Santa Lucia Vacations from $1,196

Book a Hotel + Flight or Car together to unlock savings

Photo by William Keller

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Santa Lucia Vacation

Take the stress and hassle out of planning your next break by booking a Santa Lucia vacation package. Immerse yourself in the sounds and sights of this wonderful neighborhood and enjoy everything it has to offer. Your trip to Santa Lucia wouldn't be complete without seeing popular attractions nearby such as Cathedral of Syracuse, Temple of Apollo and Museo Archeologico Regionale Paolo Orsi. Don't just dream it — take action! Secure your ideal Santa Lucia vacation with Expedia and enjoy traveling your way.

The Latest Santa Lucia Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Continental

Hotel Continental

Taormina City Centre
$1,196
per person
Oct 14 - Oct 19
just found
Roundtrip non-stop flight included
Boston (BOS) to Catania (CTA)
9.2/10 Wonderful! (670 reviews)
Eurostars Monte Tauro

Eurostars Monte Tauro

Save 100% on your flight
$2,013
per person
Oct 14 - Oct 19
just found
Roundtrip non-stop flight included
Boston (BOS) to Catania (CTA)
8.6/10 Excellent! (486 reviews)
Great staff and excellent pool facilities.

Reviewed on Aug 31, 2026

San Domenico Palace, Taormina, A Four Seasons Hotel

San Domenico Palace, Taormina, A Four Seasons Hotel

Taormina City Centre
Save 100% on your flight
$6,609
per person
Oct 13 - Oct 19
found 12 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Catania (CTA)
9.4/10 Exceptional! (301 reviews)
This was one of the best experiences we’ve had, and really appreciate the staff at this beautiful hotel. The space is lovely, as are the rooms. The location is incredible and the views can’t be beat. Finally, the team there were so helpful and genuinely invested in our comfort. They went way out of their way to accommodate vegan diets and did an incredible incredible job. Easily in the top 5 of our hotel experiences and could be the top spot. Highly recommended!

Reviewed on Aug 23, 2026

Palazzo Vecchio Taormina

Palazzo Vecchio Taormina

Taormina City Centre
$1,628
per person
Nov 15 - Nov 19
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Catania (CTA)
9.8/10 Exceptional! (61 reviews)
Hotel Metropole Taormina

Hotel Metropole Taormina

Taormina City Centre
Save 100% on your flight
$3,408
per person
Oct 13 - Oct 19
found 12 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Catania (CTA)
9.4/10 Exceptional! (277 reviews)
Amazing

Reviewed on Jul 12, 2026

Where to stay in Santa Lucia

Find the best Santa Lucia areas and neighborhoods for the activities you enjoy most. Learn more about Santa Lucia
Ancient ruins with stone columns and a building with green shutters in the background.

Ortigia

4 out of top 10 points of interest in this area

The historic heart of Syracuse is dotted with churches and atmospheric piazzas, where visitors enjoy sweeping sea views while dining at gourmet restaurants.

Find hotels in Ortigia
Ancient ruins with stone steps and walls, surrounded by trees.

Neapolis

2 out of top 10 points of interest in this area

While visiting Neapolis, you might make a stop by sights like Archaeological Park of Neapolis and Greek Theatre of Syracuse.

Find hotels in Neapolis
An ancient amphitheater with stone ruins and a grassy field.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider a stop by Ionian Sea while you're exploring the neighborhood.

Find hotels in Tiche
A coastal cityscape with modern buildings, palm trees, and a rocky cliff.

Grottasanta

1 out of top 10 points of interest in this area

Grottasanta is noteworthy for its historic sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

Find hotels in Grottasanta
An aerial view of a coastal city with a prominent fortified structure and a densely built urban area in the background.

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

Find hotels in Acradina

Santa Lucia Hotel Deals

Grande Albergo Alfeo

Grande Albergo Alfeo

Via Nino Bixio 5 Syracuse SR
$116 nightly
$133 total
Oct 2 - Oct 3
Total with taxes and fees
8.6/10 Excellent! (692 reviews)
"Great spot in Siracusa and easy walk into Ortigia. The staff was friendly and Alessandro was a great help to us and answered our questions in English and Italian. Plus who can resist the refreshingly delicious free granita."

Reviewed on Aug 25, 2026

Grande Albergo Alfeo
Caportigia Boutique Hotel

Caportigia Boutique Hotel

Viale Montedoro 76 Syracuse SR
$211 nightly
$244 total
Sep 3 - Sep 4
Total with taxes and fees
Caportigia Boutique Hotel
Fortaleza Charme House

Fortaleza Charme House

Via Eritrea 6 Syracuse SR
$190 nightly
$216 total
Sep 28 - Sep 29
Total with taxes and fees
10/10 Exceptional! (39 reviews)
"Amazing place!"

Reviewed on Aug 26, 2026

Fortaleza Charme House
See all 3,825 properties in Santa Lucia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations
Golf Vacations
Golf Vacations
Luxury Vacations
Luxury Vacations
Romantic Vacations
Romantic Vacations
Ski Vacations
Ski Vacations
Gay Friendly Vacations
LGBTQ Friendly Vacations
LGBTQ Friendly Vacations
Adventure Vacations
Adventure Vacations
Vacations in Month
Where to go when
Where to go when
Honeymoon Vacations
Honeymoon Vacations
Mountain Vacations
Mountain Vacations
Fishing Vacations
Fishing Vacations
Adults Only Vacations
Adults Only Vacations
Waterpark Vacations
Waterpark Vacations
Scuba Diving Vacations
Scuba Diving Vacations
Yoga Vacations
Yoga Vacations
Cheap Vacations
Cheap Vacations
Solo Vacations
Solo Vacations

Stay near popular Santa Lucia attractions

Porto Piccolo

8.8/10 (189 reviews)
Explore the waterfront in Syracuse with a trip to Porto Piccolo. Wander the seaside in this culturally rich area.
See properties

Madonna delle Lacrime

8.8/10 (16 reviews)
You can study the exhibits at Madonna delle Lacrime, a museum with a story of its own, during your trip to Syracuse. Wander the seaside in this culturally rich area.
See properties

Syracuse Forum Ruins

You can learn about the history of Syracuse with a trip to Syracuse Forum Ruins. Wander the beautiful beaches and seaside in this culturally rich area.
See properties

Santa Lucia al Sepolcro Basilica

Find out about the history of Syracuse when you take a trip to Santa Lucia al Sepolcro Basilica. Wander the seaside in this culturally rich area.
See properties

Piazza Santa Lucia

8.0/10 (1 review)
You can find out about the history of Syracuse with a trip to Piazza Santa Lucia. Wander the beautiful beaches and seaside in this culturally rich area.
See properties

Santa Lucia Bridge

8.8/10 (13 reviews)
Santa Lucia Bridge is just one of the places to see in Syracuse, so why not enjoy the other things to explore during your travels? Discover the museums and monuments in this walkable area.
See properties

Papyrus Museum

8.0/10 (1 review)
You can browse the exhibits at Papyrus Museum, a museum with a storied past, during your travels to Syracuse. Wander the seaside in this culturally rich area.
See properties

Things to do

Syracuse: Ortigia Island and Sea Caves Boat Tour

Syracuse: Ortigia Island and Sea Caves Boat Tour

$23
per adult
Syracuse: Ortigia Island and Sea Caves Boat Tour
Siracusa: Ortygia Island Boat Tour with Grotto Visit

Siracusa: Ortygia Island Boat Tour with Grotto Visit

$29
per adult
Siracusa: Ortygia Island Boat Tour with Grotto Visit
Syracuse: Pillirina, Ortigia, and Sea Caves Tour by Boat

Syracuse: Pillirina, Ortigia, and Sea Caves Tour by Boat

$47
per adult
Syracuse: Pillirina, Ortigia, and Sea Caves Tour by Boat
See all activities in Syracuse
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.