Midtown Vacations from $395

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Your Midtown Vacation

Lock in a vacation package to Midtown and experience everything this busy neighborhood has to offer. Known for its shopping, cafes and nightlife, your next epic adventure can be found right here. Start your trip to Midtown by visiting nearby attractions such as Alamo, Alamodome and San Antonio Zoo and Aquarium. Stop dreaming and start doing. When you're ready to lock in your dream vacation to Midtown, Expedia is here to help.

The Latest Midtown Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Joshua Creek Ranch

Joshua Creek Ranch

$395
per person
Sep 11 - Sep 14
found 16 hours ago
Roundtrip flight included
Atlanta (ATL) to San Antonio (SAT)
9/10 Wonderful! (75 reviews)
The staff was extremely helpful. They even took us for a tour around the property. Laura was very knowledgeable about the history and seasonal details about the hunting and lodging amenities. Property is very well maintained. Food and drinks were great. Would definitely consider returning.

Reviewed on Aug 7, 2026

Tx Home Group- San Antonio

Tx Home Group- San Antonio

Midtown
Save 100% on your flight
$1,102
per person
Oct 12 - Oct 19
found 1 day ago
Roundtrip non-stop flight included
Islip (ISP) to San Antonio (SAT)
7.8/10 Good! (10 reviews)
The St. Anthony, A Luxury Collection Hotel, San Antonio

The St. Anthony, A Luxury Collection Hotel, San Antonio

Downtown San Antonio
Save 100% on your flight
$753
per person
Oct 15 - Oct 18
found 23 hours ago
Roundtrip flight included
Atlanta (ATL) to San Antonio (SAT)
8.8/10 Excellent! (1,004 reviews)
Hotel Contessa

Hotel Contessa

Downtown San Antonio
Save 100% on your flight
$622
per person
Oct 15 - Oct 18
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to San Antonio (SAT)
9/10 Wonderful! (3,768 reviews)
pretty hotel, clean. They do have daily valet parking for around $50 . the pool was ok alot of kids running around. also got a free $15 card to spend at the bar or restruany

Reviewed on Aug 11, 2026

Club Wyndham La Cascada

Club Wyndham La Cascada

Downtown San Antonio
Save 100% on your flight
$477
per person
Oct 30 - Nov 2
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Antonio (SAT)
8.4/10 Very Good! (182 reviews)
Muy buen servicio todo muy limpio

Reviewed on Aug 1, 2026

Where to stay in Midtown

Find the best Midtown areas and neighborhoods for the activities you enjoy most. Learn more about Midtown
A boat tour on a canal with a bridge in the background.

Downtown San Antonio

5 out of top 10 points of interest in this area

Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

Find hotels in Downtown San Antonio
A city skyline reflected in a calm body of water, a bridge, and a sunset sky.

Uptown

While visiting Uptown, you might make a stop by sights like Alamo Quarry Market and San Antonio Zoo and Aquarium.

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An old church with a bell tower and arches, surrounded by greenery and a stone structure.

Far West Side

1 out of top 10 points of interest in this area

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Find hotels in Far West Side
A cityscape with a prominent tower, a large body of water, and a sunset.

Medical Center District

While visiting Medical Center District, you might make a stop by sights like USAA Corporate Office Headquarters and Cinemark San Antonio 16.

Find hotels in Medical Center District
A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

While visiting Northwest Side, you might make a stop by sights like Huebner Oaks and Crystal Ice Palace.

Find hotels in Northwest Side

Midtown Hotel Deals

Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

105 S Saint Marys Street San Antonio TX
Fully refundableReserve now, pay when you stay
$128 nightly
$151 total
Aug 17 - Aug 18
Total with taxes and fees
Drury Plaza Hotel San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

303 Blum Street San Antonio TX
Fully refundableReserve now, pay when you stay
$88 nightly
$104 total
Sep 7 - Sep 8
Total with taxes and fees
8/10 Very Good! (4,046 reviews)
"Breakfast"

Reviewed on Aug 12, 2026

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
$144 nightly
$169 total
Aug 14 - Aug 15
Total with taxes and fees
Hotel Valencia Riverwalk
See all 4,744 properties in Midtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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All Inclusive Vacations
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Romantic Vacations
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Where to go when
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Honeymoon Vacations
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Solo Vacations

Stay near popular Midtown attractions

A bronze lion statue with cubs at San Antonio Zoo.

San Antonio Zoo and Aquarium

8.8/10 (2,446 reviews)
There are nearly 800 wild and wonderful species at the zoo in the center of Brackenridge Park, not far from the city center.
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A stone bridge with a thatched roof over a river, surrounded by lush greenery and flowering plants.
Photo by 🦋GoLdEn AnN🦋

Brackenridge Park

8.8/10 (8 reviews)
Brackenridge Park is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Experience the great live music and acclaimed theater scene in this walkable area.
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The DoSeum

7.6/10 (4 reviews)
You can take time to visit The DoSeum during your travels to San Antonio. Experience the acclaimed theater scene and lively festivals in this walkable area.
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San Pedro Springs Park

San Pedro Springs Park is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Experience the great live music and acclaimed theater scene in this walkable area.
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Historic Brackenridge Golf Course

Enjoy a round of golf in San Antonio at Historic Brackenridge Golf Course. Experience the entertainment choices and acclaimed theater scene in this walkable area.
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McFarlin Tennis Center

Catch an event at McFarlin Tennis Center during your trip to San Antonio. Stroll along the area's riverfront or simply enjoy its bars.
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Stable Hall in Pearl Brewery - San Antonio

You can get tickets for a performance at Stable Hall in Pearl Brewery - San Antonio during your trip to San Antonio. Stroll along the area's riverfront or simply enjoy its bars.
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Paper Tiger

You can enjoy a show at Paper Tiger on your trip to San Antonio. Stroll along the area's riverfront or simply enjoy its bars.
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Things to do

Picture 5 for Activity San Antonio: Six Flags Fiesta Texas Admission Ticket

San Antonio: Six Flags Fiesta Texas Admission Ticket

$49
per adult
80% of travellers recommend
San Antonio: Six Flags Fiesta Texas Admission Ticket
San Antonio: Discovery Tour at Natural Bridge Caverns

San Antonio: Discovery Tour at Natural Bridge Caverns

$38
per adult
98% of travellers recommend
San Antonio: Discovery Tour at Natural Bridge Caverns
San Antonio: Botanical Garden Admission Ticket

San Antonio: Botanical Garden Admission Ticket

$18
per adult
100% of travellers recommend
San Antonio: Botanical Garden Admission Ticket
See all activities in San Antonio
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.