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Vacation Homes in Defiance

Stunning 1890's Home - Sleeps 8!

10.0 out of 10, Exceptional, (67)
"Beautiful house and location."
$391 nightly
The price is $401
Aug 3 - Aug 4
Total includes taxes and fees
Stunning 1890's Home - Sleeps 8!

AK's STL Pearl Grey House - Game Room

9.4 out of 10, Exceptional, (6)
"Quiet neighborhood, comfortable house, well-stocked kitchen. We would stay here again."
$543 nightly
The price is $543
Aug 4 - Aug 5
Total includes taxes and fees
AK's STL Pearl Grey House - Game Room

Honky Tonk Hideaway

9.2 out of 10, Wonderful, (5)
"Great place to stay"
Honky Tonk Hideaway

Spacious*Outdoor Space*Modern*Family*Groups*Modern*Artistic

9.6 out of 10, Exceptional, (53)
"Lovely home within a neighborhood subdivision. Clean, beautifully decorated, plenty of bedrooms and bathroom for our group. Close to restaurants and shopping. "
$382 nightly
The price is $382
Jul 27 - Jul 28
Total includes taxes and fees
Spacious*Outdoor Space*Modern*Family*Groups*Modern*Artistic

Stunning Lakeside Retreat at Innsbrook w/ Swing, Canoe and 3 Kayaks

10.0 out of 10, Exceptional, (52)
"We had a great time. The home was great for our group of 7.! "
Stunning Lakeside Retreat at Innsbrook w/ Swing, Canoe and 3 Kayaks

Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

9.6 out of 10, Exceptional, (44)
"This was our third stay in this house! It’s the perfect location for visiting our son who attends Lindenwood. Quiet neighborhood, great place to walk our fur baby, comfy beds and decorated so cute!"
$324 nightly
The price is $324
Jul 27 - Jul 28
Total includes taxes and fees
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

Residence on the Roundabout

9.6 out of 10, Exceptional, (133)
"We had a nice stay in this cute home. St. Charles is a wonderful place to visit! "
Residence on the Roundabout

St. Charles 1860's Gem - Sleeps 6!

9.8 out of 10, Exceptional, (110)
"Great time and nice and quiet :) "
$256 nightly
The price is $256
Jul 27 - Jul 28
Total includes taxes and fees
St. Charles 1860's Gem - Sleeps 6!

Charming 3BR/2BA home—peaceful country vibes, perfect for relaxing stays!

6.8 out of 10, (3)
"The house was great and Nicole was a great host. "
Charming 3BR/2BA home—peaceful country vibes, perfect for relaxing stays!

Walk to St Charles Main St. Shops, Eateries & Bars!

10.0 out of 10, Exceptional, (69)
"The house was just as described and the location is just a few blocks from the historic area."
Walk to St Charles Main St. Shops, Eateries & Bars!

1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo.

10.0 out of 10, Exceptional, (260)
"It was a wonderful getaway it was close to St Peter's Church and downtown."
1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo.

🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟

9.8 out of 10, Exceptional, (63)
"Had a great stay! Perfect place and super cute! Perfect distance from downtown st. Charles!! Will stay here again!!!!"
🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟

Newly Updated Charming and Cozy Home near Historic Main Street in Frenchtown.

10.0 out of 10, Exceptional, (34)
"Very clean and had everything we needed. TV had a lot of options and overall was very cozy and comfortable. "
Newly Updated Charming and Cozy Home near Historic Main Street in Frenchtown.

Private St Peters Home Patio Pool Table

10.0 out of 10, Exceptional, (23)
"Very nice house to stay, Highly recommend "
Private St Peters Home Patio Pool Table

Pet Friendly - Private Home - Fenced Yard

10.0 out of 10, Exceptional, (20)
"Great rental property that was perfect for our stay! The hosts thought of everything and the home was clean and well appointed. If we are in town again I would absolutely stay here again."
Pet Friendly - Private Home - Fenced Yard

TJ’s Country Getaway- Dog Friendly

10.0 out of 10, Exceptional, (41)
"It had everything you need for a relaxing stay. "
$133 nightly
The price is $133
Jul 30 - Jul 31
Total includes taxes and fees
TJ’s Country Getaway- Dog Friendly

Washington Guest House

10.0 out of 10, Exceptional, (35)
"Wonderful weekend. House was comfy even with single digit temperatures outside. Very clean and well stocked. Enough room for the six of us to play games, cook and eat as well as spread out and make hand knitted blankets. Several fun things in house that allows you a peek into the personality of the owners. Thank you for sharing your house with us. "
$337 nightly
The price is $378
Jul 28 - Jul 29
Total includes taxes and fees
Washington Guest House

Judge’s Quarters: Exquisite Luxury Apartment

10.0 out of 10, Exceptional, (22)
"Perfect stay for the weekend! It was cozy and I was able to walk all around town from the apartment. Everything was just perfect!"
Judge’s Quarters: Exquisite Luxury Apartment

Hilltop Hideaway with Lake Front Access

Hilltop Hideaway with Lake Front Access

Luxe Innsbrook Resort Home - Lakes/Golf/Trails

9.6 out of 10, Exceptional, (17)
"House was very large and accommodated our group of 10 very well. The house had everything we needed during our stay. Access to the community pool was also nice. We would return again."
Luxe Innsbrook Resort Home - Lakes/Golf/Trails
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews