Find hotels near Highlands Regional Medical Center, Prestonsburg from $68

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Compare 129 hotels close to Highlands Regional Medical Center with room rates, reviews, and availability. Most hotels are fully refundable.

Comfort Suites Prestonsburg West

2.5 star property
5.2 mi from Highlands Regional Medical Center
8.6 out of 10, Excellent, (687)
"Room clean and staff just excellent!"
United States
Stephanie
$101 nightly
The price is $115
Dec 28 - Dec 29
Total with taxes and fees
Comfort Suites Prestonsburg West

Quality Inn & Suites Prestonsburg next to Mountain Arts Center

2.5 star property
5.1 mi from Highlands Regional Medical Center
8.0 out of 10, Very Good, (356)
"Nice clean place. Great rooms and price. Very friendly staff. "
United States
Jason
$105 nightly
The price is $119
Dec 7 - Dec 8
Total with taxes and fees
Quality Inn & Suites Prestonsburg next to Mountain Arts Center

Ramada Hotel & Conference Center by Wyndham Paintsville

2.5 star property
6.4 mi from Highlands Regional Medical Center
8.8 out of 10, Excellent, (543)
"Beautiful hotel, wonderful breakfast and staff, couldnt be happier with our stay"
United States
Sandra
$108 nightly
The price is $119
Jan 1 - Jan 2, 2026
Total with taxes and fees
Ramada Hotel & Conference Center by Wyndham Paintsville

Super 8 by Wyndham Prestonsburg

2.0 star property
5.2 mi from Highlands Regional Medical Center
6.4 out of 10, (515)
"Staff Was great. Especially the Head Lady . Place is going through renovations and yet they still kept all good, "
United States
Michael
$62 nightly
The price is $68
Dec 21 - Dec 22
Total with taxes and fees
Super 8 by Wyndham Prestonsburg

Days Inn by Wyndham Paintsville

2.0 star property
6.1 mi from Highlands Regional Medical Center
7.6 out of 10, Good, (513)
"Room clean Front desk friendly Reasonable rate"
United States
Richard
$63 nightly
The price is $69
Jan 5 - Jan 6, 2026
Total with taxes and fees
Days Inn by Wyndham Paintsville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Highlands Regional Medical Center Hotel Reviews

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Frequently asked questions

What's the area like around Highlands Regional Medical Center?
Highlands Regional Medical Center is located in Prestonsburg. You'll find 15 hotels and other accommodations within a few miles for a convenient home base.
What's the best hotel to stay near Highlands Regional Medical Center?
Jenny Wiley State Resort Park is one of the top choices for your stay based on our traveler data, and this hotel offers a marina and a restaurant. It's located 3.4 mi (5.5 km) from Highlands Regional Medical Center. Other good choices in the area include Comfort Suites Prestonsburg West and Days Inn by Wyndham Paintsville.
How many hotels will I be able to find near Highlands Regional Medical Center?
Expedia has 15 hotels and other accommodations a few miles from Highlands Regional Medical Center.
If I need to cancel the hotel reservation for my stay near Highlands Regional Medical Center, will I receive a refund?
Yes! You'll find that most room reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might still have the option to cancel and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can filter by "fully refundable" to review the top deals on offer near Highlands Regional Medical Center.
Where can I learn more about changing or cancelling my trip in the area near Highlands Regional Medical Center?
To find more details about changing or cancelling your stay near Highlands Regional Medical Center, click here.
What can I see and do near Highlands Regional Medical Center?
You'll want to browse the exhibits at East Kentucky Science Center & Varia Planetarium and Loretta Lynn's Home. Sights like Loretta Lynn's Birthplace - Butcher Hollow and Samuel May House highlight some of the local culture. You might spend a leisurely day outdoors at Jenny Wiley State Resort Park and Archer Park.