Guadalupe District Vacations from $698

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Your Guadalupe District Vacation

Experience all the wonderful things this neighborhood has to offer with a customized Guadalupe District vacation package. However you picture yourself spending your days here, you'll find endless opportunities for adventure, relaxation and fun. When it's time to head out and explore, you'll find loads of big-name attractions nearby including Palace of the Governors, Museum of International Folk Art and Museum of Indian Arts and Culture. Visit one, two or more during your trip to Guadalupe District. Expedia will help turn your dream Guadalupe District vacation into reality, whatever your budget or travel plans.

The Latest Guadalupe District Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Inn at Vanessie

The Inn at Vanessie

Downtown Santa Fe
$698
per person
Dec 24 - Dec 27
found 1 day ago
Roundtrip flight included
Houston (HOU) to Albuquerque (ABQ)
8.8/10 Excellent! (1,005 reviews)
Good location. Poor lighting in room and hallway. Breakfast was good. Property not well kept. It would be hard to recommend the room re stayed in.

Reviewed on Oct 16, 2026

The Hacienda & Spa at Hotel Santa Fe

The Hacienda & Spa at Hotel Santa Fe

Downtown Santa Fe
Save 100% on your flight
$951
per person
Nov 26 - Nov 29
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Albuquerque (ABQ)
9.4/10 Exceptional! (1,012 reviews)
Beautiful hotel but under construction so we checked in and our room was 10 steps from that front desk in another building. We couldn't do happy hour, see the spa or gym or if there were any restaurants. Our room was nice but driving behind the building to park was something too. We will give it another shot once construction is done.

Reviewed on Oct 12, 2026

Rosewood Inn of the Anasazi

Rosewood Inn of the Anasazi

Downtown Santa Fe
Save 100% on your flight
$1,984
per person
Nov 26 - Nov 29
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Albuquerque (ABQ)
9.6/10 Exceptional! (918 reviews)
Staff gets an A+ for exceptional hospitality, great comfortable beds/bedding - cool ambiance overall!

Reviewed on Oct 14, 2026

La Fonda on the Plaza

La Fonda on the Plaza

Downtown Santa Fe
$1,228
per person
Dec 26 - Dec 29
found 1 day ago
Roundtrip non-stop flight included
Minneapolis (MSP) to Albuquerque (ABQ)
9.4/10 Exceptional! (1,296 reviews)
Hotel Albuquerque at Old Town

Hotel Albuquerque at Old Town

Sawmill Area
$998
per person
Nov 20 - Nov 26
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Albuquerque (ABQ)
9.2/10 Wonderful! (1,774 reviews)

Where to stay in Guadalupe District

Find the best Guadalupe District areas and neighborhoods for the activities you enjoy most. Learn more about Guadalupe District
A sculpture in front of a building with a unique architectural style.

Downtown Santa Fe

5 out of top 10 points of interest in this area

Visitors to Downtown Santa Fe rave about its fascinating museums, popular shops, and acclaimed art galleries. You might also want to make some time to see Lensic Performing Arts Center or Georgia O'Keefe Museum while you're exploring the neighborhood.

Find hotels in Downtown Santa Fe
A cathedral interior with stained glass windows, arched ceilings, and religious statues.

Southside

1 out of top 10 points of interest in this area

Southside is known for its popular shops, and with sights like Meow Wolf and Regal Santa Fe Place, you won't get bored spending a day wandering around this part of Santa Fe.

Find hotels in Southside
A stone wall with a window featuring five vertical wooden beams.

Historic Eastside

1 out of top 10 points of interest in this area

While visiting Historic Eastside, you might make a stop by sights like Canyon Road and Skateboard Park.

Find hotels in Historic Eastside
A church with two bell towers and a large circular window.

Northeast Santa Fe

If you're looking for some top things to see and do in Northeast Santa Fe and surrounding area, you can visit New Mexico Museum of Art and Cathedral Basilica of Saint Francis of Assisi.

Find hotels in Northeast Santa Fe
A winding road through a mountainous landscape with dense greenery and distant hills.

North Hills

While North Hills might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Skateboard Park and Canyon Road.

Find hotels in North Hills

Guadalupe District Hotel Deals

Guadalupe Inn

Guadalupe Inn

604 Agua Fria St. Santa Fe NM
Fully refundableReserve now, pay when you stay
$136 nightly
$156 total
Nov 16 - Nov 17
Total with taxes and fees
Guadalupe Inn
Perfect downtown location in historic district- 9.5 walk score! Historic home.

Perfect downtown location in historic district- 9.5 walk score! Historic home.

Santa Fe NM
9.8/10 Exceptional! (122 reviews)
"This was my 65th birthday trip with family. The house was great, everything we need was available and the location was perfect! It was just a 20-minute walk to the Plaza. The only thing that could have made our stay better was a wider selection of TV channels for movie night."

Reviewed on Oct 12, 2026

Get rates
Perfect downtown location in historic district- 9.5 walk score! Historic home.
Eldorado Hotel & Spa

Eldorado Hotel & Spa

309 W San Francisco Street Santa Fe NM
Fully refundableReserve now, pay when you stay
$250 nightly
$283 total
Nov 15 - Nov 16
Total with taxes and fees
8.8/10 Excellent! (1,608 reviews)
"Roll away beds were a problem"

Reviewed on Oct 17, 2026

Eldorado Hotel & Spa
See all 1,684 properties in Guadalupe District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Guadalupe District attractions

Santa Fe Railyard

8.8/10 (1,473 reviews)
During your visit to Santa Fe, you can do some window-shopping at Santa Fe Railyard. Experience the fascinating museums and acclaimed art scene in this romantic area.
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Santuario De Nuestra Senora de Guadalupe

Find out about the history of Santa Fe when you take a trip to Santuario De Nuestra Senora de Guadalupe. Add the area's stunning cathedral or shops to your travel plans.
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Santa Fe Farmers Market

You can browse for the perfect souvenirs at Santa Fe Farmers Market during your trip to Santa Fe. Add the area's stunning cathedral or shops to your travel plans.
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Art Vault

You can spend time studying the exhibits at Art Vault in Santa Fe. Make time to visit the area's shops, or simply enjoy its top-notch restaurants.
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El Museo Cultural

You can spend time browsing the exhibits at El Museo Cultural during your trip to Santa Fe. Add the area's stunning cathedral or shops to your travel plans.
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TAI Modern

You can spend time exploring the galleries in TAI Modern during your trip to Santa Fe. Make time to visit the area's shops, or simply enjoy its top-notch restaurants.
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Things to do

Santa Fe: Meow Wolf's House of Eternal Return Ticket

Santa Fe: Meow Wolf The House of Eternal Return Ticket

$37
per adult
100% of travellers recommend
Santa Fe: Meow Wolf The House of Eternal Return Ticket
Tumbleroot Brewery and Distillery Tour and Tasting

Tumbleroot Brewery and Distillery Tour and Tasting

$25
per adult
100% of travellers recommend
Tumbleroot Brewery and Distillery Tour and Tasting
Santa Fe: Canyon Road Arts District Walking Tour

Santa Fe: Canyon Road Art & History Walking Tour

$70
per adult
100% of travellers recommend
Santa Fe: Canyon Road Art & History Walking Tour
See all activities in Santa Fe
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.