Grand Center Vacations from $491

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Your Grand Center Vacation

Book one of our vacation packages to Grand Center and experience the wonders of this interesting neighborhood. Especially renowned for its culture, your next awesome adventure can be found right here. Some popular nearby attractions to see during your trip to Grand Center include Busch Stadium, Gateway Arch and Dome at America’s Center. Don't just dream it — turn it into a reality! Reserve your ideal Grand Center vacation with Expedia and experience travel your way.

The Latest Grand Center Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Crowne Plaza St. Louis Airport by IHG

Crowne Plaza St. Louis Airport by IHG

3.5 out of 5
Save 100% on your flight
Price was $762, price is now $491 per person
$491
per person
Apr 20 - Apr 27
found 20 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8/10 Very Good! (1,004 reviews)
Centrally located, great park and fly, breakfast is great. The only thing I do not like is for police officers to park outside and go to eat breakfast. It appears that there is trouble at the hotel.

Reviewed on Mar 9, 2026

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was $1,722, price is now $884 per person
$884
per person
Apr 20 - Apr 27
found 20 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,626 reviews)
We stayed for 1 night, overall good experience. The pool water was pretty cold and the hot tub is small (max occupancy 2). I was a little disappointed in the continental breakfast. Make your own waffles, cereal, and assorted breads. Wished for a larger selection and ready-made hot foods.

Reviewed on Mar 8, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Save 100% on your flight
Price was $1,199, price is now $765 per person
$765
per person
Apr 20 - Apr 27
found 20 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,056 reviews)
The property was beautiful and unique. The food was a disappointment. Unfortunately it was just too greasy for us.

Reviewed on Mar 6, 2026

The Cheshire

The Cheshire

4 out of 5
Save 100% on your flight
Price was $1,078, price is now $714 per person
$714
per person
Apr 20 - Apr 27
found 20 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.6/10 Excellent! (1,001 reviews)
Bar and restaurant were both great!

Reviewed on Mar 9, 2026

The Knight Center at Washington University

The Knight Center at Washington University

2.5 out of 5
Save 100% on your flight
Price was $996, price is now $666 per person
$666
per person
Apr 20 - Apr 27
found 20 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.4/10 Exceptional! (486 reviews)
The property locates on campus, convenient location. Newly renovated, quiet and clean. It would be great if the hotel can provide day time hot coffee in the lobby.

Reviewed on Mar 9, 2026

Where to stay in Grand Center

Find the best Grand Center areas and neighborhoods for the activities you enjoy most. Learn more about Grand Center
Meeting of the Waters Fountain showing a statue or sculpture and a fountain

Downtown St. Louis

3 out of top 10 points of interest in this area
4/5(4,004 area reviews)

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Find hotels in Downtown St. Louis

Grand Center Hotel Deals

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
3550 Samuel Sheppard Drive St. Louis MO
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $149 total per night from Mar 11 to Mar 12
$149 total
Mar 11 - Mar 12
Total with taxes and fees
8.8/10 Excellent! (1,065 reviews)
We have stayed here several times over the last 8 years or so. We even had our wedding party stay here on our wedding night. Our first few experiences were fantastic. But, as the years continue the only thing I have seen gone downhill is the cleanliness of the rooms. In our room there was hair left ...

Reviewed on Mar 8, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
White House at Grand Central

White House at Grand Central

4 out of 5
3805 Lindell Blvd St. Louis MO
$121 nightly
The price is $135 total per night from Mar 24 to Mar 25
$135 total
Mar 24 - Mar 25
Total with taxes and fees
White House at Grand Central
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $122 total per night from Mar 22 to Mar 23
$122 total
Mar 22 - Mar 23
Total with taxes and fees
8.8/10 Excellent! (3,123 reviews)
The water pressure in our room's shower was the worst I've ever experienced.

Reviewed on Mar 9, 2026

Clayton Plaza Hotel & Extended Stay
See all 1,877 properties in Grand Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Grand Center

Fox Theater showing signage

Fox Theater

Enjoy an evening of comedic, dramatic and musical entertainment at this grand theater. Delve into its history on a guided tour, including behind-the-scenes details.

Fox Theater
Pulitzer Foundation for the Arts which includes modern architecture

Pulitzer Foundation for the Arts

Immerse yourself in modern art, architecture, culture and ideas at this unusual gallery.

Pulitzer Foundation for the Arts

Sheldon Concert Hall

You can enjoy a show at Sheldon Concert Hall during your stay in St. Louis. Experience the area's great live music or attend a baseball game.

Sheldon Concert Hall

Things to do

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$24
per adult
St. Louis Ghost Tour: Sinister Sins & Shadows
Lemp Haunted Neighborhood Walking Tour

Lemp Haunted Neighborhood Walking Tour

$30
per adult
84% of travellers recommend
Lemp Haunted Neighborhood Walking Tour
St. Louis Premium Driving Tour with Boat Ride & Arch

St. Louis Premium Driving Tour with Boat Ride & Arch

$174
per adult
100% of travellers recommend
St. Louis Premium Driving Tour with Boat Ride & Arch
See all activities in St. Louis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.