Mayo Clinic Vacations from $223

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The Latest Mayo Clinic Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Scottsdale Plaza Resort

Scottsdale Plaza Resort

4 out of 5
per person
Sep 25 - Sep 28
found 1 day ago
Roundtrip flight included
Denver (DEN) to Phoenix (PHX)
9/10 Wonderful! (2,284 reviews)
Excellent amenities and proximity to restaurants and town events. The villa I stayed in was nice. Housekeeping woke me up when I requested them not to several times for two days.

Reviewed on Jul 12, 2025

Westgate Painted Mountain Golf Resort

Westgate Painted Mountain Golf Resort

4 out of 5
East Mesa
Save 100% on your flight
per person
Sep 11 - Sep 14
found 1 day ago
Roundtrip flight included
Denver (DEN) to Phoenix (PHX)
8.2/10 Very Good! (1,005 reviews)
Very nice place for this price it's just amazing.

Reviewed on Jul 15, 2025

Hotel Valley Ho

Hotel Valley Ho

4.5 out of 5
Old Town
Save 100% on your flight
per person
Sep 25 - Sep 28
found 1 day ago
Roundtrip flight included
Denver (DEN) to Phoenix (PHX)
9.6/10 Exceptional! (1,764 reviews)
Hotel was nice and clean. Staff was great only con is you could hear screaming outside at night.

Reviewed on Jul 15, 2025

Sedona Springs Resort

Sedona Springs Resort

3 out of 5
West Sedona
Save 100% on your flight
per person
Oct 7 - Oct 12
found 20 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Phoenix (PHX)
9.2/10 Wonderful! (1,112 reviews)
It's nice closed to drive on the main rd. main town attractions Quiet and clean suites. Nice privacy. Dislikes the room studio has muskty smell and the air does not circulate when the air is on smell like cigarette smoke. The shower curtain smell and needed to wash

Reviewed on Jul 5, 2025

Creekside Inn Sedona

Creekside Inn Sedona

4 out of 5
Chapel
Save 100% on your flight
per person
Aug 29 - Sep 1
found 1 day ago
Roundtrip flight included
Denver (DEN) to Phoenix (PHX)
9.8/10 Exceptional! (56 reviews)
This place is amazing and the staff super friendly 👍

Reviewed on Jun 8, 2025

Where to stay in Mayo Clinic

Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most. Learn more about Mayo Clinic
Downtown Phoenix which includes signage and night scenes

Downtown Phoenix

3 out of top 10 points of interest in this area
3.5/5(2,458 area reviews)

A true urban neighborhood, Downtown Phoenix boasts major sports venues like Chase Field and Footprint Center, as well as cultural attractions such as the Arizona Science Center and Phoenix Art Museum. Easily accessible via Valley Metro Light Rail, enjoy walkable streets, friendly cafes, and local businesses.

Find hotels in Downtown Phoenix

Mayo Clinic Hotel Deals

Talking Stick Resort

Talking Stick Resort

4 out of 5
9800 E. Talking Stick Way, Scottsdale, AZ
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $173 total per night from Jul 21 to Jul 22
$173 total
Jul 21 - Jul 22
Total includes taxes and fees
9.2/10 Wonderful! (3,522 reviews)
We'll be back!!
"We came here as locals to celebrate our 44th wedding anniversary and everything was wonderful. Staff great and accommodating, friendly, food was great at several locations that we tried. Bell and Valet service excellent and very timely. We would stay here again."

Reviewed on Jul 14, 2025

Talking Stick Resort
Arizona Grand Resort & Spa

Arizona Grand Resort & Spa

4 out of 5
8000 S. Arizona Grand Parkway, Phoenix, AZ
$185 nightly
The price is $210 total per night from Jul 22 to Jul 23
$210 total
Jul 22 - Jul 23
Total includes taxes and fees
8.4/10 Very Good! (1,979 reviews)
"-"

Reviewed on Jul 13, 2025

Arizona Grand Resort & Spa
Hilton Phoenix Resort at the Peak

Hilton Phoenix Resort at the Peak

4 out of 5
7677 N 16th St, Phoenix, AZ
Fully refundableReserve now, pay when you stay
$154 nightly
The price is $174 total per night from Jul 20 to Jul 21
$174 total
Jul 20 - Jul 21
Total includes taxes and fees
7.6/10 Good! (3,149 reviews)
"Its very good !!"

Reviewed on Jul 13, 2025

Hilton Phoenix Resort at the Peak
See all 13,195 properties in Mayo Clinic
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Discover the most popular places to visit in Mayo Clinic

Grady Gammage Memorial Auditorium

Arizona State University

4.5/5(1,877 reviews)

Explore the campus of Arizona State University, a top college in Tempe. Amble around the area's lakeside or seek out the jogging trails.

Arizona State University
Phoenix Convention Center

Phoenix Convention Center

4/5(959 reviews)

During your trip, find out what's happening at Phoenix Convention Center, a top convention center in Phoenix. Experience the fascinating museums and acclaimed theater scene in this vibrant area.

Phoenix Convention Center
Come catch a GCU baseball game. Number 1 team in the WAC.

Grand Canyon University

4.5/5(631 reviews)

Enjoy the collegiate vibe with a visit to Grand Canyon University, a well-known college in Phoenix. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

Grand Canyon University

Things to do

Phoenix: Self-Drive ATV/UTV Rental in the Sonoran Desert

Phoenix: Self-Drive ATV/UTV Rental in the Sonoran Desert

$102
per traveler
100% of travellers recommend
Phoenix: Self-Drive ATV/UTV Rental in the Sonoran Desert
Let's Fly!

Sunrise Hot Air Balloon Ride in Phoenix with Breakfast

$199
per adult
100% of travellers recommend
Sunrise Hot Air Balloon Ride in Phoenix with Breakfast
Phoenix Sunrise Hot Air Balloon Ride

Phoenix Sunrise Hot Air Balloon Ride

$209
per adult
94% of travellers recommend
Phoenix Sunrise Hot Air Balloon Ride
See all activities in Phoenix
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.