Mediterranean Region Vacations from $307

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Mediterranean Region vacation packages

Price found within the past 48 hours. Click for updated prices.
Creekside Inn
YotelPad Miami
Avi Lux Stay
The Marlin Hotel
Henrosa Hotel
Don't see what you're looking for?
See all available trips from Columbus to Mediterranean Region
View all trips

Where to stay in Mediterranean Region

Find the best Mediterranean Region areas and neighborhoods for the activities you enjoy most. Learn more about Mediterranean Region

Stay near popular Mediterranean Region attractions

Mediterranean Region Hotel Deals

Barcelona Airport Hotel

Barcelona Airport Hotel

4 out of 5
Plaza de la Volateria, 3 El Prat de Llobregat
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $161 total per night from Nov 21 to Nov 22
$161 total
Nov 21 - Nov 22
Total with taxes and fees
Barcelona Airport Hotel
Hotel101- Madrid

Hotel101- Madrid

4 out of 5
Av. de las Fuerzas Armadas, 328 Madrid
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $78 total per night from Nov 29 to Nov 30
$78 total
Nov 29 - Nov 30
Total with taxes and fees
Hotel101- Madrid
Palais Moulay Said & SPA

Palais Moulay Said & SPA

3 out of 5
60 Riad Zitoun Lakdim Marrakech Marrakech-Safi
$98 nightly
The price is $115 total per night from Dec 8 to Dec 9
$115 total
Dec 8 - Dec 9
Total with taxes and fees
8.8/10 Excellent! (1,063 reviews)
"Unfortunately, we had no hot water in our shower on the first evening. After raising this with staff, we were moved to another room, only to experience the same issue. Although the water became warm the following day, it was never properly hot. While we understand that these issues happen, the communication ..."

Reviewed on Nov 6, 2026

Palais Moulay Said & SPA
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mediterranean Region Vacation Packages

More vacations you might like

Frequently asked questions

How do vacation package prices compare across popular destinations in the Mediterranean Region?
The Mediterranean Region offers a range of vacation package prices across its popular destinations, with typical week-long trips spanning from around $1,350 to $1,550 per adult.

*Package prices shown are the average total cost per adult across Expedia bookings over the past year and may change depending on availability, dates, and demand.
How can I save money on a Mediterranean Region vacation package?
When you bundle, you can save up to 30%*. To save money on a Mediterranean Region package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.
What's included in a Mediterranean Region vacation package?
A Mediterranean Region vacation package lets you combine flights, hotel stays, and rental cars, based in one of the region's top destinations like Rome, Madrid, or Barcelona. In Rome, most hotels offer airport shuttle service and most also include free breakfast. Madrid also sees most hotels providing airport shuttle service and free breakfast. For Barcelona, nearly all hotels offer airport shuttle service, and most include free breakfast.

Exactly what's included will vary by hotel and package, so it's worth reviewing the details before you confirm your booking.
Which destinations in the Mediterranean Region offer the best-value vacation package deals?
Athens, Marrakech, Madrid, Barcelona, and Rome are some of the top destinations for cheap Mediterranean Region vacation package deals. For an affordable weekend getaway, Marrakech is often among the most budget-friendly options, with package prices starting around $200 per adult. For notable bundle savings, Rome is often among the best options, with flight-and-hotel bundles saving around $95 per adult.

Browse cheap vacation packages in the Mediterranean Region on Expedia to compare current deals.

*Package prices shown are the average total cost per adult across Expedia bookings over the past year and may change depending on availability, dates, and demand.
When is the best time to visit the top destinations in the Mediterranean Region?
The best time for a Mediterranean Region vacation package depends on which destination you choose.

Rome is busiest from June to July, and in September, when highs are around 74°F to 82°F. The Rome Marathon also takes place in March. If you'd prefer fewer crowds, from January to February and in November are quieter, with highs around 47°F to 54°F in January.

Lisbon sees its highest demand in July and September, with highs around 70°F to 80°F. For a quieter trip, from January to March are less busy, with highs around 54°F to 59°F in January.

Florence is busiest in June and September, when highs are around 70°F to 81°F. If you'd prefer fewer visitors, from January to February and in November are quieter, with highs around 41°F to 49°F in January.

Marrakech is most popular in April and December, with highs around 65°F to 78°F in April and 56°F to 69°F in December. For fewer crowds, in January and from July to August are quieter, with highs around 53°F to 66°F in January.

Athens experiences peak demand in June and September, when highs are around 77°F to 85°F. If you'd prefer fewer crowds, from January to February and in December are quieter, with highs around 49°F to 55°F in January.
What package types are available across the top destinations in the Mediterranean Region?
The Mediterranean Region offers a variety of vacation package types across its popular destinations like Rome, Madrid, Barcelona, Lisbon, and Athens:
  • Budget: In Rome, Green Garden, rated 9.7 out of 10 by travelers, provides comfortable stays with free WiFi.
  • Family: Martinhal Lisbon Chiado in Lisbon, rated 9.2 out of 10 by travelers, is well-suited for families with its family rooms and kitchenettes.
  • Pet-friendly: In Barcelona, Hotel Regina Barcelona, rated 8.7 out of 10 by travelers, welcomes pets and offers family rooms.
  • Couples: The Principal Madrid, rated 8.8 out of 10 by travelers, features a fitness center and spa, making it a great choice for couples.
  • Luxury: In Athens, Altar Suites, rated 9.2 out of 10 by travelers, offers free breakfast and concierge services for a premium experience.
Which destinations should I consider for a Mediterranean Region vacation?
For a Mediterranean Region vacation, your ideal base depends on your travel style:
  • Rome: A top choice for cultural trips and city exploration, offering a wealth of historic sites and urban attractions, and a popular package base.
  • Madrid: Excellent for family-friendly city breaks and urban sightseeing, with a strong focus on cultural experiences.
  • Barcelona: Ideal for travelers seeking a vibrant city experience with cultural attractions and family-friendly activities, also a popular package base.
  • Lisbon: A great option for those interested in cultural attractions and city life, with a good range of lodging choices.
  • Athens: Perfect for a cultural trip focused on ancient history and urban exploration, with many package options available.
  • Florence: A strong lodging base for cultural and urban attractions, particularly appealing for those interested in art and history.
Is the Mediterranean Region better suited for a beach vacation or a cultural trip?
The Mediterranean Region offers a rich blend of cultural experiences and urban attractions, with some destinations also providing beach access.

Cities like Rome, Florence, and Athens are primarily cultural hubs, known for their historic sites such as the Acropolis and Ponte Vecchio. Other cities like Barcelona and Lisbon offer a mix of city life and cultural exploration, with Barcelona also featuring beaches like Barceloneta Beach.

Overall, a Mediterranean Region vacation is strongly suited for cultural exploration and city sightseeing, with opportunities for beach relaxation in specific areas.
Which airports serve the main destinations in the Mediterranean Region?
For a Mediterranean Region vacation, several major airports serve its key destinations. Leonardo da Vinci Airport (FCO) is the primary gateway for Rome, while Lisbon Airport (LIS) serves Lisbon. Athens International Airport (ATH) is the main airport for Athens. For travelers heading to Spain, Madrid-Adolfo Suárez Madrid-Barajas (MAD) serves Madrid, and Barcelona International Airport (BCN) serves Barcelona. Marrakech Menara Airport (RAK) is the main airport for Marrakech, and Florence Peretola Airport (FLR) serves Florence.
What are the top things to do across the destinations in the Mediterranean Region?
A Mediterranean Region vacation offers a diverse array of experiences across its many destinations:

Browse and book things to do in the Mediterranean Region on Expedia.
Which destinations in the Mediterranean Region have all-inclusive resorts?
In the Mediterranean Region, all-inclusive resorts are primarily found in Marrakech, offering a convenient option for your Mediterranean Region vacation package:

Browse all-inclusive resorts in the Mediterranean Region on Expedia.
Are there family vacation packages in the Mediterranean Region with kid-friendly amenities?
Yes, family vacation packages in the Mediterranean Region can include hotels with a range of kid-friendly amenities across destinations like Rome, Madrid, Barcelona, Lisbon, and Marrakech:
  • In Rome, the 5-star Aleph Rome Hotel Curio Collection by Hilton, rated 8.7 out of 10 by travelers, offers family rooms, indoor and outdoor pools, and a kids club, with travelers praising the spacious rooms and attentive staff.
  • The 4-star Novotel Madrid Center in Madrid, rated 8.7 out of 10 by travelers, features family rooms, a game room, and a playground, with travelers highlighting the great food and spacious rooms.
  • In Barcelona, the 5-star Kimpton Vividora Hotel by IHG, rated 8.4 out of 10 by travelers, provides family rooms, a kids club, and a game room, with travelers often noting the wonderful overall experience and great location.
  • Lisbon's 5-star Altis Grand Hotel, rated 9 out of 10 by travelers, includes family rooms and an indoor pool, with travelers praising the staff for their attentiveness.
  • In Marrakech, the 5-star Mövenpick Hotel Mansour Eddahbi Marrakech, rated 8.6 out of 10 by travelers, offers family rooms, a kids club, and a game room, with travelers appreciating the great staff and breakfast.
What luxury vacation packages are available in the Mediterranean Region?
The Mediterranean Region's top destinations offer a range of luxury vacation packages, often centered around exquisite hotels:

Review the hotel included in each Mediterranean Region vacation package. Browse luxury vacation packages in the Mediterranean Region on Expedia to compare options.
Which destinations in the Mediterranean Region have adults-only resorts?
Several destinations in the Mediterranean Region offer adults-only resorts that can be part of your Mediterranean Region vacation package:

Browse adults-only resorts in the Mediterranean Region on Expedia to compare options.
When should I book vacation packages for the top destinations in the Mediterranean Region?
When planning a Mediterranean Region vacation package, most travelers book around 7 to 9 weeks ahead, though the ideal timing can vary by destination.

Travelers tend to book trips to these destinations most often in March, May, from July to August, and November. If you're planning a spontaneous getaway, Expedia also offers last-minute Mediterranean Region vacation packages.
How many days do you need for a Mediterranean Region vacation?
Most Mediterranean Region vacation packages last around 6 to 7 days, but the ideal trip length depends on where you're going and what you'd like to experience.

Rome, a city primarily known for its cultural attractions, is typically visited for around 7 days, with week-long and two-week stays both popular enough to explore iconic sites like the Colosseum.

Madrid, a vibrant city known for its urban attractions and outdoor activities, is often enjoyed for around 6 days, with week-long trips being a popular choice to experience areas like Gran Via.

Athens, a destination rich in cultural attractions, also sees typical stays of around 7 days, with week-long and two-week trips being common for travelers to immerse themselves in history at the Acropolis.
Can I change or cancel my Mediterranean Region vacation package if my plans change?
Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.
Do One Key members get extra savings when booking Mediterranean Region vacation packages?
Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.
Does Expedia offer Book Now, Pay Later Mediterranean Region vacation packages?
Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Mediterranean Region vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.
How do I find last-minute vacation packages to Mediterranean Region?
To find last-minute vacation packages to Mediterranean Region, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.
How does free cancellation work on Mediterranean Region vacation packages?
Free cancellation on a Mediterranean Region vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.
Is it cheaper to book a Mediterranean Region vacation as a package or separately?
An Expedia vacation package could land you great savings when compared to arranging flights and hotels separately. Better still, you can tailor your Mediterranean Region getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
Why should I book my Mediterranean Region vacation package with Expedia?
Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.