East Cape Girardeau Vacation Rentals

Start date: Check-in selected.
To Date
End date: Check-out

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

In two weeks
Dec 26 - Dec 28
In two months
Feb 6 - Feb 8
In three months
Mar 6 - Mar 8
In four months
Apr 3 - Apr 5

Our top choices for East Cape Girardeau vacation rentals

Interior
Charming 2-bedroom with AC, WiFi in lovely Jonesboro

Charming 2-bedroom with AC, WiFi in lovely Jonesboro

Charming 2-bedroom with AC, WiFi in lovely Jonesboro
Jonesboro
10.0 out of 10, Exceptional, (3)
"great place. wonderful host."
United States
Carla m.
$237 nightly
The price is $252
Dec 14 - Dec 15
Total with taxes and fees
Charming 2-bedroom with AC, WiFi in lovely Jonesboro
Interior
Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite
2.0 star property
Anna
$139 nightly
The price is $148
Dec 14 - Dec 15
Total with taxes and fees
Cozy and Updated Farmhouse with King Suite
Interior
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Cape Girardeau
9.4 out of 10, Exceptional, (45)
"This place is AWESOME! It's clean, artsy, fun, and if we ever have a chance, we will certainly return!"
United States
Jordan S.
$132 nightly
The price is $138
Dec 14 - Dec 15
Total with taxes and fees
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Living area
Little Blue Cottage on Spanish

Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.6 out of 10, Excellent, (48)
"I would definitely stay here again!"
United States
Bonita
$101 nightly
The price is $101
Dec 15 - Dec 16
Total with taxes and fees
Little Blue Cottage on Spanish
Dining
Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (35)
"Beautiful place, host was kind and and quick to respond to messages "
United States
Melissa W.
$133 nightly
The price is $140
Dec 22 - Dec 23
Total with taxes and fees
Cozy cabins on beautiful Horseshoe Lake
1 bedroom, desk, iron/ironing board, WiFi
The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (2)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
$197 nightly
The price is $197
Dec 14 - Dec 15
Total with taxes and fees
The Cottage, Rusted Route Farms
Property grounds
Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre
Dongola
10.0 out of 10, Exceptional, (101)
"Location was great, everything was great for what we were there for. Already booked again for November. "
United States
carlton h.
$265 nightly
The price is $281
Dec 21 - Dec 22
Total with taxes and fees
Charming cottage overlooking Lake Acre
Interior
Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
10.0 out of 10, Exceptional, (11)
"Our stay was amazing. Everything was so clean organized, and anything you would possibly need was in the room. We will definitely be staying there again when in the area!!"
United States
Karen P.
$172 nightly
The price is $185
Jan 2 - Jan 3, 2026
Total with taxes and fees
Villa B offers peace and quiet with beautiful views of the countryside.
Exterior
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.6 out of 10, Excellent, (36)
"Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! "
United States
Emily D.
$206 nightly
The price is $214
Dec 15 - Dec 16
Total with taxes and fees
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Dining
Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (148)
"Such a great place and location"
United States
Tracy H.
$229 nightly
The price is $245
Dec 14 - Dec 15
Total with taxes and fees
Serenity South -- Gardens, River-Views, and Refreshing Space
Exterior
The Rested Duck Mallard Room

The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
9.2 out of 10, Wonderful, (25)
"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"
United States
mike b.
$133 nightly
The price is $140
Dec 21 - Dec 22
Total with taxes and fees
The Rested Duck Mallard Room
TV, fireplace
Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (3)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
$310 nightly
The price is $310
Dec 15 - Dec 16
Total with taxes and fees
Gorgeous 1856 Log Cabin, Completely Renovated
Interior
The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (27)
"The place was awesome very clean the host was very accommodating. Nice a quiet for a relaxing stay highly recommend "
United States
Gary C.
$289 nightly
The price is $301
Dec 15 - Dec 16
Total with taxes and fees
The Twisted Sassafras Treehouse
Pool
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.6 out of 10, Exceptional, (7)
"Nice place, great times"
United States
Jace W.
$422 nightly
The price is $438
Dec 15 - Dec 16
Total with taxes and fees
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Fridge, microwave, oven, stovetop
Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A
Jackson
10.0 out of 10, Exceptional, (33)
"Great place to stay, felt like home away from home. "
United States
Brittany
$172 nightly
The price is $185
Dec 17 - Dec 18
Total with taxes and fees
Relax in the country at Countryside Villas! - Villa A
Exterior
Magical Victorian near hiking / wine trail

Magical Victorian near hiking / wine trail

Magical Victorian near hiking / wine trail
Anna
10.0 out of 10, Exceptional, (4)
"The house was beautiful! We were in awe of the decor and layout. This is a must-stay if you are in southern Illinois!"
United States
Lori C.
$333 nightly
The price is $378
Dec 14 - Dec 15
Total with taxes and fees
Magical Victorian near hiking / wine trail
Terrace/patio
Contemporary Glamping with Native American Appeal!

Contemporary Glamping with Native American Appeal!

Contemporary Glamping with Native American Appeal!
Anna
10.0 out of 10, Exceptional, (102)
"We loved our stay! The accommodations were clean and comfortable. The cabin atmosphere very was relaxing. We will be back. "
United States
Beth C.
$294 nightly
The price is $309
Dec 14 - Dec 15
Total with taxes and fees
Contemporary Glamping with Native American Appeal!
Meeting facility
Building at Cape Girardeau Regional Airport

Building at Cape Girardeau Regional Airport

Building at Cape Girardeau Regional Airport
Scott City
$571 nightly
The price is $611
Dec 14 - Dec 15
Total with taxes and fees
Building at Cape Girardeau Regional Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top East Cape Girardeau Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Very friendly staff and great breakfast"
Ray 1-night trip
Posted 4 days ago
Drury Inn & Suites Cape Girardeau

Find out more about East Cape Girardeau

Everything you need to know about East Cape Girardeau vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the East Cape Girardeau vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect East Cape Girardeau vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

East Cape Girardeau vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in East Cape Girardeau. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit East Cape Girardeau in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $101 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on East Cape Girardeau rentals

At Expedia, we put the best East Cape Girardeau vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top East Cape Girardeau rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream East Cape Girardeau vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around East Cape Girardeau. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Are there vacation rentals in East Cape Girardeau?

Yes, there are vacation rentals near well known sights in East Cape Girardeau, or you can select a more secluded option if you'd like a relaxing place to stay.

What are some of the best vacation home rentals that East Cape Girardeau has to offer?

Little Blue Cottage on Spanish: This vacation home near East Cape Girardeau comes with WiFi so you can feel at home during your trip.

What’s there to see and do in East Cape Girardeau?

Explore the area and family-friendly sights such as Cape Splash Family Aquatic Center, or get out into nature at a spot like Cape Rock Park. Isle Casino Cape Girardeau and Southeast Missouri State University are a couple of places you'll find in the larger area.

What’s a vacation rental in East Cape Girardeau like?

A vacation rental is a private property you can book for a couple of days or more in East Cape Girardeau. Vacation rentals offer extras like WiFi and washers and dryers so you'll have everything you need. If you're concerned about a clean environment, a vacation rental can provide a sense of privacy away from shared hotel elevators and busy front desks while still allowing you the excitement and enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for a small group gathering.