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Expedia has no hotel listings in or around San Jose de Mayo itself.
50 miles from San Jose de Mayo is Montevideo, where you can visit the Oceanographic Museum and Puerto del Buceo Marina. The Sheraton Montevideo Hotel and Radisson Montevideo Victoria Plaza Hotel are just some of the great lodging options in Montevideo. Or, you could consider staying in Atlantida, 60 miles to the southeast of San Jose de Mayo, where you can choose from the Hotel Argentina and Paradise Spa & Complejo Turistico. The Atlantida Zoo and Founders of Atlantida Plaza are a couple of the most popular attractions to explore when you're in Atlantida.