Matthews Vacations from $520

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The Latest Matthews vacation packages

Price found within the past 48 hours. Click for updated prices.
The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel

2 out of 5
Price was $539, price is now $520 per person
$520
per person
Aug 6 - Aug 9
found 1 day ago
Roundtrip flight included
Pittsburgh (PIT) to Cape Girardeau (CGI)
9.6/10 Exceptional! (4 reviews)
Very nice clean room with comfortable bed and nice shower. Kitchenette was good with microwave and mini fridge, basic dishes. The owner was very easy to communicate with. Good location with Mary Jane’s restaurant bar next door had excellent food and nice atmosphere. My only small suggestion would be to put variable light switches so you could turn down the lighting at night. I would definitely recommend and would stay here again on my next trip to Perryville.

Reviewed on May 3, 2026

Makanda Inn

Makanda Inn

3.5 out of 5
Price was $693, price is now $625 per person
$625
per person
Aug 6 - Aug 9
found 1 day ago
Roundtrip flight included
Pittsburgh (PIT) to Cape Girardeau (CGI)
10/10 Exceptional! (37 reviews)
Jackie was amazing. She was very informative and helpful. Great communication. The room was really comfortable. And breakfast was great.

Reviewed on May 10, 2026

EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

3 out of 5
Price was $1,166, price is now $1,080 per person
$1,080
per person
Aug 5 - Aug 9
found 1 day ago
Roundtrip flight included
Fayetteville (FAY) to Cape Girardeau (CGI)
9.6/10 Exceptional! (101 reviews)
This boutique hotel is awesome. It’s clean and it has a really good restaurant. Cristy was super nice as well :)

Reviewed on Jun 16, 2026

The Mediterranean House 1858

The Mediterranean House 1858

2 out of 5
Price was $1,383, price is now $1,300 per person
$1,300
per person
Aug 6 - Aug 9
found 1 day ago
Roundtrip flight included
Pittsburgh (PIT) to Cape Girardeau (CGI)
No reviews
The Riverview

The Riverview

4 out of 5
Price was $1,229, price is now $1,170 per person
$1,170
per person
Aug 5 - Aug 9
found 1 day ago
Roundtrip flight included
Fayetteville (FAY) to Cape Girardeau (CGI)
9.4/10 Exceptional! (598 reviews)
The view of the river from the 3rd floor.Starbucks downstairs.Big open room and bathroom.

Reviewed on Jun 28, 2026

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Matthews Hotel Deals

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $128 total per night from Jul 6 to Jul 7
$128 total
Jul 6 - Jul 7
Total with taxes and fees
9.6/10 Exceptional! (1,004 reviews)
"Quick check-in. Room was very clean and nice. Staff was helpful. Would definitely stay here again."

Reviewed on Jun 28, 2026

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $78 total per night from Jul 2 to Jul 3
$78 total
Jul 2 - Jul 3
Total with taxes and fees
7.2/10 Good! (1,001 reviews)
"Rooms are nice and clean although fixtures could be updated. There is no central air and heat, room is cooled by a wall unit. Room was extremely hot when I first entered."

Reviewed on Jun 24, 2026

Days Inn and Suites by Wyndham Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $97 total per night from Jul 26 to Jul 27
$97 total
Jul 26 - Jul 27
Total with taxes and fees
8.4/10 Very Good! (1,005 reviews)
"The staff are really nice and friendly. Breakfast is very good too. Pretty close to a convenience store. Only problem was the musty smell through the hallways and into the room. We had to fan out the room before staying inside for too long. We also saw a dead cockroach on the window."

Reviewed on Jun 28, 2026

Best Western Plus Sikeston I-55
See all 42 properties in Matthews
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Matthews Vacation Packages

Matthews Essential Information

Language
English
Currency
U.S dollars
Population
630

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Frequently asked questions

How much does a Matthews vacation package cost?
You'll find cheap prices from $520 on Expedia for your Matthews escape. However, a range of factors like the length of stay, hotel choice and season will determine how much your vacation to Matthews costs.
What are the cheapest months to go to Matthews?
If you're hoping to score a cheap Matthews vacation package, consider traveling in January, September and November. You're likely to find better prices on flights and accommodations during these months — perfect for travelers wishing to save money.
How many days is enough for Matthews?
Usually, a handful of days is enough to visit the major attractions during your Matthews vacation. But if you want to have time to chill out or take day tours, think about extending your trip.
How to find the best Matthews package deals?
Begin your search for a Matthews package deal by entering your travel dates and destination under our "Packages" tab. Then apply some filters, like "Property type" and "Guest rating," to tailor the results to your exact needs. You can also sort by "Package discount" and browse offers that come with unbeatable savings. If you don't find the ideal Matthews package deal right away, just change your dates and search again. Keep in mind that deals are only available for a limited time, so book early and get your Matthews escape off to a flying start.
Is it cheaper to book a Matthews vacation as a package?
An Expedia vacation package could score you significant savings when compared to arranging accommodations and flights separately. Better still, you can customize your Matthews trip to fit your exact needs. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
When to book a vacation package to Matthews?
If you've got your Matthews travel dates locked in, book as early as you can to bag some unbeatable deals. With Expedia, you can often reserve some flights up to a year in advance. Prefer spur-of-the-moment trips? Our last-minute deals are ideal for traveling on a whim.
Does Expedia offer Book Now, Pay Later Matthews vacation packages?
Your Matthews getaway should be a relaxing escape from your busy life, not a reason for money worries. So to allow you that extra flexibility, we've joined up with online lender Affirm to bring you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and spread the cost over 3, 6 or 12 months. Plus, there aren't any hidden or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.