Santa Clara Vacations from $862

Book a Hotel + Flight or Car together to unlock savings

Your Santa Clara Vacation

Lock in a Santa Clara vacation package that has everything you need without any unnecessary extras. Great for distilleries and craft breweries, bars and pubs and cafes, think about staying in the neighborhood of El Cangrejo. A trip to Santa Clara is an excellent opportunity to take in the sights. Make sure you visit big-name attractions such as Multiplaza Pacific Mall, Avenida Balboa and Via Espana. A few clicks is all it takes to create a customized Santa Clara vacation on Expedia.

The Latest Santa Clara Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Villa Botero By Casa Mojito B&B

Villa Botero By Casa Mojito B&B

3 out of 5
Price was $1,302, price is now $862 per person
$862
per person
Jan 10 - Jan 16
found 10 hours ago
Roundtrip flight included
New York (JFK) to Panama City (PTY)
9.8/10 Exceptional! (60 reviews)
Host was excellent. Great communication and very helpful. The rooms were nice and great value.

Reviewed on Apr 18, 2025

Central Hotel Bocas del Toro

Central Hotel Bocas del Toro

3 out of 5
Save 100% on your flight
Price was $4,340, price is now $2,333 per person
$2,333
per person
Dec 5 - Dec 12
found 15 hours ago
Roundtrip flight included
New York (JFK) to Panama City (PTY)
No reviews
La Coralina Island House

La Coralina Island House

3.5 out of 5
Save 100% on your flight
Price was $2,777, price is now $1,840 per person
$1,840
per person
Dec 5 - Dec 12
found 15 hours ago
Roundtrip flight included
New York (JFK) to Panama City (PTY)
9.4/10 Exceptional! (91 reviews)
Everything was great , lovely and peaceful place.

Reviewed on Sep 29, 2025

Nowhere

Nowhere

3 out of 5
Price was $1,274, price is now $863 per person
$863
per person
Dec 5 - Dec 12
found 15 hours ago
Roundtrip flight included
New York (JFK) to Panama City (PTY)
9.2/10 Wonderful! (17 reviews)
What a uniqe location! Get up early, take your time to take in amazing birds and wildlife surrounding you!

Reviewed on Feb 28, 2025

Tropical Suites Hotel

Tropical Suites Hotel

3.5 out of 5
Save 100% on your flight
Price was $2,031, price is now $1,392 per person
$1,392
per person
Dec 5 - Dec 12
found 15 hours ago
Roundtrip flight included
New York (JFK) to Panama City (PTY)
9.2/10 Wonderful! (285 reviews)
Very professional staff and very well organized

Reviewed on Sep 13, 2025

Where to stay in Santa Clara

Find the best Santa Clara areas and neighborhoods for the activities you enjoy most. Learn more about Santa Clara
Default Image

Casco Viejo

4.5/5(178 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Find hotels in Casco Viejo

Santa Clara Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $126 total per night from Nov 5 to Nov 6
$126 total
Nov 5 - Nov 6
Total with taxes and fees
9/10 Wonderful! (4,445 reviews)
The room was spotless.

Reviewed on Oct 30, 2025

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
Fully refundable
$124 nightly
The price is $136 total per night from Nov 27 to Nov 28
$136 total
Nov 27 - Nov 28
Total with taxes and fees
8.4/10 Very Good! (2,272 reviews)
It was a nice property

Reviewed on Oct 28, 2025

Crowne Plaza Panama Airport by IHG
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
Fully refundableReserve now, pay when you stay
$272 nightly
The price is $272 total per night from Dec 3 to Dec 4
$272 total
Dec 3 - Dec 4
Total with taxes and fees
7.4/10 Good! (1,003 reviews)
Had a great stay. I would definitely recommend it to others. On the downside, the rooms could use an upgrade and cleaning of the rooms could be better.

Reviewed on Oct 21, 2025

Dreams Playa Bonita Panama - All Inclusive
See all 1,552 properties in Santa Clara
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Clara

Rainy day in Panama City but the charm of this city never ends. A beautiful rainbow over the city invites us to spend a bright day in paradise. #LifeAtExpedia

Multiplaza Pacific Mall

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Cinta Costera

Cinta Costera

Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera
Cinta Costera a wonderful pedestrian walkway with a separate lane for bicyclists and skateboarders #OrbitzTravel

Avenida Balboa

You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa

Things to do

Panama City: Zip Line Experience Over The City & a Cocktail

Panama City: Zip Line Experience Over The City

$40
per adult
90% of travellers recommend
Panama City: Zip Line Experience Over The City
The Panama Barcrawl - The OG Crawl

The Panama Barcrawl - The OG Crawl (Panama City, Panama)

$65
per adult
96% of travellers recommend
The Panama Barcrawl - The OG Crawl (Panama City, Panama)
Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

$44
per adult
96% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.