Sant' Ambrogio Vacations from $1,742

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Your Sant Ambrogio Vacation

Make travel planning simple by locking in a vacation package to Sant Ambrogio. We'll take care of the finer points, so you can concentrate on discovering everything this neighborhood can offer. Your trip to Sant Ambrogio wouldn't be complete without seeing leading attractions nearby such as Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia will help turn your dream Sant Ambrogio vacation into reality, whatever your budget or travel plans.

The Latest Sant' Ambrogio Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Aurum Firenze

Aurum Firenze

4 out of 5
Historic Centre of Florence
Price was $2,603, price is now $1,742 per person
$1,742
per person
May 23 - May 29
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Florence (FLR)
7.6/10 Good! (1,008 reviews)
It's clearly a block of flats that has been converted to a hotel. My room was a bit cramped but for a few nights, I could live with it. There is a slight smell which in high summer is likely to be prominent. If you don't expect a 5 star experience, then it's OK. My room was clean, the staff friendly enough and walking distance to all the major sights. If I was back in Florence, would I stay there again, probably not, but I've no real complaints. Just don't expect too much and you'll be fine.

Reviewed on Mar 16, 2026

Hotel La Scaletta Al Ponte Vecchio

Hotel La Scaletta Al Ponte Vecchio

4 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was $4,267, price is now $2,767 per person
$2,767
per person
May 8 - May 14
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
8.8/10 Excellent! (971 reviews)
Fantastic location for everything whilst not being in the middle of it all. The staff were all lovely and everything super clean. Only issue was the aircon didn't work and we couldn’t open the windows due to mosquitoes (discovered this after the first night with it open - didn’t make that mistake again!). It’s quite an unusual interior with a tiny lift and lots of stairs so just be aware of that - it didn’t bother us though, we loved the charm.

Reviewed on Mar 12, 2026

Maxim Axial

Maxim Axial

3 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was $2,982, price is now $1,973 per person
$1,973
per person
May 8 - May 14
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
8.6/10 Excellent! (1,005 reviews)
Great location and wonderful room! Will book again!

Reviewed on Mar 6, 2026

Hotel Duomo Firenze

Hotel Duomo Firenze

3 out of 5
Historic Centre of Florence
Price was $3,072, price is now $2,057 per person
$2,057
per person
Jun 2 - Jun 5
found 14 hours ago
Roundtrip non-stop flight included
Dallas (DFW) to Florence (FLR)
9.2/10 Wonderful! (1,002 reviews)
We loved staying here for our first visit to Florence.. perfect location , warm & friendly staff , lovely room with balcony & comfy bed as well as a fantastic breakfast… Hopefully will return! X

Reviewed on Mar 8, 2026

Where to stay in Sant' Ambrogio

Find the best Sant' Ambrogio areas and neighborhoods for the activities you enjoy most. Learn more about Sant' Ambrogio
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Sant' Ambrogio Hotel Deals

Hotel Bodoni

Hotel Bodoni

2 out of 5
Via Martiri del Popolo, 27 Florence FI
$96 nightly
The price is $116 total per night from Mar 23 to Mar 24
$116 total
Mar 23 - Mar 24
Total with taxes and fees
8.2/10 Very Good! (805 reviews)
The staff were great and the rooms were clean and beds comfortable. The hotel is dated but I don't mind, its got charm. The only concern I had is that there is no chain or bolt on the inside of the bedroom doors. This is concerning as a female solo traveller and makes it hard for me to sleep at night ...

Reviewed on Mar 16, 2026

Hotel Bodoni
Hotel Bavaria

Hotel Bavaria

1 out of 5
Borgo Albizi 26 Florence FI
$75 nightly
The price is $91 total per night from Mar 19 to Mar 20
$91 total
Mar 19 - Mar 20
Total with taxes and fees
8.2/10 Very Good! (424 reviews)
Close to everything. All walking distance. Nice size room and bathroom. Great shower with loads of hot water and water pressure. Beautiful old building, but with it, no elevator. Lots of stairs to get to rooms. That is truly the only negative issue.

Reviewed on Mar 15, 2026

Hotel Bavaria
Hotel Regency

Hotel Regency

5 out of 5
Piazza M. D'Azeglio, 3 Florence FI
Fully refundableReserve now, pay when you stay
$371 nightly
The price is $427 total per night from Mar 18 to Mar 19
$427 total
Mar 18 - Mar 19
Total with taxes and fees
Hotel Regency
See all 521 properties in Sant' Ambrogio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
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Discover the most popular places to visit in Sant' Ambrogio

Great Synagogue of Florence

Great Synagogue of Florence is just one of the places to see in Florence, so why not enjoy the other things to explore during your travels? Experience the fascinating museums and acclaimed art scene in this vibrant area.

Great Synagogue of Florence

Church of Sant'Ambrogio

After visiting Church of Sant'Ambrogio, make a plan to see the other sights and activities in Florence. Stroll along the riverfront or visit the churches in this vibrant area.

Church of Sant'Ambrogio

Piazza Massimo D'Azeglio

Find out about the history of Florence when you take a trip to Piazza Massimo D'Azeglio. Stroll along the riverfront or visit the churches in this vibrant area.

Piazza Massimo D'Azeglio

Things to do

Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

$26
per adult
80% of travellers recommend
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
Micheal Angelo's David

Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket

$37
per adult
86% of travellers recommend
Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket
Uffizi Gallery Small-Group Guided Tour with Skip-the-Line

Uffizi Gallery: Small Group Guided Tour or Reserved Entry Ticket

$50
per adult
86% of travellers recommend
Uffizi Gallery: Small Group Guided Tour or Reserved Entry Ticket
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.