An ornate hall with red chairs, a long table, and elaborate frescoes on the ceiling.

Mosel Wine Region Vacations from $2,144

Book a Hotel + Flight or Car together to unlock savings

Your Mosel Wine Region Vacation

Reserve a vacation package to Mosel Wine Region and go wherever your adventurous soul takes you. This destination has plenty to offer, including its nature, history, festivals, and so much more. Start your trip to Mosel Wine Region with some time in Trier visiting popular sights like Trier Roman Amphitheatre and Trier Christmas Market. Koblenz is another top city that draws crowds from far and wide. Deutsches Eck and Ehrenbreitstein Fortress are two of the leading places to see in this destination. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Mosel Wine Region vacation today.

The Latest Mosel Wine Region Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A modern hotel lobby with a long reception desk, a coffee machine, and a buffet area with fruits and vegetables.
    Dec 19 - Dec 25

    ibis Frankfurt Airport + Flight

    Kelsterbach
    5 nights
    3.0 star property
    8.4/10 - Very good (433 reviews)
    Roundtrip • Dallas (DFW) - Frankfurt (FRA)
    DFW - FRA • Nonstop FRA - DFW • Nonstop
    $2,623
    $2,144
    per traveler
    found 20 hours ago
    ibis Frankfurt Airport
  • A modern building with a glass facade and a prominent '12' sign.
    Dec 19 - Dec 25

    Holiday Inn Frankfurt - Alte Oper by IHG + Flight

    Bahnhofsviertel
    5 nights
    4.0 star property
    8.8/10 - Excellent (884 reviews)
    Roundtrip • Dallas (DFW) - Frankfurt (FRA)
    DFW - FRA • Nonstop FRA - DFW • Nonstop
    $2,703
    $2,180
    per traveler
    found 20 hours ago
    Holiday Inn Frankfurt - Alte Oper by IHG
  • A modern lobby with seating areas, a reception desk, and a large hanging light fixture.
    Dec 19 - Dec 25

    ATLANTIC Hotel Frankfurt - New opening + Flight

    Gallus
    5 nights
    4.5 star property
    9.0/10 - Wonderful (50 reviews)
    Roundtrip • Dallas (DFW) - Frankfurt (FRA)
    DFW - FRA • Nonstop FRA - DFW • Nonstop
    $2,745
    $2,253
    per traveler
    found 20 hours ago
    ATLANTIC Hotel Frankfurt - New opening
  • An outdoor seating area with tables and chairs, a building with classical architecture, and a clock tower in the background.
    Dec 19 - Dec 25

    Welcome Hotel Darmstadt City Center + Flight

    Mitte
    5 nights
    4.0 star property
    8.8/10 - Excellent (451 reviews)
    Roundtrip • Dallas (DFW) - Frankfurt (FRA)
    DFW - FRA • Nonstop FRA - DFW • Nonstop
    $2,709
    $2,226
    per traveler
    found 20 hours ago
    Welcome Hotel Darmstadt City Center
  • A modern hotel lobby with a mix of seating areas, including sofas and armchairs, arranged around coffee tables and a central dining table. Large windows provide natural light and a view of the cityscape.
    Dec 19 - Dec 25

    Capri by Fraser Frankfurt + Flight

    Gallus
    5 nights
    4.5 star property
    9.2/10 - Wonderful (1,000 reviews)
    "I stayed for just one night, on Saturday, and was quite disappointed to find that the bar was closed over the weekend. The rooms were excellent and the staff were very helpful and friendly. However, the breakfast was very poor and definitely needs improvement."
    Reviewed November 8, 2026
    Roundtrip • Dallas (DFW) - Frankfurt (FRA)
    DFW - FRA • Nonstop FRA - DFW • Nonstop
    $2,680
    $2,205
    per traveler
    found 20 hours ago
    Capri by Fraser Frankfurt

Discover the most popular places to visit in Mosel Wine Region

A castle on a hill with a cobblestone path leading up to it.

Burg Eltz

9.0/10 (262 reviews)
You can learn about the history of Wierschem when you stop by Burg Eltz. Wander the riverfront in this quaint area.
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Mosel Wine Region Hotel Deals

A hotel room with a bed, a wardrobe, and a floor lamp.

Goldene Traube - by Neugart

Goldene Traube - by Neugart
3.5 star property
3.7 mi from Mosel Wine Region
9.8 out of 10, Exceptional, (101 reviews)
"The breakfast was excellent, the staff were very helpful and spoke perfect English, the property doesn’t look as nice from the outside, and its towards the back of the town, and parking isn’t onsite, but we managed to find a place very close by with no charge. I would definitely recommend staying here the roof terrace and honesty bar were a nice touch too. "
$125 nightly
The price is $138
Nov 25 - Nov 26
Total with taxes and fees
Goldene Traube - by Neugart
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Mosel Wine Region
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.