An ornate hall with red chairs, a long table, and elaborate frescoes on the ceiling.

Mosel Wine Region Vacations from $403

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Your Mosel Wine Region Vacation

Reserve a vacation package to Mosel Wine Region and go wherever your adventurous soul takes you. This destination has plenty to offer, including its nature, history, festivals, and so much more. Start your trip to Mosel Wine Region with some time in Trier visiting popular sights like Trier Roman Amphitheatre and Trier Christmas Market. Koblenz is another top city that draws crowds from far and wide. Deutsches Eck and Ehrenbreitstein Fortress are two of the leading places to see in this destination. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Mosel Wine Region vacation today.

The Latest Mosel Wine Region Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • An outdoor café with tables and chairs, surrounded by greenery and a stone wall.
    Dec 28 - Dec 31

    Hotel Parc Plaza + Flight

    Uewerstad
    3 nights
    3.0 star property
    8.0/10 - Very good (563 reviews)
    "Staffs are not very friendly. There's no door to the shower room from the short entrance hallway."
    Reviewed October 22, 2026
    Roundtrip • Madrid (MAD) - Luxembourg (LUX)
    MAD - LUX • Nonstop LUX - MAD • Nonstop
    $509
    $403
    per traveler
    found 12 hours ago
    Hotel Parc Plaza
  • Room
    Dec 28 - Dec 31

    Sofitel Luxembourg Le Grand Ducal + Flight

    Bonnevoie
    3 nights
    5.0 star property
    9.4/10 - Exceptional (987 reviews)
    "Wonderful stay, comfortable bed and quiet room. Breakfast was fantastic and the servers were so lovely."
    Reviewed November 6, 2026
    Roundtrip • Madrid (MAD) - Luxembourg (LUX)
    MAD - LUX • Nonstop LUX - MAD • Nonstop
    $766
    $601
    per traveler
    found 1 day ago
    Sofitel Luxembourg Le Grand Ducal
  • Meeting facility
    Dec 28 - Dec 31

    Sofitel Luxembourg Europe + Flight

    Kirchberg
    3 nights
    5.0 star property
    9.2/10 - Wonderful (570 reviews)
    Roundtrip • Madrid (MAD) - Luxembourg (LUX)
    MAD - LUX • Nonstop LUX - MAD • Nonstop
    $749
    $589
    per traveler
    found 1 day ago
    Sofitel Luxembourg Europe
  • Meeting facility
    Dec 28 - Dec 31

    Novotel Luxembourg Centre + Flight

    Bonnevoie
    3 nights
    4.0 star property
    8.8/10 - Excellent (1,000 reviews)
    Roundtrip • Madrid (MAD) - Luxembourg (LUX)
    MAD - LUX • Nonstop LUX - MAD • Nonstop
    $576
    $461
    per traveler
    found 1 day ago
    Novotel Luxembourg Centre
  • A modern high-rise building with a cylindrical glass tower, surrounded by other contemporary buildings.
    Dec 19 - Dec 25

    Holiday Inn Frankfurt - Alte Oper by IHG + Flight

    Bahnhofsviertel
    5 nights
    4.0 star property
    8.8/10 - Excellent (885 reviews)
    Roundtrip • Dallas (DFW) - Frankfurt (FRA)
    DFW - FRA • Nonstop FRA - DFW • Nonstop
    $2,703
    $2,180
    per traveler
    found 1 day ago
    Holiday Inn Frankfurt - Alte Oper by IHG

Discover the most popular places to visit in Mosel Wine Region

A castle on a hill with a cobblestone path leading up to it.

Burg Eltz

9.0/10 (262 reviews)
You can learn about the history of Wierschem when you stop by Burg Eltz. Wander the riverfront in this quaint area.
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Mosel Wine Region Hotel Deals

A hotel sign with a logo and name, a red brick building, and a white building with windows.

Goldene Traube - by Neugart

Goldene Traube - by Neugart
3.5 star property
3.7 mi from Mosel Wine Region
9.8 out of 10, Exceptional, (101 reviews)
"The breakfast was excellent, the staff were very helpful and spoke perfect English, the property doesn’t look as nice from the outside, and its towards the back of the town, and parking isn’t onsite, but we managed to find a place very close by with no charge. I would definitely recommend staying here the roof terrace and honesty bar were a nice touch too. "
$125 nightly
The price is $138
Nov 25 - Nov 26
Total with taxes and fees
Goldene Traube - by Neugart
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Mosel Wine Region
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.