Santa Clara Vacations from $899

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Your Santa Clara Vacation

Lock in a Santa Clara vacation package that has everything you need without any unnecessary extras. Great for distilleries and craft breweries, bars and pubs and cafes, think about staying in the neighborhood of El Cangrejo. A trip to Santa Clara is an excellent opportunity to take in the sights. Make sure you visit big-name attractions such as Multiplaza Pacific Mall, Avenida Balboa and Via Espana. A few clicks is all it takes to create a customized Santa Clara vacation on Expedia.

The Latest Santa Clara Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Riande Aeropuerto Hotel & Casino

$899

per person

Oct 14 - Oct 18

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

8.6/10 Excellent! (1,811 reviews)

Stay the night in transit. Convenient for travellers.

Reviewed on Sep 6, 2026

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

$1,364

per person

Nov 10 - Nov 16

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9.2/10 Wonderful! (1,001 reviews)

Staff was amazing

Reviewed on Sep 6, 2026

Megapolis Hotel Panamá

San Francisco

Save 100% on your flight

$1,108

per person

Oct 7 - Oct 12

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

8.4/10 Very Good! (1,692 reviews)

Casa Mallet by Wynwood House

Casco Viejo

Save 100% on your flight

$1,328

per person

Nov 18 - Nov 22

found 1 day ago

Roundtrip flight included

Georgetown (GEO) to Panama City (PTY)

9.8/10 Exceptional! (29 reviews)

Nice apartment ! Clean and great location

Reviewed on Aug 13, 2026

Decapolis Hotel Panama City

San Francisco

$966

per person

Oct 7 - Oct 12

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

8.6/10 Excellent! (1,716 reviews)

Where to stay in Santa Clara

Find the best Santa Clara areas and neighborhoods for the activities you enjoy most. Learn more about Santa Clara

A waterfront cityscape with historic buildings and a prominent clock tower.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

A cityscape with modern skyscrapers, including a distinctive twisting tower.

Bella Vista

1 out of top 10 points of interest in this area

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

A bridge over a body of water with several boats.

San Francisco

1 out of top 10 points of interest in this area

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

A coastal city skyline with high-rise buildings, palm trees, and a clear sky.

Calidonia

2 out of top 10 points of interest in this area

You might enjoy the shopping while in Calidonia. Via Espana is a notable sight, and you can get around town at Lotería Station or Santo Tomás Station to see more of the city.

Santa Clara Hotel Deals

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama

Fully refundableReserve now, pay when you stay

$123 nightly

$135 total

Sep 28 - Sep 29

Total with taxes and fees

9/10 Wonderful! (5,937 reviews)

"To stay at this hotel is the best decision you can make."

Reviewed on Sep 7, 2026

Central Hotel Panama Casco Viejo

Plaza de la Independencia Casco Viejo Panama City Panama

Fully refundableReserve now, pay when you stay

$183 nightly

$202 total

Oct 6 - Oct 7

Total with taxes and fees

9/10 Wonderful! (1,009 reviews)

"Staff was amazing"

Reviewed on Sep 6, 2026

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama

Fully refundable

$132 nightly

$145 total

Oct 6 - Oct 7

Total with taxes and fees

8.6/10 Excellent! (2,713 reviews)

"Stay was great"

Reviewed on Sep 6, 2026

See all 1,821 properties in Santa Clara

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.