Ocean Isle Estates Vacations from $746

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Your Ocean Isle Estates Vacation

Organizing your next getaway just got easier with a vacation package to Ocean Isle Estates. Immerse yourself in everything this neighborhood has to offer while making fond memories that'll stay with you for years. Hoping to sightsee during your trip to Ocean Isle Estates? Make sure you stop by nearby attractions such as Caribbean Club Bar, MarineLab Undersea Laboratory and Key Largo Hammocks State Botanical Site. Whatever your travel goals or the size of your budget, booking your ideal Ocean Isle Estates vacation has never been easier with Expedia.

The Latest Ocean Isle Estates Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Eurostars Winter Haven
Henrosa Hotel
The Retreat Collection at 1 Hotel & Homes South Beach
501 First Studio Balcony by Palermo Home
1 Hotel South Beach

Where to stay in Ocean Isle Estates

Find the best Ocean Isle Estates areas and neighborhoods for the activities you enjoy most. Learn more about Ocean Isle Estates

Ocean Isle Estates Hotel Deals

Reefhouse Resort & Marina

Reefhouse Resort & Marina

4.5 out of 5
103800 Overseas Hwy Key Largo FL
Fully refundableReserve now, pay when you stay
$259 nightly
The price is $286 total per night from Nov 29 to Nov 30
$286 total
Nov 29 - Nov 30
Total with taxes and fees
Reefhouse Resort & Marina
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

4 out of 5
97000 Overseas Hwy Key Largo FL
Fully refundableReserve now, pay when you stay
$312 nightly
The price is $351 total per night from Nov 29 to Nov 30
$351 total
Nov 29 - Nov 30
Total with taxes and fees
8.8/10 Excellent! (1,199 reviews)
"This was an amazing resort. Highly recommend!"

Reviewed on Nov 14, 2026

Baker's Cay Resort Key Largo, Curio Collection by Hilton
The Pelican Key Largo Cottages

The Pelican Key Largo Cottages

2 out of 5
99340 Overseas Highway Key Largo FL
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $115 total per night from Dec 2 to Dec 3
$115 total
Dec 2 - Dec 3
Total with taxes and fees
9/10 Wonderful! (1,000 reviews)
"Great time"

Reviewed on Nov 10, 2026

The Pelican Key Largo Cottages
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.