Santa Clara Vacations
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Your Santa Clara Vacation
Lock in a Santa Clara vacation package that has everything you need without any unnecessary extras. Great for distilleries and craft breweries, bars and pubs and cafes, think about staying in the neighborhood of El Cangrejo. A trip to Santa Clara is an excellent opportunity to take in the sights. Make sure you visit big-name attractions such as Multiplaza Pacific Mall, Avenida Balboa and Via Espana. A few clicks is all it takes to create a customized Santa Clara vacation on Expedia.
Price found within the past 48 hours. Click for updated prices.
- Yoo by Wynwood House
Aug 21 - Aug 29Yoo by Wynwood House + Flight
Calidonia8 nights9.4/10 - Exceptional (6 reviews)"Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about..."Reviewed July 26, 2025Roundtrip • Georgetown (GEO) - Panama City (PTY)GEO - PTY • Nonstop PTY - GEO • Nonstop - Central Hotel Panama Casco Viejo
Jul 4 - Jul 11Central Hotel Panama Casco Viejo + Flight
Casco Viejo7 nights9.2/10 - Wonderful (1,003 reviews)"The staff were so helpful and friendly. Great location and atmosphere."Reviewed June 3, 2026Roundtrip • New York (JFK) - Panama City (PTY)JFK - PTY • Nonstop PTY - JFK • Nonstop - Hotel Riu Plaza Panama
Aug 18 - Aug 23Hotel Riu Plaza Panama + Flight
Bella Vista5 nights9.0/10 - Wonderful (5,539 reviews)"My stay at the Riu in Panama was excellent , customer service, meals and staff was outstanding. I highly recommend this property"Reviewed June 4, 2026Roundtrip • New York (JFK) - Panama City (PTY)JFK - PTY • Nonstop PTY - JFK • Nonstop$1,410$928found 1 day agoper traveler - Megapolis Hotel Panamá
Aug 18 - Aug 23Megapolis Hotel Panamá + Flight
San Francisco5 nights8.4/10 - Very Good (1,544 reviews)"Rooms were great. We had a balcony room, great view! I love that there were food options in the hotel and you could walk right over to the outlet mall! Great location. Uber rides were so easy. Breakfast being included was such a plus and it was tasty!! I would definitely stay here again! And the shower!!!! Always had hot water! It was relaxing. Along with the ice cold room AC. We will be back!"Reviewed June 3, 2026Roundtrip • New York (JFK) - Panama City (PTY)JFK - PTY • Nonstop PTY - JFK • Nonstop$1,637$1,083found 1 day agoper traveler - Casa Lefevre By Wynwood House
Aug 21 - Aug 29Casa Lefevre By Wynwood House + Flight
Casco Viejo8 nights9.6/10 - Exceptional (15 reviews)"If you want to explore Casco Viejo, the location does not get any better than this. The balcony faces Cathedral Plaza and is a quick walk to many galleries, restaurants and clubs. The apartment I was in had lots of charm and a great use of space. The check in and check out process was super easy. Also, the Wynwood team is always available on WhatsApp if there are any issues or if you need anything. "Reviewed May 19, 2026Roundtrip • Georgetown (GEO) - Panama City (PTY)GEO - PTY • Nonstop PTY - GEO • Nonstop
Where to stay in Santa Clara
Find the best Santa Clara areas and neighborhoods for the activities you enjoy most. Learn more about Santa Clara
Casco Viejo
4.5/5(179 area reviews)
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Santa Clara Hotel Deals
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $127 total per night from Jun 29 to Jun 30
$127 total
Jun 29 - Jun 30
Total with taxes and fees
9/10 Wonderful! (5,539 reviews)
"My stay at the Riu in Panama was excellent , customer service, meals and staff was outstanding. I highly recommend this property"
Reviewed on Jun 4, 2026
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$137 nightly
The price is $151 total per night from Jun 29 to Jun 30
$151 total
Jun 29 - Jun 30
Total with taxes and fees
8.6/10 Excellent! (2,575 reviews)
"I highly recommend to persons who want a hassle free trip to and from the airport."
Reviewed on Jun 3, 2026
Dreams Playa Bonita Panama - All Inclusive
KM 7, Road to Veracruz Veracruz Panama
Fully refundableReserve now, pay when you stay
$268 nightly
The price is $268 total per night from Jul 5 to Jul 6
$268 total
Jul 5 - Jul 6
Total with taxes and fees
7.6/10 Good! (1,001 reviews)
"Nice"
Reviewed on Jun 1, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Clara
Multiplaza Pacific Mall
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Cinta Costera
After visiting Cinta Costera, make a plan to see the other sights and activities in Panama City. While you're in the area, stroll along the seaside.
Avenida Balboa
You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.
Things to do
Panama City: POIN Swing Experience
$29
per adult
100% of travellers recommend
Panama City: Poin Full Package Experience
$140
per adult
98% of travellers recommend
All-inclusive 8-hour catamaran tour to Isla Taboga from Panama City
$89
per adult
96% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.