Title: Misiliscemi Vacation Packages 2026 from $1,657 | Expedia.com

[Misiliscemi Travel Guide](https://expedia.com/Misiliscemi.dx919192130721861632)[Hotels in Misiliscemi](https://expedia.com/Misiliscemi-Hotels.d919192130721861632.Travel-Guide-Hotels)[Vacation Rentals in Misiliscemi](https://expedia.com/Misiliscemi-Vacation-Rentals.d919192130721861632.Travel-Guide-VacationRentals)[Flights to Misiliscemi](https://expedia.com/Cheap-Flights-To-Misiliscemi.d919192130721861632.Travel-Guide-Flights)[Car Rentals in Misiliscemi](https://expedia.com/Car-Rentals-In-Misiliscemi.d919192130721861632.Car-Rental-Guide)

![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_packages.jpeg?impolicy=fcrop&w=1200&h=300&q=medium)

# Misiliscemi Vacations from $1,657

## Book a Hotel + Flight or Car together to unlock savings

## The Latest Misiliscemi vacation packages

Price found within the past 48 hours. Click for updated prices.

![NH Collection Palermo Palazzo Sitano](https://images.trvl-media.com/lodging/4000000/3940000/3935700/3935684/1411684b_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### NH Collection Palermo Palazzo Sitano

Palermo Historical Center

$1,657

per person

Apr 26 - May 2

found 17 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Palermo (PMO)

8.2/10 Very Good! (963 reviews)

Beautiful property in the heart of the city. Easily walkable to many attractions. Clean, modern rooms with very friendly staff.

Reviewed on Mar 3, 2026

![Hotiday San Vito Lo Capo](https://images.trvl-media.com/lodging/115000000/114660000/114653800/114653788/011d459b_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hotiday San Vito Lo Capo

Save 100% on your flight

$2,143

per person

Apr 26 - May 2

found 17 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Palermo (PMO)

8.6/10 Excellent! (12 reviews)

Abbiamo soggiornato due notti all’Hotel Panoramic di San Vito Lo Capo ed è stata un’esperienza indimenticabile. La posizione è fantastica, con un panorama mozzafiato che si gode da alcune camera e dalle terrazze. La colazione, servita con vista mare, è ricca e di qualità: prodotti freschi, dolci fatti in casa e tanta varietà. Il servizio è stato impeccabile: staff gentile, attento e sempre disponibile. Un soggiorno breve ma davvero perfetto.

Reviewed on Sep 28, 2025

![Eurostars Centrale Palace](https://images.trvl-media.com/lodging/1000000/60000/54200/54144/053d322b_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Eurostars Centrale Palace

Palermo Historical Center

$1,723

per person

May 21 - May 25

found 1 day ago

Roundtrip flight included

New York (JFK) to Palermo (PMO)

8.4/10 Very Good! (1,000 reviews)

Clean room, comfortable bed, great shower and location

Reviewed on Feb 23, 2026

![Grand Hotel et Des Palmes](https://images.trvl-media.com/lodging/1000000/30000/23200/23108/560147f0_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Grand Hotel et Des Palmes

Politeama

$4,643

per person

Apr 19 - Apr 25

found 1 day ago

Roundtrip flight included

Boston (BOS) to Palermo (PMO)

8.4/10 Very Good! (1,002 reviews)

The breakfast was excellent as well as the dinner

Reviewed on Jan 11, 2026

![The Signature Level at Grand Palladium Sicilia Resort & Spa](https://images.trvl-media.com/lodging/43000000/42030000/42025800/42025780/de48ab7f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### The Signature Level at Grand Palladium Sicilia Resort & Spa

$1,991

per person

Jun 3 - Jun 8

found 14 hours ago

Roundtrip non-stop flight included

New York (NYC) to Palermo (PMO)

9.4/10 Exceptional! (17 reviews)

The drinking glasses were dirty most of the time. That was disappointing. The staff were lovely and pleasant. Dinner timings and options were limited. We were signature level and would have expected options for sea view, but those seemed to only be for the main building Food was okay.

Reviewed on Oct 7, 2025

Don't see what you're looking for?

See all available trips from Columbus to Misiliscemi

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-10/2026-04-17/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=TPS&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

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## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_919192130721861632)

### What to do in Misiliscemi

![Marsala: Winery Tour with Wine Tasting and Local Products](https://mediaim.expedia.com/localexpert/45946886/b61ec7f0-74de-4c2e-882d-e224e586fff7.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Marsala: Winery Tour with Wine Tasting and Local Products

$24

per adult

**100%** of travellers recommend

[](https://expedia.com/things-to-do/marsala-winery-tour-with-wine-tasting-and-local-products.a45946886.activity-details)

![Discovering Marsala in the historic Pellegrino Cellars](https://mediaim.expedia.com/localexpert/48319005/e0a91daa-a024-484d-bd23-2cc00d3dd9ed.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Discovering Marsala in the historic Pellegrino Cellars

$24

per adult

[](https://expedia.com/things-to-do/discovering-marsala-in-the-historic-pellegrino-cellars.a48319005.activity-details)

![Trapani_Aperitif at sunset](https://mediaim.expedia.com/localexpert/46338389/0df8935c-0af1-4de7-ae56-4cb7cd0983ae.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Trapani\_Aperitif at sunset

$71

per adult

[](https://expedia.com/things-to-do/trapaniaperitif-at-sunset.a46338389.activity-details)

[See all activities in Misiliscemi](https://expedia.com/things-to-do/search?rid=919192130721861632)

## Misiliscemi Hotel Deals

![Agriturismo Vultaggio](https://images.trvl-media.com/lodging/6000000/5370000/5361300/5361288/7c8f3551_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Agriturismo Vultaggio

Contrada Misiliscemi, 4 Guarrato Misiliscemi TP

Fully refundableReserve now, pay when you stay

$118 nightly

$129 total

Mar 11 - Mar 12

Total with taxes and fees

8.6/10 Excellent! (49 reviews)

Comfortable rooms, friendly and professional staff, wonderful breakfast. Impressive pool.

Reviewed on Sep 24, 2025

[](https://expedia.com/Hotel-Search?startDate=3%2F11%2F2026&endDate=3%2F12%2F2026&selected=5361288&PinnedHotelID=5361288&HadPinnedHotel=true&regionId=919192130721861632)

![Venere di Erice Resort](https://images.trvl-media.com/lodging/93000000/92500000/92492300/92492268/8c03926b_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Venere di Erice Resort

Via Erice Valderice TP

$79 nightly

$93 total

Mar 15 - Mar 16

Total with taxes and fees

8.8/10 Excellent! (73 reviews)

Room is spacious, fresh air as it is next to orchard, the owner is very kind, definitely recommended.

Reviewed on Feb 14, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F15%2F2026&endDate=3%2F16%2F2026&selected=92492268&PinnedHotelID=92492268&HadPinnedHotel=true&regionId=919192130721861632)

![Residence La Gancia](https://images.trvl-media.com/lodging/4000000/3820000/3811200/3811156/bf38e02d_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Residence La Gancia

Piazza Mercato del Pesce Trapani TP

$95 nightly

$113 total

Mar 22 - Mar 23

Total with taxes and fees

9.4/10 Exceptional! (359 reviews)

바다 바로 옆. 전자레인지 있음. 객실 깨끗.

Reviewed on Feb 13, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F22%2F2026&endDate=3%2F23%2F2026&selected=3811156&PinnedHotelID=3811156&HadPinnedHotel=true&regionId=919192130721861632)

[See all 3,800 properties in Misiliscemi](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F11%2F2026&endDate=3%2F12%2F2026&regionId=919192130721861632)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Misiliscemi Vacation Packages

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\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.