An ornate hall with red chairs, a long table, and elaborate frescoes on the ceiling.

Mosel Wine Region Vacations from $1,410

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Your Mosel Wine Region Vacation

Reserve a vacation package to Mosel Wine Region and go wherever your adventurous soul takes you. This destination has plenty to offer, including its nature, history, festivals, and so much more. Start your trip to Mosel Wine Region with some time in Trier visiting popular sights like Trier Roman Amphitheatre and Trier Christmas Market. Koblenz is another top city that draws crowds from far and wide. Deutsches Eck and Ehrenbreitstein Fortress are two of the leading places to see in this destination. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Mosel Wine Region vacation today.

The Latest Mosel Wine Region Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A hotel with a prominent sign reading "HOLLÄNDER HOF RESTAURANT" at night.
    Dec 13 - Dec 19

    City Partner Hotel Holländer Hof + Flight

    Heidelberg City Centre
    5 nights
    3.5 star property
    9.4/10 - Exceptional (1,001 reviews)
    Roundtrip • New York (NYC) - Frankfurt (FRA)
    JFK - FRA • Nonstop FRA - EWR • 1 stop
    $1,580
    $1,410
    per traveler
    found 1 day ago
    City Partner Hotel Holländer Hof
  • A breakfast buffet with various food items, drinks, and a view of greenery outside.
    Dec 18 - Dec 25

    Villa Westend Hotel an der Messe + Flight

    Westend-Süd
    6 nights
    4.0 star property
    8.2/10 - Very good (205 reviews)
    "I was very happy to find this boutique hotel within shouting distance of the Messe. For many years I stayed at the Marriott but wanted a change. It is a charming, quiet and comfortable hotel. The staff are particularly good natured and helpful. I hope no one reads this review so the rates don’t go up too much for next year. Be aware though it’s not fancy or upscale so if that is what you are after it may not be the right fit for you."
    Reviewed October 9, 2026
    Roundtrip • Nashville (BNA) - Frankfurt (FRA)
    BNA - FRA • 1 stop FRA - BNA • 1 stop
    $1,660
    $1,415
    per traveler
    found 1 day ago
    Villa Westend Hotel an der Messe
  • An outdoor patio area with stone flooring, tables, chairs, and potted plants.
    Dec 18 - Dec 25

    Landhaus Danielshof + Flight

    Bedburg
    6 nights
    4.0 star property
    8.6/10 - Excellent (99 reviews)
    Roundtrip • Nashville (BNA) - Cologne (CGN)
    BNA - FRA • 2 stops FRA - BNA • 1 stop
    $1,651
    $1,443
    per traveler
    found 1 day ago
    Landhaus Danielshof
  • A modern outdoor spa area with heated loungers, a hot tub, and a wooden deck.
    Dec 17 - Dec 22

    FAVORITE Parkhotel I Spa – Business – Fine Dining + Flight

    Oberstadt
    4 nights
    4.5 star property
    8.6/10 - Excellent (294 reviews)
    "The hotel is very well equipped and the staff were courteous and helpful. My personal criticism is the rooms are poorly soundproofed and having the Gym on the top floor is not the best option. I could hear every dropped dumbbell. Such a shame as the location is great."
    Reviewed August 13, 2026
    Roundtrip • New York (NYC) - Frankfurt (FRA)
    JFK - FRA • Nonstop FRA - EWR • 1 stop
    $1,881
    $1,653
    per traveler
    found 1 day ago
    FAVORITE Parkhotel I Spa – Business – Fine Dining
  • A breakfast setting with croissants, a fruit bowl, a coffee cup, and a vase with flowers on a table.
    Dec 19 - Dec 26

    Lindner Hotel Cologne Am Dom, part of JdV by Hyatt + Flight

    Old Town Cologne
    6 nights
    4.0 star property
    8.6/10 - Excellent (1,000 reviews)
    "Great staff, took good care of me after my first night was downgraded. Property was nice, breakfast was great and the restaurant inside is good too."
    Reviewed October 7, 2026
    Roundtrip • Nashville (BNA) - Cologne (CGN)
    BNA - CGN • 1 stop CGN - BNA • 1 stop
    $2,835
    $2,542
    per traveler
    found 1 day ago
    Lindner Hotel Cologne Am Dom, part of JdV by Hyatt

Discover the most popular places to visit in Mosel Wine Region

A castle on a hill with a cobblestone path leading up to it.

Burg Eltz

9.0/10 (262 reviews)
You can learn about the history of Wierschem when you stop by Burg Eltz. Wander the riverfront in this quaint area.
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Mosel Wine Region Hotel Deals

A modern kitchen with a dining area, large windows, and pendant lighting.

Hotel Zehnthof

Hotel Zehnthof
12.2 mi from Mosel Wine Region
9.0 out of 10, Wonderful, (386 reviews)
$128 nightly
The price is $137
Dec 10 - Dec 11
Total with taxes and fees
Hotel Zehnthof
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Mosel Wine Region
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.