
Defiance Vacations from $327
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Your Defiance Vacation
Its lively atmosphere, progressive thinking and friendly locals are among the many reasons to book a vacation package to Defiance. Whatever brings you to this rural city, you're bound to have an awesome time. If your trip to Defiance includes a little sightseeing, visit major attractions such as Chandler Hill Vineyards, Historic Daniel Boone Home and Heritage Center and Montelle Winery. Whoever you're taking time off with and whether your budget is big or small, your ultimate Defiance vacation is just a few clicks away with Expedia.
The Latest Defiance vacation packages

The Wildwood Hotel
Reviewed on Aug 22, 2025

Hilton Garden Inn Chesterfield
Reviewed on Jul 26, 2025

The Knight Center at Washington University
Reviewed on Aug 22, 2025

The Principal Hotel
Reviewed on Aug 18, 2025

Discover the most popular places to visit in Defiance

Busch Stadium
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's great live music or attend a baseball game.

St. Louis Union Station
You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's fascinating museums or attend a baseball game.

Gateway Arch
Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.
What to do in Defiance

St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour

Best of St. Louis Small Group Tour w/ Arch & River Cruise

St. Louis Ghosts: Gateway Ghouls and Hauntings
Defiance Hotel Deals

Hollywood Casino & Hotel St. Louis
Reviewed on Aug 19, 2025

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Reviewed on Aug 21, 2025

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Reviewed on Aug 23, 2025