Matlacha Isles Vacations
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Your Matlacha Isles Vacation
Make planning your travels simple by locking in a vacation package to Matlacha Isles. We'll look after the details, so you can focus on soaking up everything this neighborhood has to offer. If you'd love to sightsee during your trip to Matlacha Isles, don't miss nearby attractions such as Royal Tee Golf Club. Don't just wish for it — make it a reality! Lock in your perfect Matlacha Isles vacation with Expedia and get to where you're going your way.
Price found within the past 48 hours. Click for updated prices.
- The Perry Hotel Naples
Aug 26 - Aug 29The Perry Hotel Naples + Flight
Naples3 nights9.6/10 - Exceptional (843 reviews)"The location was very nice. The roof top restaurant was very good and the staff were very friendly and kind. If book on Expedia be aware that there will be an extra charge because of third-party."Reviewed June 4, 2026Roundtrip • Boston (BOS) - Miami (MIA)BOS - MIA • Nonstop MIA - BOS • Nonstop$572$386found 1 day agoper traveler - LaPlaya Beach & Golf Resort - A Noble House Resort
Jul 6 - Jul 11LaPlaya Beach & Golf Resort - A Noble House Resort + Flight
Vanderbilt Beach5 nights9.0/10 - Wonderful (1,008 reviews)"The location was great however I was expecting a lot more from the property itself. We stayed on the junior suite and the room looked old, the mirror had black stains on it and the balcony furniture was stained. I pulled the extra pillow and cover in the closet for my daughter and it was definitely used before, it had hairs on the pillow and lipstick. From our room, we had to crossed a street that was pretty busy to get to the main property which was not ideal since it rained a couple of days..."Reviewed June 4, 2026Roundtrip • Boston (BOS) - Fort Myers (RSW)BOS - RSW • Nonstop RSW - BOS • Nonstop$1,626$981found 1 day agoper traveler - Chadwick Cove Resort & Marina
Aug 7 - Aug 10Chadwick Cove Resort & Marina + Flight
Manasota Key3 nights9.4/10 - Exceptional (20 reviews)Roundtrip • New York (EWR) - Fort Myers (RSW)EWR - RSW • 1 stop RSW - EWR • 1 stop$805$525found 1 day agoper traveler - A Wave From it All
Jul 25 - Aug 3A Wave From it All + Flight
Siesta Isle9 nightsRoundtrip • Boston (BOS) - Fort Myers (RSW)BOS - RSW • Nonstop RSW - BOS • Nonstop - Casa Ybel Resort
Aug 19 - Aug 23Casa Ybel Resort + Flight
Mid Island4 nights8.8/10 - Excellent (357 reviews)"Absolutely loved my stay at Casa Ybel. The beach is steps away and all of the units have back doors/ porches to make accessing the beach even easier. Check in was ok. The young lady helping me even held my groceries since our room was not ready yet and then had them delivered to our room. Some of the young maintenance staff came in while I was checking in and seemed to try and start an argument with her, but she kept professional. I would absolutely stay here again."Reviewed May 23, 2026Roundtrip • Boston (BOS) - Fort Myers (RSW)BOS - RSW • Nonstop RSW - BOS • Nonstop
Where to stay in Matlacha Isles
Find the best Matlacha Isles areas and neighborhoods for the activities you enjoy most. Learn more about Matlacha Isles
Pelican
1 out of top 10 points of interest in this area
4.5/5(47 area reviews)
If you're spending some time in Pelican, Tarpon Point and Chabad Jewish Center are top sights worth seeing.
Matlacha Isles Hotel Deals
Baymont by Wyndham Fort Myers Central
4850 S Cleveland Ave Fort Myers FL
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $74 total per night from Jul 1 to Jul 2
$74 total
Jul 1 - Jul 2
Total with taxes and fees
6.8/10 (1,114 reviews)
"It was good but the blinds were horrible, they did not block out any light, air great, clean and comfortable"
Reviewed on Jun 4, 2026
Marriott Sanibel Harbour Resort & Spa
17260 Harbour Pointe Dr Fort Myers FL
Fully refundableReserve now, pay when you stay
$270 nightly
The price is $301 total per night from Jun 7 to Jun 8
$301 total
Jun 7 - Jun 8
Total with taxes and fees
8.6/10 Excellent! (1,009 reviews)
"We had an amazing stay that started and continued with the Valet Staff, the Front Desk Staff, the Restaurant Staff and the Housekeeping Staff. Great associates that want your stay to be the best! Loved the views from our room of the water and the sunsets. We saw dolphins each night. Thanks for a ..."
Reviewed on Jun 1, 2026
Margaritaville Beach Resort Fort Myers
251 Crescent Street Fort Myers Beach FL
$254 nightly
The price is $283 total per night from Jun 8 to Jun 9
$283 total
Jun 8 - Jun 9
Total with taxes and fees
9/10 Wonderful! (2,169 reviews)
"Family friendly with plenty to entertain the kids. Prices are a little high Staff is helpful and accommodating Only downside is it is a long walk to the beach and pool if you are not staying at the Beach House. All in all, a very pleasant location"
Reviewed on Jun 4, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Matlacha Isles
Sun Splash Water Park
4/5(56 reviews)
Enjoy the thrill rides with your kiddos at Sun Splash Water Park during your trip to Cape Coral. Stroll along the marina or discover the beautiful sunsets in this family-friendly area.
Four Mile Cove Ecological Preserve
Enjoy the beautiful sunsets and explore Four Mile Cove Ecological Preserve, a lovely green space in Cape Coral. Amble around this family-friendly area's beautiful beaches or attend a baseball game.
Dolphin Marina
Explore the waterfront of Dolphin Marina and enjoy other activities such as boating in Cape Coral. Wander the beautiful beaches and seaside in this family-friendly area.
Things to do
Fort Myers Beach Sunset and Dolphin Watching Cruise
$70
per adult
100% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.