Midtown Vacations from $212

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Your Midtown Vacation

Lock in a vacation package to Midtown and experience everything this busy neighborhood has to offer. Known for its shopping, cafes and nightlife, your next epic adventure can be found right here. Start your trip to Midtown by visiting nearby attractions such as Alamo, Alamodome and San Antonio Zoo and Aquarium. Stop dreaming and start doing. When you're ready to lock in your dream vacation to Midtown, Expedia is here to help.

The Latest Midtown Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Express & Suites San Antonio Medical-Six Flags by IHG

Holiday Inn Express & Suites San Antonio Medical-Six Flags by IHG

2.5 out of 5
Northwest Side
Save 100% on your flight
Price was $326, price is now $212 per person
$212
per person
Apr 25 - Apr 29
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Antonio (SAT)
7.8/10 Good! (1,082 reviews)
Dirty towels left in the bathroom.

Reviewed on Mar 19, 2026

Signia by Hilton La Cantera Resort & Spa

Signia by Hilton La Cantera Resort & Spa

4 out of 5
La Cantera District
Save 100% on your flight
Price was $1,640, price is now $1,101 per person
$1,101
per person
May 21 - May 27
found 1 day ago
Roundtrip flight included
Chicago (CHI) to San Antonio (SAT)
9/10 Wonderful! (1,031 reviews)
Clean room | Amazing staff |

Reviewed on Mar 19, 2026

OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio

2 out of 5
Medical Center District
Save 100% on your flight
Price was $355, price is now $264 per person
$264
per person
Apr 23 - Apr 28
found 10 hours ago
Roundtrip flight included
Denver (DEN) to San Antonio (SAT)
7.2/10 Good! (229 reviews)
Staff was courteous and professional and the room is nice.

Reviewed on Dec 29, 2025

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
Far West Side
Price was $839, price is now $632 per person
$632
per person
May 20 - May 24
found 17 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to San Antonio (SAT)
9/10 Wonderful! (1,504 reviews)
The amenities are awesome but the rooms are showing their age. Paint overspray everywhere, our toilet ran, the shower pull was frozen and the GFCI plug in the bathroom was nonfunctional. They fixed the shower first day but everything else remained. Brautiful setting...

Reviewed on Mar 19, 2026

The St. Anthony, A Luxury Collection Hotel, San Antonio

The St. Anthony, A Luxury Collection Hotel, San Antonio

4.5 out of 5
Downtown San Antonio
Price was $1,164, price is now $881 per person
$881
per person
Apr 26 - Apr 30
found 13 hours ago
Roundtrip flight included
Chicago (CHI) to San Antonio (SAT)
8.8/10 Excellent! (1,004 reviews)
It was a beautiful hotel, easy check in, ans centrally located.

Reviewed on Mar 15, 2026

Where to stay in Midtown

Find the best Midtown areas and neighborhoods for the activities you enjoy most. Learn more about Midtown
Downtown - Riverwalk which includes heritage architecture, boating and a river or creek

Downtown San Antonio

4 out of top 10 points of interest in this area
4/5(9,564 area reviews)

Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

Find hotels in Downtown San Antonio

Midtown Hotel Deals

Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $116 total per night from Apr 5 to Apr 6
$116 total
Apr 5 - Apr 6
Total with taxes and fees
8/10 Very Good! (6,396 reviews)
El staff le falta preparación. Los pasillos sucios. El desayuno mediocre. Expedia me cobró por 3 habitaciones 608.00, cuando llegué al hotel un enrredo horrible.

Reviewed on Mar 19, 2026

Riverwalk Plaza
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
$165 nightly
The price is $194 total per night from Mar 22 to Mar 23
$194 total
Mar 22 - Mar 23
Total with taxes and fees
9.4/10 Exceptional! (2,562 reviews)
Great location, quite quaint

Reviewed on Mar 20, 2026

Hotel Valencia Riverwalk
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive San Antonio TX
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $155 total per night from Apr 13 to Apr 14
$155 total
Apr 13 - Apr 14
Total with taxes and fees
9/10 Wonderful! (1,520 reviews)
Great area! Makes you feel like you're 100 miles from the city.

Reviewed on Mar 19, 2026

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
See all 4,745 properties in Midtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
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Beach Vacations
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Kid Friendly Vacations

Discover the most popular places to visit in Midtown

Hippos swimming in a vibrant aquatic exhibit at San Antonio Zoo and Aquarium in Texas

San Antonio Zoo and Aquarium

There are nearly 800 wild and wonderful species at the zoo in the center of Brackenridge Park, not far from the city center.

San Antonio Zoo and Aquarium
SanAntonio_TrinityUniversity_502633_03

Trinity University

Enjoy the collegiate vibe at Trinity University during your stay in San Antonio. Experience the great live music and entertainment choices in this walkable area.

Trinity University
Brackenridge Park

Brackenridge Park

Brackenridge Park is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Experience the lively festivals and acclaimed theater scene in this walkable area.

Brackenridge Park

Things to do

Picture 1 for Activity San Antonio: Twisted Trails Zip Rails, Ropes & Climbing Wall

San Antonio: Twisted Trails Zip Rails, Ropes & Climbing Wall

$42
per adult
San Antonio: Twisted Trails Zip Rails, Ropes & Climbing Wall
San Antonio: Fredericksburg Wineries Day Trip with Tastings

San Antonio: Fredericksburg Wineries Day Trip with Tastings

$179
per adult
100% of travellers recommend
San Antonio: Fredericksburg Wineries Day Trip with Tastings
San Antonio: Discovery Tour at Natural Bridge Caverns

San Antonio: Discovery Tour at Natural Bridge Caverns

$36
per adult
98% of travellers recommend
San Antonio: Discovery Tour at Natural Bridge Caverns
See all activities in San Antonio
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.