Sant' Ambrogio Vacations from $634

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Your Sant Ambrogio Vacation

Make travel planning simple by locking in a vacation package to Sant Ambrogio. We'll take care of the finer points, so you can concentrate on discovering everything this neighborhood can offer. Your trip to Sant Ambrogio wouldn't be complete without seeing leading attractions nearby such as Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia will help turn your dream Sant Ambrogio vacation into reality, whatever your budget or travel plans.

The Latest Sant' Ambrogio Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Villa Marsili

Hotel Villa Marsili

4 out of 5
Cortona Old Town
Price was $851, price is now $634 per person
$634
per person
Oct 30 - Nov 3
found 1 day ago
Roundtrip flight included
New York (NYC) to Florence (FLR)
10/10 Exceptional! (309 reviews)
This hotel gets 5 stars in my book. The staff was welcoming as soon as we arrived and continued to be help throughout our stay. The rooms were old world elegant and so clean. The breakfast was world class, we have never had such large selections of food that were extremely delicious. They really go above and beyond to treat each of their guests like royalty.

Reviewed on Aug 18, 2025

Aurum Uffizi

Aurum Uffizi

4 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was $1,621, price is now $885 per person
$885
per person
Oct 16 - Oct 21
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
7.8/10 Good! (1,004 reviews)
The room that i stayed in was really nice. It was close to places to eat and main attractions. There is A/C in the room but they have it locked on a minimum temperature wwhich wasnt cool enough for me. Room service is great and they do a good job of cleaning and replacing towels, but they turn your A/C off during the day so you come back to a hot room. The trick is to hide the remote while youre gone. Also the bed and pillows were quite uncomfortable. Its like they spent all the money remodeling the room and had none left to get a decent mattress.

Reviewed on Aug 26, 2025

Aurum Firenze

Aurum Firenze

4 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was $1,504, price is now $839 per person
$839
per person
Oct 16 - Oct 21
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
7.6/10 Good! (1,008 reviews)
Close to centre of Florence, room ok, clean

Reviewed on Aug 28, 2025

The Moon Boutique Hotel & Spa

The Moon Boutique Hotel & Spa

4 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was $1,557, price is now $964 per person
$964
per person
Oct 16 - Oct 21
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.6/10 Exceptional! (470 reviews)
The hotel is located a 25 min walk away from the heart of Florence so very easy to access the main attractions within the city. The hotel itself is immaculate and the staff are extremely helpful with dealing with any questions you may have. Being able to access the spa everyday for 1 and 30 minutes is an excellent perk as the facilities are well worth a visit, you are also able to book massages for an extra fee. The breakfast also gives a variety of options to start each day and the room itself is spacious, with the shower particularly being very comfortable.

Reviewed on Aug 13, 2025

LHP River Club

LHP River Club

5 out of 5
Santa Croce
Save 100% on your flight
Price was $1,366, price is now $890 per person
$890
per person
Oct 16 - Oct 21
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
10/10 Exceptional! (2 reviews)

Where to stay in Sant' Ambrogio

Find the best Sant' Ambrogio areas and neighborhoods for the activities you enjoy most. Learn more about Sant' Ambrogio
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Sant' Ambrogio Hotel Deals

Hotel Bavaria

Hotel Bavaria

1 out of 5
Borgo Albizi 26, Florence, FI
$81 nightly
The price is $98 total per night from Aug 31 to Sep 1
$98 total
Aug 31 - Sep 1
Total with taxes and fees
Hotel Bavaria
Hotel Bodoni

Hotel Bodoni

2 out of 5
Via Martiri del Popolo, 27, Florence, FI
$111 nightly
The price is $133 total per night from Aug 30 to Aug 31
$133 total
Aug 30 - Aug 31
Total with taxes and fees
8/10 Very Good! (735 reviews)
"Good location.And very enjoy the morning view."

Reviewed on Aug 14, 2025

Hotel Bodoni
Hotel Regency

Hotel Regency

5 out of 5
Piazza M. D'Azeglio, 3, Florence, FI
Fully refundableReserve now, pay when you stay
$430 nightly
The price is $491 total per night from Aug 30 to Aug 31
$491 total
Aug 30 - Aug 31
Total with taxes and fees
Hotel Regency
See all 492 properties in Sant' Ambrogio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Sant' Ambrogio

Great Synagogue of Florence

4.5/5(2 reviews)

Learn about the local history of Florence with a stop at Great Synagogue of Florence. Visit the stunning cathedral and notable monuments in this vibrant area.

Great Synagogue of Florence

Piazza Massimo D'Azeglio

Find out about the history of Florence when you take a trip to Piazza Massimo D'Azeglio. Stroll along the riverfront or visit the notable monuments in this vibrant area.

Piazza Massimo D'Azeglio

Piazza Donatello

You can learn about the history of Florence with a stop at Piazza Donatello. Stroll along the riverfront or visit the churches in this vibrant area.

Piazza Donatello

Things to do

Florence: Pasta Cooking Class with Unlimited Wine

Florence: Pasta Cooking Class with Unlimited Wine

$33
per adult
94% of travellers recommend
Florence: Pasta Cooking Class with Unlimited Wine
Pasta Lovers cooking class: learn to cook tagliatelle ravioli and tiramisù

Pasta Lovers cooking class: learn to cook tagliatelle ravioli and tiramisù

$40
per adult
Pasta Lovers cooking class: learn to cook tagliatelle ravioli and tiramisù
Cooking Art Brunelleschi

Cooking Art Brunelleschi

$51
per adult
Cooking Art Brunelleschi
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.