Santa Cruz Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Santa Cruz Hotel Deals

Hotel de Turistas Iquitos

Hotel de Turistas Iquitos

3 out of 5
Napo Iquitos Loreto
Fully refundableReserve now, pay when you stay
$65 nightly
The price is $65 total per night from Aug 5 to Aug 6
$65 total
Aug 5 - Aug 6
8.8/10 Excellent! (51 reviews)
"Excellent location"

Reviewed on Jul 26, 2026

Hotel de Turistas Iquitos
DoubleTree by Hilton Iquitos

DoubleTree by Hilton Iquitos

5 out of 5
Napo 258 Iquitos
Fully refundableReserve now, pay when you stay
$113 nightly
The price is $113 total per night from Jul 29 to Jul 30
$113 total
Jul 29 - Jul 30
DoubleTree by Hilton Iquitos
El Dorado Classic Hotel

El Dorado Classic Hotel

3 out of 5
Napo 362 Iquitos Loreto
Fully refundableReserve now, pay when you stay
$47 nightly
The price is $47 total per night from Aug 28 to Aug 29
$47 total
Aug 28 - Aug 29
El Dorado Classic Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Cruz Vacation Packages

Santa Cruz Essential Information

Language
Spanish
Currency
Peruvian sols
Local Welcome
¡Hola!
Local Goodbye
Adiós

More vacations you might like

Frequently asked questions

How much does a Santa Cruz vacation package cost?
You'll find cheap prices on Expedia for your Santa Cruz getaway. However, factors like the length of stay, hotel choice and season will influence how much your vacation to Santa Cruz costs.
What are the cheapest months to go to Santa Cruz?
February, August and December are the best times to search for cheap Santa Cruz vacation packages. Choosing to travel in quieter months means you can generally find reduced prices on accommodations and flights.
How many days is enough for Santa Cruz?
Usually, a handful of days is enough to check out the major attractions during your Santa Cruz vacation. However, if you prefer to have more time to relax or take day tours, think about extending your trip.
How to find the best Santa Cruz package deals?
Bagging a cheap Santa Cruz package deal is easy with Expedia. After you've entered your trip dates and destination under our "Packages" tab, set your budget, add some filters and browse what's available. You can personalize your search by "Property class," "Number of bedrooms," "Traveler experience" and more. Order the results by "Price: low to high" to discover the most wallet-friendly Santa Cruz package deals. Want a simple trick to get the biggest savings? Be flexible with your departure dates and consider traveling on a weekday, when prices are typically lower.
Is it cheaper to book a Santa Cruz vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your hotel, flight and car rental into one great-value price and you could save hundreds of dollars. You'll usually land a better deal than booking each component individually. And you'll still get the flexibility to create a customized Santa Cruz vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Santa Cruz?
If you've got your Santa Cruz vacation dates confirmed, book as early as you can to bag some unbeatable deals. With Expedia, you can typically reserve some flights up to one year ahead of time. Prefer spur-of-the-moment adventures? Our last-minute deals are ideal for impromptu escapes.
Does Expedia offer Book Now, Pay Later Santa Cruz vacation packages?
If you're like us, you love traveling the world but don't love the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With help from online lender Affirm, you can break down the overall cost of your Santa Cruz break across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can secure great vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.