Santa Ana Vacation Rentals

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Check prices for these dates

In two weeks
Nov 20 - Nov 22
In two months
Jan 1 - Jan 3
In three months
Jan 29 - Jan 31
In four months
Feb 26 - Feb 28

Our top choices for Santa Ana vacation rentals

A compact bedroom with a bed, a small table with a plant, and a bench with pillows. A kitchenette is visible in the background.

1. Hostted

Hostted
2.5 star property
Isla de Flores
8.6 out of 10, Excellent, (14 reviews)
"everything was excellent!"
United States
Hilda
$60 nightly
The price is $69
Nov 10 - Nov 11
Total with taxes and fees
Hostted
A courtyard with wicker furniture, potted plants, and a mural of leaves on the wall.

2. Casa Astral

Casa Astral
2.0 star property
Flores
$450 nightly
The price is $549
Nov 8 - Nov 9
Total with taxes and fees
Casa Astral
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Find vacation rentals that suit your style

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Cabins
Cabins
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Apartments
Apartments

Top Santa Ana Hotel Reviews

An outdoor swimming pool area with a table and chairs, surrounded by a tiled patio.
Hotel Campestre Santa Ana

Hotel Campestre Santa Ana

Hotel Campestre Santa Ana
Santa Ana

10/10 Excellent

The hotel, consisting of separate cabanas, is conveniently located on a main road near Flores, Guatemala. We arrived in a high-roof van with a roof rack and were able to access the property without any issues. We greatly enjoyed the grilled dinner for 4. The pool was very comfortable. The staff was very friendly and helpful!
United States
Mitree
Reviewed June 8, 2026
Hotel Campestre Santa Ana

Find out more about Santa Ana

Everything you need to know about Santa Ana vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Ana vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Ana vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santa Ana vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Ana. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Ana in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $69 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santa Ana rentals

At Expedia, we put the best Santa Ana vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Ana rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Ana vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Ana. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently Asked Questions

Are there vacation rentals in Santa Ana?

Yes, you can find vacation rentals close to the most popular points of interest in Santa Ana, or you can go with a more remote option if you'd like a relaxing place to stay.

What are some of the best vacation home rentals that Santa Ana has to offer?

Casa Victoria 1: You might want to consider this vacation home rental near Santa Ana, which is equipped with a balcony, air-conditioning, and laundry facilities to help you feel comfortable during your stay. It has 8 bedrooms in addition to a kitchen with a microwave and kitchenware.

How many vacation rentals are there in Santa Ana?

With 3 Expedia vacation rentals, you're sure to find just the right place for your Santa Ana stay.

What can I see and do in Santa Ana?

While you're exploring the area, Lake Petén Itzá and Las Guacamayas Biological Station are a couple of picturesque spots to get outside and enjoy nature. San Miguel & Tayazal and Maya Mall are a couple of places you'll find in the larger area.

What are vacation rentals like in Santa Ana?

Vacation rentals are privately owned properties you can stay in for several days or longer in Santa Ana. Vacation rentals offer extras like WiFi and washers and dryers so you'll feel right at home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of seclusion away from public hotel elevators and busy lobbies while still allowing you the experience of travel. You'll also find more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a great option for a family trip or a small group gathering.