San Mateo Vacations from $236

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Your San Mateo Vacation

When a city break is calling, answer it with a San Mateo vacation package. The neighborhood of Santa Marianita, which is great for watersports, dining and views, makes a great base for your adventures. If some sightseeing is on the agenda during your trip to San Mateo, stop by popular attractions such as Universidad Laica Eloy Alfaro de Manabi. Whoever you're going away with and whether your budget is big or small, your ultimate San Mateo vacation is just a few clicks away with Expedia.

The Latest San Mateo vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Azul de la Plaza

Hotel Azul de la Plaza

Downtown Cuenca
$236
per person
Oct 22 - Oct 27
found 20 hours ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9.2/10 Wonderful! (66 reviews)
everyone was great

Reviewed on Aug 14, 2026

Hotel Boutique Santa Lucia

Hotel Boutique Santa Lucia

Downtown Cuenca
$688
per person
Oct 14 - Oct 21
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Guayaquil (GYE)
9.2/10 Wonderful! (401 reviews)
The hotel feels like a real mansion with classic furnitures. Room was large and very clean. Location can’t be better, surrounded by so many restaurants and cafes, it’s hard to count. Definitely try Goza Restaurant/Bar, located 6 minutes from the hotel. STAFF: hands down staff is the biggest asset at the hotel, they are kind, professional and extremely knowledgeable. Big shoutouts go Adrian and specially Cristina. She was patient and reorganized my detailed itinerary to be more time efficient :)

Reviewed on Aug 19, 2026

Hotel El Conquistador

Hotel El Conquistador

Downtown Cuenca
Save 100% on your flight
$289
per person
Oct 22 - Oct 27
found 20 hours ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
7.8/10 Good! (146 reviews)
Hotel del Parque

Hotel del Parque

$1,084
per person
Oct 8 - Oct 12
found 11 hours ago
Roundtrip flight included
New York (JFK) to Guayaquil (GYE)
9.8/10 Exceptional! (127 reviews)
Tuvimos problemas con el internet se demoraron en solucionarlo pero cuando lo solucionaron quedo bien El restaurante del desayuno hacia demasiado calor Entiendo q es al aire libre pero que valor Tuve q volver a bañarme

Reviewed on Aug 17, 2026

Santa Lucia Suites - Barranco

Santa Lucia Suites - Barranco

Downtown Cuenca
$246
per person
Oct 22 - Oct 27
found 21 hours ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9.4/10 Exceptional! (38 reviews)
We liked the location of the property along the river; the bedroom was quiet and dark for a good night's sleep

Reviewed on Aug 14, 2026

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What to do in San Mateo

Taste of Ecuador: Fish Market, Forest trail, Local Food & Crafts

Taste of Ecuador: Fish Market, Forest trail, Local Food & Crafts

$95
per adult
Taste of Ecuador: Fish Market, Forest trail, Local Food & Crafts
Half Day City Tour in Manta and Montecristi Landmarks

Half Day City Tour in Manta and Montecristi Landmarks

$72
per adult
Half Day City Tour in Manta and Montecristi Landmarks
See all activities in San Mateo

San Mateo Hotel Deals

Oro Verde Manta

Oro Verde Manta

Calle 23, Av. Malecon Manta Manabi
$128 nightly
$142 total
Sep 20 - Sep 21
Oro Verde Manta
Wyndham Manta Sail Plaza Hotel & Convention Center

Wyndham Manta Sail Plaza Hotel & Convention Center

Via Barbasquillo junto a Mykonos Manta Manabi
Fully refundableReserve now, pay when you stay
$122 nightly
$135 total
Sep 18 - Sep 19
7.8/10 Good! (397 reviews)
"Todo súper bien"

Reviewed on Aug 20, 2026

Wyndham Manta Sail Plaza Hotel & Convention Center
Hotel Perla Spondylus

Hotel Perla Spondylus

Avenida 3 y Calle 15 Manta Manabi
$100 nightly
$100 total
Aug 23 - Aug 24
9/10 Wonderful! (59 reviews)
"Podrian mejorar el desayuno y tener servicio de restaurante continuo, tiene servicio limitado de restaurante"

Reviewed on Aug 14, 2026

Hotel Perla Spondylus
See all 157 properties in San Mateo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best San Mateo Vacation Packages

San Mateo Essential Information

Language
Spanish
Currency
U.S dollars
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Eloy Alfaro Intl. Airport (MEC)
Top Sights
Central Bank Museum, Manabí Fisherman Statue and Universidad Laica Eloy Alfaro de Manabi

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Frequently asked questions

How much does a San Mateo vacation package cost?
Offering excellent value package deals from $236 on Expedia, you'll be pleasantly surprised at how much a vacation to San Mateo costs! Expedia's packages make travel planning easier and your savings go further.
What are the cheapest months to go to San Mateo?
November, December and January are great times to search for cheap San Mateo vacation packages. Traveling in quieter periods means you can generally find better prices on flights and accommodations.
How many days is enough for San Mateo?
The ideal duration for your San Mateo vacation depends on what you'd like to see. Usually, a handful of days to a week will give you plenty of time to tick off all the major sights and explore some hidden treasures along the way.
How to find the best San Mateo package deals?
Use Expedia's filter tool to help you find some tempting San Mateo package deals. When you start your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or browse for San Mateo package deals in the off-season. Play around with your travel dates and you may score even bigger discounts. As a rule of thumb, it's typically best to lock in your vacation package well in advance.
Is it cheaper to book a San Mateo vacation as a package?
An Expedia vacation package could land you significant savings when compared to booking hotels and flights separately. Better still, you can personalize your San Mateo trip to fit your exact style. Choose your preferred flight time, select the hotel type and add a car rental. Check out our great deals to see how much you can save.
When to book a vacation package to San Mateo?
Enjoy incredible discounts by booking your flights ahead of time with Expedia. If being spontaneous is more your style, take advantage of our last-minute deals for an impromptu San Mateo escape.
Does Expedia offer Book Now, Pay Later San Mateo vacation packages?
Your San Mateo getaway should be an escape from your busy life, not a reason for money worries. So to allow you a bit more flexibility, we've teamed up with online lender Affirm to offer our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and split up the cost over 3, 6 or 12 months. Plus, there aren't any hidden or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.