Defiance Vacations from $288

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Your Defiance Vacation

Its lively atmosphere, progressive thinking and friendly locals are among the many reasons to book a vacation package to Defiance. Whatever brings you to this rural city, you're bound to have an awesome time. If your trip to Defiance includes a little sightseeing, visit major attractions such as Chandler Hill Vineyards, Historic Daniel Boone Home and Heritage Center and Montelle Winery. Whoever you're taking time off with and whether your budget is big or small, your ultimate Defiance vacation is just a few clicks away with Expedia.

The Latest Defiance vacation packages

Price found within the past 48 hours. Click for updated prices.
HoteLumiere at the Arch - A Caesars Rewards Destination

HoteLumiere at the Arch - A Caesars Rewards Destination

4 out of 5
Downtown St. Louis
Save 100% on your flight
Price was $464, price is now $288 per person
$288
per person
Jan 31 - Feb 3
found 4 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
13.2/10 Exceptional! (1,001 reviews)
It was very nice resort

Reviewed on Nov 20, 2025

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
Price was $693, price is now $358 per person
$358
per person
Jan 7 - Jan 11
found 13 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
18.4/10 Exceptional! (1,600 reviews)
Everything was good except the hot tub was down.

Reviewed on Nov 25, 2025

The Cheshire

The Cheshire

4 out of 5
Save 100% on your flight
Price was $649, price is now $418 per person
$418
per person
Jan 7 - Jan 11
found 13 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
17.2/10 Exceptional! (1,002 reviews)
Great stay! The room could have been a tiny bit cleaner but nothing crazy! Mainly stains on the table and some dusty areas but beds and bathrooms were clean! The staff was super nice and the place was nicely decorated.

Reviewed on Nov 15, 2025

Home2 Suites by Hilton St. Louis/Forest Park

Home2 Suites by Hilton St. Louis/Forest Park

3 out of 5
The Grove
Save 100% on your flight
Price was $737, price is now $483 per person
$483
per person
Jan 7 - Jan 11
found 13 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
17.2/10 Exceptional! (1,000 reviews)
Everything was perfect A bit more attention to detail is needed. A deep clean on a regular basis.

Reviewed on Nov 10, 2025

Marriott St. Louis West

Marriott St. Louis West

3.5 out of 5
Save 100% on your flight
Price was $574, price is now $377 per person
$377
per person
Jan 7 - Jan 11
found 13 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
17.2/10 Exceptional! (1,000 reviews)
Parking area felt very safe

Reviewed on Oct 14, 2025

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Discover the most popular places to visit in Defiance

St. Louis Union Station

St. Louis Union Station

4/5(615 reviews)

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game.

St. Louis Union Station
Gateway Arch showing a city, a skyscraper and skyline

Gateway Arch

4.5/5(2,511 reviews)

Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.

Gateway Arch
St. Louis Zoo

St. Louis Zoo

4.5/5(1,212 reviews)

In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

St. Louis Zoo

What to do in Defiance

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$32
per adult
St. Louis Ghost Tour: Sinister Sins & Shadows
St. Louis Arch Walking Tour and Entrance Ticket

St Louis Arch Small Group Walking Tour and Arch Entrance Ticket

$45
per adult
74% of travellers recommend
St Louis Arch Small Group Walking Tour and Arch Entrance Ticket
Step into the shadows and discover the haunting tales of our city's past.

St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour

$30
per adult
100% of travellers recommend
St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour
See all activities in Defiance

Defiance Hotel Deals

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $98 total per night from Nov 30 to Dec 1
$98 total
Nov 30 - Dec 1
Total with taxes and fees
7.8/10 Good! (1,015 reviews)
Room was clean and staff was friendly. Just all around great place to stay.

Reviewed on Nov 21, 2025

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $98 total per night from Dec 25 to Dec 26
$98 total
Dec 25 - Dec 26
Total with taxes and fees
8.4/10 Very Good! (2,203 reviews)
Everything is great

Reviewed on Nov 19, 2025

Hollywood Casino & Hotel St. Louis
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $111 total per night from Dec 7 to Dec 8
$111 total
Dec 7 - Dec 8
Total with taxes and fees
9.2/10 Wonderful! (1,598 reviews)
Quiet

Reviewed on Nov 19, 2025

The Wildwood Hotel
See all 843 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Defiance Vacation Packages

Defiance Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)
Population
160
Max Temp Winter
40ºF
Max Temp Summer
90ºF
Top Sights
Augusta Winery, Montelle Winery and Chandler Hill Vineyards

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Frequently asked questions

How much does a Defiance vacation package cost?
You can grab a vacation package to this popular destination from $288 on Expedia. However, how much your vacation to Defiance costs will depend on factors like the season, hotel choice and length of stay.
What are the cheapest months to go to Defiance?
If you're looking to score a cheap Defiance vacation package, consider traveling in December, January and February. You'll usually find lower rates on hotels and airfares during these quieter months — perfect for a budget-friendly break.
How many days is enough for Defiance?
Typically, a handful of days is enough to visit the top attractions during your Defiance vacation. But if you prefer to have more time to relax or take day trips, think about extending your itinerary.
How to find the best Defiance package deals?
Use Expedia's filters to find some terrific Defiance package deals. When you begin your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or search for Defiance package deals in the off-season. Switch up your travel dates and you may land even bigger discounts. As a rule of thumb, it's typically best to book your vacation package well in advance.
Is it cheaper to book a Defiance vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your hotel, car rental and flight into one great-value price and you could save hundreds of dollars. You'll usually land a better deal than booking each component separately. And you'll still enjoy the flexibility to create a customized Defiance vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Defiance?
If you have your Defiance vacation dates locked in, book as soon as you can to snap up some awesome deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spontaneous getaways? Our last-minute deals are perfect for quick escapes.
Does Expedia offer Book Now, Pay Later Defiance vacation packages?
If you're anything like us, you love discovering new places but don't love the big price tag that can come with it. That's why we've created Book Now, Pay Later vacations. With help from online lender Affirm, you can spread the overall cost of your Defiance break over 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can secure great vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.