Find hotels in Defiance, MO from $85

Based on Expedia's traveler preferences, Hillside Cabin on 43 Acres w/ Private Lake & View! is a top place to stay in Defiance. Other good choices for your stay include Historic Farmhouse Wine Escape: Walk to Katy Trail and NEW! 'The Ruebling House' Historic Defiance Apt!. See all available top hotels, or vacation rentals in Defiance.

Lovely lower level for 4 guest.: You might want to consider this vacation home rental near Defiance, which has air-conditioning and WiFi to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include an oven, a microwave, and a coffee maker. See all vacation rentals in Defiance.

If you're having a hard time finding properties with enhanced cleaning that have everything you're looking for, consider Hilton Garden Inn St. Louis/O'Fallon MO, which is located 7 miles from the city center. If you're looking for an affordable option close to Defiance, Holiday Inn Express & Suites Wentzville St Louis West, an IHG Hotel is a 2.5-star property offering enhanced cleaning measures that is located within 10 miles. And for a luxurious stay, consider The Chase Park Plaza Royal Sonesta St. Louis, a 4.5-star hotel that provides enhanced cleaning and is located within 30 miles of Defiance. For more choices, browse all hotels in Defiance with enhanced sanitizing practices.

Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by free cancellation to find flexible hotel deals in Defiance.

For more information about changing or cancelling your trip to Defiance, head over to our customer service page.

Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.

One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.

Elimwood Hotel: 3-star hotel located near Ameristar Casino St. Charles. Offers free breakfast, a seasonal outdoor pool, and free parking. Another option that offers an onsite pool is Research Park Inn St Louis West – Chesterfield. View all hotels with pools in Defiance.

Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.

Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights around the area include Six Flags St. Louis, Ameristar Casino St. Charles, and Hollywood Casino. In Defiance, there are 6 hotels and other accommodations to choose from. Find out more about Defiance.

The picturesque setting of August A. Busch Memorial Conservation Area and Broemmelsiek Park exemplify the area's natural beauty. You'll also find Six Flags St. Louis and Ameristar Casino St. Charles in the area. Check out what more to see and do in Expedia's Defiance guide.

The hottest months are usually July and August with an average temp of 74°F, while the coldest months are January and December with an average of 37°F. The snowiest months in Defiance are February, January, March, and April, with each month seeing an average of 5 inches of snowfall.