
Matlacha Isles Vacations from $260
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Your Matlacha Isles Vacation
Make planning your travels simple by locking in a vacation package to Matlacha Isles. We'll look after the details, so you can focus on soaking up everything this neighborhood has to offer. If you'd love to sightsee during your trip to Matlacha Isles, don't miss nearby attractions such as Royal Tee Golf Club. Don't just wish for it — make it a reality! Lock in your perfect Matlacha Isles vacation with Expedia and get to where you're going your way.
The Latest Matlacha Isles Vacation Packages


LaPlaya Beach & Golf Resort - A Noble House Resort
Reviewed on Aug 29, 2025

Hyatt Place Fort Myers/at The Forum
Reviewed on Aug 24, 2025

Where to stay in Matlacha Isles

Pelican
If you're spending some time in Pelican, Tarpon Point and Harbour View Gallery are top sights worth seeing.
Matlacha Isles Hotel Deals

Marriott Sanibel Harbour Resort & Spa
Reviewed on Aug 24, 2025

Margaritaville Beach Resort Fort Myers
Reviewed on Aug 27, 2025

Hilton Garden Inn Ft Myers
Reviewed on Aug 23, 2025
Discover the most popular places to visit in Matlacha Isles

Four Mile Cove Ecological Preserve
Enjoy the beautiful sunsets and explore Four Mile Cove Ecological Preserve, a lovely green space in Cape Coral. Amble around this family-friendly area's beautiful beaches or attend a baseball game.
Cape Coral Yacht Club Beach
Why not spend a lazy afternoon at Cape Coral Yacht Club Beach during your trip to Cape Coral?
Sun Splash Water Park
Enjoy the thrill rides with your kiddos at Sun Splash Water Park during your trip to Cape Coral. Stroll along the beautiful beaches or discover the beautiful sunsets in this family-friendly area.
Things to do

Fort Myers Beach Sunset Excursion
