Southern Region Vacations & Trips

Book a Hotel + Flight or Car together to unlock savings

Photo by Kalunde Mbevi

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Southern Region Vacation

When adventure calls, answer it with a tailor-made vacation package to Southern Region. Wherever it is you're headed and whatever you have planned, prepare to discover a destination that'll make you truly feel alive. Your trip to Southern Region wouldn't be complete without spending some time in its best cities, starting with Blantyre. A couple of the top attractions here include Mandala House and Carlsberg Brewery. Zomba is another favorite city with Southern Region travelers. Visitors to this city enjoy Emperor's View and Williams Falls. Expedia has everything you need when it comes to organizing your Southern Region vacation. From flights and hotels, to activities and more, we know how to create a travel experience like no other.

Top destinations in Southern Region

A cityscape at dusk with a prominent building in the center, surrounded by residential areas and a mountain in the background.

Blantyre

Blantyre
A person riding a camel on a beach with the sea in the background.

Mangochi

Mangochi
A rocky shoreline with large boulders and sparse vegetation.

Cape Maclear

Cape Maclear
A large reservoir surrounded by forested hills.

Zomba

Zomba
Four lion cubs on a dry, sandy terrain with sparse vegetation.

Liwonde

Liwonde
A mountain with lush green vegetation and a tea plantation in the foreground.

Chigumula

Chigumula

Find the Best Southern Region Vacation Packages

Southern Region Essential Information

Language
Chichewa
Currency
Malawian kwachas
Closest Airport
Chileka Intl. Airport (BLZ)
Top Sights
Lake Malawi National Park, Monkey Bay Beach and Liwonde National Park

Southern Region Hotel Deals

Protea Hotel by Marriott Blantyre Ryalls

Protea Hotel by Marriott Blantyre Ryalls

2 Hannover Avenue Blantyre
Fully refundableReserve now, pay when you stay
$160 nightly
$190 total
Oct 10 - Oct 11
Total with taxes and fees
9/10 Wonderful! (155 reviews)
"Good location,clean,conveniente"

Reviewed on Oct 7, 2026

Protea Hotel by Marriott Blantyre Ryalls
Casa Mia

Casa Mia

Kabula Hill Road Blantyre
$84 nightly
$102 total
Oct 11 - Oct 12
Total with taxes and fees
Casa Mia
Crossroads Hotel Blantyre

Crossroads Hotel Blantyre

Crossroads Mall Blantyre
$134 nightly
$159 total
Oct 11 - Oct 12
Total with taxes and fees
Crossroads Hotel Blantyre
See all 108 properties in Southern Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations
Golf Vacations
Golf Vacations
Luxury Vacations
Luxury Vacations
Romantic Vacations
Romantic Vacations
Ski Vacations
Ski Vacations
Gay Friendly Vacations
LGBTQ Friendly Vacations
LGBTQ Friendly Vacations
Adventure Vacations
Adventure Vacations
Vacations in Month
Where to go when
Where to go when
Honeymoon Vacations
Honeymoon Vacations
Mountain Vacations
Mountain Vacations
Fishing Vacations
Fishing Vacations
Adults Only Vacations
Adults Only Vacations
Waterpark Vacations
Waterpark Vacations
Scuba Diving Vacations
Scuba Diving Vacations
Yoga Vacations
Yoga Vacations
Cheap Vacations
Cheap Vacations
Solo Vacations
Solo Vacations

Stay near popular Southern Region attractions

Monkey Bay Beach

8.6/10 (4 reviews)
If a restful vacation is part of your travel plans, Monkey Bay Beach might be the perfect place to seek out during your trip to Mangochi. Take in the museums while you're in the area.
See properties

Liwonde National Park

8.0/10 (1 review)
Explore the great outdoors at Liwonde National Park, a lovely green space in Liwonde.
See properties

Mangochi Museum

You can spend time exploring the galleries in Mangochi Museum in Mangochi. Take in the museums while you're in the area.
See properties

Satemwa Tea Estate

10.0/10 (1 review)
You can find out about the history of Thyolo with a visit to Satemwa Tea Estate.
See properties

The Way of the Cross/ Njira ya Mtanda

7.4/10 (3 reviews)
You can take time to visit The Way of the Cross/ Njira ya Mtanda during your travels to Blantyre. Discover the area's mountain views and churches.
See properties

What to do in Southern Region

Hikers try climbing a rock on a tour

Zomba plateau Day Hike Tour

$160
per adult
Zomba plateau Day Hike Tour
See all activities in Southern Region
Explore a world of travel with Expedia
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.