Isle of Palms South Vacations from $302
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Your Isle of Palms South Vacation
Take all the stress out of planning your next getaway with an Isle of Palms South vacation package. Immerse yourself in the sights and sounds of this appealing neighborhood and experience what it has to offer. Not sure where to go during your trip to Isle of Palms South? Nearby attractions like Jacksonville Beach Pier, Oceanfront Park and Adventure Landing are good places to begin. Stop dreaming and start doing. When you're ready to lock in your dream vacation to Isle of Palms South, Expedia is here to help.
The Latest Isle of Palms South Vacation Packages
Margaritaville Jacksonville Beach
Reviewed on Nov 29, 2025
DoubleTree by Hilton Hotel Jacksonville Riverfront
Reviewed on Nov 30, 2025
Comfort Inn & Suites Jacksonville - Orange Park Near Naval Air Station
Reviewed on Nov 30, 2025
Where to stay in Isle of Palms South
Downtown Jacksonville
Historic core with major corporations, Downtown Jacksonville offers diverse culinary and nightlife experiences at The Elbow. Explore attractions like Florida Theatre, TIAA Bank Field, and museums, while enjoying convenient transportation options.
Isle of Palms South Hotel Deals
Margaritaville Jacksonville Beach
Rooms very clean, bottles of water disappeared since last stay. Staff is nice, great island decore. Its a shame that they dont serve breakfast. Just overpriced muffins and medicore coffee. Hottub would make it excellent and shrimp cocktail.
Reviewed on Nov 28, 2025
Hyatt Regency Jacksonville
Excellent room and amenities. Beautiful view. My check in personnel let me know that it was only $20 to upgrade to a riverfront room, which was awesome! So appreciate that!
Reviewed on Nov 29, 2025
Comfort Suites Baymeadows Near Butler Blvd
The staff was wonderful, the room was nice and clean. The breakfast cause have been better I don’t like sausage patties and we had that every morning. Would I stay there again yes I would.
Reviewed on Dec 1, 2025
Discover the most popular places to visit in Isle of Palms South
Mayo Clinic Florida
Though Mayo Clinic Florida might be what brings you to town, perhaps you'll have a chance to explore more of Jacksonville while you are here.
Jacksonville Naval Air Station
After visiting Jacksonville Naval Air Station, make a plan to see the other sights and activities in Jacksonville. Experience the great live music or attend a sporting event in this family-friendly area.
Jacksonville Zoo and Gardens
Admire thousands of animals and plants across entertaining exhibits in this family-friendly zoo that also has a children’s play area and a 4-D experience.
Things to do
