Plan, book, travel with confidence
Better together
Save up to $1,045 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

The Latest La Mesa vacation packages

Price found within the past 48 hours. Click for updated prices.

Nowhere

Save 100% on your flight

$753

per person

Feb 2 - Feb 9

found 18 hours ago

Roundtrip non-stop flight included

New York (LGA) to Panama City (PTY)

18.4/10 Exceptional! (19 reviews)

Excellent stay, beautiful location - best receptionist (angie) and owner thats ever welcomed me at my stay, close to good food (pipa) and beach - highly recommended

Reviewed on Nov 20, 2025

Central Hotel Bocas del Toro

$1,570

per person

Feb 2 - Feb 9

found 18 hours ago

Roundtrip non-stop flight included

New York (LGA) to Panama City (PTY)

No reviews

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

$1,125

per person

Feb 11 - Feb 16

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

18/10 Exceptional! (1,002 reviews)

Amazing location spectacular views friendly staff dinner food bartender everything 10 star

Reviewed on Nov 23, 2025

Punta Caracol Acqua Lodge

Punta Caracol

Save 100% on your flight

$1,059

per person

Feb 2 - Feb 9

found 18 hours ago

Roundtrip non-stop flight included

New York (LGA) to Panama City (PTY)

17.6/10 Exceptional! (149 reviews)

Loved this property, and will definitely return!

Reviewed on Aug 14, 2025

Ciel y Miel

Save 100% on your flight

$1,410

per person

Jan 2 - Jan 8

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

20/10 Exceptional! (9 reviews)

Is an execelent place to relax, enjoy nice food and view. It has access to a beautiful beach which is not overcrowded and the staff is on top of everything. Me and my family are definetly coming back!!!

Reviewed on Mar 3, 2025

Don't see what you're looking for?

See all available trips from Columbus to La Mesa

View all trips

La Mesa Hotel Deals

Residential Cabo - 2 Bedroom Regular Apartment #001

Provincia de Bocas del Toro Panama

Get rates

Residential Cabo - 2 Bedroom Regular Apartment #002

Provincia de Bocas del Toro Panama

Get rates

APARTAMENTO CACAO CHANGUINOLA

El Empalme Provincia de Bocas del Toro

Security, and pool and close oriental food and shopping!

Reviewed on May 6, 2024

Get rates

See all 6 properties in La Mesa

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.