Main Street Vacations from $225

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Your Main Street Vacation

From its bars and pubs to its culture and dining, there are plenty of convincing reasons to book a vacation package to Main Street. When it's time to escape from it all, this urban neighborhood has a spot just for you. Some leading nearby attractions to check out during your trip to Main Street include University of Michigan, Michigan Stadium and University of Michigan Museum of Art. Expedia can put your travel plans into action. Book your ultimate Main Street vacation now.

The Latest Main Street Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Radisson Hotel Detroit Metro Airport

Radisson Hotel Detroit Metro Airport

3 out of 5
per person
Sep 23 - Sep 30
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Detroit (DTW)
7.2/10 Good! (1,008 reviews)
The bed was a little worn, but I slept OK. The bathroom looked pretty clean. The carpet was very worn in the room and definitely had not been vacuumed. The inside of the door to my room had something smeared all over it. The hallway leading to my room look like somebody threw a Coke up against the wall and it dripped down and it was still there dried. Overall, for the price in the short day, I just needed a quick sleep before flight. It was OK.

Reviewed on Jul 15, 2025

Hampton Inn Livonia Detroit

Hampton Inn Livonia Detroit

2.5 out of 5
Save 100% on your flight
per person
Sep 23 - Sep 30
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Detroit (DTW)
8.4/10 Very Good! (1,004 reviews)
Stay was excellent minus the pool. For us the pool is a big deal and one of the things my kids look forward to most. The pool water was green and there was so much water outside the pool on the floor there was no place to sit that was dry. Also towels were not stocked either time we used the pool. Otherwise the room was fine, staff was great and breakfast was average.

Reviewed on Jul 7, 2025

Weber's Hotel & Restaurant

Weber's Hotel & Restaurant

4 out of 5
Lakewood
Save 100% on your flight
per person
Aug 28 - Sep 2
found 24 hours ago
Roundtrip flight included
New York (NYC) to Detroit (DTW)
9.4/10 Exceptional! (1,247 reviews)
Location, cleanliness and friendly staff

Reviewed on Jul 13, 2025

Hotel Indigo Detroit Downtown by IHG

Hotel Indigo Detroit Downtown by IHG

3.5 out of 5
Downtown Detroit
Save 100% on your flight
per person
Aug 15 - Aug 17
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Detroit (DTW)
7.8/10 Good! (1,006 reviews)
Accommodating staff

Reviewed on Jul 14, 2025

Baymont by Wyndham Detroit Airport/Romulus

Baymont by Wyndham Detroit Airport/Romulus

2.5 out of 5
Save 100% on your flight
per person
Sep 23 - Sep 30
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Detroit (DTW)
7.8/10 Good! (1,570 reviews)
Overall this properrty was good, but in my room, the toilet seat was not attached to the actual toilet and there was stuff visibly sitting in the sink drain. Appreciated the shuttle, staff and breakfast.

Reviewed on Jul 14, 2025

Where to stay in Main Street

Find the best Main Street areas and neighborhoods for the activities you enjoy most. Learn more about Main Street
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South Central

3 out of top 10 points of interest in this area

While visiting South Central, you might make a stop by sights like Yost Ice Arena and Michigan Stadium.

Find hotels in South Central

Main Street Hotel Deals

Wyndham Garden Ann Arbor

Wyndham Garden Ann Arbor

3 out of 5
2900 Jackson Ave, Ann Arbor, MI
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $105 total per night from Aug 6 to Aug 7
$105 total
Aug 6 - Aug 7
Total includes taxes and fees
7.2/10 Good! (1,200 reviews)

Reviewed on Jul 11, 2025

Wyndham Garden Ann Arbor
Weber's Hotel & Restaurant

Weber's Hotel & Restaurant

4 out of 5
3050 Jackson Road, Ann Arbor, MI
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $176 total per night from Jul 22 to Jul 23
$176 total
Jul 22 - Jul 23
Total includes taxes and fees
9.2/10 Wonderful! (1,252 reviews)
"Our stay was great! Bar dinner was exceptional. I’m disappointed that The Weber uses single shampoo, rinse and body soaps creating more waste. Also a lot of recycling waste is put in the garbage."

Reviewed on Jul 14, 2025

Weber's Hotel & Restaurant
The Kensington Hotel

The Kensington Hotel

3.5 out of 5
3500 South State Street, Ann Arbor, MI
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $172 total per night from Jul 20 to Jul 21
$172 total
Jul 20 - Jul 21
Total includes taxes and fees
8.6/10 Excellent! (1,015 reviews)
"Staff was super nice. Room was clean and check in was quick"

Reviewed on Jul 12, 2025

The Kensington Hotel
See all 658 properties in Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Discover the most popular places to visit in Main Street

University of Michigan as well as a couple

University of Michigan

4.5/5(1,101 reviews)

Come to see the ivied halls, grassy quads, cultural performances and athletic events at this renowned university, one of the world’s most prestigious.

University of Michigan
Michigan Football.

Michigan Stadium

4.5/5(445 reviews)

Catch an event at Michigan Stadium during your trip to Ann Arbor. Experience the area's lively festivals or attend a sporting event.

Michigan Stadium
Exhibit Museum of Natural History at the University Of Michigan featuring interior views

Exhibit Museum of Natural History at the University Of Michigan

3/5(2 reviews)

Science and history are fun to explore at this family-friendly museum. Exhibits are geared to appeal to students, community members and visitors.

Exhibit Museum of Natural History at the University Of Michigan
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.