Greenville Vacations from $784

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The Latest Greenville vacation packages

Price found within the past 48 hours. Click for updated prices.
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

3 out of 5
Price was $851, price is now $784 per person
$784
per person
Aug 6 - Aug 9
found 20 hours ago
Roundtrip non-stop flight included
Raleigh (RDU) to Cape Girardeau (CGI)
9.6/10 Exceptional! (95 reviews)
It was a very neat experience! Highly recommend you stop here and get away from big chain hotels for a night. The staff were super friendly and the restaurant/store was so nostalgic!

Reviewed on Jun 7, 2026

Rockwood Inn

Rockwood Inn

2 out of 5
Price was $958, price is now $882 per person
$882
per person
Aug 6 - Aug 9
found 20 hours ago
Roundtrip non-stop flight included
Raleigh (RDU) to Cape Girardeau (CGI)
10/10 Exceptional! (20 reviews)
My stay was cozy, warm and inviting, and absolutely wonderful shower. I will definitely be returning!

Reviewed on Dec 28, 2025

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
Price was $913, price is now $875 per person
$875
per person
Aug 6 - Aug 9
found 20 hours ago
Roundtrip non-stop flight included
Raleigh (RDU) to Cape Girardeau (CGI)
9.4/10 Exceptional! (1,005 reviews)
I will definitely be staying here next time I visit SEMO.

Reviewed on Jun 5, 2026

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
Price was $1,131, price is now $1,087 per person
$1,087
per person
Aug 27 - Aug 31
found 1 day ago
Roundtrip flight included
Oakland (OAK) to Cape Girardeau (CGI)
9.6/10 Exceptional! (1,011 reviews)
Very clean, helpful staff

Reviewed on Jun 2, 2026

Makanda Inn

Makanda Inn

3.5 out of 5
Price was $1,284, price is now $1,243 per person
$1,243
per person
Aug 27 - Aug 31
found 1 day ago
Roundtrip flight included
Oakland (OAK) to Cape Girardeau (CGI)
10/10 Exceptional! (37 reviews)
Jackie was amazing. She was very informative and helpful. Great communication. The room was really comfortable. And breakfast was great.

Reviewed on May 10, 2026

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Greenville Hotel Deals

Riverfront Retreat w/ Porch & Views in Des Arc!

Riverfront Retreat w/ Porch & Views in Des Arc!

Des Arc Missouri
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Riverfront Retreat w/ Porch & Views in Des Arc!
Camp Minnow Beach House

Camp Minnow Beach House

Wappapello MO
9.2/10 Wonderful! (17 reviews)
"Overall a great stay. Just wish there was a guest accessible WiFi."

Reviewed on May 16, 2026

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Camp Minnow Beach House
Lake Wappapello 2 Bedroom Home 1/8 mile to beach and boat ramp

Lake Wappapello 2 Bedroom Home 1/8 mile to beach and boat ramp

Wappapello MO
9.6/10 Exceptional! (5 reviews)
"The property was clean and comfortable. Thomas was prompt and communicated very well. We really enjoyed our stay and so will you!"

Reviewed on May 27, 2026

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Lake Wappapello 2 Bedroom Home 1/8 mile to beach and boat ramp
See all 42 properties in Greenville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Greenville Vacation Packages

Greenville Essential Information

Language
English
Currency
U.S dollars
Population
490

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Frequently asked questions

How much does a Greenville vacation package cost?
Offering great value package deals from $784 on Expedia, you'll be surprised at how little a vacation to Greenville costs! Expedia's packages simplify travel planning and maximize your savings.
What are the cheapest months to go to Greenville?
If you're hoping to book a cheap Greenville vacation package, consider planning a trip in December, January and February. You'll generally find better prices on hotels and flights during these months — ideal for budget-conscious travelers.
How many days is enough for Greenville?
With a well-organized schedule, you can easily hit the main Greenville sights in a handful of days. But if you'd like to discover lesser-known spots or take day trips, consider booking your Greenville vacation for longer.
How to find the best Greenville package deals?
Begin your search for a Greenville package deal by entering your preferred trip dates and destination under our "Packages" tab. Then add some filters, like "Popular locations" and "Property type," to fine-tune the results to your exact needs. You can also sort by "Package discount" and discover offers that come with huge savings. If you don't find the ideal Greenville package deal straight away, simply play around with your dates and search again. Remember that deals are only available for a limited time, so book early and get your Greenville escape underway.
Is it cheaper to book a Greenville vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your car rental, hotel and flight into one great-value price and you could save hundreds of dollars. You'll usually land a better deal than booking each component separately. And you'll still have the freedom to create a personalized Greenville vacation by choosing your favorite accommodation type, airline and car class.
When to book a vacation package to Greenville?
Land incredible bargains by booking your flights in advance with Expedia. If spontaneity is more your thing, snap up one of our last-minute deals for a spur-of-the-moment Greenville escape.
Does Expedia offer Book Now, Pay Later Greenville vacation packages?
Your Greenville break should be an escape from your daily routine, not a source of money-related stress. So to give you more flexibility, we've partnered with online lender Affirm to offer you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and split up the total cost over 3, 6 or 12 months. Plus, there are no hidden or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.