San Isidro Vacations from $436

Book a Hotel + Flight or Car together to unlock savings

Your San Isidro Vacation

When a break in the city is calling, answer it with a San Isidro vacation package. The neighborhood of Flamenco, which is good for underwater activities, coastal beaches and nature, makes a fantastic base for your adventures. Fill your schedule with visits to Flamenco Beach, Culebrita Beach and Flamenco Peninsula, some of the things you should see during a trip to San Isidro. Browse Expedia's wide range of travel options and book your dream vacation to San Isidro now.

The Latest San Isidro vacation packages

Price found within the past 48 hours. Click for updated prices.
Mamacita's Guest House

Mamacita's Guest House

2.5 out of 5
Culebra Pueblo
Save 100% on your flight
Price was $586, price is now $436 per person
$436
per person
Nov 8 - Nov 14
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Culebra (CPX)
8/10 Very Good! (456 reviews)
Only thing the WIFI is very weak.

Reviewed on Aug 24, 2025

Las Quintas Reserve

Las Quintas Reserve

3 out of 5
Price was $1,775, price is now $1,389 per person
$1,389
per person
Nov 8 - Nov 14
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Culebra (CPX)
No reviews
Don't see what you're looking for?
See all available trips from Columbus to San Isidro
View all trips

Discover the most popular places to visit in San Isidro

Playa Tortola

Why not spend a lazy afternoon at Playa Tortola during your trip to San Isidro?

Playa Tortola

San Isidro Hotel Deals

Sea Gate Hotel

Sea Gate Hotel

2.5 out of 5
Route 989 Km .04, Vieques
$96 nightly
The price is $105 total per night from Sep 6 to Sep 7
$105 total
Sep 6 - Sep 7
Total with taxes and fees
Sea Gate Hotel
Old Crow Hotel and Suites

Old Crow Hotel and Suites

2.5 out of 5
Carretera 201, KM. 1.3, Barrio Florida, Vieques, Puerto Rico
$131 nightly
The price is $143 total per night from Sep 6 to Sep 7
$143 total
Sep 6 - Sep 7
Total with taxes and fees
Old Crow Hotel and Suites
Mamacita's Guest House

Mamacita's Guest House

2.5 out of 5
Calle Castelar #64, Culebra
$152 nightly
The price is $165 total per night from Oct 2 to Oct 3
$165 total
Oct 2 - Oct 3
Total with taxes and fees
Mamacita's Guest House
See all 299 properties in San Isidro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a San Isidro vacation package cost?
Offering great value package deals from $436 on Expedia, you'll be thrilled with how little a vacation to San Isidro costs! Expedia's packages make travel planning easier and your savings go further.
What are the cheapest months to go to San Isidro?
You can usually find lower prices and greater availability in July, September and October. Browse our cheap San Isidro vacation packages and you could score some great off-season discounts.
How many days is enough for San Isidro?
The ideal duration of your San Isidro vacation depends on what you'd like to do and see. Generally, a few days to a week will give you enough time to check out all the main attractions and explore some hidden spots along the way.
How to find the best San Isidro package deals?
Begin your search for a San Isidro package deal by entering your destination and preferred travel dates under our "Packages" tab. Then select some filters, like "Property type" and "Guest rating," to tailor the results to your exact needs. You can also sort by "Package discount" and discover offers that come with big savings. If you don't find the perfect San Isidro package deal right away, simply tweak your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your San Isidro adventure underway.
Is it cheaper to book a San Isidro vacation as a package?
You can enjoy significant savings on your next San Isidro escape by booking a personalized vacation package. Click on the "Package" heading, then select your destination and travel dates to view the best hotel prices and airfares. Bundling can save travelers hundreds of dollars. Consider adding a rental car and you may land a better deal.
When to book a vacation package to San Isidro?
Secure incredible bargains by reserving your flights early with Expedia. If being spontaneous is more your style, snap up one of our last-minute deals for a spur-of-the-moment San Isidro break.
Does Expedia offer Book Now, Pay Later San Isidro vacation packages?
Your San Isidro getaway should be an escape from your busy life, not a source of money worries. So to give you that extra flexibility, we've partnered with online lender Affirm to bring you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and break down the total cost over 3, 6 or 12 months. Plus, there are no late payment fees or hidden costs to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.