Defiance Vacations from CLP 317,612

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Your Defiance Vacation

Its lively atmosphere, progressive thinking and friendly locals are among the many reasons to book a vacation package to Defiance. Whatever brings you to this rural city, you're bound to have an awesome time. If your trip to Defiance includes a little sightseeing, visit major attractions such as Chandler Hill Vineyards, Historic Daniel Boone Home and Heritage Center and Montelle Winery. Whoever you're taking time off with and whether your budget is big or small, your ultimate Defiance vacation is just a few clicks away with Expedia.

The Latest Defiance Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Chesterfield
The Wildwood Hotel
The Principal Hotel
Marriott St. Louis West
Hilton Garden Inn St. Louis/O'Fallon MO

Find the Best Defiance Vacation Packages

Defiance Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)
Population
160
Max Temp Winter
40ºF
Max Temp Summer
90ºF
Top Sights
Augusta Winery, Montelle Winery and Chandler Hill Vineyards

Defiance Hotel Deals

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
Fully refundableReserve now, pay when you stay
8.2/10 Very Good! (2,082 reviews)
"Perfect place to stay if you’re going to a concert at the Hollywood amphitheater. I would definitely recommend using the shuttle!!"

Reviewed on 19 Aug, 2025

Hollywood Casino & Hotel St. Louis
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive, Fenton, MO
Fully refundableReserve now, pay when you stay
8.2/10 Very Good! (1,006 reviews)
"all good"

Reviewed on 17 Aug, 2025

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

3 out of 5
13639 Riverport Dr, Maryland Heights, MO
Fully refundableReserve now, pay when you stay
7.2/10 Good! (1,001 reviews)
"I love the free breakfast and how convenient and spacious the suites are"

Reviewed on 19 Aug, 2025

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Defiance

What to do in Defiance

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.