East Main Street, CO

Grand Junction

Independence Monument in Colorado National Monument

Popular places to visit


East Main Street Hotel Deals

Downtown craftsman home with hot tub. 3 blocks from restaurants, shops and bars.

Downtown craftsman home with hot tub. 3 blocks from restaurants, shops and bars.

Grand Junction CO
$285 nightly
The price is $327 total per night from Mar 25 to Mar 26
$327 total
Mar 25 - Mar 26
Total with taxes and fees
Stay at this vacation home in Grand Junction. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Museum of the West and Western Colorado ...
10/10 Exceptional! (31 reviews)
Great house and even a greater location! We could walk to all activities on Main St. House was very comfortable and we certainly enjoyed the hot tub after a day out visiting all the wineries, shopping, and great food! Thanks to our host, Ron, that answered all my questions!

Reviewed on Mar 3, 2026

Downtown craftsman home with hot tub. 3 blocks from restaurants, shops and bars.
Launch your Colorado adventures – Historic Downtown convenience

Launch your Colorado adventures – Historic Downtown convenience

Grand Junction CO
$175 nightly
The price is $201 total per night from Apr 14 to Apr 15
$201 total
Apr 14 - Apr 15
Total with taxes and fees
Stay at this vacation home in Grand Junction. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Museum of the West and Western Colorado ...
10/10 Exceptional! (97 reviews)
Clean, really cute, and well decorated

Reviewed on Mar 10, 2026

Launch your Colorado adventures – Historic Downtown convenience
Early Check-in Pet Friendly Grand Lodge Groups and Families

Early Check-in Pet Friendly Grand Lodge Groups and Families

Grand Junction CO
Book a stay at this family-friendly vacation home in Grand Junction. Enjoy free WiFi, a water park, and a garden. Popular attractions Museum of the West and ...
9.8/10 Exceptional! (20 reviews)
Great location, cute property. Had everything we needed.

Reviewed on Mar 14, 2026

Early Check-in Pet Friendly Grand Lodge Groups and Families
Grand Vista Hotel

Grand Vista Hotel

3.5 out of 5
2790 Crossroads Blvd Grand Junction CO
$63 nightly
The price is $73 total per night from Mar 22 to Mar 23
$73 total
Mar 22 - Mar 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful ...
8.2/10 Very Good! (3,528 reviews)
Key card never worked so you'd have to get it redone every day. Upcharges for every little thing like parking and an expensive daily pet fee.

Reviewed on Mar 15, 2026

Grand Vista Hotel
La Quinta Inn & Suites by Wyndham Grand Junction

La Quinta Inn & Suites by Wyndham Grand Junction

3 out of 5
2761 Crossroads Blvd Grand Junction CO
$80 nightly
The price is $92 total per night from Mar 29 to Mar 30
$92 total
Mar 29 - Mar 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (2,860 reviews)
Room was ok but the beds weren’t comfortable and pillows were small and uncomfortable. Pool outside was messy and have chairs thrown in empty pool

Reviewed on Mar 16, 2026

La Quinta Inn & Suites by Wyndham Grand Junction
Clarion Inn Grand Junction

Clarion Inn Grand Junction

2.5 out of 5
755 Horizon Drive Grand Junction CO
$81 nightly
The price is $93 total per night from Mar 22 to Mar 23
$93 total
Mar 22 - Mar 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the ...
8.4/10 Very Good! (1,720 reviews)
Needs fresh update to rooms

Reviewed on Mar 15, 2026

Clarion Inn Grand Junction
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around East Main Street

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Lincoln Park Historic District

While Lincoln Park Historic District might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Western Colorado Botanical Gardens and Western Colorado Center for the Arts.

Lincoln Park Historic District
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Washington Park

While Washington Park isn't home to many top sights, Western Colorado Center for the Arts and Western Colorado Botanical Gardens are some notable places to visit nearby.

Washington Park
Bisbee, a historical mining town in South-Eastern Arizona, America, USA. A small town founded in 1880 with amazing old buildings, architecture and a fun travel destination.

7th Street Historic District

When in 7th Street Historic District, you can plan a visit to Western Colorado Center for the Arts and Western Colorado Botanical Gardens, some noteworthy sights in the nearby area.

7th Street Historic District
Aerial View of Christmas Lights in Grand Junction, Colorado at Dusk

Downtown

While there might not be top attractions in Downtown, you can explore the larger area and discover places like Western Colorado Botanical Gardens and Bananas Fun Park.

Downtown
Sunrise at the Grand View Overlook in Colorado National Monument

Historic Grand Junction

Historic Grand Junction is popular for its abundant dining options, and you can check out Museum of the West, a top attraction in the neighborhood.

Historic Grand Junction
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Grandview

While there might not be top attractions in Grandview, you can explore the larger area and discover places like Western Colorado Center for the Arts and Western Colorado Botanical Gardens.

Grandview


East Main Street, CO

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