Santa Clara Vacations from $650

Book a Hotel + Flight or Car together to unlock savings

Your Santa Clara Vacation

Lock in a Santa Clara vacation package that has everything you need without any unnecessary extras. Great for distilleries and craft breweries, bars and pubs and cafes, think about staying in the neighborhood of El Cangrejo. A trip to Santa Clara is an excellent opportunity to take in the sights. Make sure you visit big-name attractions such as Multiplaza Pacific Mall, Avenida Balboa and Via Espana. A few clicks is all it takes to create a customized Santa Clara vacation on Expedia.

The Latest Santa Clara Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Nowhere

Nowhere

3 out of 5
Save 100% on your flight
Price was $959, price is now $650 per person
$650
per person
Nov 5 - Nov 12
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
9/10 Wonderful! (16 reviews)
What a uniqe location! Get up early, take your time to take in amazing birds and wildlife surrounding you!

Reviewed on Feb 28, 2025

Central Hotel Bocas del Toro

Central Hotel Bocas del Toro

3 out of 5
Price was $3,552, price is now $1,776 per person
$1,776
per person
Nov 5 - Nov 12
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
No reviews
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $2,544, price is now $1,400 per person
$1,400
per person
Nov 10 - Nov 17
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (976 reviews)
An exquisite home base for an exploration of Casco Viejo. VERY reasonably priced for what you get.

Reviewed on Aug 30, 2025

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was $1,262, price is now $856 per person
$856
per person
Nov 10 - Nov 17
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (4,208 reviews)
The property was very clean and staff

Reviewed on Sep 1, 2025

La Coralina Island House

La Coralina Island House

3.5 out of 5
Save 100% on your flight
Price was $1,971, price is now $1,350 per person
$1,350
per person
Oct 18 - Oct 25
found 10 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.4/10 Exceptional! (84 reviews)
Beautiful grounds and love the included yoga, meditation, and work outs. They provided free cooked to order breakfast with coffee and juice. Staff was friendly and helpful

Reviewed on Aug 30, 2025

Where to stay in Santa Clara

Find the best Santa Clara areas and neighborhoods for the activities you enjoy most. Learn more about Santa Clara
Default Image

Casco Viejo

4.5/5(178 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Santa Clara Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $120 total per night from Sep 2 to Sep 3
$120 total
Sep 2 - Sep 3
Total with taxes and fees
Hotel Riu Plaza Panama
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
Fully refundableReserve now, pay when you stay
$217 nightly
The price is $217 total per night from Sep 28 to Sep 29
$217 total
Sep 28 - Sep 29
Total with taxes and fees
Dreams Playa Bonita Panama - All Inclusive
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi, Panama City
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $89 total per night from Sep 2 to Sep 3
$89 total
Sep 2 - Sep 3
Total with taxes and fees
Waymore Hotel Spa & Casino
See all 1,527 properties in Santa Clara
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Clara

Rainy day in Panama City but the charm of this city never ends. A beautiful rainbow over the city invites us to spend a bright day in paradise. #LifeAtExpedia

Multiplaza Pacific Mall

4.5/5(634 reviews)

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Cinta Costera

Cinta Costera

4.5/5(456 reviews)

Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera
Cinta Costera a wonderful pedestrian walkway with a separate lane for bicyclists and skateboarders #OrbitzTravel

Avenida Balboa

4/5(554 reviews)

You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa

Things to do

Slingshot Tour Panama

Slingshot Tour Panama

$120
per adult
80% of travellers recommend
Slingshot Tour Panama
Day Tour

Day Tour in San Blas Islands All Included Visiting 4 Islands

$149
per adult
94% of travellers recommend
Day Tour in San Blas Islands All Included Visiting 4 Islands
Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

$50
per adult
96% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.