Mission Hills Vacations from $483

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Your Mission Hills Vacation

Reserving a Mission Hills vacation package is an excellent way to become familiar with this unique neighborhood. From its must-visit places to its lesser-known gems, you won't be short of adventures. Some leading nearby attractions to check out during your trip to Mission Hills include San Diego Zoo, Balboa Park and University of San Diego. Expedia can help turn your dream Mission Hills vacation into reality, no matter your budget or travel plans.

The Latest Mission Hills Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Quiet Mind Mountain Lodge, Retreat and Spa

Quiet Mind Mountain Lodge, Retreat and Spa

4.5 out of 5
Save 100% on your flight
per person
Sep 8 - Sep 15
found 1 day ago
Roundtrip non-stop flight included
Dallas (DFW) to San Diego (SAN)
9.2/10 Wonderful! (521 reviews)
I loved the decor, nice comfortable bed and the breakfast offered. Parking is unpaved and unmarked with a truck obstructing the narrow way in a spot. I would have appreciated the disclosure of a bonafide statue of an idol in the ad, however. It made me uncomfortable.

Reviewed on Aug 4, 2025

Alila Marea Beach Resort Encinitas, a Hyatt Luxury Resort

Alila Marea Beach Resort Encinitas, a Hyatt Luxury Resort

5 out of 5
Save 100% on your flight
per person
Sep 24 - Sep 28
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
8.8/10 Excellent! (196 reviews)
Great property will most likely come back and beautiful views. Great pool and view from pool.

Reviewed on Jul 22, 2025

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Save 100% on your flight
per person
Oct 10 - Oct 14
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
9/10 Wonderful! (966 reviews)
Clean and attractive rooms ,spacious.Great pool area and public areas.Restaurant and bar convenient and tasty.Close to many places, walking distance. WIll stay again!!!

Reviewed on Aug 2, 2025

Omni La Costa Resort & Spa Carlsbad

Omni La Costa Resort & Spa Carlsbad

4 out of 5
La Costa
Save 100% on your flight
per person
Oct 11 - Oct 18
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
8.2/10 Very Good! (1,002 reviews)
The bed comfort was one of the best I experienced. The ambiance was outstanding put you in a relax & tranquil state of mind. Overall great! The food was tasty & flavorful.

Reviewed on Aug 4, 2025

The Beau Downtown San Diego Gaslamp Quar

The Beau Downtown San Diego Gaslamp Quar

3 out of 5
Downtown San Diego
Save 100% on your flight
per person
Oct 17 - Oct 23
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
8.8/10 Excellent! (341 reviews)
GREAT hotel! Loved the mix of old world charm with modern finishes. I also love the coffee station and the garden area. NOTE: the hotel does NOT have an elevator and it has quite a few stairs. Lastly, not a huge deal but what's with no clocks in the room? Guess it's a new trend.

Reviewed on Aug 5, 2025

Where to stay in Mission Hills

Find the best Mission Hills areas and neighborhoods for the activities you enjoy most. Learn more about Mission Hills
US Grant Hotel

Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Find hotels in Downtown San Diego

Mission Hills Hotel Deals

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
$177 nightly
The price is $205 total per night from Sep 1 to Sep 2
$205 total
Sep 1 - Sep 2
Total includes taxes and fees
8.2/10 Very Good! (5,808 reviews)
"Property is a bit dated and in need of remodeling, but still acceptable… *except that electrical outlets are worn out and devices won’t stay plugged or make a connection. Also, not enough outlets (or splitters) to accommodate everything that must be plugged in. For example, can’t operate the coffee ..."

Reviewed on Aug 6, 2025

Wyndham San Diego Bayside
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
$184 nightly
The price is $212 total per night from Aug 17 to Aug 18
$212 total
Aug 17 - Aug 18
Total includes taxes and fees
8.8/10 Excellent! (3,618 reviews)
"We really liked this hotel, it had great views of the bay from our room which we enjoyed in the evenings. We did get woken up in the middle of the night by a group of kids being really loud outside our room. However, overall, great stay and experience."

Reviewed on Aug 5, 2025

The Dana on Mission Bay
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
$217 nightly
The price is $252 total per night from Aug 31 to Sep 1
$252 total
Aug 31 - Sep 1
Total includes taxes and fees
8.8/10 Excellent! (2,787 reviews)
"Great spot !"

Reviewed on Aug 4, 2025

Manchester Grand Hyatt San Diego
See all 8,462 properties in Mission Hills
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Mission Hills

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

Whether you come for Comic-Con or a medical convention, this huge gathering place in the Marina District of San Diego will more than satisfy your needs.

San Diego Convention Center
Mission Bay featuring a sandy beach

Mission Bay

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay

Things to do

San Diego Whale Watching Tour

San Diego Whale Watching Tour

$71
per adult
88% of travellers recommend
San Diego Whale Watching Tour
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway

San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway

$124
per adult
86% of travellers recommend
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway
San Diego: Luggage Storage in Marina

San Diego: Luggage Storage in Marina

$9
per adult
San Diego: Luggage Storage in Marina
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.