Isle of Palms South Vacations from $248

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Your Isle of Palms South Vacation

Take all the stress out of planning your next getaway with an Isle of Palms South vacation package. Immerse yourself in the sights and sounds of this appealing neighborhood and experience what it has to offer. Not sure where to go during your trip to Isle of Palms South? Nearby attractions like Jacksonville Beach Pier, Oceanfront Park and Adventure Landing are good places to begin. Stop dreaming and start doing. When you're ready to lock in your dream vacation to Isle of Palms South, Expedia is here to help.

The Latest Isle of Palms South Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Wyndham Garden Jacksonville

Wyndham Garden Jacksonville

3 out of 5
Southside
Price was $346, price is now $248 per person
$248
per person
Nov 8 - Nov 12
found 5 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Jacksonville (JAX)
7.8/10 Good! (1,717 reviews)
We heard people getting ice all night long. And one person with a very loud voice was in the hallway while on her cell using the speaker phone. It must have been 3 in the morning. This wasn't the fault of the hotel. Other than that it was a nice stay at a reasonable price. The location was near restaurants and major highways. We will definitely return.

Reviewed on Aug 26, 2025

Hammock Beach Golf Resort & Spa

Hammock Beach Golf Resort & Spa

4 out of 5
Save 100% on your flight
Price was $1,058, price is now $683 per person
$683
per person
Nov 7 - Nov 10
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Daytona Beach (DAB)
8.6/10 Excellent! (1,004 reviews)
We have a great family time

Reviewed on Aug 25, 2025

DoubleTree by Hilton Hotel Jacksonville Riverfront

DoubleTree by Hilton Hotel Jacksonville Riverfront

4 out of 5
Downtown Jacksonville
Save 100% on your flight
Price was $539, price is now $359 per person
$359
per person
Nov 8 - Nov 12
found 5 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Jacksonville (JAX)
6.6/10 (1,369 reviews)
The building is beautiful and is situated right by the St. John's Riverwalk and the Friendship Fountain, which are gorgeous. It was quiet and the room was clean. However, the bathroom was very small and the tub/shower was very awkward and difficult to get in and out of safely. There was no counter space and it was difficult to get hot water without losing water pressure. There was no refrigerator in the room and no streaming options on the TV. Overall, since we had other things to do in Jax and spent a limited amount of time in the room, we just dealt with it, but it was far from the best hotel experience I've had.

Reviewed on Aug 16, 2025

Legacy Vacation Resorts Palm Coast

Legacy Vacation Resorts Palm Coast

3 out of 5
Save 100% on your flight
Price was $503, price is now $348 per person
$348
per person
Oct 3 - Oct 7
found 2 hours ago
Roundtrip flight included
Boston (BOS) to Daytona Beach (DAB)
8.8/10 Excellent! (1,471 reviews)
This was a perfect place to stay, to get to know the area as we were looking for our new house around the community.

Reviewed on Aug 10, 2025

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

4.5 out of 5
Southside
Save 100% on your flight
Price was $609, price is now $422 per person
$422
per person
Nov 8 - Nov 12
found 5 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Jacksonville (JAX)
No reviews

Where to stay in Isle of Palms South

Find the best Isle of Palms South areas and neighborhoods for the activities you enjoy most. Learn more about Isle of Palms South
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Southside

3 out of top 10 points of interest in this area
4/5(912 area reviews)

If you're spending some time in Southside, St. Johns Town Center and The Avenues are top sights worth seeing.

Find hotels in Southside

Isle of Palms South Hotel Deals

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

2.5 out of 5
715 1st St N, Jacksonville Beach, FL
Fully refundableReserve now, pay when you stay
$164 nightly
The price is $186 total per night from Aug 28 to Aug 29
$186 total
Aug 28 - Aug 29
Total with taxes and fees
8.8/10 Excellent! (3,124 reviews)
"My stay was good. Great property. Over all experience was good."

Reviewed on Aug 24, 2025

Margaritaville Jacksonville Beach
Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

4 out of 5
225 E Coastline Dr, Jacksonville, FL
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $172 total per night from Aug 31 to Sep 1
$172 total
Aug 31 - Sep 1
Total with taxes and fees
8.8/10 Excellent! (1,266 reviews)
"Staff was very helpful."

Reviewed on Aug 25, 2025

Hyatt Regency Jacksonville
Wyndham Garden Jacksonville

Wyndham Garden Jacksonville

3 out of 5
4660 Salisbury Road, I-95 Exit 344 (Butler Boulevard), Jacksonville, FL
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Sep 2 to Sep 3
$79 total
Sep 2 - Sep 3
Total with taxes and fees
7.6/10 Good! (1,728 reviews)
"Front desk staff was very helpful with kids."

Reviewed on Aug 23, 2025

Wyndham Garden Jacksonville
See all 2,881 properties in Isle of Palms South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Isle of Palms South

Pretty

Mayo Clinic Florida

Though Mayo Clinic Florida might be what brings you to town, perhaps you'll have a chance to explore more of Jacksonville while you are here.

Mayo Clinic Florida
Jacksonville Naval Air Station

Jacksonville Naval Air Station

After visiting Jacksonville Naval Air Station, make a plan to see the other sights and activities in Jacksonville. Experience the great live music or attend a sporting event in this family-friendly area.

Jacksonville Naval Air Station
EverBank Field which includes a lake or waterhole

EverBank Stadium

Capable of seating over 80,000 fans, this modern football stadium is the exciting home of the Jacksonville Jaguars, international soccer games and music events.

EverBank Stadium

Things to do

3 Hour Coastal Fun Cruise

3 Hour Coastal Fun Cruise

$150
per adult
3 Hour Coastal Fun Cruise
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

$140
per traveler
90% of travellers recommend
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports
Chocolate Bar Class

Chocolate Bar Class - Hands on class

$20
per adult
Chocolate Bar Class - Hands on class
See all activities in Jacksonville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.