Find hotels in East Main Street, Grand Junction

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Dec 12 - Dec 14
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Our top choices for East Main Street hotels

Restaurant
Tru by Hilton Grand Junction Downtown

Tru by Hilton Grand Junction Downtown

2.5 star property
Historic Grand Junction, 0.9 mi from East Main Street
9.2 out of 10, Wonderful, (972)
"Spotless and modern rooms, great friendly staff. "
United States
Ruben
$79 nightly
The price is $91
Dec 21 - Dec 22
Total with taxes and fees
Tru by Hilton Grand Junction Downtown
Free continental breakfast
La Quinta Inn & Suites by Wyndham Grand Junction

La Quinta Inn & Suites by Wyndham Grand Junction

3.0 star property
Horizon Drive District, 3.3 mi from East Main Street
8.8 out of 10, Excellent, (2707)
"Easy to check-in was a great quick stay"
United States
Stephanie
$75 nightly
The price is $86
Dec 16 - Dec 17
Total with taxes and fees
La Quinta Inn & Suites by Wyndham Grand Junction
Rooftop terrace
Hotel Maverick

Hotel Maverick

4.0 star property
Capitol Hill, 1 mi from East Main Street
9.6 out of 10, Exceptional, (1004)
"Excellent place to stay in Grand Junction. "
United States
Steve
$168 nightly
The price is $192
Jan 4 - Jan 5, 2026
Total with taxes and fees
Hotel Maverick
Terrace/patio
Home2 Suites by Hilton Grand Junction Northwest

Home2 Suites by Hilton Grand Junction Northwest

3.0 star property
24 Road Corridor, 3.6 mi from East Main Street
9.2 out of 10, Wonderful, (871)
"Great location, clean room, very pleasant staff "
United States
Allison
$127 nightly
The price is $146
Dec 17 - Dec 18
Total with taxes and fees
Home2 Suites by Hilton Grand Junction Northwest
Breakfast served
Grand Vista Hotel

Grand Vista Hotel

3.5 star property
Horizon Drive District, 3.4 mi from East Main Street
8.2 out of 10, Very Good, (3440)
"Good place to stay"
United States
Ramona
$65 nightly
The price is $75
Dec 11 - Dec 12
Total with taxes and fees
Grand Vista Hotel
Exterior
Holiday Inn & Suites Grand Junction by IHG

Holiday Inn & Suites Grand Junction by IHG

3.0 star property
Horizon Drive District, 3.3 mi from East Main Street
8.6 out of 10, Excellent, (1005)
"Room clean and comfortable, staff was awesome and attentive "
United States
Kirstin
$89 nightly
The price is $102
Jan 5 - Jan 6, 2026
Total with taxes and fees
Holiday Inn & Suites Grand Junction by IHG
Billiards
Clarion Inn Grand Junction

Clarion Inn Grand Junction

2.5 star property
Horizon Drive District, 3.3 mi from East Main Street
8.4 out of 10, Very Good, (1693)
"Very Clean, great beds, nice pool, great staff "
Canada
Deborah
$72 nightly
The price is $83
Dec 21 - Dec 22
Total with taxes and fees
Clarion Inn Grand Junction
Exterior
WoodSpring Suites Grand Junction

WoodSpring Suites Grand Junction

2.5 star property
24 Road Corridor, 3.7 mi from East Main Street
6.4 out of 10, (892)
"I enjoy my stay here so much, I have decided to make it my long term resudence for a while. "
United States
Heather
$54 nightly
The price is $62
Dec 14 - Dec 15
Total with taxes and fees
WoodSpring Suites Grand Junction
Reception
Ramada by Wyndham Grand Junction

Ramada by Wyndham Grand Junction

2.5 star property
Horizon Drive District, 3.3 mi from East Main Street
8.4 out of 10, Very Good, (1854)
"We very much enjoyed our stay there!"
United States
Kathryn
$59 nightly
The price is $67
Dec 14 - Dec 15
Total with taxes and fees
Ramada by Wyndham Grand Junction
Property amenity
SpringHill Suites by Marriott Grand Junction Downtown/Historic Main St.

SpringHill Suites by Marriott Grand Junction Downtown/Historic Main St.

3.5 star property
Historic Grand Junction, 0.9 mi from East Main Street
9.0 out of 10, Wonderful, (1002)
"Very nice family hotel with good breakfast."
United States
Margarita
$117 nightly
The price is $134
Dec 21 - Dec 22
Total with taxes and fees
SpringHill Suites by Marriott Grand Junction Downtown/Historic Main St.
Exterior
Hampton Inn Grand Junction Downtown/Historic Main Street

Hampton Inn Grand Junction Downtown/Historic Main Street

2.5 star property
Historic Grand Junction, 0.9 mi from East Main Street
8.8 out of 10, Excellent, (1001)
"Love being in downtown Grand Junction. The hotel was very nice."
United States
Sherri
$87 nightly
The price is $100
Dec 21 - Dec 22
Total with taxes and fees
Hampton Inn Grand Junction Downtown/Historic Main Street
Lobby
Comfort Inn & Suites Fruita - Grand Junction

Comfort Inn & Suites Fruita - Grand Junction

2.5 star property
11.5 mi from East Main Street
8.4 out of 10, Very Good, (1002)
"Room was clean, Staff were friendly, and the site was clean and very accessible."
United States
Theresa
$68 nightly
The price is $77
Dec 11 - Dec 12
Total with taxes and fees
Comfort Inn & Suites Fruita - Grand Junction
Terrace/patio
Courtyard by Marriott Grand Junction

Courtyard by Marriott Grand Junction

3.0 star property
Horizon Drive District, 3.5 mi from East Main Street
8.4 out of 10, Very Good, (1000)
"Friendly staff and clean room "
United States
Jennifer
$93 nightly
The price is $107
Dec 14 - Dec 15
Total with taxes and fees
Courtyard by Marriott Grand Junction
Lobby
Quality Inn Grand Junction near University

Quality Inn Grand Junction near University

3.0 star property
Horizon Drive District, 3 mi from East Main Street
8.6 out of 10, Excellent, (1000)
"Great staff."
United States
Manford
$63 nightly
The price is $72
Dec 21 - Dec 22
Total with taxes and fees
Quality Inn Grand Junction near University
Terrace/patio
Doubletree Hotel Grand Junction

Doubletree Hotel Grand Junction

4.0 star property
Horizon Drive District, 3.1 mi from East Main Street
8.0 out of 10, Very Good, (1000)
"Good value, nice big room, convenient"
United States
Kathy
$90 nightly
The price is $103
Jan 4 - Jan 5, 2026
Total with taxes and fees
Doubletree Hotel Grand Junction
Dinner served
Wine Country Inn Palisade

Wine Country Inn Palisade

3.5 star property
10.6 mi from East Main Street
9.6 out of 10, Exceptional, (1001)
"We loved the location near the wineries. Great place to stay!!"
United States
Sara
$159 nightly
The price is $177
Dec 11 - Dec 12
Total with taxes and fees
Wine Country Inn Palisade
Lobby
Comfort Inn Grand Junction I-70

Comfort Inn Grand Junction I-70

2.5 star property
Horizon Drive District, 3.3 mi from East Main Street
8.6 out of 10, Excellent, (1003)
"Manager was wonderful at check in, breakfast was good. "
United States
Dean
$74 nightly
The price is $85
Dec 14 - Dec 15
Total with taxes and fees
Comfort Inn Grand Junction I-70
Exterior
Holiday Inn Express & Suites Grand Junction by IHG

Holiday Inn Express & Suites Grand Junction by IHG

2.5 star property
24 Road Corridor, 3.7 mi from East Main Street
8.6 out of 10, Excellent, (1000)
"The room was great and the staff was very nice. "
United States
Clarissa
$156 nightly
The price is $179
Dec 12 - Dec 13
Total with taxes and fees
Holiday Inn Express & Suites Grand Junction by IHG
Free daily continental breakfast
Super 8 by Wyndham Fruita

Super 8 by Wyndham Fruita

2.0 star property
11.5 mi from East Main Street
8.4 out of 10, Very Good, (1001)
"Nice place with lots of food choices within a walkable block."
United States
Daniel
$64 nightly
The price is $73
Dec 11 - Dec 12
Total with taxes and fees
Super 8 by Wyndham Fruita
Property entrance
Best Western Grande River Inn & Suites

Best Western Grande River Inn & Suites

2.5 star property
5.4 mi from East Main Street
8.8 out of 10, Excellent, (791)
"Room and breakfast was typucal, ut bummed the pool and hot tub were closed."
United States
Phil
$93 nightly
The price is $98
Dec 16 - Dec 17
Total with taxes and fees
Best Western Grande River Inn & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in East Main Street

Find the best East Main Street areas and neighborhoods for the activities you enjoy most.

Redlands

You'll enjoy the mountain views and wineries in Redlands. You might want to make time for a stop at Colorado National Monument or Redlands Mesa Golf Club.

Downtown

While there might not be top attractions in Downtown, you can explore the larger area and discover places like Western Colorado Botanical Gardens and Bananas Fun Park.

Pear Park

If you're spending some time in Pear Park, Colorado River and James M. Robb – Colorado River State Park are top sights worth seeing.

Historic Grand Junction

Historic Grand Junction is popular for its abundant dining options, and you can check out Museum of the West, a top attraction in the neighborhood.

Horizon Drive District

While there might not be top attractions in Horizon Drive District, you can explore the larger area and discover places like Grand Junction Motor Speedway and Canyon View Park.

Top East Main Street Hotel Reviews

La Quinta Inn & Suites by Wyndham Grand Junction

La Quinta Inn & Suites by Wyndham Grand Junction

10/10 Excellent
"Ebjoyed our stay with our dog aswell very pet friendly no extra charge"
jaaron 1-night trip
Posted 18 hours ago
La Quinta Inn & Suites by Wyndham Grand Junction

Frequently asked questions

What's it like in East Main Street?
Travelers will be sure to enjoy their time in Grand Junction's East Main Street neighborhood.
Where is the best hotel for a stay in East Main Street?
Based on our traveler data, Downtown craftsman home with hot tub. 3 blocks from restaurants, shops and bars. is one of the top choices for your stay in East Main Street. This guesthouse offers private balconies and a fitness center. Other good choices for your stay in the area include Grand Junction Vacation Rental w/ Fire Pit! and Launch your Colorado adventures – Historic Downtown convenience.
How many hotels will I be able to find in the East Main Street area?
If you're searching for places to stay in Grand Junction, Expedia has something to meet your needs with 22 East Main Street hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in East Main Street, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you have a reservation that's non-refundable, you might be able to cancel it and be given a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to get top deals in East Main Street.
Where can I learn more about changing or cancelling my trip to East Main Street?
To find more details about updating your trip to East Main Street or cancelling it, go to https://www.expedia.com/service/.
What is there to do around this Grand Junction neighborhood?
A few places to visit in the area around East Main Street include Museum of the West, Western Colorado Botanical Gardens, and Elliott Tennis Center. While you're out sightseeing, Western Colorado Center for the Arts and Tennis Junction Indoor Center are a couple of additional sights to visit in Grand Junction.