Situated in Jacksonville Coast, this health care institution is worth a visit. But you'll find loads more to explore in the area. St. Johns Town Center, University of North Florida, and TPC Sawgrass aren't too far from Mayo Clinic Florida.

Plan a trip to see Mayo Clinic Florida

Price found within the past 48 hours. Click for updated prices.

Legacy Vacation Resorts Palm Coast

Save 100% on your flight

$553

per person

Dec 6 - Dec 13

found 1 hour ago

Roundtrip flight included

Boston (BOS) to Daytona Beach (DAB)

8.8/10 Excellent! (1,499 reviews)

Safe area and security, staff was friendly and accommodating. They communicated regular to make sure everything was ok and if qe had any issues.

Reviewed on Oct 20, 2025

Omni Amelia Island Resort & Spa

Save 100% on your flight

$586

per person

Dec 7 - Dec 11

found 2 hours ago

Roundtrip flight included

Boston (BOS) to Jacksonville (JAX)

8.6/10 Excellent! (1,008 reviews)

Very cool self contained resort

Reviewed on Oct 23, 2025

The Ritz-Carlton, Amelia Island

Amelia City

Save 100% on your flight

$1,175

per person

Dec 7 - Dec 11

found 2 hours ago

Roundtrip flight included

Boston (BOS) to Jacksonville (JAX)

9.2/10 Wonderful! (372 reviews)

Leticia at the front desk was fantastic! I had a health related attack on the way back from Atlanta and we decided to stay at the Ritz so I could rest. We stayed at this Ritz on our honeymoon over 30 years ago, had my 50th birthday party at Salt with guests for a weekend, stayed there for our 30th wedding anniversary and had dinner at Salt also (I highly recommend Salt), stayed many holidays with our children and friends, car shows, and it is still such a wonderful resort. You cannot go wrong staying at this beautiful resort. We have loved it for over 30 years and hope to keep going there for many more years to come. All of the staff is great, but a special shout out to Leticia. Thank you for helping us.

Reviewed on Sep 6, 2025

Reviews of Mayo Clinic Florida

4.5

Top Destination

5 - Excellent

294

4 - Good

76

3 - Okay

46

2 - Disappointing

7

1 - Terrible

10

5/5 - Excellent

Verified traveler

This place is amazing it’s a little drive from the hotel which we didn’t know at first but it made having to stay an extra day for more texts bearable.

5/5 - Excellent

Verified traveler

The Mayo Clinic is SOO organized--your schedule is printed out, and every dept. knows where you should be and when! So impressed with this routine and with the doctors we had been scheduled to see. Also, the café has a great selection of foods for everyone and more than reasonably priced! We even decided to go to the café for lunch prior to my husband's appt. Everyone is so very helpful and understanding!

5/5 - Excellent

Verified traveler

Great location 7 minutes from Mayo

5/5 - Excellent

Verified traveler

The Red Roof Inn Plus is directly west of the Mayo Clinic if you stay on Rte 202. Once you get on the 202 at the San Pablo Rd exit by Mayo Clinic you don't have to get off of the 202 until you end up basically just blocks from the Red Roof Inn. It takes about 1/2 hour depending on traffic to make the trip but an easy route.

5/5 - Excellent

Verified traveler

Hotel is a great location for visiting Mayo Clinic.

5/5 - Excellent

Verified traveler

Very conveinient to Mayo and easy to find.

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