Title: Sanctuary Vacation Packages 2026 from $254 | Expedia.com

[Hotels in Sanctuary](https://expedia.com/Sanctuary-Sanibel-Hotels.0-n553248635976469368-0.Travel-Guide-Filter-Hotels)[Flights to Sanibel](https://expedia.com/Cheap-Flights-To-Sanibel.d9791.Travel-Guide-Flights)[Things to do in Sanibel](https://expedia.com/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities)[Car Rentals in Sanctuary](https://expedia.com/Car-Rentals-In-Sanctuary.d553248635976469368.Car-Rental-Guide)

![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_packages.jpeg?impolicy=fcrop&w=1200&h=300&q=medium)

# Sanctuary Vacations from $254

## Book a Hotel + Flight or Car together to unlock savings

- ##  
Plan, book, travel with confidence
- ###  
Better together  
Save up to $1,045 when you book a flight and hotel together\*
- ###  
Find the right fit  
With over 300,000 hotels worldwide, it's easy to create a perfect package
- ###  
Rest easy  
Plan, book, and manage your trip all in one place

## Your Sanctuary Vacation

When it's time for your next epic getaway, lock in a Sanctuary vacation package. From its golfing to a whole lot more, there are endless great reasons to stay in this neighborhood. Can't wait to head out and see the sights during your trip to Sanctuary? Be sure to check out nearby attractions such as [Bowmans Beach](https://www.expedia.com/Bowmans-Beach-Sanibel.d6296151.Vacation-Attraction), [Turner Beach](https://www.expedia.com/Turner-Beach-Captiva.d6182811.Vacation-Attraction) and [Blind Pass Beach](https://www.expedia.com/Blind-Pass-Beach-Fort-Myers.d553248635976197711.Vacation-Attraction). Expedia can help turn your ideal Sanctuary vacation into reality, no matter your budget or travel plans.

## The Latest Sanctuary Vacation Packages

Price found within the past 48 hours. Click for updated prices.

![Courtyard by Marriott Fort Myers Cape Coral](https://images.trvl-media.com/lodging/1000000/30000/22400/22386/d60a7543_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Courtyard by Marriott Fort Myers Cape Coral

Save 100% on your flight

$254

per person

Mar 23 - Mar 26

found 1 day ago

Roundtrip flight included

Boston (BOS) to Fort Myers (RSW)

8.2/10 Very Good! (997 reviews)

Room was ok a little dated with a couple spots on sofa team there are great

Reviewed on Feb 18, 2026

![LaPlaya Beach & Golf Resort - A Noble House Resort](https://images.trvl-media.com/lodging/1000000/30000/25200/25199/d2442103_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### LaPlaya Beach & Golf Resort - A Noble House Resort

Vanderbilt Beach

Save 100% on your flight

$1,376

per person

Apr 26 - May 1

found 1 day ago

Roundtrip flight included

Boston (BOS) to Fort Myers (RSW)

9/10 Wonderful! (1,000 reviews)

Proximity to beach and gulf. Great staff and experience.

Reviewed on Feb 19, 2026

![The Perry Hotel Naples](https://images.trvl-media.com/lodging/103000000/102390000/102386400/102386398/0ad2742c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### The Perry Hotel Naples

Save 100% on your flight

$599

per person

Apr 26 - May 1

found 1 day ago

Roundtrip flight included

Boston (BOS) to Fort Myers (RSW)

9.6/10 Exceptional! (477 reviews)

We stayed for a night. Wonderful to be charged resort fees. The hotel was nice. Beds were standard. It wasn't the super awesome experience you would think it would be

Reviewed on Feb 20, 2026

![Matanzas Inn Bayside Resort and Marina](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665085/fc463bf9_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Matanzas Inn Bayside Resort and Marina

Save 100% on your flight

$668

per person

Apr 26 - May 1

found 1 day ago

Roundtrip flight included

Boston (BOS) to Fort Myers (RSW)

9.2/10 Wonderful! (1,001 reviews)

Clean room and staff.

Reviewed on Feb 19, 2026

![Hyatt Vacation Club at Coconut Cove, Bonita Springs](https://images.trvl-media.com/lodging/1000000/1000000/991200/991114/fedffc57_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hyatt Vacation Club at Coconut Cove, Bonita Springs

Save 100% on your flight

$507

per person

Apr 26 - May 1

found 1 day ago

Roundtrip flight included

Boston (BOS) to Fort Myers (RSW)

9.2/10 Wonderful! (704 reviews)

Wonder people like Teri and Marcelo make this place special. So convenient to everything, Hyatt Regency Tarpon Bay is excellent! Spa manicure service is superb as well ( had a detailed and perfect manicure from Tetiana!) highly recommend!

Reviewed on Feb 14, 2026

## Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most. [Learn more about Sanctuary](https://expedia.com/Fort-Myers-Sanctuary.dx553248635976469368)

![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Mid Island

2 out of top 10 points of interest in this area

 While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach. 

[Find hotel + flight trips in Mid Island](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Mid%20Island&DestID=977663677668896768&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### West End

4 out of top 10 points of interest in this area

 While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach. 

[Find hotel + flight trips in West End](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=West%20End&DestID=977664051587067904&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### East End

3 out of top 10 points of interest in this area

 While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse. 

[Find hotel + flight trips in East End](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=East%20End&DestID=977663465835589632&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Periwinkle Way which includes cycling as well as an individual femail](https://images.trvl-media.com/place/6298863/b93364c4-18dc-4358-9389-6eed83739c80.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Beachview Country Club Estates

 If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing. 

[Find hotel + flight trips in Beachview Country Club Estates](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Beachview%20Country%20Club%20Estates&DestID=553248635976658737&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Shell Harbor

 Though Shell Harbor might not have many top sights, you can venture to the surrounding area to see attractions like Sanibel Moorings Botanical Gardens and Sanibel Sea School. 

[Find hotel + flight trips in Shell Harbor](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Shell%20Harbor&DestID=553248635976472731&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

## Sanctuary Hotel Deals

![Margaritaville Beach Resort Fort Myers ](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/w3998h2821x0y0-a77e6574_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Margaritaville Beach Resort Fort Myers 

251 Crescent Street Fort Myers Beach FL

$543 nightly

$606 total

Feb 22 - Feb 23

Total with taxes and fees

8.8/10 Excellent! (1,897 reviews)

United airlines is the worst its know wonder why I have over a million miles with American

Reviewed on Feb 19, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F22%2F2026&endDate=2%2F23%2F2026&selected=95126992&PinnedHotelID=95126992&HadPinnedHotel=true&regionId=553248635976469368)

![Sanibel Island Beach Resort](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/w2247h1500x326y0-2ea06bb5_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Sanibel Island Beach Resort

1231 Middle Gulf Dr Sanibel FL

Fully refundableReserve now, pay when you stay

$434 nightly

$482 total

Mar 18 - Mar 19

Total with taxes and fees

9/10 Wonderful! (1,627 reviews)

Great location, easy access to beach - service was fantastic - rooms are very nice

Reviewed on Feb 19, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F18%2F2026&endDate=3%2F19%2F2026&selected=17298818&PinnedHotelID=17298818&HadPinnedHotel=true&regionId=553248635976469368)

![Lani Kai Beachfront Resort](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/b5b17142_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Lani Kai Beachfront Resort

1400 Estero Blvd Fort Myers Beach FL

Fully refundableReserve now, pay when you stay

$293 nightly

$327 total

Feb 24 - Feb 25

Total with taxes and fees

9/10 Wonderful! (1,241 reviews)

Stayed one night. Worked out great.

Reviewed on Feb 19, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F24%2F2026&endDate=2%2F25%2F2026&selected=438796&PinnedHotelID=438796&HadPinnedHotel=true&regionId=553248635976469368)

[See all 13,001 properties in Sanctuary](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F22%2F2026&endDate=2%2F23%2F2026&regionId=553248635976469368)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

All Inclusive Vacations

[](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Beach Vacations

[](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Kid Friendly Vacations

[](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Golf Vacations

[](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Luxury Vacations

[](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Romantic Vacations

[](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Ski Vacations

[](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click)

![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

LGBTQ Friendly Vacations

[](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adventure Vacations

[](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click)

![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Where to go when

[](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Honeymoon Vacations

[](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Mountain Vacations

[](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Fishing Vacations

[](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adults Only Vacations

[](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Waterpark Vacations

[](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Scuba Diving Vacations

[](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Yoga Vacations

[](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Cheap Vacations

[](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Solo Vacations

[](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click)

### Discover the most popular places to visit in Sanctuary

![Seashells on Sanibel Island, Florida](https://images.trvl-media.com/place/553248635976194887/1681d0fb-bad0-43e3-9dad-05ad6264d3a8.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Sanibel Island Southern Beach

Why not spend a lazy afternoon at Sanibel Island Southern Beach during your trip to Sanibel? 

[](https://expedia.com/Sanibel-Island-Southern-Beach-West-End.d553248635976194887.Vacation-Attraction)

![Sanibel Island Lighthouse which includes a beach, general coastal views and a sunset](https://images.trvl-media.com/place/6123905/4ca6a8bf-bcd7-4194-afd1-f40b40c7afaf.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Sanibel Island Lighthouse

Although nobody knows how many shipwrecks it’s prevented, this lighthouse has been a welcome beacon for over a century. Visit it on an island that’s noted for shell collecting.

[](https://expedia.com/Sanibel-Island-Lighthouse-East-End.d6123905.Vacation-Attraction)

![Bowman\'s Beach which includes general coastal views and a sandy beach](https://images.trvl-media.com/place/6296151/4495298b-a31a-40fc-a275-ded1cba6e62a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Bowman's Beach

Relax and revel in a visit to one of the area’s most beautiful beaches, great for swimming, fishing and finding special seashells.

[](https://expedia.com/Bowmans-Beach-West-End.d6296151.Vacation-Attraction)

### Things to do

![Fort Myers Beach Sunset and Dolphin Watching Cruise](https://mediaim.expedia.com/localexpert/49585125/64783586-41c3-41b7-833b-538357650a0d.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Fort Myers Beach Sunset and Dolphin Watching Cruise

$70

per adult

**100%** of travellers recommend

[](https://expedia.com/things-to-do/fort-myers-beach-sunset-and-dolphin-watching-cruise.a49585125.activity-details)

![Copacetic Day Sail](https://mediaim.expedia.com/localexpert/3146061/ce46a7d1-6271-4a2e-9229-41a28a522002.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Copacetic Day Sail

$70

per adult

**100%** of travellers recommend

[](https://expedia.com/things-to-do/copacetic-day-sail.a3146061.activity-details)

![Southwest Florida Sunset Sail](https://mediaim.expedia.com/localexpert/3146060/208129dd-2c36-4c94-bbae-6379e223335e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Southwest Florida Sunset Sail

$70

per adult

**100%** of travellers recommend

[](https://expedia.com/things-to-do/southwest-florida-sunset-sail.a3146060.activity-details)

[See all activities in Sanibel](https://expedia.com/things-to-do/search?rid=553248635976469368)

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.