A town with historic buildings, a prominent clock tower, and a water tower.

Eastern Panhandle Vacations from $289

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Your Eastern Panhandle Vacation

Leave the planning to us with an Eastern Panhandle vacation package. With everything arranged before you depart, the only thing you'll need to do is sit back, chill out and experience this destination's wonders to the fullest. With so much to explore on a trip to Eastern Panhandle, it can be difficult to know where to start. Kick off your journey in Winchester at Shenandoah Valley Discovery Museum and Dinosaur Land — two leading attractions here. Another city worthy of a spot on your itinerary is Martinsburg. Don't miss Martinsburg Mall and Chesapeake and Ohio Canal. Expedia is a one-stop shop for organizing your Eastern Panhandle vacation. From hotels and flights, to activities and more, we're here to help you curate a travel experience like no other.

The Latest Eastern Panhandle Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A spacious living room with a brick wall, a round dining table with chairs, and a ceiling fan.
    Jan 12 - Jan 17

    Convention center Indoor free parking + Flight

    Downtown Baltimore
    5 nights
    4.0 star property
    Roundtrip • Atlanta (ATL) - Baltimore (BWI)
    ATL - BWI • Nonstop BWI - ATL • Nonstop
    $462
    $289
    per traveler
    found 1 day ago
    Convention center Indoor free parking
  • Exterior
    Jan 12 - Jan 17

    Sofitel Washington DC Lafayette Square + Flight

    Downtown Washington D.C.
    5 nights
    5.0 star property
    9.0/10 - Wonderful (1,295 reviews)
    "Nothing like any Sofitel I knew in other cities and worse than few years ago when I visited here. Bed sheaths were unclean( stain on it!) and even though I took them off, they put them back again. Will not come back here."
    Reviewed November 3, 2026
    Roundtrip • Atlanta (ATL) - Baltimore (BWI)
    ATL - BWI • Nonstop BWI - ATL • Nonstop
    $942
    $566
    per traveler
    found 1 day ago
    Sofitel Washington DC Lafayette Square
  • A modern kitchen with dark cabinets, stainless steel appliances, and a dining area with a sofa and table.
    Jan 12 - Jan 17

    Harbor free indoor parking + Flight

    Downtown Baltimore
    5 nights
    4.0 star property
    Roundtrip • Atlanta (ATL) - Baltimore (BWI)
    ATL - BWI • Nonstop BWI - ATL • Nonstop
    $718
    $438
    per traveler
    found 1 day ago
    Harbor free indoor parking
  • A modern hotel entrance with a glass canopy, large windows, and potted plants.
    Jan 12 - Jan 17

    Eurostars Saint Gregory Dupont Circle Georgetown + Flight

    Downtown Washington D.C.
    5 nights
    4.0 star property
    8.6/10 - Excellent (1,002 reviews)
    "Well positioned hotel very close to DuPont Circle, close to many cafes and Downtown. Rooms are large, very clean and well maintained."
    Reviewed November 5, 2026
    Roundtrip • Atlanta (ATL) - Baltimore (BWI)
    ATL - BWI • Nonstop BWI - ATL • Nonstop
    Save 100% on your flight
    $736
    $462
    per traveler
    found 1 day ago
    Eurostars Saint Gregory Dupont Circle Georgetown
  • A Sheraton hotel with a landscaped garden featuring a pond and rocks.
    Dec 16 - Dec 21

    Sheraton Baltimore North Hotel + Flight

    Towson
    5 nights
    3.5 star property
    8.4/10 - Very good (1,001 reviews)
    "Great stay! Would stay again absolutely!"
    Reviewed November 5, 2026
    Roundtrip • Atlanta (ATL) - Baltimore (BWI)
    ATL - IAD • Nonstop BWI - ATL • Nonstop
    $532
    $346
    per traveler
    found 1 day ago
    Sheraton Baltimore North Hotel

Discover the most popular places to visit in Eastern Panhandle

A town with a church, a river, and a bridge.

Harpers Ferry National Historical Park

9.4/10 (865 reviews)
Browse exhibitions, hike across Civil War battlefields and take part in cooking, blacksmithing and tin-making workshops at this historic park.
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Eastern Panhandle Hotel Deals

A hotel entrance with a covered porch, a stone facade, and a car parked in front.

Keyser Inn

Keyser Inn
2.5 star property
21.9 mi from Eastern Panhandle
9.0 out of 10, Wonderful, (1,001 reviews)
"Location was my first choice stayed one night and everything was fine."
$80 nightly
The price is $90
Nov 7 - Nov 8
Total with taxes and fees
Keyser Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Eastern Panhandle
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.