Panama Vacations from $459

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Your Panama Vacation

Reserve a Panama vacation package and get ready to experience the best of this lively city. Consider staying in the neighborhood of Celoron, which is great for watersports, walking and fishing. During your trip to Panama, carve some time in your schedule for sightseeing. One of the best places to start exploring is Ashville Bay. Don't delay visiting this destination any longer. The perfect Panama vacation is a couple of clicks away with Expedia.

The Latest Panama vacation packages

Price found within the past 48 hours. Click for updated prices.
Baymont by Wyndham Erie

Baymont by Wyndham Erie

2.5 out of 5
Price was $483, price is now $459 per person
$459
per person
Apr 15 - Apr 18
found 1 day ago
Roundtrip flight included
Tampa (TPA) to Erie (ERI)
8.6/10 Excellent! (2,317 reviews)
Room was super clean, smelled nice. Lobby was clean staff was amazing! Would recommend

Reviewed on Mar 2, 2026

The Spencer Hotel & Spa

The Spencer Hotel & Spa

2.5 out of 5
Price was $842, price is now $784 per person
$784
per person
May 30 - Jun 1
found 1 day ago
Roundtrip non-stop flight included
Sioux Falls (FSD) to Jamestown (JHW)
8/10 Very Good! (16 reviews)
This is a historic property. It was quaint, quiet, and clean. We were made to feel very welcome. It was so fun to walk around and see all the homes and amenities in the Chautauqua Institute.

Reviewed on Sep 23, 2025

Cobblestone Hotel & Suites - Harborcreek

Cobblestone Hotel & Suites - Harborcreek

3 out of 5
Price was $977, price is now $930 per person
$930
per person
May 16 - May 18
found 1 day ago
Roundtrip flight included
Sioux Falls (FSD) to Erie (ERI)
8.6/10 Excellent! (1,003 reviews)
Good hotel at low price

Reviewed on Mar 3, 2026

Webb's Year Round Resort

Webb's Year Round Resort

2.5 out of 5
Price was $704, price is now $671 per person
$671
per person
May 30 - Jun 1
found 1 day ago
Roundtrip non-stop flight included
Sioux Falls (FSD) to Jamestown (JHW)
7.2/10 Good! (209 reviews)
The room was in good condition but I would not stay there again. The pool was broke and the hot tub did not bubble!

Reviewed on Feb 23, 2026

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Panama Hotel Deals

Holiday Inn Express Hotel & Suites in North East (Erie) by IHG

Holiday Inn Express Hotel & Suites in North East (Erie) by IHG

2.5 out of 5
6310 Old Station Road North East PA
Fully refundable
$95 nightly
The price is $107 total per night from Mar 5 to Mar 6
$107 total
Mar 5 - Mar 6
Total with taxes and fees
9/10 Wonderful! (1,183 reviews)
Very efficient snow removal after it snowed on walks, driveways and parking lot. Friendly, helpful staff with a great selection of items for breakfast. We enjoyed our stay and will definitely have use this hotel again.

Reviewed on Mar 2, 2026

Holiday Inn Express Hotel & Suites in North East (Erie) by IHG
Peek'n Peak Resort Trademark Collection by Wyndham

Peek'n Peak Resort Trademark Collection by Wyndham

3.5 out of 5
1405 Olde Road Clymer NY
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $117 total per night from Mar 8 to Mar 9
$117 total
Mar 8 - Mar 9
Total with taxes and fees
8.6/10 Excellent! (1,004 reviews)
Great time and easy access. Most places to eat were not open even though the website said they were

Reviewed on Mar 2, 2026

Peek'n Peak Resort Trademark Collection by Wyndham
Enjoy fall on the lake - colorful leaves, the grape harvest. Or, Winter snuggle.

Enjoy fall on the lake - colorful leaves, the grape harvest. Or, Winter snuggle.

North East PA
10/10 Exceptional! (90 reviews)
Lovely stay at this property. The home was lovely and comfortable. Check in was easy. The area had lots to do, even in the winter. And the amenities at the home were fantastic as were the views. Would 100% recommend.

Reviewed on Feb 16, 2026

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Enjoy fall on the lake - colorful leaves, the grape harvest. Or, Winter snuggle.
See all 545 properties in Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Panama Vacation Packages

Panama Essential Information

Language
English
Currency
U.S dollars
Top Sights
Midway State Park, Long Point on Lake Chatauqua State Park and Chautauqua Lake

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Frequently asked questions

How much does a Panama vacation package cost?
Offering excellent value package deals from $459 on Expedia, you'll be thrilled with how little a vacation to Panama costs! Our packages mean less travel planning for you and greater savings.
What are the cheapest months to go to Panama?
If you're looking to book a cheap Panama vacation package, consider planning a trip in November, December and January. You'll usually find better prices on hotels and flights during these months — perfect for budget-conscious travelers.
How many days is enough for Panama?
Usually, a handful of days is enough to check out the top sights during your Panama vacation. However, if you want to have some time to rest or take day trips, consider extending your itinerary.
How to find the best Panama package deals?
Begin your search for a Panama package deal by entering your preferred travel dates and destination under our "Packages" tab. Then add some filters, like "Popular locations" and "Amenities," to tailor the results to your exact needs. You can also sort by "Package discount" and browse offers that come with irresistible savings. If you don't find the ideal Panama package deal straight away, just change your dates and search again. Remember that deals are only available for a limited time, so book early and get your Panama adventure off to a flying start.
Is it cheaper to book a Panama vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your flight, hotel and car rental into one great-value price and enjoy significant savings. You'll usually land a better deal than booking each component individually. And you'll still get the freedom to create a customized Panama vacation by choosing your preferred accommodation type, airline and car class.
When to book a vacation package to Panama?
If you're considering a spontaneous Panama getaway, browse our last-minute deals that can be booked up to a week before you take off. Don't want to leave things to the last minute? You can score sensational deals on your hotels and flights by booking well in advance.
Does Expedia offer Book Now, Pay Later Panama vacation packages?
If you're anything like us, you love traveling but don't love the big price tag that can sometimes come with it. That's why we've created Book Now, Pay Later vacations. With the help of online lender Affirm, you can break down the overall cost of your Panama break over 3, 6 or 12 months. There are also no hidden or late payment fees, so you can secure cheap vacation packages with payment plans as soon as you see them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.