Isle of Palms South Vacations from $331

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Your Isle of Palms South Vacation

Take all the stress out of planning your next getaway with an Isle of Palms South vacation package. Immerse yourself in the sights and sounds of this appealing neighborhood and experience what it has to offer. Not sure where to go during your trip to Isle of Palms South? Nearby attractions like Jacksonville Beach Pier, Oceanfront Park and Adventure Landing are good places to begin. Stop dreaming and start doing. When you're ready to lock in your dream vacation to Isle of Palms South, Expedia is here to help.

The Latest Isle of Palms South Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Delta Hotels by Marriott Jacksonville Deerwood

Delta Hotels by Marriott Jacksonville Deerwood

4 out of 5
Southside
per person
Aug 13 - Aug 17
found 1 day ago
Roundtrip flight included
Boston (BOS) to Jacksonville (JAX)
8.4/10 Very Good! (293 reviews)
I like the cleaniness and famiky friendly atmosphere

Reviewed on Jun 30, 2025

Legacy Vacation Resorts Palm Coast

Legacy Vacation Resorts Palm Coast

3 out of 5
Save 100% on your flight
per person
Sep 18 - Sep 23
found 19 hours ago
Roundtrip flight included
Dallas (DFW) to Daytona Beach (DAB)
8.8/10 Excellent! (1,447 reviews)
Great property, excellent amenities, easy access to stores and restaurants

Reviewed on Jul 4, 2025

Hammock Beach Golf Resort & Spa

Hammock Beach Golf Resort & Spa

4 out of 5
Save 100% on your flight
per person
Sep 19 - Sep 22
found 1 day ago
Roundtrip flight included
Boston (BOS) to Daytona Beach (DAB)
8.4/10 Very Good! (1,010 reviews)
We liked the pools. It had a lazy river and 1 water slide for everyone. They had an adult pool and 2 kids pools. The hotel is on the beach. The beach had shells, which was nice too. Beach was clean, no seaweed.

Reviewed on Jul 1, 2025

Omni Amelia Island Resort & Spa

Omni Amelia Island Resort & Spa

4 out of 5
Save 100% on your flight
per person
Aug 12 - Aug 18
found 1 day ago
Roundtrip flight included
Boston (BOS) to Jacksonville (JAX)
8.6/10 Excellent! (1,000 reviews)
Nice property. Would have liked more breakfast options and securing a seat at the pool was insane.

Reviewed on Jul 4, 2025

Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

4 out of 5
Downtown Jacksonville
per person
Aug 13 - Aug 17
found 1 day ago
Roundtrip flight included
Boston (BOS) to Jacksonville (JAX)
9/10 Wonderful! (1,244 reviews)
Property was nice but highly overpriced rooms are not as described

Reviewed on Jun 30, 2025

Where to stay in Isle of Palms South

Find the best Isle of Palms South areas and neighborhoods for the activities you enjoy most. Learn more about Isle of Palms South
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Southside

3 out of top 10 points of interest in this area
4/5(912 area reviews)

If you're spending some time in Southside, St. Johns Town Center and The Avenues are top sights worth seeing.

Find hotels in Southside

Isle of Palms South Hotel Deals

Margaritaville Jacksonville Beach
Margaritaville Jacksonville Beach
2.5 out of 5
715 1st St N, Jacksonville Beach, FL
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $178 total per night from Aug 3 to Aug 4
$178 total
Aug 3 - Aug 4
Total includes taxes and fees
9/10 Wonderful! (2,936 reviews)
"Wonderful as always!"

Reviewed on Jul 4, 2025

Margaritaville Jacksonville Beach
Embassy Suites by Hilton Jacksonville Baymeadows
Embassy Suites by Hilton Jacksonville Baymeadows
3.5 out of 5
9300 Baymeadows Road, Jacksonville, FL
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $125 total per night from Jul 31 to Aug 1
$125 total
Jul 31 - Aug 1
Total includes taxes and fees
8.4/10 Very Good! (1,011 reviews)
"Had a wonderful stay! Place is very clean, very polite guests and staff! Would stay again 100%"

Reviewed on Jul 6, 2025

Embassy Suites by Hilton Jacksonville Baymeadows
Wyndham Garden Jacksonville
Wyndham Garden Jacksonville
3 out of 5
4660 Salisbury Road, I-95 Exit 344 (Butler Boulevard), Jacksonville, FL
Fully refundableReserve now, pay when you stay
$71 nightly
The price is $81 total per night from Jul 13 to Jul 14
$81 total
Jul 13 - Jul 14
Total includes taxes and fees
7.6/10 Good! (1,661 reviews)
"I’ve stayed at this hotel because the housekeeping is excellent. They are very respectful, and the rooms are consistently clean. If I encounter any problems, they address them promptly. Overall, this place is certainly a great option for accommodation while visiting Jacksonville."

Reviewed on Jul 3, 2025

Wyndham Garden Jacksonville
See all 2,912 properties in Isle of Palms South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Discover the most popular places to visit in Isle of Palms South

Pretty

Mayo Clinic Florida

4.5/5(433 reviews)

Though Mayo Clinic Florida might be what brings you to town, perhaps you'll have a chance to explore more of Jacksonville while you are here.

Mayo Clinic Florida
EverBank Field which includes a lake or waterhole

EverBank Stadium

4/5(386 reviews)

Capable of seating over 80,000 fans, this modern football stadium is the exciting home of the Jacksonville Jaguars, international soccer games and music events.

EverBank Stadium
Jacksonville Naval Air Station

Jacksonville Naval Air Station

4/5(300 reviews)

After visiting Jacksonville Naval Air Station, make a plan to see the other sights and activities in Jacksonville. Experience the great live music or attend a sporting event in this family-friendly area.

Jacksonville Naval Air Station

Things to do

3 Hour Coastal Fun Cruise

3 Hour Coastal Fun Cruise

$150
per adult
3 Hour Coastal Fun Cruise
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

$140
per traveler
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports
Learn what lurks beneath the waves.

Jacksonville Ghosts and Ghouls Tour By US Ghost Adventures

$32
per adult
100% of travellers recommend
Jacksonville Ghosts and Ghouls Tour By US Ghost Adventures
See all activities in Jacksonville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.