Sant' Ambrogio Vacations from $802

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Your Sant Ambrogio Vacation

Make travel planning simple by locking in a vacation package to Sant Ambrogio. We'll take care of the finer points, so you can concentrate on discovering everything this neighborhood can offer. Your trip to Sant Ambrogio wouldn't be complete without seeing leading attractions nearby such as Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia will help turn your dream Sant Ambrogio vacation into reality, whatever your budget or travel plans.

The Latest Sant' Ambrogio Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Bencista

Hotel Bencista

3 out of 5
Save 100% on your flight
per person
Aug 22 - Aug 27
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Florence (FLR)
7.2/10 Good! (12 reviews)
Palazzo Firenze by Baglioni Hotels & Resorts

Palazzo Firenze by Baglioni Hotels & Resorts

5 out of 5
Historic Centre of Florence
Save 100% on your flight
per person
Aug 18 - Aug 25
found 1 hour ago
Roundtrip flight included
New York (NYC) to Florence (FLR)
9.4/10 Exceptional! (225 reviews)
Great service esp Fillippo and Daniel at the breakfast service

Reviewed on Jul 6, 2025

Monastero di Cortona Hotel & Spa

Monastero di Cortona Hotel & Spa

5 out of 5
Cortona Old Town
Save 100% on your flight
per person
Sep 22 - Sep 29
found 1 day ago
Roundtrip flight included
New York (NYC) to Florence (FLR)
10/10 Exceptional! (212 reviews)
Amazing hotel, a must stay if visiting Cortona..best hotel in Tuscany

Reviewed on Jul 5, 2025

Collegio alla Querce - Auberge Resorts

Collegio alla Querce - Auberge Resorts

5 out of 5
Le Cure
Save 100% on your flight
per person
Aug 10 - Aug 16
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
10/10 Exceptional! (1 review)
Eurostars Florence Boutique

Eurostars Florence Boutique

4 out of 5
Historic Centre of Florence
Save 100% on your flight
per person
Sep 21 - Sep 27
found 21 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
8.6/10 Excellent! (462 reviews)
Breakfast was very good and the staff were excellent. Expresso in the morning was on point.

Reviewed on Jul 5, 2025

Where to stay in Sant' Ambrogio

Find the best Sant' Ambrogio areas and neighborhoods for the activities you enjoy most. Learn more about Sant' Ambrogio
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Sant' Ambrogio Hotel Deals

Hotel Bodoni
Hotel Bodoni
2 out of 5
Via Martiri del Popolo, 27, Florence, FI
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $122 total per night from Jul 9 to Jul 10
$122 total
Jul 9 - Jul 10
Total includes taxes and fees
8.2/10 Very Good! (718 reviews)
"Location is great for the price. The hotel itself is odd. Breakfast is good. The paid parking service worked well"

Reviewed on Jul 4, 2025

Hotel Bodoni
Hotel Regency
Hotel Regency
5 out of 5
Piazza M. D'Azeglio, 3, Florence, FI
Fully refundableReserve now, pay when you stay
$354 nightly
The price is $408 total per night from Aug 3 to Aug 4
$408 total
Aug 3 - Aug 4
Total includes taxes and fees
9.2/10 Wonderful! (430 reviews)
"Loved it! Great place and very convenient"

Reviewed on Jul 4, 2025

Hotel Regency
Hotel Rita Major
Hotel Rita Major
2 out of 5
Via della Mattonaia, 43, Florence, FI
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $108 total per night from Jul 13 to Jul 14
$108 total
Jul 13 - Jul 14
Total includes taxes and fees
9.2/10 Wonderful! (122 reviews)
"2 star rated but 5 star service. Simple rooms, Beds were nice, regular non-touristy neighborhood. staff could not be better. No need to pay for an expensive hotel with the same room."

Reviewed on Jun 27, 2025

Hotel Rita Major
See all 496 properties in Sant' Ambrogio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Discover the most popular places to visit in Sant' Ambrogio

Great Synagogue of Florence

4.5/5(2 reviews)

Learn about the local history of Florence with a stop at Great Synagogue of Florence. Visit the stunning cathedral and notable monuments in this vibrant area.

Great Synagogue of Florence

Piazza Massimo D'Azeglio

Find out about the history of Florence when you take a trip to Piazza Massimo D'Azeglio. Stroll along the riverfront or visit the stunning cathedral in this vibrant area.

Piazza Massimo D'Azeglio

Mercato di Sant'Ambrogio

5/5(1 review)

You can browse for the perfect souvenirs at Mercato di Sant'Ambrogio during your trip to Florence. Discover the fascinating museums and notable monuments in this vibrant area.

Mercato di Sant'Ambrogio

Things to do

Florence: Pasta Cooking Class with Unlimited Wine

Florence: Pasta Cooking Class with Unlimited Wine

$32
per adult
98% of travellers recommend
Florence: Pasta Cooking Class with Unlimited Wine
Pasta Lovers cooking class: learn to cook tagliatelle ravioli and tiramisù

Pasta Lovers cooking class: learn to cook tagliatelle ravioli and tiramisù

$40
per adult
Pasta Lovers cooking class: learn to cook tagliatelle ravioli and tiramisù
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.