Isolotto Vacations from $937

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Your Isolotto Vacation

Reserving a tailor-made Isolotto vacation package is a good way to know the ins and outs of this unique neighborhood. From its must-see spots to its lesser-known delights, there's a lot to delve into. When it's time to head out and explore, you'll find plenty of popular attractions nearby including Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Visit one, two or more during your trip to Isolotto. Stop dreaming and start doing. When it's time to book your next vacation to Isolotto, Expedia is here to help.

The Latest Isolotto Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Aurum Firenze

Aurum Firenze

Historic Centre of Florence
$937
per person
Nov 8 - Nov 14
found 24 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
7.6/10 Good! (1,003 reviews)
The room was clean, staff reasonably friendly, breakfast breads were stale, air conditioning worked well. Conveniently located for train station

Reviewed on Sep 2, 2026

The Moon Boutique Hotel & Spa

The Moon Boutique Hotel & Spa

Historic Centre of Florence
$997
per person
Nov 8 - Nov 14
found 24 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
9.6/10 Exceptional! (588 reviews)
All the staff were amazing and helpful! The kitchen staff for breakfast catered for all out needs. The spa was excellent too and I’d highly recommended this hotel to anyone. It’s in a Great location with good links to the airport and tourist spots across the city.

Reviewed on Aug 29, 2026

Aurum Uffizi

Aurum Uffizi

Historic Centre of Florence
$1,161
per person
Oct 24 - Oct 29
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Florence (FLR)
7.6/10 Good! (1,001 reviews)
My daughter and I stayed here. The staff were very good and helpful. The room was always cleaned perfectly. Everything was very kind and professional.

Reviewed on Sep 5, 2026

Hotel Santa Maria Novella

Hotel Santa Maria Novella

Historic Centre of Florence
$1,337
per person
Nov 8 - Nov 14
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.6/10 Exceptional! (1,041 reviews)
Wonderful hotel in the perfect location close to the highlights of Florence and then some. They have an amazing breakfast that is served by the sweetest professional staff in a memorable setting. We couldn’t have asked for anything more. The hotel is beautiful and so clean!

Reviewed on Sep 6, 2026

Hotel degli Orafi

Hotel degli Orafi

Historic Centre of Florence
$1,318
per person
Oct 29 - Nov 1
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.6/10 Exceptional! (1,010 reviews)

Where to stay in Isolotto

Find the best Isolotto areas and neighborhoods for the activities you enjoy most. Learn more about Isolotto
A river with buildings on the right bank.

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

A historic building with ornate carvings and statues, featuring large wooden doors and steps leading up to it.

Duomo

Framed by a magnificent cathedral and charming streets lined with churches and restaurants, this neighborhood rests at the very heart of Florence.

A historic church with intricate architecture and a large open plaza with people.

Santa Maria Novella

Spend some time in an attractive neighborhood close to the city center that encompasses ancient buildings and churches and a large park of outstanding beauty.

A stone bridge with green shutters over a river.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

A bustling European square with historic buildings, shops, and a prominent clock tower.

Santa Croce

One of the historic districts of Florence has a network of medieval streets lined with opulent churches, leather stores, markets and atmospheric restaurants.

Isolotto Hotel Deals

Plus Florence - Hostel

Plus Florence - Hostel

Via Santa Caterina D'Alessandria, 15 Florence FI
Fully refundableReserve now, pay when you stay
$136 nightly
$159 total
Sep 13 - Sep 14
Total with taxes and fees
Plus Florence - Hostel
The Social Hub Florence Lavagnini

The Social Hub Florence Lavagnini

Viale Spartaco Lavagnini 70 72 Florence FI
Fully refundableReserve now, pay when you stay
$191 nightly
$226 total
Sep 13 - Sep 14
Total with taxes and fees
9/10 Wonderful! (1,571 reviews)
"Let me start by saying that the only big flaw with this hotel is the room design. Our first room had a sewer stench as soon as you walked in. The shower stall wasn’t sealed and the entire floor flooded after every shower unless you pointed the shower head at just the right angle. The staff very kindly ..."

Reviewed on Sep 6, 2026

The Social Hub Florence Lavagnini
The Social Hub Florence Belfiore

The Social Hub Florence Belfiore

Viale Belfiore, 55 Florence FI
Fully refundableReserve now, pay when you stay
$157 nightly
$189 total
Sep 13 - Sep 14
Total with taxes and fees
9.4/10 Exceptional! (718 reviews)
"This hotel was great! All new amenities, very clean and in a location ideal for access to the main train station. The pool was a highlight and, although it did get busy, we never waited long for a sun lounger. Would definitely recommend!"

Reviewed on Sep 6, 2026

The Social Hub Florence Belfiore
See all 11,763 properties in Isolotto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Things to do

City Sightseeing Florence Hop-on Hop-off

City Sightseeing Florence Hop-on Hop-off Bus Tour

$29
per adult
76% of travellers recommend
City Sightseeing Florence Hop-on Hop-off Bus Tour
Florence: Pasta Cooking Class with Unlimited Wine

Florence: Pasta Cooking Class with Unlimited Wine

$19
per adult
94% of travellers recommend
Florence: Pasta Cooking Class with Unlimited Wine
Michaelangelo's David

Accademia timed-entry Ticket with Instant Delivery & Priority Access

$45
per adult
94% of travellers recommend
Accademia timed-entry Ticket with Instant Delivery & Priority Access
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.