Defiance Vacations from $154

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Your Defiance Vacation

Its lively atmosphere, progressive thinking and friendly locals are among the many reasons to book a vacation package to Defiance. Whatever brings you to this rural city, you're bound to have an awesome time. If your trip to Defiance includes a little sightseeing, visit major attractions such as Chandler Hill Vineyards, Historic Daniel Boone Home and Heritage Center and Montelle Winery. Whoever you're taking time off with and whether your budget is big or small, your ultimate Defiance vacation is just a few clicks away with Expedia.

The Latest Defiance vacation packages

Price found within the past 48 hours. Click for updated prices.
HoteLumiere at the Arch - A Caesars Rewards Destination

HoteLumiere at the Arch - A Caesars Rewards Destination

4 out of 5
Downtown St. Louis
Price was $214, price is now $154 per person
$154
per person
Jun 1 - Jun 3
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
6.8/10 (1,006 reviews)
Definitely needs some updates and a little TLC

Reviewed on Mar 9, 2026

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
Price was $711, price is now $383 per person
$383
per person
May 22 - May 26
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,627 reviews)
The breakfaat was average, thou fresh. There was enough street parking nearby, safe.

Reviewed on Mar 30, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Save 100% on your flight
Price was $309, price is now $215 per person
$215
per person
Jun 1 - Jun 3
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,049 reviews)
nice place! stayed two nights. had to ask for more towels, washcloths and room coffee , even with service thing on door. Other than that, i hope to stay there again!

Reviewed on Apr 9, 2026

Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

3 out of 5
Save 100% on your flight
Price was $539, price is now $382 per person
$382
per person
May 22 - May 26
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.2/10 Very Good! (810 reviews)
Room was clean. Had Netflix on tv

Reviewed on Mar 16, 2026

Crowne Plaza St. Louis Airport by IHG

Crowne Plaza St. Louis Airport by IHG

3.5 out of 5
Price was $839, price is now $628 per person
$628
per person
Jun 24 - Jun 28
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
8/10 Very Good! (1,000 reviews)
Beautiful hotel, absolutely loved the waterfall at night time. My room opened up to the sound, it also a very nice balcony overlooking the hotel pool and waterfall. Make sure to get a room overlooking the pool with deck.

Reviewed on Apr 10, 2026

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Discover the most popular places to visit in Defiance

Union Station, St. Louis, MO

St. Louis Union Station

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's fascinating museums or attend a baseball game.

St. Louis Union Station
Busch Stadium

Busch Stadium

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's great live music or attend a baseball game.

Busch Stadium
Gateway Arch

Gateway Arch

Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.

Gateway Arch

What to do in Defiance

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$24
per adult
St. Louis Ghost Tour: Sinister Sins & Shadows
Lemp Haunted Neighborhood Walking Tour

Lemp Haunted Neighborhood Walking Tour

$30
per adult
84% of travellers recommend
Lemp Haunted Neighborhood Walking Tour
St. Louis Walking Tour with St Louis Arch Ticket

St. Louis Walking Tour with St Louis Arch Ticket

$79
per adult
St. Louis Walking Tour with St Louis Arch Ticket
See all activities in Defiance

Defiance Hotel Deals

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $143 total per night from Apr 12 to Apr 13
$143 total
Apr 12 - Apr 13
Total with taxes and fees
8.4/10 Very Good! (2,200 reviews)
Everything way too expensive! No places for vending machines rooms wete ok just plain. I tjought thry would be more upgrsde being in a casino environment

Reviewed on Apr 9, 2026

Hollywood Casino & Hotel St. Louis
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $103 total per night from Apr 12 to Apr 13
$103 total
Apr 12 - Apr 13
Total with taxes and fees
8/10 Very Good! (1,195 reviews)
The hotel appeared to look clean. However, upon arriving there were large crackers/chips in the floor by the air unit in the room. Additionally, one of the elevators had what appeared to be puke/stool. The front desk attendant was notified and 4 hours later it was still not cleaned. The next morning ...

Reviewed on Apr 10, 2026

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $107 total per night from Apr 29 to Apr 30
$107 total
Apr 29 - Apr 30
Total with taxes and fees
9.2/10 Wonderful! (1,629 reviews)
Place was absolutely amazing however there was a couple of angry geese acting like bouncers in front

Reviewed on Apr 8, 2026

The Wildwood Hotel
See all 870 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Defiance Vacation Packages

Defiance Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)
Population
160
Max Temp Winter
40ºF
Max Temp Summer
90ºF
Top Sights
Augusta Winery, Montelle Winery and Chandler Hill Vineyards

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Frequently asked questions

How much does a Defiance vacation package cost?
You can grab a vacation package to this popular destination from $154 on Expedia. However, how much your vacation to Defiance costs will depend on factors like the season, hotel choice and length of stay.
What are the cheapest months to go to Defiance?
If you're looking to score a cheap Defiance vacation package, consider traveling in December, January and February. You'll usually find lower rates on hotels and airfares during these quieter months — perfect for a budget-friendly break.
How many days is enough for Defiance?
Typically, a handful of days is enough to visit the top attractions during your Defiance vacation. But if you prefer to have more time to relax or take day trips, think about extending your itinerary.
How to find the best Defiance package deals?
Use Expedia's filters to find some terrific Defiance package deals. When you begin your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or search for Defiance package deals in the off-season. Switch up your travel dates and you may land even bigger discounts. As a rule of thumb, it's typically best to book your vacation package well in advance.
Is it cheaper to book a Defiance vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your hotel, car rental and flight into one great-value price and you could save hundreds of dollars. You'll usually land a better deal than booking each component separately. And you'll still enjoy the flexibility to create a customized Defiance vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Defiance?
If you have your Defiance vacation dates locked in, book as soon as you can to snap up some awesome deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spontaneous getaways? Our last-minute deals are perfect for quick escapes.
Does Expedia offer Book Now, Pay Later Defiance vacation packages?
If you're anything like us, you love discovering new places but don't love the big price tag that can come with it. That's why we've created Book Now, Pay Later vacations. With help from online lender Affirm, you can spread the overall cost of your Defiance break over 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can secure great vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.