Defiance Vacations from $204
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Defiance Vacation
Its lively atmosphere, progressive thinking and friendly locals are among the many reasons to book a vacation package to Defiance. Whatever brings you to this rural city, you're bound to have an awesome time. If your trip to Defiance includes a little sightseeing, visit major attractions such as Chandler Hill Vineyards, Historic Daniel Boone Home and Heritage Center and Montelle Winery. Whoever you're taking time off with and whether your budget is big or small, your ultimate Defiance vacation is just a few clicks away with Expedia.
The Latest Defiance vacation packages
Price found within the past 48 hours. Click for updated prices.
The Cheshire
Save 100% on your flight
Price was $447, price is now $271 per person
$271
per person
Sep 23 - Sep 26
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,001 reviews)
Bedding had blood stains. We called the front desk about the stained bedding and they went new sheets up but expected us to strip bed and put new sheets on ourselves. We were going to do that but the new sheets were damp so we requested a different room instead. Likely won’t stay here again.
Reviewed on Jul 11, 2026
Hilton Garden Inn Chesterfield
Save 100% on your flight
Price was $346, price is now $222 per person
$222
per person
Sep 23 - Sep 26
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.4/10 Very Good! (831 reviews)
Very clean and very nice as a little home away from home. It’s just up the road from shops and all kinds of restaurants. When I make another trip back up there this will be my first choice again!!
Reviewed on Jul 7, 2026
Ameristar Casino Resort and Spa
Save 100% on your flight
Price was $611, price is now $409 per person
$409
per person
Sep 23 - Sep 26
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.6/10 Excellent! (1,000 reviews)
We had a great time at the hotel/casino. There is a lot of places to eat and drink on site. We will definitely be back to swim in the pool.
Reviewed on Jul 10, 2026
What to do in Defiance
StL's Signature "Sights and Bites" - Private Tour in St. Louis
$165
per adult
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
100% of travellers recommend
St. Louis Premium Small Group Tour With Arch & River Cruise
$169
per adult
84% of travellers recommend
Defiance Hotel Deals
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $109 total per night from Jul 13 to Jul 14
$109 total
Jul 13 - Jul 14
Total with taxes and fees
7.8/10 Good! (1,432 reviews)
"Not a clean room. Smoking outside came through the window air conditioner. Odd smell in room."
Reviewed on Jul 11, 2026
Hollywood Casino & Hotel St. Louis
777 Casino Center Drive Maryland Heights MO
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $136 total per night from Jul 13 to Jul 14
$136 total
Jul 13 - Jul 14
Total with taxes and fees
8.6/10 Excellent! (2,213 reviews)
"Room was clean. Check in and out were quick and efficient."
Reviewed on Jul 10, 2026
Hilton St. Louis Frontenac
1335 S Lindbergh Blvd Frontenac MO
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $121 total per night from Jul 17 to Jul 18
$121 total
Jul 17 - Jul 18
Total with taxes and fees
8.8/10 Excellent! (1,008 reviews)
"We got a junior suite which was located in the Clayton building. It was clean and comfortable. Not extravagant, but nice. We did open the couch bed for my kids and the cover was dirty and there were no blankets or pillows. The front desk had someone to our room within about 20 minutes to put a brand ..."
Reviewed on Jul 12, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Defiance Vacation Packages
Defiance Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Population | 160 |
Max Temp Winter | 40ºF |
Max Temp Summer | 90ºF |
Top Sights | Augusta Winery, Montelle Winery and Chandler Hill Vineyards |
More vacations you might like
Frequently asked questions
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
