Defiance Vacations from $256
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Your Defiance Vacation
Its lively atmosphere, progressive thinking and friendly locals are among the many reasons to book a vacation package to Defiance. Whatever brings you to this rural city, you're bound to have an awesome time. If your trip to Defiance includes a little sightseeing, visit major attractions such as Chandler Hill Vineyards, Historic Daniel Boone Home and Heritage Center and Montelle Winery. Whoever you're taking time off with and whether your budget is big or small, your ultimate Defiance vacation is just a few clicks away with Expedia.
The Latest Defiance vacation packages
Price found within the past 48 hours. Click for updated prices.
Crowne Plaza St. Louis Airport by IHG
Price was $352, price is now $256 per person
$256
per person
Dec 15 - Dec 18
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8/10 Very Good! (1,005 reviews)
Perfect hotel for my three day trip! Nice breakfast buffet, gym and overall ambience. Rooms could use some updating as they have not been remodeled in several years. I would definitely stay again.
Reviewed on Sep 27, 2025
The Wildwood Hotel
Save 100% on your flight
Price was $846, price is now $446 per person
$446
per person
Nov 26 - Nov 30
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9.2/10 Wonderful! (1,581 reviews)
Quiet, super clean, kind and respectful staff, awesome room!
Reviewed on Oct 9, 2025
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
Price was $428, price is now $294 per person
$294
per person
Dec 15 - Dec 18
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,005 reviews)
This is a wonderful hotel. The staff are incredibly helpful and courteous. The temp in the room was easily adjustable, the shower was spacious, and the bed comfortable. The decor in the different colored rooms was so fun. I had the green room and felt as if I landed in the Emerald City. Spectacular visit - thanks Angad!
Reviewed on Oct 8, 2025
Marriott St. Louis West
Price was $663, price is now $477 per person
$477
per person
Nov 26 - Nov 30
found 24 hours ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
8.6/10 Excellent! (1,002 reviews)
All of the staff were extremely nice and the lobby had tons of good meet up spaces, but the room wasn't amazing. I stayed here 20 years ago and remember the rooms feeling a little dated. Nothing has changed since then. Aside from that, it did feel clean and I did sleep well all three nights. I would pass on the breakfast - seemed out of basic items most mornings, like eggs, fruit, etc., but maybe I just picked the wrong time to go.
Reviewed on Sep 29, 2025
Discover the most popular places to visit in Defiance
Busch Stadium
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
St. Louis Union Station
You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game.
Gateway Arch
Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.
What to do in Defiance
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
Lemp Haunted Neighborhood Walking Tour
$27
per adult
84% of travellers recommend
St. Louis Ghosts: Gateway Ghouls and Hauntings
$32
per adult
100% of travellers recommend
Defiance Hotel Deals
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
1088 South Highway Drive, Fenton, MO
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $98 total per night from Nov 2 to Nov 3
$98 total
Nov 2 - Nov 3
Total with taxes and fees
8/10 Very Good! (1,010 reviews)
"Clean room and staff was great"
Reviewed on Oct 6, 2025
Hollywood Casino & Hotel St. Louis
777 Casino Center Drive, Maryland Heights, MO
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $117 total per night from Oct 19 to Oct 20
$117 total
Oct 19 - Oct 20
Total with taxes and fees
8.4/10 Very Good! (2,158 reviews)
"Room was nice and the bed was comfortable. It would've been nice to have info on TV in the room. Also, the USB charging ports on the bedside tables and the TV did not work as my phone or watch were charged in the AM - but it's always something with technology. Overall GREAT price for the room, bed ..."
Reviewed on Oct 4, 2025
La Quinta Inn & Suites by Wyndham St. Louis Westport
11805 Lackland Rd, Maryland Heights, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $104 total per night from Oct 19 to Oct 20
$104 total
Oct 19 - Oct 20
Total with taxes and fees
7/10 Good! (1,062 reviews)
"Got to our room and noticed our towels had poop marks. Unfortunately was not able to dry off with a towel. But other than that the room was clean."
Reviewed on Oct 7, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Defiance Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Population | 160 |
Max Temp Winter | 40ºF |
Max Temp Summer | 90ºF |
Top Sights | Augusta Winery, Montelle Winery and Chandler Hill Vineyards |
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Frequently asked questions
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.