Mosel Wine Region Vacations from $529

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your Mosel Wine Region Vacation

Reserve a vacation package to Mosel Wine Region and go wherever your adventurous soul takes you. This destination has plenty to offer, including its nature, history, festivals, and so much more. Start your trip to Mosel Wine Region with some time in Trier visiting popular sights like Trier Roman Amphitheatre and Trier Christmas Market. Koblenz is another top city that draws crowds from far and wide. Deutsches Eck and Ehrenbreitstein Fortress are two of the leading places to see in this destination. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Mosel Wine Region vacation today.

The Latest Mosel Wine Region vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Imperial

Hotel Imperial

Ehrenfeld
$529
per person
Nov 6 - Nov 11
found 20 hours ago
Roundtrip non-stop flight included
London (LHR) to Cologne (CGN)
8.8/10 Excellent! (115 reviews)
The staff were very friendly. They offered a lot of tips on shopping and dining options a few meters away. Bed and pillows were extra comfortable.

Reviewed on May 13, 2026

Villahotel Rheinblick

Villahotel Rheinblick

Rodenkirchen
Save 100% on your flight
$578
per person
Nov 6 - Nov 11
found 17 hours ago
Roundtrip flight included
London (LHR) to Cologne (CGN)
9.2/10 Wonderful! (158 reviews)
Very clean and accommodating. We arrived earlier then our check in. The staff allowed us to store our luggage.

Reviewed on Sep 1, 2026

Althoff Grandhotel Schloss Bensberg

Althoff Grandhotel Schloss Bensberg

Save 100% on your flight
$853
per person
Nov 6 - Nov 11
found 20 hours ago
Roundtrip non-stop flight included
London (LHR) to Cologne (CGN)
9.4/10 Exceptional! (592 reviews)
Great building, nice location, glitchy phone that beeped all night…

Reviewed on Sep 23, 2026

Kunibert der Fiese

Kunibert der Fiese

Old Town Cologne
$587
per person
Nov 6 - Nov 11
found 22 hours ago
Roundtrip flight included
London (LHR) to Cologne (CGN)
7.2/10 Good! (342 reviews)
Very close to the downtown.

Reviewed on Sep 28, 2026

Novotel Köln City

Novotel Köln City

Old Town Cologne
$540
per person
Nov 6 - Nov 11
found 20 hours ago
Roundtrip non-stop flight included
London (LHR) to Cologne (CGN)
9/10 Wonderful! (1,002 reviews)
Bain-douche un peu haute pour personnes âgées.

Reviewed on Oct 2, 2026

Don't see what you're looking for?
See all available trips from Columbus to Mosel Wine Region
View all trips

Where to stay in Mosel Wine Region

Find the best Mosel Wine Region areas and neighborhoods for the activities you enjoy most. Learn more about Mosel Wine Region
A large classical building with symmetrical architecture, a well-maintained garden with hedges and flower beds, and a clear sky.

Altstadt Koblenz

2 out of top 10 points of interest in this area

You'll enjoy the museums and riverfront in Altstadt Koblenz. You might want to make time for a stop at Koblenz Theatre or Koblenz Town Hall.

A historic stone building with arched windows and a dome.

Altstadt Trier

3 out of top 10 points of interest in this area

Altstadt Trier is noteworthy for its historic sites, and you can make a stop at top attractions like Trier Christmas Market and Karl Marx House.

A historic square with a prominent clock tower, traditional buildings, and a cobblestone street.

Mitte

Mitte is noteworthy for its historic sites, and you can make a stop at top attractions like Frankenturm and Trier Christmas Market.

A stone archway with a view of a river and a town below.

Historic Downtown

The restaurants and wineries are a few reasons travelers visit Historic Downtown. Want to see more of the surrounding area? Landshut Castle and Winery Dr. Loosen are a few top sights nearby.

A nighttime cityscape with a river reflecting lights, a prominent castle-like building, and a bridge.

Mitte

Unique features of Mitte include the river views and bars. Make a stop by Rhein Mosel Halle Congress Center or Rhine while you're exploring the area.

Stay near popular Mosel Wine Region attractions

A castle on a hill with a cobblestone path leading up to it.

Burg Eltz

9.0/10 (262 reviews)
You can learn about the history of Wierschem when you stop by Burg Eltz. Wander the riverfront in this quaint area.
See properties
A river with boats, a castle on a hill, and a church with a tall spire.

Moselle Promenade

9.0/10 (473 reviews)
Explore the great outdoors at Moselle Promenade, a lovely green space in Cochem. While you're in the area, stroll along the riverfront.
See properties
A river with boats, a castle on a hill, and a church with a spire.

Reichsburg Cochem

9.0/10 (379 reviews)
Reichsburg Cochem is just one of the places to see in Cochem, so why not enjoy the other things to explore during your travels? While you're in the area, stroll along the riverfront.
See properties
A river with a bridge, a statue, and a waterfront promenade with flags.

Deutsches Eck

9.0/10 (491 reviews)
Watch the boats at the meeting of two grand rivers and inspect the replica of a momentous sculpture at the German Corner.
See properties
A historic stone building with arched windows and a dome.

Porta Nigra

9.2/10 (803 reviews)
Glimpse the ancient world when you explore the interior chambers of this Roman relic, the largest surviving city gate north of the Alps and a UNESCO World Heritage Site.
See properties
A historic church with two towers and a large clock.

Trier Cathedral

9.4/10 (525 reviews)
Study the majestic design of this fortress-like structure, which is the largest church in the city and one of Germany’s oldest cathedrals.
See properties
A historic castle on a hill overlooking a calm river, with buildings and a bridge in the foreground.

Ehrenbreitstein Fortress

8.8/10 (295 reviews)
Take the cable car on a scenic journey to a mountaintop to see one of the largest preserved forts in Europe.
See properties

Vulkaneifel Thermal Spa

8.8/10 (53 reviews)
Explore the great outdoors at Vulkaneifel Thermal Spa, a lovely green space in Bad Bertrich. While you're in the area, stroll along the riverfront.
See properties

Mosel Wine Region Hotel Deals

bestprice Hotel Koblenz

bestprice Hotel Koblenz

Bahnhofpl. 1 Koblenz RP
Fully refundableReserve now, pay when you stay
$60 nightly
$64 total
Oct 11 - Oct 12
Total with taxes and fees
8/10 Very Good! (94 reviews)
"Lacking in soft furnishings which makes the room and dining room feel less cosy but this is only an opinion. It was still excellent one night."

Reviewed on Sep 16, 2026

bestprice Hotel Koblenz
Schloss Lieser, Autograph Collection

Schloss Lieser, Autograph Collection

Moeselstrasse 33 Lieser
Fully refundableReserve now, pay when you stay
$166 nightly
$177 total
Nov 4 - Nov 5
Total with taxes and fees
Schloss Lieser, Autograph Collection
Mercure Hotel Trier Porta Nigra

Mercure Hotel Trier Porta Nigra

Porta-Nigra-Platz 1 Trier RP
Fully refundableReserve now, pay when you stay
$94 nightly
$104 total
Nov 2 - Nov 3
Total with taxes and fees
8.6/10 Excellent! (1,003 reviews)
"A great location for visiting Trier with an ample car park. Rooms with a view of the Porta Nigra are a particularly nice. Staff are pleasant, welcoming and efficient."

Reviewed on Oct 3, 2026

Mercure Hotel Trier Porta Nigra
See all 3,299 properties in Mosel Wine Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mosel Wine Region Vacation Packages

Mosel Wine Region Essential Information

Language
German
Currency
Euros
Local Welcome
Guten Tag
Local Goodbye
Tschüss
Closest Airport
Frankfurt Intl. Airport (FRA)

More vacations you might like

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.