South America Vacation Packages (Flight + Hotel)

Visit South America to discover a diverse range of countries and terrain. From the salt flats of Bolivia, to the golden beaches of Brazil, to Argentina’s towering mountain ranges, adventure always awaits. Hike up active volcanos, cheer alongside passionate soccer fans at a national stadium and go swimming with the local marine life just offshore.

South America was home to influential ancient civilizations, whose legacy can still be felt today. Explore the fabled ruins of Machu Picchu in Peru and survey the monumental stone head statues on Easter Island.

The continent’s European colonial rulers have also left their mark. Spanish is spoken across much of the continent and Portuguese dominates in Brazil, though many tribes and indigenous people still speak their own native languages. 

Make the city of Cuzco your base while exploring the Andes Mountains in Peru. See the floating reed islands of Lake Titicaca, which straddles Peru and Bolivia, or walk the colorful streets of lively Lima.

Ecuador offers enchanting colonial towns such as Quito, as well as rainforest treks through the Amazon. Journey offshore to Ecuador’s Galapagos Islands, where one-of-a-kind species, including giant tortoises and blue-footed boobies roam free.

Get a feel for Brazilian culture in Rio de Janeiro, a beachside city known for its street markets, love of soccer and fun-loving culture. Get in on the action with a match at Maracana Stadium.

For beautiful colonial architecture, head for Cartagena on Colombia’s northern coast.

At the southern tip of South America, Chile and Argentina are where you’ll find rolling vineyards and plenty of adventure sport opportunities. Whether you enjoy mountain biking, horseback riding or hiking, Patagonia is the place for you.

With plenty of international airports, South America is easier than ever to explore. Use local buses to get you from one place to another. Sign up for guided tours and treks to explore the continent efficiently and safely.

Whether you’re after rugged mountain interiors, sandy coastlines or remote islands, South America has everything you need for a memorable vacation.

*Savings based on all vacation package bookings with Flight + Hotel on Expedia.com from January through December 2020, as compared to price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages. For Free Flight or 100% Off Flight deals, package savings is greater than or equal to the current cost of one component, when both are priced separately.