
Isolotto Vacations from $732
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Your Isolotto Vacation
Reserving a tailor-made Isolotto vacation package is a good way to know the ins and outs of this unique neighborhood. From its must-see spots to its lesser-known delights, there's a lot to delve into. When it's time to head out and explore, you'll find plenty of popular attractions nearby including Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Visit one, two or more during your trip to Isolotto. Stop dreaming and start doing. When it's time to book your next vacation to Isolotto, Expedia is here to help.
The Latest Isolotto Vacation Packages


The Moon Boutique Hotel & Spa
Reviewed on Jan 2, 2026


Four Seasons Hotel Firenze
Reviewed on Nov 1, 2025

Rocco Forte Hotel Savoy
Reviewed on Sep 30, 2025
Where to stay in Isolotto

Historic Centre of Florence
Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.
Isolotto Hotel Deals

IQ Hotel Firenze
The staff was very nice willing to assist us in every request. The hotel was excellent with premium amenities. The room was amazing spacious and with a very modern decoration. The bathroom was spacious and isolated!!!! Recommend 100%
Reviewed on Dec 30, 2025

25hours Hotel Florence Piazza San Paolino
Very detailed decor and very clean!
Reviewed on Jan 5, 2026

Grand Hotel Cavour
Wonderful room, excellent location, and kind & helpful staff. Wonderful hotel to experience Florence.
Reviewed on Jan 5, 2026
Discover the most popular places to visit in Isolotto

Piazza di Santa Maria Novella
Relax before or after a long trip in this renovated piazza just a few minutes from Florence’s main train station.

Ponte Vecchio
Take a trip over Florence’s iconic bridge, spared by the Nazis for its beauty and home to jewelers for more than four centuries.

Cathedral of Santa Maria del Fiore
The “Saint Mary of the Flower” cathedral and its towering dome have come to symbolize Florence.
Things to do

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket























