
Defiance Vacations from CLP 317,612
Book a Hotel + Flight or Car together to unlock savings
Your Defiance Vacation
Its lively atmosphere, progressive thinking and friendly locals are among the many reasons to book a vacation package to Defiance. Whatever brings you to this rural city, you're bound to have an awesome time. If your trip to Defiance includes a little sightseeing, visit major attractions such as Chandler Hill Vineyards, Historic Daniel Boone Home and Heritage Center and Montelle Winery. Whoever you're taking time off with and whether your budget is big or small, your ultimate Defiance vacation is just a few clicks away with Expedia.
The Latest Defiance Vacation Packages

Hilton Garden Inn Chesterfield
Reviewed on 26 Jul, 2025

The Wildwood Hotel
Reviewed on 20 Aug, 2025

The Principal Hotel
Reviewed on 18 Aug, 2025

Marriott St. Louis West
Reviewed on 16 Aug, 2025

Hilton Garden Inn St. Louis/O'Fallon MO
Reviewed on 30 Jun, 2025
Find the Best Defiance Vacation Packages
Defiance Essential Information
Language | English |
---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Population | 160 |
Max Temp Winter | 40ºF |
Max Temp Summer | 90ºF |
Top Sights | Augusta Winery, Montelle Winery and Chandler Hill Vineyards |
Defiance Hotel Deals

Hollywood Casino & Hotel St. Louis
Reviewed on 19 Aug, 2025

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Reviewed on 17 Aug, 2025

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Reviewed on 19 Aug, 2025
Discover the most popular places to visit in Defiance

Busch Stadium
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's great live music or attend a baseball game.

St. Louis Union Station
You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's fascinating museums or attend a baseball game.

Gateway Arch
Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.
What to do in Defiance

St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour

Best of St. Louis Small Group Tour w/ Arch & River Cruise

St. Louis: Guided Small Group City Tour with River Cruise
Other vacations you might like
- Vacations from Atlanta
- Vacations from Austin
- Vacations from Boston
- Vacations from Chicago
- Vacations from Dallas
- Vacations from Houston
- Vacations from Las Vegas
- Vacations from Los Angeles
- Vacations from Miami
- Vacations from New York
- Vacations from Orlando
- Vacations from Philadelphia
- Vacations from Phoenix
- Vacations from Pittsburgh
- Vacations from Seattle
- Vacations from Washington
- January Vacations and Deals
- February Vacations and Deals
- March Vacations and Deals
- April Vacations and Deals
- May Vacations and Deals
- June Vacations and Deals
- July Vacations and Deals
- August Vacations and Deals
- September Vacations and Deals
- October Vacations and Deals
- November Vacations and Deals
- December Vacations and Deals