Wingate by Wyndham St. Louis/Fenton Route 66

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
3.0 star property
Maryland Heights
7.4 out of 10, Good, (1000)
"Spacious suite, friendly staff. Check in was easy and everything looked clean"
United States
Jonathan
$66 nightly
The price is $77
Jan 4 - Jan 5, 2026
Total with taxes and fees
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.4 out of 10, Good, (1001)
"Nice,clean hotel.Friendly staff "
United States
Desiree
$73 nightly
The price is $84
Jan 6 - Jan 7, 2026
Total with taxes and fees
Baymont by Wyndham Warrenton

Drury Plaza Hotel St. Louis Creve Coeur

Drury Plaza Hotel St. Louis Creve Coeur
3.0 star property
Creve Coeur
9.2 out of 10, Wonderful, (1003)
"Love there was a restaurant connected, pool and spa were clean, and breakfast was great!"
United States
Emily
$115 nightly
The price is $133
Dec 29 - Dec 30
Total with taxes and fees
Drury Plaza Hotel St. Louis Creve Coeur

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1001)
"Everything was great!"
United States
Rita
$116 nightly
The price is $134
Jan 18 - Jan 19, 2026
Total with taxes and fees
Country Inn & Suites by Radisson, St. Charles Historic District

Economy Inn Wentzville

Economy Inn Wentzville
2.0 star property
Wentzville
6.4 out of 10, (508)
"The Building has a nice exterior"
United States
Christopher
$60 nightly
The price is $68
Dec 25 - Dec 26
Total with taxes and fees
Economy Inn Wentzville

Comfort Inn Near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very Good, (877)
"Everything was great"
United States
Sarah
$92 nightly
The price is $105
Jan 11 - Jan 12, 2026
Total with taxes and fees
Comfort Inn Near Six Flags St. Louis
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

More cheap stays in Defiance

Hotels in Defiance with star-rating

Find out more about Defiance

Top reasons to visit Defiance

  • Outdoor Adventures: Defiance offers scenic recreational areas with hiking trails, perfect for nature enthusiasts.
  • Charming Downtown: Stroll through downtown Defiance, featuring charming shops and local eateries that embody small-town charm.
  • Family-Friendly Attractions: Enjoy a mix of state parks and amusement parks, catering to family fun and entertainment.
  • Romantic Escapes: Ideal for couples seeking peaceful retreats and memorable outdoor experiences.
  • Diverse Accommodations: A variety of inviting hotels, including pet-friendly and LGBTQIA-welcoming options, enhance your stay.

Find great hotels near Defiance

Discover a range of inviting hotel accommodations in Defiance, Missouri, perfect for every type of traveler. Whether you're seeking business-friendly amenities, pet-friendly options, or an LGBTQIA-welcoming atmosphere, you'll find a variety of choices to enhance your stay. Explore the top hotels and available options that ensure a memorable vacation experience in this charming destination.

  • Sonesta ES Suites St. Louis - Chesterfield: This welcoming 3-star hotel is an ideal choice for pet lovers looking to explore the charming region of Defiance. Located 12 miles away, Sonesta ES Suites offers a home-like atmosphere with spacious suites featuring full kitchens, making it perfect for extended stays. The pet-friendly policy allows for a worry-free experience, as pets are permitted with certain restrictions. Guests appreciate the complimentary amenities, including free breakfast, Wi-Fi, and access to on-site fitness facilities. With a warm and inviting environment, this hotel ensures a comfortable and enjoyable vacation for both you and your furry friends.
  • The Wildwood Hotel: A unique blend of nature and business, The Wildwood Hotel is a stylish 3.5-star lodging located 9 miles from Defiance. This stunning hotel is perfect for nature enthusiasts and business travelers alike, offering a serene escape with its rustic decor and lush surroundings. With a range of business amenities such as a 24-hour business center and multiple meeting rooms, this hotel caters to corporate needs while providing a tranquil retreat. The pet-friendly policy allows guests to bring their four-legged companions along, ensuring a memorable stay surrounded by nature's beauty.
  • Hyatt Place St. Louis/Chesterfield: This family-friendly 3-star hotel, situated 12 miles from Defiance, is a perfect choice for travelers looking for comfort and convenience. Hyatt Place St. Louis/Chesterfield features spacious rooms equipped with modern amenities and offers a variety of services for business guests, including a 24-hour business center and flexible meeting spaces. Families will appreciate the kid-friendly services, while pet owners can enjoy a welcoming atmosphere for their dogs. With complimentary breakfast and a convenient location, this hotel promises a delightful and hassle-free stay for all.

Where to stay near Defiance

Defiance, Missouri, offers a delightful blend of outdoor adventures and romantic escapes, perfect for any traveler. Stroll through downtown Defiance, where charming shops and local eateries await. Enjoy leisurely walks that showcase the area's historical vibes and family-friendly atmosphere. Whether you're seeking a relaxing break or an adventurous outing, Defiance and its nearby regions promise memorable experiences that capture the essence of small-town charm and community spirit.

  • Chesterfield: Located 12 miles from Defiance, Chesterfield is a vibrant city that offers a delightful mix of family-friendly entertainment and urban experiences. Known for its seasonal visitor peaks in April and from June to July, Chesterfield boasts attractions such as an arcade adventure zone, a local theater, and a bustling amusement park. The area is also home to a variety of popular landmarks, including a theme park and a stadium, making it an ideal destination for those seeking a fun-filled getaway.
  • O'Fallon: Situated 13 miles away from Defiance, O'Fallon is another great city perfect for family outings and outdoor adventures. Like Chesterfield, O'Fallon sees a surge in visitors around April and during the summer months. The city features an array of entertainment options, including an arena entertainment facility, an arcade adventure zone, and a shopping mall center. With its urban parks and sports facilities, O'Fallon offers a dynamic blend of relaxation and excitement for visitors of all ages.
  • Saint Albans: Just 4 miles from Defiance, Saint Albans is a charming city that invites travelers to immerse themselves in outdoor adventures and family activities. Peak tourist seasons occur in April, July, and September, with visitors drawn to attractions like an arcade adventure zone, an amusement park, and a shopping center. The area is also notable for its scenic landmarks, including a beautiful lake and a convention center, making it a picturesque spot for both relaxation and exploration.

Things to do in and around Defiance

Defiance, Missouri, is perfect for a romantic and adventurous getaway, offering a range of outdoor activities for an unforgettable experience. You can explore its scenic recreational areas, enjoy the hiking trails, and immerse yourself in nature. Whether you're looking for a peaceful retreat or an active vacation, Defiance provides the ideal backdrop for memorable moments in the great outdoors.

Shopping

The nearest shopping destination is St. Louis Premium Outlets, located 7 miles away, offering a variety of entertainment, shopping, and family-friendly vibes. If you're up for a drive, check out Taubman Prestige Outlets, 10 miles away, or the Wentzville Flea Market, 13 miles away, for unique finds.

Recreation

Catch a live show at The Factory for vibrant entertainment just 10 miles from Defiance. Enjoy a round of golf at Missouri Bluffs Golf Course, surrounded by scenic landscapes, located 7 miles away. For relaxation, unwind at Broemmelsiek Park, where wellness and tranquility await right in Defiance.

Adventure

At Hidden Valley Ski Resort, located 9 miles from Defiance, enjoy thrilling skiing adventures amid beautiful snowy landscapes. Hurricane Harbor, 10 miles away, offers water-based fun with slides and attractions perfect for family entertainment. Explore the scenic Matson Hill Park Trailhead right in Defiance for hiking and outdoor experiences.

Nightlife

Experience the excitement at Chesterfield Sports Fusion, an arcade adventure zone 9 miles from Defiance. For a cultural night out, catch a show at the New Jewish Theatre, 20 miles away. Don't miss Sky Zone Indoor Trampoline Park, an adventure zone 10 miles from Defiance for a fun evening.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Defiance

To save money on your trip to Defiance, Missouri, consider visiting during the off-peak months of December to February, when prices are lower. Booking your stay on a Monday can also help you save, as Saturday is the most expensive day. Use Expedia to compare hotel prices, and consider booking a package that includes flights and activities for better deals. Joining Expedia's One Key membership can unlock exclusive discounts and allow you to earn rewards for future bookings. Look for free activities in the area to enhance your travel experience without breaking the bank.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Defiance are December to February, where the prices are slightly lower. This is in comparison to May to July, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Defiance is Monday. The most expensive day to stay in Defiance is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia's search tool to narrow down your options based on your budget, desired location, and preferred hotel type. To find the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by booking a package with Expedia that combines your Defiance hotel with flights and activities.
  • Become a One Key member: Join Expedia's One Key membership program for exclusive discounts and deals on hotel bookings. You can also earn OneKeyCash to use on future selected hotels.

Find the best attractions in and around Defiance

Defiance, Missouri, offers a delightful mix of outdoor adventures and romantic escapes. Visitors can explore local attractions such as state and urban parks, as well as amusement parks, perfect for family fun. Whether you're seeking a nature hike, a thrilling ride, or a peaceful picnic, Defiance caters to travelers looking for both city experiences and serene landscapes, making it an ideal destination for entertainment-themed vacations.

  • Six Flags St. Louis: Experience the thrill of exhilarating rides and family-friendly entertainment at this vibrant amusement park, located 10 miles from Defiance. With a variety of attractions, it offers an adventurous atmosphere perfect for creating lasting memories.
  • August A. Busch Memorial Conservation Area: Nestled within Defiance, this beautiful reserve features scenic trails and friendly wildlife. It's an ideal spot for family outings and excursions, making it a perfect place to enjoy nature and connect with the outdoors.
  • Purina Farms: Located 10 miles away, this charming farm showcases beautiful scenery and offers interactive experiences with animals. It’s a delightful destination for animal lovers and families looking to enjoy a relaxing day in the countryside.

Best time to go to Defiance

The best time to visit Defiance is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are moderately high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly cloudy with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January31.6°F (-0.2°C)Light RainMostly CloudyModerately LowSlightly Low
February34.7°F (1.5°C)Light RainMostly SunnyAverageSlightly Low
March46.4°F (8.0°C)Light RainMostly SunnyAverageAverage
April55.9°F (13.3°C)Light RainMostly SunnyModerately HighAverage
May66.2°F (19.0°C)Light RainMostly SunnyAverageSlightly High
June75.9°F (24.4°C)Light RainMostly SunnyAverageSlightly High
July79.0°F (26.1°C)Light RainMostly SunnyModerately HighSlightly High
August77.2°F (25.1°C)Light RainMostly SunnyAverageAverage
September70.9°F (21.6°C)Light RainMostly SunnyModerately HighAverage
October58.5°F (14.7°C)Light RainMostly SunnyAverageAverage
November46.2°F (7.9°C)Light RainMostly SunnyModerately LowAverage
December37.6°F (3.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to Defiance

When visiting Defiance, Missouri, you have convenient access to two major airports. St. Louis Lambert International Airport (STL) is approximately 23 miles away and offers a variety of nearby hotels, including the 5-star Ritz-Carlton, St. Louis, and the 4.5-star Royal Sonesta Chase Park Plaza, both within 9 miles. The Spirit of St. Louis Airport (SUS) is closer at about 7 miles from Defiance, with excellent accommodations such as the 4-star DoubleTree by Hilton Hotel St. Louis - Chesterfield just 4 miles away. These hotels provide easy transportation options to both airports, ensuring a smooth start to your vacation.

Frequently asked questions

When is the best time to go to Defiance?
The most popular time to visit Defiance is during the summer months, particularly July. This is when the weather is at its finest, with temperatures typically ranging from the mid-70s to low 80s Fahrenheit. Such pleasant conditions create a great backdrop for enjoying outdoor activities and exploring the scenic beauty of this charming town.

During the peak season from June to August, Defiance comes alive with a variety of local festivals, outdoor concerts, and vibrant community events. For those who appreciate attentive service and a relaxed pace, this bustling atmosphere offers numerous opportunities to engage with locals and immerse yourself in the culture. Whether you're wandering along the picturesque riverfront or enjoying a leisurely bike ride on one of the many scenic trails, the summer months provide an inviting environment for exploration.

If you're seeking something that fits their needs tranquility, consider visiting in September. While the crowds begin to thin, the weather remains delightful, allowing you to enjoy the stunning fall foliage as the leaves start to change. This time also brings slightly lower accommodation rates, making it a wonderful option for travelers who appreciate quality without stretching their budget.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Defiance.
How can I save on a Defiance hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Defiance hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Defiance hotel?
Prices for hotels in Defiance often vary, but you can find a great deal from $67 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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