Main Street Vacations from $276

Book a Hotel + Flight or Car together to unlock savings

Your Main Street Vacation

From its bars and pubs to its culture and dining, there are plenty of convincing reasons to book a vacation package to Main Street. When it's time to escape from it all, this urban neighborhood has a spot just for you. Some leading nearby attractions to check out during your trip to Main Street include University of Michigan, Michigan Stadium and University of Michigan Museum of Art. Expedia can put your travel plans into action. Book your ultimate Main Street vacation now.

The Latest Main Street Vacation Packages

Price found within the past 48 hours. Click for updated prices.
La Quinta Inn by Wyndham Detroit Southgate

La Quinta Inn by Wyndham Detroit Southgate

3 out of 5
Price was $388, price is now $276 per person
$276
per person
Dec 8 - Dec 14
found 22 hours ago
Roundtrip flight included
Atlanta (ATL) to Detroit (DTW)
6.8/10 (1,013 reviews)
First room was bad. But we were moved to a MUCH better room.

Reviewed on Oct 19, 2025

Saint John's Resort

Saint John's Resort

4 out of 5
Price was $748, price is now $524 per person
$524
per person
Dec 24 - Dec 27
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Detroit (DTW)
9.6/10 Exceptional! (1,002 reviews)
Beautiful rooms and wedding venue. The lamp in our room did not work but not a big deal as plenty of other lights

Reviewed on Oct 26, 2025

Downtown Detroit Apartments by Landing

Downtown Detroit Apartments by Landing

4 out of 5
Downtown Detroit
Save 100% on your flight
Price was $847, price is now $596 per person
$596
per person
Dec 8 - Dec 14
found 22 hours ago
Roundtrip flight included
Atlanta (ATL) to Detroit (DTW)
No reviews
Graduate by Hilton Ann Arbor

Graduate by Hilton Ann Arbor

4 out of 5
Kerrytown
Save 100% on your flight
Price was $664, price is now $476 per person
$476
per person
Dec 14 - Dec 19
found 24 hours ago
Roundtrip flight included
Atlanta (ATL) to Detroit (DTW)
9/10 Wonderful! (1,013 reviews)
very clean and the beds very comfortable that’s all you need and love the decor is like Napoleon time

Reviewed on Oct 19, 2025

American Inn and Suites Dundee

American Inn and Suites Dundee

2 out of 5
Price was $604, price is now $444 per person
$444
per person
Nov 26 - Nov 30
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Detroit (DTW)
6.8/10 (951 reviews)
The staff has been very helpful and very nice. My room was clean and comfortable. It's been very quiet and safe. Even when it was busy, it was quiet.

Reviewed on Oct 24, 2025

Where to stay in Main Street

Find the best Main Street areas and neighborhoods for the activities you enjoy most. Learn more about Main Street
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South Central

3 out of top 10 points of interest in this area

While visiting South Central, you might make a stop by sights like Yost Ice Arena and Michigan Stadium.

Find hotels in South Central

Main Street Hotel Deals

Wyndham Garden Ann Arbor

Wyndham Garden Ann Arbor

3 out of 5
2900 Jackson Ave, Ann Arbor, MI
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $70 total per night from Nov 9 to Nov 10
$70 total
Nov 9 - Nov 10
Total with taxes and fees
7.2/10 Good! (1,299 reviews)
Rooms were clean, comfortable enough. The hotel main area and pool area could use a refresh.

Reviewed on Oct 25, 2025

Wyndham Garden Ann Arbor
Ann Arbor Regent Hotel & Suites

Ann Arbor Regent Hotel & Suites

3 out of 5
2455 Carpenter Road, Ann Arbor, MI
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $143 total per night from Nov 2 to Nov 3
$143 total
Nov 2 - Nov 3
Total with taxes and fees
8.8/10 Excellent! (1,227 reviews)
This hotel doesn’t look modern; however the quality they use for bathroom was not bad at all! Great coffee and good choices of coffee creamer is a must! Waffle was awesome! The breakfast serving lady was super awesome! Toilet paper in bathroom was great not the cheap stuff that some Hilton hotels ...

Reviewed on Oct 21, 2025

Ann Arbor Regent Hotel & Suites
Weber's Hotel & Restaurant

Weber's Hotel & Restaurant

4 out of 5
3050 Jackson Road, Ann Arbor, MI
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $176 total per night from Oct 28 to Oct 29
$176 total
Oct 28 - Oct 29
Total with taxes and fees
9.4/10 Exceptional! (1,382 reviews)
Restaurant and staff are incredible. I feel Very fancy dining and staying here. This is our go to place for special occasions

Reviewed on Oct 26, 2025

Weber's Hotel & Restaurant
See all 701 properties in Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Main Street

University of Michigan as well as a couple

University of Michigan

4.5/5(1,101 reviews)

Come to see the ivied halls, grassy quads, cultural performances and athletic events at this renowned university, one of the world’s most prestigious.

University of Michigan
Michigan Football.

Michigan Stadium

4.5/5(445 reviews)

Catch an event at Michigan Stadium during your trip to Ann Arbor. Experience the area's lively festivals or attend a sporting event.

Michigan Stadium
University of Michigan Museum of Art showing modern architecture as well as a couple

University of Michigan Museum of Art

4.5/5(130 reviews)

Browse one of the nation’s greatest and oldest university art collections at this museum on the prestigious University of Michigan campus.

University of Michigan Museum of Art
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.