Midtown Vacations from $305

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Your Midtown Vacation

Lock in a vacation package to Midtown and experience everything this busy neighborhood has to offer. Known for its shopping, cafes and nightlife, your next epic adventure can be found right here. Start your trip to Midtown by visiting nearby attractions such as Alamo, Alamodome and San Antonio Zoo and Aquarium. Stop dreaming and start doing. When you're ready to lock in your dream vacation to Midtown, Expedia is here to help.

The Latest Midtown Vacation Packages

Price found within the past 48 hours. Click for updated prices.
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
Medical Center District
Save 100% on your flight
Price was $567, price is now $305 per person
$305
per person
Dec 6 - Dec 13
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to San Antonio (SAT)
8.6/10 Excellent! (3,018 reviews)
The room and staff were fine. After four days of checking out, I found that I had left a pair of boots behind. I called the hotel and spoke to Ester. She told me she would check and get back to me. About an hour later she called advising me that they had my boots. My son went to pick them up later that day. Thank you so much for holding on to one of my favorite pair of boots.

Reviewed on Oct 29, 2025

Crockett Hotel

Crockett Hotel

3 out of 5
Downtown San Antonio
Save 100% on your flight
Price was $972, price is now $567 per person
$567
per person
Dec 6 - Dec 13
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to San Antonio (SAT)
9/10 Wonderful! (2,459 reviews)
The staff was awesome! The hotel was a bit outdated, but overall we enjoyed ourselves.

Reviewed on Nov 1, 2025

Cozy 3BR Home Family-friendly Near Attractions

Cozy 3BR Home Family-friendly Near Attractions

2 out of 5
Uptown
Save 100% on your flight
Price was $1,354, price is now $854 per person
$854
per person
Dec 6 - Dec 13
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to San Antonio (SAT)
No reviews
Holiday Inn Express & Suites San Antonio Medical-Six Flags by IHG

Holiday Inn Express & Suites San Antonio Medical-Six Flags by IHG

2.5 out of 5
Northwest Side
Save 100% on your flight
Price was $551, price is now $360 per person
$360
per person
Dec 6 - Dec 13
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to San Antonio (SAT)
7.8/10 Good! (1,011 reviews)
my stay was pretty good. We love our room, the only bad thing is the hot water wasn’t working the last day but other than that was amazing. We’ll stay again in out next trip.

Reviewed on Oct 31, 2025

Staybridge Suites San Antonio by IHG

Staybridge Suites San Antonio by IHG

3 out of 5
Uptown
Save 100% on your flight
Price was $653, price is now $444 per person
$444
per person
Dec 6 - Dec 13
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to San Antonio (SAT)
8.4/10 Very Good! (1,001 reviews)
Clean room, very nice staff

Reviewed on Oct 27, 2025

Where to stay in Midtown

Find the best Midtown areas and neighborhoods for the activities you enjoy most. Learn more about Midtown
Downtown - Riverwalk which includes heritage architecture, boating and a river or creek

Downtown San Antonio

4 out of top 10 points of interest in this area
4/5(9,525 area reviews)

Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

Find hotels in Downtown San Antonio

Midtown Hotel Deals

Crockett Hotel

Crockett Hotel

3 out of 5
320 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $89 total per night from Nov 17 to Nov 18
$89 total
Nov 17 - Nov 18
Total with taxes and fees
8.8/10 Excellent! (2,457 reviews)
Location is fantastic. Walking distance to everything.

Reviewed on Oct 30, 2025

Crockett Hotel
Sonesta ES Suites San Antonio Downtown Alamo Plaza

Sonesta ES Suites San Antonio Downtown Alamo Plaza

3 out of 5
425 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $103 total per night from Nov 16 to Nov 17
$103 total
Nov 16 - Nov 17
Total with taxes and fees
8.2/10 Very Good! (1,827 reviews)
Rooms were great nice and clean ...staff was ok Not too friendly didn't feel welcome but the valley parking guy was amazing didn't get his name blonde hair also the kitchen girl was very nice kept asking if i needed anything....not very good selection on the vending stuff but over all we enjoyed ...

Reviewed on Oct 30, 2025

Sonesta ES Suites San Antonio Downtown Alamo Plaza
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St, San Antonio, TX
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $189 total per night from Nov 16 to Nov 17
$189 total
Nov 16 - Nov 17
Total with taxes and fees
9.4/10 Exceptional! (2,098 reviews)
Hotel Valencia was one of the best hoteles we have stayed at. The staff was fantastic

Reviewed on Oct 27, 2025

Hotel Valencia Riverwalk
See all 4,563 properties in Midtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Midtown

San Antonio Zoo and Aquarium featuring interior views, zoo animals and marine life

San Antonio Zoo and Aquarium

There are nearly 800 wild and wonderful species at the zoo in the center of Brackenridge Park, not far from the city center.

San Antonio Zoo and Aquarium
Brackenridge Park

Brackenridge Park

Brackenridge Park is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene and lively festivals in this walkable area.

Brackenridge Park

Trinity University

Enjoy the collegiate vibe at Trinity University during your stay in San Antonio. Experience the entertainment choices and great live music in this walkable area.

Trinity University

Things to do

San Antonio: San Antonio Zoo Any Day Ticket

San Antonio: San Antonio Zoo Any Day Ticket

$30
per adult
94% of travellers recommend
San Antonio: San Antonio Zoo Any Day Ticket
SEA LIFE San Antonio

SEA LIFE San Antonio

$25
per adult
78% of travellers recommend
SEA LIFE San Antonio
San Antonio Old Town Trolley Hop-on Hop-Off Tour

San Antonio Old Town Trolley Hop-on Hop-Off Tour

$52
per adult
96% of travellers recommend
San Antonio Old Town Trolley Hop-on Hop-Off Tour
See all activities in San Antonio
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.