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Your Isolotto Vacation
Reserving a tailor-made Isolotto vacation package is a good way to know the ins and outs of this unique neighborhood. From its must-see spots to its lesser-known delights, there's a lot to delve into. When it's time to head out and explore, you'll find plenty of popular attractions nearby including Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Visit one, two or more during your trip to Isolotto. Stop dreaming and start doing. When it's time to book your next vacation to Isolotto, Expedia is here to help.
The Latest Isolotto Vacation Packages

Aurum Uffizi
Reviewed on Oct 3, 2025

The Moon Boutique Hotel & Spa
Reviewed on Oct 1, 2025

Dimora Palanca Boutique & SPA
Reviewed on Sep 13, 2025

Eurostars Florence Boutique
Reviewed on Aug 6, 2025
Where to stay in Isolotto

Historic Centre of Florence
Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.
Isolotto Hotel Deals

The Social Hub Florence Lavagnini
Reviewed on Oct 3, 2025

Hotel Machiavelli Palace
Reviewed on Sep 27, 2025

c-hotels Ambasciatori
Reviewed on Sep 26, 2025
Discover the most popular places to visit in Isolotto

Uffizi Gallery
Art lovers will be in their element in this famous museum, home to the most extensive and important collection of masterpieces in the world.

Ponte Vecchio
Take a trip over Florence’s iconic bridge, spared by the Nazis for its beauty and home to jewelers for more than four centuries.

Cathedral of Santa Maria del Fiore
The “Saint Mary of the Flower” cathedral and its towering dome have come to symbolize Florence.
Things to do

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

Florence: Pasta Cooking Class with Unlimited Wine
