San Mateo Vacations from $208

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Your San Mateo Vacation

When a city break is calling, answer it with a San Mateo vacation package. The neighborhood of Santa Marianita, which is great for watersports, dining and views, makes a great base for your adventures. If some sightseeing is on the agenda during your trip to San Mateo, stop by popular attractions such as Universidad Laica Eloy Alfaro de Manabi. Whoever you're going away with and whether your budget is big or small, your ultimate San Mateo vacation is just a few clicks away with Expedia.

The Latest San Mateo vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel El Conquistador

Hotel El Conquistador

4 out of 5
Downtown Cuenca
Price was $278, price is now $208 per person
$208
per person
Nov 14 - Nov 16
found 1 day ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
7.8/10 Good! (128 reviews)
Right in the heart of the historic district

Reviewed on Apr 29, 2024

Hotel Rio Guayas

Hotel Rio Guayas

2.5 out of 5
Las Peñas
Price was $2,753, price is now $1,238 per person
$1,238
per person
Oct 1 - Oct 7
found 19 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Guayaquil (GYE)
10/10 Exceptional! (1 review)
I absolutely loved my stay at Hotel Rio Guayas! The staff was incredibly kind, attentive, and made me feel truly welcome. One of the highlights was the stunning river view from the restaurant absolutely unforgettable. The hotel feels luxurious, with beautiful artwork and elegant decor throughout. Everything was spotless and comfortable. I highly recommend this place and would love to stay again! For Sureeee

Reviewed on Jul 30, 2025

Hotel Cruz del Vado

Hotel Cruz del Vado

4.5 out of 5
Save 100% on your flight
Price was $574, price is now $400 per person
$400
per person
Nov 14 - Nov 16
found 1 day ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9.4/10 Exceptional! (38 reviews)
Beautiful! Great service

Reviewed on Aug 12, 2025

Mansión Alcázar Boutique Hotel

Mansión Alcázar Boutique Hotel

4 out of 5
Downtown Cuenca
Price was $1,223, price is now $923 per person
$923
per person
Sep 29 - Oct 4
found 1 day ago
Roundtrip flight included
New York (NYC) to Guayaquil (GYE)
9.4/10 Exceptional! (300 reviews)
This is a beautifully restored building with a lovely garden, immaculate rooms, and in a convenient location.

Reviewed on Aug 29, 2025

Hotel Boutique Santa Lucia

Hotel Boutique Santa Lucia

4 out of 5
Downtown Cuenca
Price was $353, price is now $270 per person
$270
per person
Nov 14 - Nov 16
found 1 day ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9.2/10 Wonderful! (351 reviews)
Hot beverages were good

Reviewed on Aug 17, 2025

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Discover the most popular places to visit in San Mateo

Manta Port

Explore the waterfront in Manta with a trip to Manta Port. Wander the beaches and seaside in the area.

Manta Port

Universidad Laica Eloy Alfaro de Manabi

Walk around the campus at Universidad Laica Eloy Alfaro de Manabi during your visit to Manta. Wander the seaside and beaches in the area.

Universidad Laica Eloy Alfaro de Manabi

Mall del Pacífico

You can search for that perfect souvenir at Mall del Pacífico during your trip to Manta. Wander the beaches and seaside in the area.

Mall del Pacífico

What to do in San Mateo

Mother nature at her best

Rainforest Wildlife, Panama Hat makers, Traditional Cuisine. SHORE TOUR

$110
per adult
Rainforest Wildlife, Panama Hat makers, Traditional Cuisine. SHORE TOUR
Pacoche Hiking Tour

Pacoche Hiking Tour

$320
per adult
Pacoche Hiking Tour
See all activities in San Mateo

San Mateo Hotel Deals

Oro Verde Manta

Oro Verde Manta

4.5 out of 5
Calle 23, Av. Malecon, Manta, Manabi
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $142 total per night from Sep 1 to Sep 2
$142 total
Sep 1 - Sep 2
Oro Verde Manta
Wyndham Manta Sail Plaza Hotel & Convention Center

Wyndham Manta Sail Plaza Hotel & Convention Center

4.5 out of 5
Via Barbasquillo junto a Mykonos, Manta, Manabi
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $102 total per night from Sep 12 to Sep 13
$102 total
Sep 12 - Sep 13
Wyndham Manta Sail Plaza Hotel & Convention Center
Balandra Hotel

Balandra Hotel

4 out of 5
Avenida 7 Calle 20, Manta
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $109 total per night from Sep 1 to Sep 2
$109 total
Sep 1 - Sep 2
Balandra Hotel
See all 186 properties in San Mateo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does a San Mateo vacation package cost?
Offering excellent value package deals from $208 on Expedia, you'll be pleasantly surprised at how much a vacation to San Mateo costs! Expedia's packages make travel planning easier and your savings go further.
What are the cheapest months to go to San Mateo?
November, December and January are great times to search for cheap San Mateo vacation packages. Traveling in quieter periods means you can generally find better prices on flights and accommodations.
How many days is enough for San Mateo?
The ideal duration for your San Mateo vacation depends on what you'd like to see. Usually, a handful of days to a week will give you plenty of time to tick off all the major sights and explore some hidden treasures along the way.
How to find the best San Mateo package deals?
Use Expedia's filter tool to help you find some tempting San Mateo package deals. When you start your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or browse for San Mateo package deals in the off-season. Play around with your travel dates and you may score even bigger discounts. As a rule of thumb, it's typically best to lock in your vacation package well in advance.
Is it cheaper to book a San Mateo vacation as a package?
An Expedia vacation package could land you significant savings when compared to booking hotels and flights separately. Better still, you can personalize your San Mateo trip to fit your exact style. Choose your preferred flight time, select the hotel type and add a car rental. Check out our great deals to see how much you can save.
When to book a vacation package to San Mateo?
Enjoy incredible discounts by booking your flights ahead of time with Expedia. If being spontaneous is more your style, take advantage of our last-minute deals for an impromptu San Mateo escape.
Does Expedia offer Book Now, Pay Later San Mateo vacation packages?
Your San Mateo getaway should be an escape from your busy life, not a reason for money worries. So to allow you a bit more flexibility, we've teamed up with online lender Affirm to offer our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and split up the cost over 3, 6 or 12 months. Plus, there aren't any hidden or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.