Quebrada San Isidro Vacations from $848

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The Latest Quebrada San Isidro vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Casa Panamá

Hotel Casa Panamá

4 out of 5
Casco Viejo
Price was $1,259, price is now $848 per person
$848
per person
Aug 15 - Aug 22
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
7.6/10 Good! (694 reviews)
El hotel muy bonito, el trato del personal excelente. Un sólo detalle que cuando estuve se fue la luz en la ciudad casi completa y ellos no tienen generador. De lo de más todo estuvo bien.

Reviewed on Jun 1, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $2,386, price is now $1,343 per person
$1,343
per person
Aug 15 - Aug 22
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (1,004 reviews)
We thoroughly enjoyed our stay. Relaxing, clean and sophisticated vibe there. Central location can’t be beat. So comfortable! We liked the breakfast buffet as well. Staff was friendly. Would stay again! Very pleased :)

Reviewed on Jun 7, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $1,788, price is now $1,120 per person
$1,120
per person
Jul 24 - Jul 27
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,543 reviews)
Everything was GREAT!! the only hiccup I have experienced twice was the Conceirge, he was a little on the lazy side.

Reviewed on Jun 10, 2026

Las Clementinas

Las Clementinas

3.5 out of 5
Casco Viejo
Price was $1,784, price is now $1,196 per person
$1,196
per person
Aug 15 - Aug 22
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.4/10 Exceptional! (192 reviews)
Best location. Beautiful heritage place and lovely restaurant attached.

Reviewed on Jun 1, 2026

Yoo by Wynwood House

Yoo by Wynwood House

4 out of 5
Calidonia
Price was $1,783, price is now $1,239 per person
$1,239
per person
Jul 11 - Jul 16
found 1 day ago
Roundtrip flight included
Port of Spain (POS) to Panama City (PTY)
9.4/10 Exceptional! (6 reviews)
Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about this. We still have not been contacted by anyone.

Reviewed on Jul 26, 2025

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Quebrada San Isidro Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós

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Frequently asked questions

How much does a Quebrada San Isidro vacation package cost?
You can grab a vacation package to this popular destination from $848 on Expedia. But how much your vacation to Quebrada San Isidro costs will depend on factors like the length of stay, hotel choice and season.
What are the cheapest months to go to Quebrada San Isidro?
July, September and December are the best times to look for cheap Quebrada San Isidro vacation packages. Traveling in less busy months means you can usually find reduced prices on flights and accommodations.
How many days is enough for Quebrada San Isidro?
The ideal duration of your Quebrada San Isidro vacation depends on what you'd like to see and do. Generally, a handful of days to a week will give you enough time to check out all the leading attractions and discover some hidden treasures along the way.
How to find the best Quebrada San Isidro package deals?
Start your search for a Quebrada San Isidro package deal by entering your destination and preferred trip dates under our "Packages" tab. Then select a few filters, like "Property type" and "Amenities," to fine-tune the results to your exact style. You can also sort by "Package discount" and discover offers that come with huge savings. If you don't find the ideal Quebrada San Isidro package deal straight away, simply tweak your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Quebrada San Isidro escape off to a flying start.
Is it cheaper to book a Quebrada San Isidro vacation as a package?
You can enjoy significant savings on your Quebrada San Isidro escape by booking a tailored vacation package. Check the "Package" heading, then enter your destination and travel dates to view the best hotel prices and airfares. Bundle everything into a neat package and you can save hundreds of dollars. Consider adding a car rental and you may score a better deal.
When to book a vacation package to Quebrada San Isidro?
If you're considering a spontaneous Quebrada San Isidro getaway, browse our last-minute deals that can be booked up to a week before you take off. Prefer not to wait until the last minute? You can land incredible deals on your hotels and flights by booking well in advance.
Does Expedia offer Book Now, Pay Later Quebrada San Isidro vacation packages?
Your Quebrada San Isidro getaway is meant to be an escape from your busy life, not a reason for money-related stress. So to allow you that extra flexibility, we've partnered with online lender Affirm to offer you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and split up the cost over 3, 6 or 12 months. Plus, there aren't any hidden costs or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.