Title: TOP 10 Hotels in Defiance, MO (from $70) - COMPETITIVE PRICES | Expedia.com [Defiance Travel Guide](https://expedia.com/Defiance.dx6353634)[Vacation Rentals in Defiance](https://expedia.com/Defiance-Vacation-Rentals.d6353634.Travel-Guide-VacationRentals)[Flights to Defiance](https://expedia.com/Cheap-Flights-To-Defiance.d6353634.Travel-Guide-Flights)[Car Rentals in Defiance](https://expedia.com/Car-Rentals-In-Defiance.d6353634.Car-Rental-Guide)[Defiance Vacation Packages](https://expedia.com/Defiance.d6353634.Destination-Travel-Guides) ![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Defiance Pool [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-04&d1=2026-04-04&endDate=2026-04-06&d2=2026-04-06&amenities=POOL) Family friendly [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-04&d1=2026-04-04&endDate=2026-04-06&d2=2026-04-06&travelerType=family_friendly) Pet friendly [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-04&d1=2026-04-04&endDate=2026-04-06&d2=2026-04-06&amenities=PETS) Cabin [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-04&d1=2026-04-04&endDate=2026-04-06&d2=2026-04-06&lodging=CABIN) Hot tub [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-04&d1=2026-04-04&endDate=2026-04-06&d2=2026-04-06&amenities=HOT_TUB) Cottage [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-04&d1=2026-04-04&endDate=2026-04-06&d2=2026-04-06&lodging=COTTAGE) Waterpark [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-04&d1=2026-04-04&endDate=2026-04-06&d2=2026-04-06&amenities=WATER_PARK) Apart­ment [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-04&d1=2026-04-04&endDate=2026-04-06&d2=2026-04-06&lodging=APARTMENT) Condo [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-04&d1=2026-04-04&endDate=2026-04-06&d2=2026-04-06&lodging=CONDO) Chalet [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-04&d1=2026-04-04&endDate=2026-04-06&d2=2026-04-06&lodging=CHALET) ## Check prices for these dates Tonight [Mar 21 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-03-21&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 22 - Mar 23](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-03-22&endDate=2026-03-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Defiance hotels ![Indoor pool](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/188fac9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business center](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/ac863486.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/97b3b5d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/51c38da4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Warrenton [](https://www.expedia.com/Warrenton-Hotels-Baymont-By-Wyndham-Warrenton.h124484.Hotel-Information) Warrenton 7.6/10 Good (1,002 reviews) "The front desk stuff were nice and welcoming. The room was clean and the breakfast was great. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dan $80 nightly $91 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Warrenton-Hotels-Baymont-By-Wyndham-Warrenton.h124484.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/20625a7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/8d754889.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/e299ff16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/fadbec1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### WoodSpring Suites St Peters-OFallon [](https://www.expedia.com/St-Louis-Hotels-Woodspring-Suites-St-Peters-Ofallon.h108921961.Hotel-Information) St. Peters 9.0/10 Wonderful (54 reviews) "Newly open and no complaints, staff is accommodating and nice. Rooms are very clean, first time I ever put my clothing items in a drawer and unpacked. Right off the highway and close to everything " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cassie $91 nightly $105 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Woodspring-Suites-St-Peters-Ofallon.h108921961.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/b53f4594.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/c9087452.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/70cee110.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/aadfb5be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham [](https://www.expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information) Fenton 8.0/10 Very Good (1,143 reviews) "Clean room, very friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jordan $89 nightly $103 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1210000/1206500/1206489/3e0ca2c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1210000/1206500/1206489/c06ddb8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1210000/1206500/1206489/b0c1520e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1210000/1206500/1206489/dbfe312f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express St. Louis West - O'Fallon by IHG [](https://www.expedia.com/St-Louis-Hotels-Holiday-Inn-Express-St-Louis-West-OFallon.h1206489.Hotel-Information) O'Fallon 8.6/10 Excellent (885 reviews) "It was a wonderful stay for my girls and her birthday. She had a blast and the room was Lovely 😍🌹" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amanda $95 nightly $112 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Holiday-Inn-Express-St-Louis-West-OFallon.h1206489.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/40200/40102/5429427c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40200/40102/w1200h1088x0y0-5acdc4f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/50000/40200/40102/be84c5ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/50000/40200/40102/81efc7c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wingate by Wyndham St. Louis/Fenton Route 66 [](https://www.expedia.com/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Fenton.h40102.Hotel-Information) Fenton 7.8/10 Good (1,164 reviews) "Great location, comfy and clean rooms " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nestor $84 nightly $97 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Fenton.h40102.Hotel-Information) ![Standard Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/470000/460100/460034/4f8a0b30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/470000/460100/460034/0603ac51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/470000/460100/460034/b2add733.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/470000/460100/460034/8032c924.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Warrenton [](https://www.expedia.com/Warrenton-Hotels-Super-8-By-Wyndham-Warrenton.h460034.Hotel-Information) Warrenton 7.4/10 Good (634 reviews) "The parking was easy, the room was verry clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gary $54 nightly $62 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Warrenton-Hotels-Super-8-By-Wyndham-Warrenton.h460034.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/55269a5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/2adbd684.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/2edd84af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, pillowtop beds, desk](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/140ce6ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Foristell [](https://www.expedia.com/Warrenton-Hotels-Quality-Inn.h16210.Hotel-Information) Foristell 8.2/10 Very Good (952 reviews) "Clean rooms, pleasant staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen $78 nightly $88 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Warrenton-Hotels-Quality-Inn.h16210.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/42200/42127/04c6573d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/42200/42127/0d3776cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/50000/42200/42127/fbb15b56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42200/42127/b1c04063.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Fenton [](https://www.expedia.com/St-Louis-Hotels-Best-Western-Plus-Fenton.h42127.Hotel-Information) Fenton 9.2/10 Wonderful (237 reviews) "Friendly staff, clean room, quiet, nice amenities." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Catherine $99 nightly $115 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Best-Western-Plus-Fenton.h42127.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41500/41453/68bc6d17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41500/41453/141b0a99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/50000/41500/41453/cf4e5d0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41500/41453/0c7d61f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites St. Louis St. Peters [](https://www.expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-St-Peters.h41453.Hotel-Information) St. Peters 9.4/10 Exceptional (1,000 reviews) "Great stay! Very clean and staff was very nice. Definitely will be staying there on my return visit to the area!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roxanne $110 nightly $126 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-St-Peters.h41453.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/3a1e3bea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/d2118181.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free full breakfast](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/70eb43b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking, Refrigerator & Microwave (with Sofabed) | Egyptian cotton sheets, premium bedding, pillowtop beds, desk](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/fecb1b2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Washington Hotel [](https://www.expedia.com/Washington-Hotels-Best-Western-Plus-Washington-Hotel.h1077183.Hotel-Information) Washington 9.2/10 Wonderful (664 reviews) "Great stay and accommodations. The pool was very nice. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shane $129 nightly $147 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/Washington-Hotels-Best-Western-Plus-Washington-Hotel.h1077183.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/035dee6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Jetted Tub | Jetted tub](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/801c113b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Jetted Tub | Jetted tub](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/66ab3de8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Wildwood Hotel [](https://www.expedia.com/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information) Wildwood 9.2/10 Wonderful (1,635 reviews) "Staff was wonderful, location is great for our needs, and it was a quiet stay-which we loved. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica $92 nightly $107 total Mar 23 - Mar 24 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1660000/1659000/1658956/a165f739.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/2000000/1660000/1659000/1658956/b4171890.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1660000/1659000/1658956/b1e08b2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/2000000/1660000/1659000/1658956/ad47a940.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West [](https://www.expedia.com/St-Louis-Hotels-Larkspur-Landing-Extended-Stay-Suites-St-Louis-Riverport-Airport-West.h1658956.Hotel-Information) Maryland Heights 7.6/10 Good (1,005 reviews) "It was a very nice stay. Only complaint is the hallways stunk. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Levi $73 nightly $85 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Larkspur-Landing-Extended-Stay-Suites-St-Louis-Riverport-Airport-West.h1658956.Hotel-Information) ![Studio, 2 Double Beds, Accessible, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/70000/66100/66038/4060a2fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/70000/66100/66038/0145b96a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/66100/66038/0a526cf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/70000/66100/66038/a541015d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Extended Stay America Suites St Louis St Peters [](https://www.expedia.com/St-Louis-Hotels-Extended-Stay-America-Suites-St-Louis-St-Peters.h66038.Hotel-Information) St. Peters 7.0/10 Good (630 reviews) "Location was perfect" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tara $80 nightly $92 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Extended-Stay-America-Suites-St-Louis-St-Peters.h66038.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/d38dcff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/660bdaf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/ac681623.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/50b5788d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Wentzville St Louis West by IHG [](https://www.expedia.com/St-Louis-Hotels-Holiday-Inn-Express-Suites-Wentzville-St-Louis-West.h35848753.Hotel-Information) Wentzville 9.4/10 Exceptional (883 reviews) "Perfect place to stay. Everything was great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jason $144 nightly $171 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Holiday-Inn-Express-Suites-Wentzville-St-Louis-West.h35848753.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/6093d918.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/159a98ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Multiple Beds, Non Smoking (2 Queen, 2 Person Sofa Bed) | In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/68f10652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/897465ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites St Charles - St Louis [](https://www.expedia.com/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information) St. Charles 8.4/10 Very Good (1,000 reviews) "Over all our stay was good. The room was a good size, we are thankful there was an ironing board and iron in the room. Good options at breakfast and the staff we encountered we are very pleasant. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elizabeth $93 nightly $106 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information) ![Premium bedding, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/10000/800/704/12181f11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/1000000/10000/800/704/79b70294.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/800/704/60ad8e4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/1000000/10000/800/704/557cf01e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham St Charles [](https://www.expedia.com/St-Louis-Hotels-Super-8-By-Wyndham-St-Charles.h704.Hotel-Information) St. Charles 8.0/10 Very Good (1,001 reviews) "Hotel was clean. Located in a good area, would stay here again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christy $84 nightly $97 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Super-8-By-Wyndham-St-Charles.h704.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/10100/10074/b34d85ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/20000/10100/10074/109bb8e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/10100/10074/c8120022.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/10100/10074/d5af958a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Near Six Flags St. Louis [](https://www.expedia.com/Pacific-Hotels-Quality-Inn-Near-Six-Flags-St-Louis.h10074.Hotel-Information) Pacific 8.4/10 Very Good (366 reviews) "Excellent staff & very clean room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen $109 nightly $125 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/Pacific-Hotels-Quality-Inn-Near-Six-Flags-St-Louis.h10074.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/18000000/17400000/17395600/17395579/d446d190.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/18000000/17400000/17395600/17395579/41a6853d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/18000000/17400000/17395600/17395579/1d29e551.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17400000/17395600/17395579/9950450a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn St. Louis Wentzville [](https://www.expedia.com/St-Louis-Hotels-Hampton-Inn-By-Hilton-Wentzville.h17395579.Hotel-Information) Wentzville 9.0/10 Wonderful (672 reviews) "The room was clean and staff were nice. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rachel $119 nightly $136 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Hampton-Inn-By-Hilton-Wentzville.h17395579.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/980000/976200/976140/416a6a90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/980000/976200/976140/56c93a46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/980000/976200/976140/f8b9cd17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/980000/976200/976140/w3840h2559x0y1-9ec7e104.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Southwest St. Louis [](https://www.expedia.com/St-Louis-Hotels-Drury-Inn-Suites-Southwest-St-Louis.h976140.Hotel-Information) Valley Park 9.6/10 Exceptional (1,000 reviews) "Very clean place with great food and friendly staff. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Kara $115 nightly $135 total Apr 3 - Apr 4 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Drury-Inn-Suites-Southwest-St-Louis.h976140.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/1d22ac52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/68b7c425.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/15695a25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, Queen Accessible Roll In Shower, Non Smoking | Blackout drapes, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/7c7fdb3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn St. Charles St. Peters [](https://www.expedia.com/St-Louis-Hotels-Hampton-Inn-St-LouisSt-Charles.h20181.Hotel-Information) St. Charles 8.0/10 Very Good (1,000 reviews) "Great location and friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Heather $106 nightly $122 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Hampton-Inn-St-LouisSt-Charles.h20181.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-04&endDate=2026-04-05®ionId=6353634&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDefiance-Hotels.d6353634.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDefiance-Hotels.d6353634.Travel-Guide-Hotels) ## Stay near popular Defiance attractions ![Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine. ](https://images.trvl-media.com/place/553248621532648567/f82f9409-75a2-47f3-a8fc-2d7c278cc07c.jpg) Photo by Pages of Travel ### Chandler Hill Vineyards This elegant Missouri winery showcases local and California wines from its hillside setting. Savor varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648567) ![Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri](https://images.trvl-media.com/place/6160337/5138d652-49fb-41de-8fd4-a7bb27471f3e.jpg) ### August A. Busch Memorial Conservation Area This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6160337) ### Historic Daniel Boone Home and Heritage Center Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648566) ### Sugar Creek Winery Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648612) ### Matson Hill Park Trailhead Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendor. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=641530089696399360) ### Yellow Farmhouse Winery This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648568) ### Broemmelsiek Park This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621561876810) ### Hamburg Trail Trailhead This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=641529175733194752) ## Learn more about Defiance Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside. [See all hotels in Defiance](https://www.expedia.com/Hotel-Search?startDate=2026-04-04&endDate=2026-04-05&adults=2®ionId=6353634) ![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high) ## Top Defiance Hotel Reviews ![Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/b53f4594_y.jpg) ### Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham 8/10 Good "Highway noise was really loud. Not many gluten-free options for breakfast. Room was clean and staff were kind" [](https://expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information) ![Best Western Plus Fenton](https://images.trvl-media.com/lodging/1000000/50000/42200/42127/04c6573d_y.jpg) ### Best Western Plus Fenton 10/10 Excellent "Staff was all friendly and helpful." [](https://expedia.com/St-Louis-Hotels-Best-Western-Plus-Fenton.h42127.Hotel-Information) ![Hollywood Casino & Hotel St. Louis](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/76ca3207_y.jpg) ### Hollywood Casino & Hotel St. Louis 6/10 Okay "No, the airport shuttle was not available for the time we were there. They said it was because of the ACHA Hockey Championships bein held in the Centenne Arena, they were concentrating on that service. There are two shuttle busses sitting in front of the hotel. Yes, I used the shuttle to the rink, but it was not always available. We were promised a room cleaning twice while we were there from March 14 to 20\. We had to ask for new towels and where to empty the garbage. The last day, the 19, a maid came to our room to see if we wanted it cleaned, I declined. The hallways had litter in the floors for 2 or 3 days in a row. I stay in a lot of hotels, for the price, the service was less than adequate. If they are short on staff and we have to do their job, I should think the price should reflect this." [](https://expedia.com/St-Louis-Hotels-Hollywood-Casino-Hotel-St-Louis.h82568.Hotel-Information) ![Sonesta ES Suites St. Louis - Chesterfield](https://images.trvl-media.com/lodging/1000000/10000/500/422/6f160867_y.jpg) ### Sonesta ES Suites St. Louis - Chesterfield 6/10 Okay "Staff was as excellent just dealing with a dated asset that seems to be mediocre legacy apartment conversion. So our unit was fine for our purposes as it was large (sleeping 6 with a loft) but it was over sprayed with air freshener and the furniture and carpet needed to be replaced 10 years ago. Site touts fireplace but boarded over. TV in main living area the size of a large computer monitor. Anyhow I likely would not pick this place again but for a no frills or quick layover for a large family or group it works." [](https://expedia.com/St-Louis-Hotels-Sonesta-ES-Suites-St-Louis-Chesterfield.h422.Hotel-Information) ![Drury Plaza Hotel St. Louis Chesterfield](https://images.trvl-media.com/lodging/2000000/1350000/1346800/1346760/69d580ec_y.jpg) ### Drury Plaza Hotel St. Louis Chesterfield 10/10 Excellent "We enjoyed a comfortable 2 day stay at The Drury Plaza Hotel. The room was clean and adequate , the lobby area was inviting and the staff was very courteous. The meals were delicious and the Happy Hour was a welcome addition to the stay . I will definitely stay at another Drury Hotel for my future travels." [](https://expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-Chesterfield.h1346760.Hotel-Information) ![Fairfield Inn & Suites by Marriott St. Louis Chesterfield](https://images.trvl-media.com/lodging/1000000/130000/126800/126794/f06ceba4_y.jpg) ### Fairfield Inn & Suites by Marriott St. Louis Chesterfield 8/10 Good "Good staff" [](https://expedia.com/St-Louis-Hotels-SpringHill-Suites-By-Marriott-St-Louis-Chesterfield.h126794.Hotel-Information) ![Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West](https://images.trvl-media.com/lodging/2000000/1660000/1659000/1658956/a165f739_y.jpg) ### Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West 10/10 Excellent "Close to everything breakfast could have more options " [](https://expedia.com/St-Louis-Hotels-Larkspur-Landing-Extended-Stay-Suites-St-Louis-Riverport-Airport-West.h1658956.Hotel-Information) ![Ameristar Casino Resort and Spa](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/70b128db_y.jpg) ### Ameristar Casino Resort and Spa 8/10 Good "Rooms are spacious. " [](https://expedia.com/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information) ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/035dee6c_y.jpg) ### The Wildwood Hotel 10/10 Excellent "the hotel is very comfortable and the staff was very helpful. " [](https://expedia.com/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information) ## More cheap stays in Defiance ![Days Inn and Suites by Wyndham St. Louis/Westport Plaza](https://images.trvl-media.com/lodging/1000000/60000/55200/55161/40483d14_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn and Suites by Wyndham St. Louis/Westport Plaza 1970 Craig Rd Maryland Heights MO $65 nightly $75 total Mar 24 - Mar 25 Total with taxes and fees 4.6/10 (1,002 reviews) [](https://expedia.com/St-Louis-Hotels-Days-Inn-And-Suites-By-Wyndham-St-LouisWestport-Plaza.h55161.Hotel-Information) ![Sleep Inn & Suites O'Fallon MO - Technology Drive](https://images.trvl-media.com/lodging/16000000/15590000/15583900/15583887/07f8c63c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Sleep Inn & Suites O'Fallon MO - Technology Drive 1147 Technology Drive O'Fallon MO $79 nightly $93 total Apr 13 - Apr 14 Total with taxes and fees 9/10 Wonderful! (1,002 reviews) [](https://expedia.com/St-Louis-Hotels-Sleep-Inn-Suites-OFallon-MO-Technology-Drive.h15583887.Hotel-Information) ![Comfort Suites St Charles - St Louis](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/6093d918_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Comfort Suites St Charles - St Louis 1400 S 5th St St. Charles MO $93 nightly $106 total Apr 19 - Apr 20 Total with taxes and fees 8.4/10 Very Good! (1,000 reviews) [](https://expedia.com/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information) ![Best Western Plus St. Louis West-Westport](https://images.trvl-media.com/lodging/1000000/50000/41500/41448/00255b25_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Plus St. Louis West-Westport 12220 Dorsett Rd Maryland Heights MO $98 nightly $114 total Apr 3 - Apr 4 Total with taxes and fees 8/10 Very Good! (1,055 reviews) [](https://expedia.com/St-Louis-Hotels-Best-Western-Plus-St-Louis-West-Westport.h41448.Hotel-Information) ![Country Inn & Suites by Radisson, St. Charles Historic District](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/001d26f2_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Country Inn & Suites by Radisson, St. Charles Historic District 1190 S Main St St. Charles MO $128 nightly $147 total Apr 19 - Apr 20 Total with taxes and fees 9.4/10 Exceptional! (1,002 reviews) [](https://expedia.com/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information) ![Relax Inn Saint Charles ](https://images.trvl-media.com/lodging/2000000/1010000/1000800/1000712/49b4298c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Relax Inn Saint Charles 3800 Harry S Truman Blvd St. Charles MO [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F4%2F2026&endDate=4%2F5%2F2026&selected=1000712&PinnedHotelID=1000712&HadPinnedHotel=true®ionId=6353634) 6.8/10 (1,001 reviews) [](https://expedia.com/St-Louis-Hotels-Relax-Inn-Saint-Charles.h1000712.Hotel-Information) ## Hotels in Defiance with star-rating ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 7 properties [](https://expedia.com/4Star-Defiance-Hotels.s40-0-d6353634.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 114 properties [](https://expedia.com/3Star-Defiance-Hotels.s30-0-d6353634.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 156 properties [](https://expedia.com/2Star-Defiance-Hotels.s20-0-d6353634.Travel-Guide-Filter-Hotels) ## Find out more about Defiance ### Top reasons to visit Defiance - **Scenic Outdoor Activities:** Enjoy hiking on the beautiful Defiance Studio Trail and explore nearby state and urban parks. - **Romantic Getaways:** Perfect for couples, Defiance offers a charming atmosphere for a memorable escape. - **Live Music and Entertainment:** Unwind with local live music performances, enhancing your vacation experience. - **Family-Friendly Attractions:** Visit amusement parks and engage in activities suitable for visitors of all ages. - **Diverse Accommodations:** Choose from pet-friendly and LGBTQIA-friendly lodging options to suit your needs. ### Find great hotels near Defiance Defiance, Missouri, offers a variety of lodging options to cater to every traveler's needs, from business trips to leisurely getaways. Whether you prefer a comfortable hotel, a cozy apartment, or a welcoming motel, you'll find accommodations that are pet-friendly and LGBTQIA-friendly. Explore the charm of Defiance while enjoying amenities tailored for a memorable stay, whether you're visiting for work or pleasure. - **[Sonesta ES Suites St. Louis - Chesterfield: ](https://www.expedia.com/St-Louis-Hotels-Sonesta-ES-Suites-St-Louis-Chesterfield.h422.Hotel-Information)** This 3-star hotel boasts a guest rating of 8.0 and is located 12 miles from Defiance. Sonesta ES Suites St. Louis - Chesterfield is ideal for pet lovers, offering a range of pet-friendly amenities including food and water bowls, and a variable pet fee. The hotel features spacious suites with fully equipped kitchens, perfect for guests seeking a home-like experience. Its convenient location allows easy access to local attractions, making it a comfortable retreat for travelers looking to explore the area with their furry friends. - **[The Wildwood Hotel: ](https://www.expedia.com/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information)** With a 3.5-star rating and an impressive guest rating of 9.2, The Wildwood Hotel is located 9 miles from Defiance and is perfect for adventure enthusiasts. Guests can easily access ski lifts and shuttles, along with nearby options for biking, hiking, and mountain climbing. The hotel features cozy accommodations and various recreational activities both on-site and in the surrounding area. This hotel is a fantastic choice for those seeking an exhilarating outdoor vacation amid beautiful surroundings. - **[Sleep Inn & Suites O'Fallon MO - Technology Drive: ](https://www.expedia.com/St-Louis-Hotels-Sleep-Inn-Suites-OFallon-MO-Technology-Drive.h15583887.Hotel-Information)** This budget-friendly option holds a guest rating of 9.0 and is situated 7 miles from Defiance. Designed with business travelers in mind, Sleep Inn & Suites O'Fallon MO offers modern amenities and a comfortable atmosphere for working professionals. Guests can enjoy complimentary breakfast, free Wi-Fi, and convenient access to local business hubs. The hotel combines practicality with comfort, ensuring a pleasant stay for those visiting the area for work. ### Where to stay in and around Defiance Defiance, Missouri, offers a delightful blend of outdoor adventures and romantic escapes. Nestled near the scenic Missouri River, visitors can explore charming neighborhoods and enjoy family-friendly activities. Just a short drive from St. Louis, the area is rich in history and friendly vibes, making it perfect for both relaxation and exploration. Whether you seek entertainment or a peaceful retreat, Defiance and its surroundings promise a memorable vacation experience. - **[Chesterfield: ](https://www.expedia.com/Chesterfield-Hotels.d9530.Travel-Guide-Hotels)** Located 12 miles away from Defiance, Chesterfield is a vibrant city that offers a mix of family-friendly and entertainment-themed experiences. With peak visitor numbers in April and the summer months, Chesterfield is a hub for fun activities. Travelers can enjoy a variety of attractions, including theaters, music concerts, and an arcade adventure zone. Additionally, the city boasts prominent landmarks such as a theme park and a sports facility stadium, making it an ideal destination for those seeking a lively atmosphere. - **[Saint Albans: ](https://www.expedia.com/Saint-Albans-Hotels.d3000445473.Travel-Guide-Hotels)** Just 4 miles from Defiance, Saint Albans is a charming city that appeals to outdoor enthusiasts and families alike. With peak visitation in spring and summer, this area offers adventure-filled experiences, including an amusement park and recreational areas perfect for picnics and outdoor activities. Visitors can also explore nearby attractions like a convention center and a picturesque lake, making it a great spot for those looking to connect with nature while enjoying family time. - **[Hamburg: ](https://www.expedia.com/Hamburg-Hotels.d553248635975869538.Travel-Guide-Hotels)** Nestled within the area of Defiance, Hamburg is a quaint village that provides a romantic and outdoor-oriented experience. Although the number of travelers remains fairly stable throughout the year, peak visits occur during the summer months. Hamburg is perfect for couples and families seeking a peaceful retreat, with plenty of opportunities for outdoor activities. Enjoy the serene surroundings and local entertainment options that make this village a delightful stop on your vacation. ### Things to do near Defiance Defiance, Missouri, is perfect for outdoor and romantic getaways, offering a variety of activities like hiking on the scenic Defiance Studio Trail and enjoying the beautiful recreational areas. Visitors can immerse themselves in outdoor experiences and unwind with live music, making it an ideal destination for entertainment and adventure. **Shopping** In Defiance, you can enjoy local shops and boutiques offering unique gifts and souvenirs. If you're up for a drive, visit the nearby Mid Rivers Mall for a wider selection, including popular brands and specialty stores perfect for finding that special keepsake. **Recreation** Experience luxury at Bellerive Country Club, located 16 miles from Defiance. Enjoy world-class amenities, indulge in fine dining, and relax in a serene environment. Engage in recreational activities like golfing and spa treatments, perfect for rejuvenating your mind and body amidst beautiful surroundings. **Adventure** Defiance offers thrilling outdoor adventures, including kayaking along the scenic Missouri River, where you can explore its beautiful banks and wildlife. For hiking enthusiasts, the nearby Klondike Park features trails with stunning views and opportunities for birdwatching among native flora and fauna. **Nightlife** Defiance offers a charming nightlife with cozy bars like the Defiance Ridge Vineyards, where you can enjoy local wines. For a more social vibe, visit The Defiance House, featuring live music and a warm atmosphere perfect for mingling with locals. \*Distances are measured in a straight line; actual driving distances may vary depending on the route. ### Booking tips and Expedia advantages for Defiance - **The most and least expensive months on average to stay in a hotel:** The cheapest months to stay in Defiance are December to February, where the prices are slightly lower. This is in comparison to May to July, where prices are slightly higher. - **The most and least expensive days on average to stay in a hotel:** The least expensive day to stay in Defiance is Monday. The most expensive day to stay in Defiance is Saturday. - **Find cheap hotels on Expedia:** Utilize Expedia's search tool to tailor your options based on your budget, desired location, and preferred hotel type. For instance, selecting the Eco-certified filter will highlight sustainable and eco-friendly hotels that are currently available. To find the best prices and deals, simply sort the price filter from low to high. - **Consider bundling your trip:** You can save money by combining your hotel reservations in Defiance with your flights and activities through an Expedia package deal. ### Find the best attractions in and around Defiance Defiance, Missouri, is perfect for outdoor enthusiasts and couples seeking a romantic getaway. Visitors can explore nearby attractions like state parks, urban parks, and amusement parks, offering a variety of experiences for families and city adventurers alike. Whether you're hiking scenic trails or enjoying thrilling rides, Defiance has something for everyone looking to unwind and enjoy the great outdoors. - **[August A. Busch Memorial Conservation Area: ](https://www.expedia.com/August-A-Busch-Memorial-Conservation-Area-Hotels.0-l6160337-0.Travel-Guide-Filter-Hotels)** Explore this beautiful reserve located in Defiance, perfect for families and nature lovers. Enjoy walking trails, wildlife viewing, and engaging excursions that connect you with friendly locals and the great outdoors. - **[Six Flags St. Louis: ](https://www.expedia.com/Six-Flags-St-Louis-Hotels.0-l6147083-0.Travel-Guide-Filter-Hotels)** Just 10 miles from Defiance, this thrilling amusement park offers a wide range of rides and attractions for all ages. Experience the excitement of roller coasters and live entertainment, making it a perfect destination for adventure seekers and families alike. - **[Purina Farms: ](https://www.expedia.com/Purina-Farms-Hotels.0-l553248621532648557-0.Travel-Guide-Filter-Hotels)** Also situated 10 miles from Defiance, this charming farm features scenic views and interactive experiences with animals. Enjoy hands-on activities and learn about farm life, making it a delightful outing for visitors of all ages. ### Best time to go to Defiance The best time to visit Defiance can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Defiance falls in July, when visitor numbers are moderately high and weather is mostly sunny with light rain. The coolest average temperature in Defiance falls in January, visitor numbers are moderately low and weather is mostly cloudy with light rain. | **![calendar](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/calendar.png)Calendar Month** | **![temperature](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__hot.png)Temperature** | **![rain](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__rain.png)Precipitation** | **![mostly](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/weather__day_mostly_cloudy.png)Cloudiness** | **![occupation](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/peoplebex.png)Occupancy** | **![price](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/currency_dollar.png)Pricing** | | ---------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------- | | January | 31.6°F (-0.2°C) | Light Rain | Mostly Cloudy | Moderately Low | Slightly Low | | February | 34.7°F (1.5°C) | Light Rain | Mostly Sunny | Average | Slightly Low | | March | 46.4°F (8.0°C) | Light Rain | Mostly Sunny | Average | Average | | April | 55.9°F (13.3°C) | Light Rain | Mostly Sunny | Moderately High | Average | | May | 66.2°F (19.0°C) | Light Rain | Mostly Sunny | Average | Slightly High | | June | 75.9°F (24.4°C) | Light Rain | Mostly Sunny | Average | Slightly High | | July | 79.0°F (26.1°C) | Light Rain | Mostly Sunny | Moderately High | Slightly High | | August | 77.2°F (25.1°C) | Light Rain | Mostly Sunny | Average | Average | | September | 70.9°F (21.6°C) | Light Rain | Mostly Sunny | Moderately High | Average | | October | 58.5°F (14.7°C) | Light Rain | Mostly Sunny | Average | Average | | November | 46.2°F (7.9°C) | Light Rain | Mostly Sunny | Moderately Low | Average | | December | 37.6°F (3.1°C) | Light Rain | Mostly Sunny | Moderately Low | Slightly Low | ### The nearest major airports for your trip to Defiance To reach Defiance, Missouri, the nearest major airport is St. Louis Lambert International Airport ([STL](https://www.expedia.com/Lambert-St-Louis-Intl-Airport-Hotels.0-aSTL-0.Travel-Guide-Filter-Hotels)), located 23 miles away. Recommended hotels nearby include [The Ritz-Carlton](https://www.expedia.com/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information), St. Louis and [Ameristar Casino Resort and Spa](https://www.expedia.com/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information), both 7 miles from the airport. Another option is [ The Royal Sonesta Chase Park Plaza St. Louis](https://www.expedia.com/St-Louis-Hotels-The-Chase-Park-Plaza-Royal-Sonesta-St-Louis.h465749.Hotel-Information), situated 9 miles away. Columbia Regional Airport ([COU](https://www.expedia.com/Columbia-Regional-Airport-Hotels.0-aCOU-0.Travel-Guide-Filter-Hotels)) is 79 miles from Defiance, with good hotel choices like The Broadway Columbia and voco The Tiger Hotel, both 11 miles away. For those traveling to Fort Leonard Wood Regional Airport ([TBN](https://www.expedia.com/St-Robert-Regional-Airport-Hotels.0-aTBN-0.Travel-Guide-Filter-Hotels)), located 97 miles away, [Z Loft Extended Stay Hotel](https://www.expedia.com/Rolla-Hotels-Z-Loft-Extended-Stay-Hotel.h11603172.Hotel-Information) is a convenient option, just 6 miles from the airport. ## Frequently asked questions ### What is the best area to stay in Defiance? > The village of Defiance is small and picturesque, centered around its historic general store and a few local eateries. Hotels here are typically smaller, independently owned establishments or bed and breakfasts, providing a personalized experience. The Katy Trail, a popular walking and cycling path, runs directly through the village, making it an excellent base for outdoor enthusiasts. > > > Couples looking for a relaxing getaway will appreciate staying in this area. It's quiet and offers direct access to scenic walks and bike rides along the Missouri River. ### When is the best time to go to Defiance? > These seasons offer pleasant weather conditions, with comfortable temperatures that are ideal for outdoor activities like cycling or exploring the Katy Trail. In spring, the local vineyards begin to bloom, and in autumn, the changing leaves provide scenic views along the Missouri River. Traveling during these times also allows you to enjoy local events and festivals without the peak summer crowds. > > > For travelers looking to experience the region's natural beauty and participate in outdoor recreation, spring and fall provide the most agreeable climate. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Defiance hotel booking with Expedia? > \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo. ### How much is the nightly rate at a Defiance hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near Yellow Farmhouse Winery ](https://www.expedia.com/Yellow-Farmhouse-Winery-Hotels.0-l553248621532648568-0.Travel-Guide-Filter-Hotels) - [Hotels near Chandler Hill Vineyards ](https://www.expedia.com/Chandler-Hill-Vineyards-Hotels.0-l553248621532648567-0.Travel-Guide-Filter-Hotels) - [Hotels near Sugar Creek Winery ](https://www.expedia.com/Sugar-Creek-Winery-Hotels.0-l553248621532648612-0.Travel-Guide-Filter-Hotels) - [Hamburg Hotels ](https://www.expedia.com/Hamburg-Hotels.d553248635975869538.Travel-Guide-Hotels) - [Saint Albans Hotels ](https://www.expedia.com/Saint-Albans-Hotels.d3000445473.Travel-Guide-Hotels) - [Villas in Saint Albans ](https://www.expedia.com/Saint-Albans-Villas.d3000445473-aaVillas.Travel-Guide-Accommodation) - [Vacation Homes in Saint Albans ](https://www.expedia.com/Saint-Albans-Private-Vacation-Homes.d3000445473-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Cottages in Saint Albans ](https://www.expedia.com/Saint-Albans-Cottages.d3000445473-aaCottages.Travel-Guide-Accommodation) - [Hotels near Historic Daniel Boone Home and Heritage Center ](https://www.expedia.com/Historic-Daniel-Boone-Home-And-Heritage-Center-Hotels.0-l553248621532648566-0.Travel-Guide-Filter-Hotels) - [Hotels near Babler State Park ](https://www.expedia.com/Babler-State-Park-Hotels.0-l6293012-0.Travel-Guide-Filter-Hotels) - [Hotels near Dr. Edmund A. 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