Matlacha Isles Vacations from $581

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Your Matlacha Isles Vacation

Make planning your travels simple by locking in a vacation package to Matlacha Isles. We'll look after the details, so you can focus on soaking up everything this neighborhood has to offer. If you'd love to sightsee during your trip to Matlacha Isles, don't miss nearby attractions such as Royal Tee Golf Club. Don't just wish for it — make it a reality! Lock in your perfect Matlacha Isles vacation with Expedia and get to where you're going your way.

The Latest Matlacha Isles Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina

3 out of 5
Save 100% on your flight
Price was $1,055, price is now $581 per person
$581
per person
Feb 15 - Feb 19
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
9.2/10 Wonderful! (1,001 reviews)
We enjoyed meeting Penny and really liked our little spot on the water :)

Reviewed on Dec 13, 2025

Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers

3 out of 5
Villas
Save 100% on your flight
Price was $1,309, price is now $651 per person
$651
per person
Feb 22 - Mar 1
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Fort Myers (RSW)
8.6/10 Excellent! (1,002 reviews)
Great amenities, pool and spa, clean room, beautiful lobby and good on site restaurant

Reviewed on Dec 9, 2025

Innovation Hotel

Innovation Hotel

4 out of 5
Save 100% on your flight
Price was $2,028, price is now $1,102 per person
$1,102
per person
Feb 18 - Feb 23
found 13 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Fort Myers (RSW)
9.8/10 Exceptional! (527 reviews)
We had a great time! Modern design, great service and friendly.

Reviewed on Dec 14, 2025

The Perry Hotel Naples

The Perry Hotel Naples

4.5 out of 5
Save 100% on your flight
Price was $2,270, price is now $1,317 per person
$1,317
per person
Feb 22 - Mar 1
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Fort Myers (RSW)
9.6/10 Exceptional! (477 reviews)
Food quality was excellent, staff was very polite, professional, and accommodating especially Reuben at the front desk, the hotel is under a year old so very current with technology, and lastly it's a beautiful hotel!

Reviewed on Dec 15, 2025

South Seas Resort

South Seas Resort

3.5 out of 5
Save 100% on your flight
Price was $2,011, price is now $1,185 per person
$1,185
per person
Feb 5 - Feb 11
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
8.4/10 Very Good! (1,001 reviews)
Fantastic place for perfect relaxation, hammocks are placed perfectly for a tropical feel staff is outstanding customer service. A top of the cap to Jeff and Anthony at the front desk.

Reviewed on Dec 10, 2025

Where to stay in Matlacha Isles

Find the best Matlacha Isles areas and neighborhoods for the activities you enjoy most. Learn more about Matlacha Isles
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Pelican

1 out of top 10 points of interest in this area
4.5/5(46 area reviews)

If you're spending some time in Pelican, Tarpon Point and Harbour View Gallery are top sights worth seeing.

Find hotels in Pelican

Matlacha Isles Hotel Deals

Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

4 out of 5
17260 Harbour Pointe Dr Fort Myers FL
Fully refundableReserve now, pay when you stay
$221 nightly
The price is $247 total per night from Dec 16 to Dec 17
$247 total
Dec 16 - Dec 17
Total with taxes and fees
8.2/10 Very Good! (1,001 reviews)
Great view from mini suite. Only real issue is self-parking is a nightmare. If you don't mind $35 per day plus tips, use the valet parking. The quality and presentation of the buffet breakfast is not on par with the rest of the facility, which is beautiful!

Reviewed on Dec 7, 2025

Marriott Sanibel Harbour Resort & Spa
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street Fort Myers Beach FL
$274 nightly
The price is $306 total per night from Dec 19 to Dec 20
$306 total
Dec 19 - Dec 20
Total with taxes and fees
8.8/10 Excellent! (1,697 reviews)
This hotel had spectacular sunsets from your hotel room! We were able to look at the waves in am and at night- so calming and peaceful. Room had a lot of space. Bathrooms were big and great showers. Staff were very professional and pleasant, and went above and beyond

Reviewed on Dec 7, 2025

Margaritaville Beach Resort Fort Myers
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 out of 5
1400 Estero Blvd Fort Myers Beach FL
Fully refundableReserve now, pay when you stay
$151 nightly
The price is $169 total per night from Dec 16 to Dec 17
$169 total
Dec 16 - Dec 17
Total with taxes and fees
9/10 Wonderful! (1,017 reviews)
First time at Lani Kai, room was clean and nice, great view off the balcony. Staff was very good. If the beach bars stayed open later on the weekends that would be a plus. Drink prices seemed inflated. Would def stay again.

Reviewed on Dec 9, 2025

Lani Kai Beachfront Resort
See all 14,357 properties in Matlacha Isles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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All Inclusive Vacations
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Kid Friendly Vacations
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Discover the most popular places to visit in Matlacha Isles

Veterans park

Four Mile Cove Ecological Preserve

Enjoy the beautiful sunsets and explore Four Mile Cove Ecological Preserve, a lovely green space in Cape Coral. Amble around this family-friendly area's beautiful beaches or attend a baseball game.

Four Mile Cove Ecological Preserve

Cape Coral Yacht Club Beach

Why not spend a lazy afternoon at Cape Coral Yacht Club Beach during your trip to Cape Coral?

Cape Coral Yacht Club Beach

Sun Splash Water Park

4/5(55 reviews)

Enjoy the thrill rides with your kiddos at Sun Splash Water Park during your trip to Cape Coral. Stroll along the marina or discover the beautiful sunsets in this family-friendly area.

Sun Splash Water Park

Things to do

Fort Myers Beach Sunset and Dolphin Watching Cruise

Fort Myers Beach Sunset and Dolphin Watching Cruise

$59
per adult
100% of travellers recommend
Fort Myers Beach Sunset and Dolphin Watching Cruise
Copacetic Day Sail

Copacetic Day Sail

$63
per adult
100% of travellers recommend
Copacetic Day Sail
Southwest Florida Sunset Sail

Southwest Florida Sunset Sail

$63
per adult
100% of travellers recommend
Southwest Florida Sunset Sail
See all activities in Cape Coral
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.