Sanctuary Vacations from $392

Book a Hotel + Flight or Car together to unlock savings

Your Sanctuary Vacation

When it's time for your next epic getaway, lock in a Sanctuary vacation package. From its golfing to a whole lot more, there are endless great reasons to stay in this neighborhood. Can't wait to head out and see the sights during your trip to Sanctuary? Be sure to check out nearby attractions such as Bowmans Beach, Turner Beach and Blind Pass Beach. Expedia can help turn your ideal Sanctuary vacation into reality, no matter your budget or travel plans.

The Latest Sanctuary Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Edison Beach House

Edison Beach House

3.5 out of 5
Save 100% on your flight
Price was $616, price is now $392 per person
$392
per person
Nov 25 - Nov 28
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Fort Myers (RSW)
9.4/10 Exceptional! (1,499 reviews)
Good service and nice people

Reviewed on Oct 14, 2025

LaPlaya Beach & Golf Resort - A Noble House Resort

LaPlaya Beach & Golf Resort - A Noble House Resort

4.5 out of 5
Vanderbilt Beach
Save 100% on your flight
Price was $1,729, price is now $996 per person
$996
per person
Jan 8 - Jan 11
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
8.8/10 Excellent! (1,002 reviews)
Our experience at La Playa was exceptional, everything was what we wanted and expected it to be

Reviewed on Sep 29, 2025

The Perry Hotel Naples

The Perry Hotel Naples

4.5 out of 5
Save 100% on your flight
Price was $937, price is now $569 per person
$569
per person
Jan 8 - Jan 11
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
9.6/10 Exceptional! (417 reviews)
I would give it excellent but we checked out around 9pm due to a few hours of the fire alarm going off. They had the fire department there but they were still working on the problem and we were concerned we wouldn’t be able to get a good night’s sleep.

Reviewed on Oct 14, 2025

Bellasera Resort

Bellasera Resort

4 out of 5
Old Naples
Save 100% on your flight
Price was $1,638, price is now $1,057 per person
$1,057
per person
Jan 8 - Jan 11
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
9.6/10 Exceptional! (2,219 reviews)
Joyful, relax and exceptional place in the center of the town. People at reception thanks to Tesse and her coworker was pleasant and welcoming , menu at Claw Bar and the London Club superbly delicious , service above and beyond accommodating , dream team of the cleaning crew (spotless clean, but invisible) , valet people friendly and entertaining . Whole experience during our stay was just perfect . Thank you , Bellasera , we will be back

Reviewed on Sep 29, 2025

Inn on Fifth

Inn on Fifth

4 out of 5
Old Naples
Save 100% on your flight
Price was $1,201, price is now $800 per person
$800
per person
Nov 21 - Nov 24
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Fort Myers (RSW)
9.4/10 Exceptional! (1,011 reviews)
Beautiful property, spacious room, attentive service.

Reviewed on Oct 8, 2025

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most. Learn more about Sanctuary
Periwinkle Way featuring cycling as well as an individual femail

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

Find hotels in Beachview Country Club Estates

Sanctuary Hotel Deals

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 out of 5
1400 Estero Blvd, Fort Myers Beach, FL
Fully refundableReserve now, pay when you stay
$191 nightly
The price is $214 total per night from Oct 21 to Oct 22
$214 total
Oct 21 - Oct 22
Total with taxes and fees
8.8/10 Excellent! (1,033 reviews)
"The thing that i did not like was that the tub was small and we had to pay for parking each day. Everything else was great."

Reviewed on Oct 11, 2025

Lani Kai Beachfront Resort
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street, Fort Myers Beach, FL
$226 nightly
The price is $253 total per night from Oct 19 to Oct 20
$253 total
Oct 19 - Oct 20
Total with taxes and fees
8.8/10 Excellent! (1,531 reviews)
"This was a great resort. I was surprised that the main hotel is across the street from the beach, but there is a bridge that makes it easy to get to the beach, pool and restaurants. We came with our teens and there were lots of families there, which made it enjoyable for all of us."

Reviewed on Oct 11, 2025

Margaritaville Beach Resort Fort Myers
Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers

3 out of 5
12600 University Dr, Fort Myers, FL
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $132 total per night from Oct 16 to Oct 17
$132 total
Oct 16 - Oct 17
Total with taxes and fees
8.6/10 Excellent! (1,004 reviews)
"I really liked that it wascebtrally located as i used public transportation and felt i could get downtown and the beach easily. Staff were super nice!"

Reviewed on Oct 11, 2025

Hilton Garden Inn Ft Myers
See all 12,603 properties in Sanctuary
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Sanctuary

Sanibel Island Southern Beach

Sanibel Island Southern Beach

4.5/5(171 reviews)

Why not spend a lazy afternoon at Sanibel Island Southern Beach during your trip to Sanibel?

Sanibel Island Southern Beach
Bowman\'s Beach which includes general coastal views and a sandy beach

Bowman's Beach

4.5/5(481 reviews)

Relax and revel in a visit to one of the area’s most beautiful beaches, great for swimming, fishing and finding special seashells.

Bowman's Beach
Sanibel Island Lighthouse which includes a beach, general coastal views and a sunset

Sanibel Island Lighthouse

4.5/5(1,092 reviews)

Although nobody knows how many shipwrecks it’s prevented, this lighthouse has been a welcome beacon for over a century. Visit it on an island that’s noted for shell collecting.

Sanibel Island Lighthouse

Things to do

Fort Myers Beach Sunset Excursion

Fort Myers Beach Sunset Excursion

$60
per adult
100% of travellers recommend
Fort Myers Beach Sunset Excursion
Southwest Florida Sunset Sail

Southwest Florida Sunset Sail

$70
per adult
100% of travellers recommend
Southwest Florida Sunset Sail
Dolphin and Sightseeing Tiki Cruise

Fort Myers Beach Dolphin & Sightseeing Tour Refreshments Included

$65
per adult
Fort Myers Beach Dolphin & Sightseeing Tour Refreshments Included
See all activities in Sanibel
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.