Matlacha Isles Vacations from $376

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Your Matlacha Isles Vacation

Make planning your travels simple by locking in a vacation package to Matlacha Isles. We'll look after the details, so you can focus on soaking up everything this neighborhood has to offer. If you'd love to sightsee during your trip to Matlacha Isles, don't miss nearby attractions such as Royal Tee Golf Club. Don't just wish for it — make it a reality! Lock in your perfect Matlacha Isles vacation with Expedia and get to where you're going your way.

The Latest Matlacha Isles Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hyatt Place Fort Myers/at The Forum

Hyatt Place Fort Myers/at The Forum

3 out of 5
The Forum
Save 100% on your flight
Price was $650, price is now $376 per person
$376
per person
Jan 22 - Jan 26
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
8.2/10 Very Good! (1,009 reviews)
The staff was helpful and accomodating when my first room didn't have working AC. There wasn't any hesitation when I asked for a different room with wroking AC. Overall the facility itself has seen better days. The furniture is starting to show wear and tear. The wallpaper is starting to peel, especially in the bathroom. The foyer furniture is worn and the elevator has dents and markings. Not a bad place to stay, just don't expect much.

Reviewed on Oct 30, 2025

Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina

3 out of 5
Price was $958, price is now $455 per person
$455
per person
Dec 6 - Dec 11
found 16 hours ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
9.2/10 Wonderful! (1,013 reviews)
Sitting right on the water on the porch was fantastic.

Reviewed on Oct 23, 2025

Innovation Hotel

Innovation Hotel

4 out of 5
Save 100% on your flight
Price was $1,469, price is now $799 per person
$799
per person
Jan 4 - Jan 8
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Fort Myers (RSW)
9.8/10 Exceptional! (522 reviews)
It is a very impressive hotel

Reviewed on Oct 29, 2025

South Seas Resort

South Seas Resort

3.5 out of 5
Save 100% on your flight
Price was $1,662, price is now $963 per person
$963
per person
Dec 12 - Dec 19
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
8.4/10 Very Good! (1,008 reviews)
Beach is very clean. Easy to get to.

Reviewed on Oct 22, 2025

LaPlaya Beach & Golf Resort - A Noble House Resort

LaPlaya Beach & Golf Resort - A Noble House Resort

4.5 out of 5
Vanderbilt Beach
Save 100% on your flight
Price was $2,316, price is now $1,360 per person
$1,360
per person
Jan 16 - Jan 19
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Fort Myers (RSW)
8.8/10 Excellent! (1,003 reviews)
Amazing!! Highly recommended

Reviewed on Oct 22, 2025

Where to stay in Matlacha Isles

Find the best Matlacha Isles areas and neighborhoods for the activities you enjoy most. Learn more about Matlacha Isles
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Pelican

1 out of top 10 points of interest in this area
4.5/5(46 area reviews)

If you're spending some time in Pelican, Tarpon Point and Harbour View Gallery are top sights worth seeing.

Find hotels in Pelican

Matlacha Isles Hotel Deals

Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street, Fort Myers Beach, FL
$234 nightly
The price is $261 total per night from Nov 4 to Nov 5
$261 total
Nov 4 - Nov 5
Total with taxes and fees
8.8/10 Excellent! (1,569 reviews)
Nice new property. Restaurant food was underwhelming with very high prices. The pool would have been fun except it had a DJ with very loud club music the whole time so we didn't bother going in. I would think the late Jimmy Buffett would not agree with club music vs. a relaxed mellow and Island style ...

Reviewed on Oct 27, 2025

Margaritaville Beach Resort Fort Myers
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 out of 5
1400 Estero Blvd, Fort Myers Beach, FL
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $196 total per night from Nov 6 to Nov 7
$196 total
Nov 6 - Nov 7
Total with taxes and fees
8.8/10 Excellent! (1,011 reviews)
They have no complimentary breakfast

Reviewed on Oct 27, 2025

Lani Kai Beachfront Resort
Baymont by Wyndham Fort Myers Central

Baymont by Wyndham Fort Myers Central

2.5 out of 5
4850 S Cleveland Ave, Fort Myers, FL
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $71 total per night from Nov 1 to Nov 2
$71 total
Nov 1 - Nov 2
Total with taxes and fees
6.4/10 (1,003 reviews)
Clean room

Reviewed on Oct 25, 2025

Baymont by Wyndham Fort Myers Central
See all 14,069 properties in Matlacha Isles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Matlacha Isles

Veterans park

Four Mile Cove Ecological Preserve

Enjoy the beautiful sunsets and explore Four Mile Cove Ecological Preserve, a lovely green space in Cape Coral. Amble around this family-friendly area's beautiful beaches or attend a baseball game.

Four Mile Cove Ecological Preserve

Cape Coral Yacht Club Beach

Why not spend a lazy afternoon at Cape Coral Yacht Club Beach during your trip to Cape Coral?

Cape Coral Yacht Club Beach

Sun Splash Water Park

4/5(55 reviews)

Enjoy the thrill rides with your kiddos at Sun Splash Water Park during your trip to Cape Coral. Stroll along the beautiful beaches or discover the beautiful sunsets in this family-friendly area.

Sun Splash Water Park

Things to do

Fort Myers Beach Sunset Excursion

Fort Myers Beach Sunset Excursion

$60
per adult
100% of travellers recommend
Fort Myers Beach Sunset Excursion
Southwest Florida Sunset Sail

Southwest Florida Sunset Sail

$70
per adult
100% of travellers recommend
Southwest Florida Sunset Sail
Dolphin and Sightseeing Tiki Cruise

Fort Myers Beach Dolphin & Sightseeing Tour Refreshments Included

$65
per adult
Fort Myers Beach Dolphin & Sightseeing Tour Refreshments Included
See all activities in Cape Coral
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.