Sanctuary Vacations from $424

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Your Sanctuary Vacation

When it's time for your next epic getaway, lock in a Sanctuary vacation package. From its golfing to a whole lot more, there are endless great reasons to stay in this neighborhood. Can't wait to head out and see the sights during your trip to Sanctuary? Be sure to check out nearby attractions such as Bowmans Beach, Turner Beach and Blind Pass Beach. Expedia can help turn your ideal Sanctuary vacation into reality, no matter your budget or travel plans.

The Latest Sanctuary Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina

3 out of 5
Price was $1,249, price is now $424 per person
$424
per person
Feb 1 - Feb 7
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
9.2/10 Wonderful! (1,001 reviews)
The staff-Erika and Penny, were so wonderful and attentive to our requests! The clean room, the beautiful grounds and the restaurant manager, Raymond, so friendly. Just a perfect stay and memories made. Thank you. Catherine & Ernie K

Reviewed on Nov 28, 2025

Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers

3 out of 5
Villas
Price was $1,473, price is now $658 per person
$658
per person
Feb 17 - Feb 24
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Fort Myers (RSW)
8.6/10 Excellent! (1,002 reviews)
In general, excellent service.

Reviewed on Nov 30, 2025

The Perry Hotel Naples

The Perry Hotel Naples

4.5 out of 5
Price was $2,587, price is now $1,270 per person
$1,270
per person
Feb 18 - Feb 25
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Fort Myers (RSW)
9.6/10 Exceptional! (477 reviews)
The bed was very comfortable. The shower was clean and updated. We enjoyed the fire pits at night.

Reviewed on Nov 27, 2025

Hyatt Vacation Club at Coconut Cove, Bonita Springs

Hyatt Vacation Club at Coconut Cove, Bonita Springs

4 out of 5
Price was $1,595, price is now $828 per person
$828
per person
Feb 4 - Feb 9
found 1 day ago
Roundtrip flight included
New York (JFK) to Fort Myers (RSW)
9.2/10 Wonderful! (704 reviews)
Dont book studio for a couple. This is definitely for families

Reviewed on Nov 30, 2025

Innovation Hotel

Innovation Hotel

4 out of 5
Price was $2,570, price is now $1,336 per person
$1,336
per person
Feb 18 - Feb 25
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Fort Myers (RSW)
9.8/10 Exceptional! (527 reviews)
El personal súper amable y todo muy limpio,la habitación excelente

Reviewed on Nov 24, 2025

Black Friday Sale

Limited-time deals: Save up to 50% on select hotels.
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Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most. Learn more about Sanctuary
Fort Myers featuring a sandy beach

West End

3 out of top 10 points of interest in this area

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

Find hotels in West End

Sanctuary Hotel Deals

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

2.5 out of 5
1538 Cape Coral Pkwy E Cape Coral FL
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $89 total per night from Dec 16 to Dec 17
$89 total
Dec 16 - Dec 17
Total with taxes and fees
9.2/10 Wonderful! (1,039 reviews)
EXCELLENT STAFF

Reviewed on Nov 30, 2025

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street Fort Myers Beach FL
$204 nightly
The price is $228 total per night from Dec 16 to Dec 17
$228 total
Dec 16 - Dec 17
Total with taxes and fees
8.8/10 Excellent! (1,676 reviews)
Professional Service !

Reviewed on Nov 29, 2025

Margaritaville Beach Resort Fort Myers
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 out of 5
1400 Estero Blvd Fort Myers Beach FL
Fully refundableReserve now, pay when you stay
$154 nightly
The price is $172 total per night from Dec 2 to Dec 3
$172 total
Dec 2 - Dec 3
Total with taxes and fees
8.8/10 Excellent! (1,038 reviews)
Everything was perfect.

Reviewed on Nov 28, 2025

Lani Kai Beachfront Resort
See all 12,845 properties in Sanctuary
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
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Kid Friendly Vacations

Discover the most popular places to visit in Sanctuary

Sanibel Island Southern Beach

Sanibel Island Southern Beach

Why not spend a lazy afternoon at Sanibel Island Southern Beach during your trip to Sanibel?

Sanibel Island Southern Beach
Bowman\'s Beach which includes general coastal views and a sandy beach

Bowman's Beach

Relax and revel in a visit to one of the area’s most beautiful beaches, great for swimming, fishing and finding special seashells.

Bowman's Beach
Sanibel Island Lighthouse which includes a beach, general coastal views and a sunset

Sanibel Island Lighthouse

Although nobody knows how many shipwrecks it’s prevented, this lighthouse has been a welcome beacon for over a century. Visit it on an island that’s noted for shell collecting.

Sanibel Island Lighthouse

Things to do

Fort Myers Beach Sunset Excursion

Fort Myers Beach Sunset Excursion

$65
per adult
100% of travellers recommend
Fort Myers Beach Sunset Excursion
Copacetic Day Sail

Copacetic Day Sail

$70
per adult
100% of travellers recommend
Copacetic Day Sail
Southwest Florida Sunset Sail

Southwest Florida Sunset Sail

$70
per adult
100% of travellers recommend
Southwest Florida Sunset Sail
See all activities in Sanibel
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.