Defiance Vacations from $395

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Your Defiance Vacation

Its lively atmosphere, progressive thinking and friendly locals are among the many reasons to book a vacation package to Defiance. Whatever brings you to this rural city, you're bound to have an awesome time. If your trip to Defiance includes a little sightseeing, visit major attractions such as Chandler Hill Vineyards, Historic Daniel Boone Home and Heritage Center and Montelle Winery. Whoever you're taking time off with and whether your budget is big or small, your ultimate Defiance vacation is just a few clicks away with Expedia.

The Latest Defiance vacation packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was $567, price is now $395 per person
$395
per person
Mar 27 - Mar 29
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,600 reviews)
Everything was great

Reviewed on Feb 23, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Price was $665, price is now $495 per person
$495
per person
Apr 27 - Apr 30
found 8 hours ago
Roundtrip flight included
Las Vegas (LAS) to St. Louis (STL)
8.8/10 Excellent! (1,022 reviews)
Great customer service. The locals there are friendly as well as the staff members

Reviewed on Feb 23, 2026

Home2 Suites by Hilton St. Louis Downtown

Home2 Suites by Hilton St. Louis Downtown

3 out of 5
Downtown West
Price was $589, price is now $464 per person
$464
per person
Apr 27 - Apr 30
found 8 hours ago
Roundtrip flight included
Las Vegas (LAS) to St. Louis (STL)
8/10 Very Good! (567 reviews)
Our room was clean and very comfortable. Warm water was very slow to arrive in the shower (5 minutes) and then it was lukewarm. The elevators were a problem. Only one working with a full hotel. Breakfast was decent .

Reviewed on Feb 17, 2026

DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park

4 out of 5
Central West End
Price was $614, price is now $490 per person
$490
per person
Apr 27 - Apr 30
found 8 hours ago
Roundtrip flight included
Las Vegas (LAS) to St. Louis (STL)
8.2/10 Very Good! (1,003 reviews)
The room was clean and comfortable, the staff was friendly and accommodating. Perfect for our stay!

Reviewed on Feb 24, 2026

Hampton Inn By Hilton St Louis Airport

Hampton Inn By Hilton St Louis Airport

2.5 out of 5
Woodson Terrace
Price was $579, price is now $466 per person
$466
per person
Apr 27 - Apr 30
found 8 hours ago
Roundtrip flight included
Las Vegas (LAS) to St. Louis (STL)
8.8/10 Excellent! (96 reviews)
The staff does not tell you that they only clean rooms every other day. I had to send for more towels and tissue. Otherwise the stay was fine. Also there is no laundry.

Reviewed on Feb 24, 2026

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Discover the most popular places to visit in Defiance

Union Station, St. Louis, MO

St. Louis Union Station

4/5(615 reviews)

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game.

St. Louis Union Station
St. Louis Cardinals Baseball.

Busch Stadium

4.5/5(1,469 reviews)

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's fascinating museums or attend a baseball game.

Busch Stadium
Gateway Arch showing a city, a skyscraper and skyline

Gateway Arch

4.5/5(2,511 reviews)

Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.

Gateway Arch

What to do in Defiance

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$32
per adult
St. Louis Ghost Tour: Sinister Sins & Shadows
Lemp Haunted Neighborhood Walking Tour

Lemp Haunted Neighborhood Walking Tour

$27
per adult
84% of travellers recommend
Lemp Haunted Neighborhood Walking Tour
St. Louis Premium Driving Tour with Boat Ride & Arch

St. Louis Premium Driving Tour with Boat Ride & Arch

$174
per adult
100% of travellers recommend
St. Louis Premium Driving Tour with Boat Ride & Arch
See all activities in Defiance

Defiance Hotel Deals

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $103 total per night from Feb 26 to Feb 27
$103 total
Feb 26 - Feb 27
Total with taxes and fees
8/10 Very Good! (1,107 reviews)
Clean room

Reviewed on Feb 24, 2026

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $114 total per night from Mar 1 to Mar 2
$114 total
Mar 1 - Mar 2
Total with taxes and fees
9.2/10 Wonderful! (1,621 reviews)
Hot tub was broken and the pool was really cold. Hotel room was nice and quiet.

Reviewed on Feb 23, 2026

The Wildwood Hotel
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
$184 nightly
The price is $215 total per night from Mar 9 to Mar 10
$215 total
Mar 9 - Mar 10
Total with taxes and fees
8.4/10 Very Good! (1,000 reviews)
Unfortunately stay was just alittle disappointing then the stay before this one. Casino not giving free coffee to room as time before and had no vending machines whatsoever. Only had one lonely ice machine. Could not get chips or soda. Guessing it’s the time we live in. Just so sad

Reviewed on Feb 24, 2026

Ameristar Casino Resort and Spa
See all 849 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Defiance Vacation Packages

Defiance Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)
Population
160
Max Temp Winter
40ºF
Max Temp Summer
90ºF
Top Sights
Augusta Winery, Montelle Winery and Chandler Hill Vineyards

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Frequently asked questions

How much does a Defiance vacation package cost?
You can grab a vacation package to this popular destination from $395 on Expedia. However, how much your vacation to Defiance costs will depend on factors like the season, hotel choice and length of stay.
What are the cheapest months to go to Defiance?
If you're looking to score a cheap Defiance vacation package, consider traveling in December, January and February. You'll usually find lower rates on hotels and airfares during these quieter months — perfect for a budget-friendly break.
How many days is enough for Defiance?
Typically, a handful of days is enough to visit the top attractions during your Defiance vacation. But if you prefer to have more time to relax or take day trips, think about extending your itinerary.
How to find the best Defiance package deals?
Use Expedia's filters to find some terrific Defiance package deals. When you begin your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or search for Defiance package deals in the off-season. Switch up your travel dates and you may land even bigger discounts. As a rule of thumb, it's typically best to book your vacation package well in advance.
Is it cheaper to book a Defiance vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your hotel, car rental and flight into one great-value price and you could save hundreds of dollars. You'll usually land a better deal than booking each component separately. And you'll still enjoy the flexibility to create a customized Defiance vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Defiance?
If you have your Defiance vacation dates locked in, book as soon as you can to snap up some awesome deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spontaneous getaways? Our last-minute deals are perfect for quick escapes.
Does Expedia offer Book Now, Pay Later Defiance vacation packages?
If you're anything like us, you love discovering new places but don't love the big price tag that can come with it. That's why we've created Book Now, Pay Later vacations. With help from online lender Affirm, you can spread the overall cost of your Defiance break over 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can secure great vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.