Matlacha Isles Vacations

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Your Matlacha Isles Vacation

Make planning your travels simple by locking in a vacation package to Matlacha Isles. We'll look after the details, so you can focus on soaking up everything this neighborhood has to offer. If you'd love to sightsee during your trip to Matlacha Isles, don't miss nearby attractions such as Royal Tee Golf Club. Don't just wish for it — make it a reality! Lock in your perfect Matlacha Isles vacation with Expedia and get to where you're going your way.

Price found within the past 48 hours. Click for updated prices.
  • Aug 26 - Aug 29

    The Perry Hotel Naples + Flight

    Naples
    3 nights
    4.5 star property
    9.6/10 - Exceptional (843 reviews)
    "The location was very nice. The roof top restaurant was very good and the staff were very friendly and kind. If book on Expedia be aware that there will be an extra charge because of third-party."
    Reviewed June 4, 2026
    Roundtrip Boston (BOS) - Miami (MIA)
    BOS - MIANonstop MIA - BOSNonstop
    $572
    $386
    per traveler
    found 1 day ago
    The Perry Hotel Naples
  • Jul 6 - Jul 11

    LaPlaya Beach & Golf Resort - A Noble House Resort + Flight

    Vanderbilt Beach
    5 nights
    4.5 star property
    9.0/10 - Wonderful (1,008 reviews)
    "The location was great however I was expecting a lot more from the property itself. We stayed on the junior suite and the room looked old, the mirror had black stains on it and the balcony furniture was stained. I pulled the extra pillow and cover in the closet for my daughter and it was definitely used before, it had hairs on the pillow and lipstick. From our room, we had to crossed a street that was pretty busy to get to the main property which was not ideal since it rained a couple of days..."
    Reviewed June 4, 2026
    Roundtrip Boston (BOS) - Fort Myers (RSW)
    BOS - RSWNonstop RSW - BOSNonstop
    $1,626
    $981
    per traveler
    found 1 day ago
    LaPlaya Beach & Golf Resort - A Noble House Resort
  • Aug 7 - Aug 10

    Chadwick Cove Resort & Marina + Flight

    Manasota Key
    3 nights
    4.0 star property
    9.4/10 - Exceptional (20 reviews)
    Roundtrip New York (EWR) - Fort Myers (RSW)
    EWR - RSW1 stop RSW - EWR1 stop
    $805
    $525
    per traveler
    found 1 day ago
    Chadwick Cove Resort & Marina
  • Jul 25 - Aug 3

    A Wave From it All + Flight

    Siesta Isle
    9 nights
    2.0 star property
    Roundtrip Boston (BOS) - Fort Myers (RSW)
    BOS - RSWNonstop RSW - BOSNonstop
    Save 100% on your flight
    $3,952
    $2,721
    per traveler
    found 1 day ago
    A Wave From it All
  • Aug 19 - Aug 23

    Casa Ybel Resort + Flight

    Mid Island
    4 nights
    2.5 star property
    8.8/10 - Excellent (357 reviews)
    "Absolutely loved my stay at Casa Ybel. The beach is steps away and all of the units have back doors/ porches to make accessing the beach even easier. Check in was ok. The young lady helping me even held my groceries since our room was not ready yet and then had them delivered to our room. Some of the young maintenance staff came in while I was checking in and seemed to try and start an argument with her, but she kept professional. I would absolutely stay here again."
    Reviewed May 23, 2026
    Roundtrip Boston (BOS) - Fort Myers (RSW)
    BOS - RSWNonstop RSW - BOSNonstop
    Save 100% on your flight
    $1,082
    $750
    per traveler
    found 1 day ago
    Casa Ybel Resort

Where to stay in Matlacha Isles

Find the best Matlacha Isles areas and neighborhoods for the activities you enjoy most. Learn more about Matlacha Isles

Matlacha Isles Hotel Deals

Baymont by Wyndham Fort Myers Central

Baymont by Wyndham Fort Myers Central

2.5 out of 5
4850 S Cleveland Ave Fort Myers FL
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $74 total per night from Jul 1 to Jul 2
$74 total
Jul 1 - Jul 2
Total with taxes and fees
6.8/10 (1,114 reviews)
"It was good but the blinds were horrible, they did not block out any light, air great, clean and comfortable"

Reviewed on Jun 4, 2026

Baymont by Wyndham Fort Myers Central
Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

4 out of 5
17260 Harbour Pointe Dr Fort Myers FL
Fully refundableReserve now, pay when you stay
$270 nightly
The price is $301 total per night from Jun 7 to Jun 8
$301 total
Jun 7 - Jun 8
Total with taxes and fees
8.6/10 Excellent! (1,009 reviews)
"We had an amazing stay that started and continued with the Valet Staff, the Front Desk Staff, the Restaurant Staff and the Housekeeping Staff. Great associates that want your stay to be the best! Loved the views from our room of the water and the sunsets. We saw dolphins each night. Thanks for a ..."

Reviewed on Jun 1, 2026

Marriott Sanibel Harbour Resort & Spa
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street Fort Myers Beach FL
$254 nightly
The price is $283 total per night from Jun 8 to Jun 9
$283 total
Jun 8 - Jun 9
Total with taxes and fees
9/10 Wonderful! (2,169 reviews)
"Family friendly with plenty to entertain the kids. Prices are a little high Staff is helpful and accommodating Only downside is it is a long walk to the beach and pool if you are not staying at the Beach House. All in all, a very pleasant location"

Reviewed on Jun 4, 2026

Margaritaville Beach Resort Fort Myers
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Matlacha Isles

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.