Santa Lucia Vacations from $588

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Your Santa Lucia Vacation

Take the stress and hassle out of planning your next break by booking a Santa Lucia vacation package. Immerse yourself in the sounds and sights of this wonderful neighborhood and enjoy everything it has to offer. Your trip to Santa Lucia wouldn't be complete without seeing popular attractions nearby such as Cathedral of Syracuse, Temple of Apollo and Museo Archeologico Regionale Paolo Orsi. Don't just dream it — take action! Secure your ideal Santa Lucia vacation with Expedia and enjoy traveling your way.

The Latest Santa Lucia Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Bed and Breakfast Opera

Bed and Breakfast Opera

3 out of 5
Catania City Centre
Price was $748, price is now $588 per person
$588
per person
Apr 17 - Apr 22
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Catania (CTA)
8/10 Very Good! (73 reviews)
This accommodation had a great location, central and close to great restaurants and sight seeing. The staff & service was excellent. I did not have the breakfast so I can't speak to that. The room quality was average. Needs an update/refresh. Street noise was very loud on busy street and difficult to sleep soundly.

Reviewed on Sep 25, 2025

Ollen apartments

Ollen apartments

4 out of 5
Picanello-Ognina-Barriera-Canalicchio
Price was $1,980, price is now $1,431 per person
$1,431
per person
Apr 18 - Apr 24
found 1 day ago
Roundtrip flight included
Boston (BOS) to Catania (CTA)
9.6/10 Exceptional! (19 reviews)
Excellent throughout. Close enough to enjoy the city center (15mins by car) and beach (20mins by car), without getting caught up in the hustle and bustle of crowds. Exceptional staff, both caring and informative.

Reviewed on Aug 4, 2025

Hotel Continental

Hotel Continental

3 out of 5
Taormina City Centre
Price was $1,464, price is now $1,079 per person
$1,079
per person
Apr 10 - Apr 14
found 21 hours ago
Roundtrip non-stop flight included
New York (JFK) to Catania (CTA)
9.2/10 Wonderful! (613 reviews)
Received the last room available at the last minute! Great hotel and beautiful area and property.

Reviewed on Oct 28, 2025

Duomo Suites & Spa

Duomo Suites & Spa

4 out of 5
Catania City Centre
Price was $2,445, price is now $1,866 per person
$1,866
per person
Apr 8 - Apr 14
found 18 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Catania (CTA)
9.2/10 Wonderful! (417 reviews)
The room was clean and the staff were very helpful. Loved this spot.

Reviewed on Feb 2, 2026

Palazzo Artemide - VRetreats

Palazzo Artemide - VRetreats

4 out of 5
Ortigia
Price was $1,287, price is now $1,005 per person
$1,005
per person
Mar 26 - Apr 1
found 21 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Catania (CTA)
9.4/10 Exceptional! (658 reviews)
Very clean, elegant and comfortable. Pleasant and helpful staff.

Reviewed on Jan 11, 2026

Where to stay in Santa Lucia

Find the best Santa Lucia areas and neighborhoods for the activities you enjoy most. Learn more about Santa Lucia
Temple of Apollo featuring a ruin and heritage elements

Ortigia

4 out of top 10 points of interest in this area
4.5/5(147 area reviews)

The historic heart of Syracuse is dotted with churches and atmospheric piazzas, where visitors enjoy sweeping sea views while dining at gourmet restaurants.

Find hotels in Ortigia

Santa Lucia Hotel Deals

Grande Albergo Alfeo

Grande Albergo Alfeo

4 out of 5
Via Nino Bixio 5 Syracuse SR
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $119 total per night from Feb 21 to Feb 22
$119 total
Feb 21 - Feb 22
Total with taxes and fees
8.6/10 Excellent! (641 reviews)
Good front desk staff, welcoming breakfast staff, clean room and good area for walking to attractions.

Reviewed on Dec 2, 2025

Grande Albergo Alfeo
Caportigia Boutique Hotel

Caportigia Boutique Hotel

5 out of 5
Viale Montedoro 76 Syracuse SR
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $149 total per night from Feb 16 to Feb 17
$149 total
Feb 16 - Feb 17
Total with taxes and fees
9.2/10 Wonderful! (259 reviews)
Valentina & Malvina

Reviewed on Jan 29, 2026

Caportigia Boutique Hotel
Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri

4 out of 5
42 Via Malta Syracuse SR
Fully refundableReserve now, pay when you stay
$126 nightly
The price is $143 total per night from Feb 6 to Feb 7
$143 total
Feb 6 - Feb 7
Total with taxes and fees
8.8/10 Excellent! (40 reviews)
Excelente ubicación!!!

Reviewed on Oct 10, 2025

Hotel Palazzo Cavalieri
See all 3,796 properties in Santa Lucia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Lucia

Porto Piccolo

4.5/5(11 reviews)

Explore the waterfront in Syracuse with a trip to Porto Piccolo. Wander the seaside in this culturally rich area.

Porto Piccolo

Syracuse Forum Ruins

You can learn about the history of Syracuse with a trip to Syracuse Forum Ruins. Wander the beautiful beaches and seaside in this family-friendly area.

Syracuse Forum Ruins

Madonna delle Lacrime

4/5(1 review)

You can study the exhibits at Madonna delle Lacrime, a museum with a story of its own, during your trip to Syracuse. Wander the seaside in this culturally rich area.

Madonna delle Lacrime

Things to do

Syracuse: Boat Tour with Captain Mirko, Snorkeling & Caves

Syracuse: Boat Tour with Captain Mirko, Snorkeling & Caves

$35
per adult
Syracuse: Boat Tour with Captain Mirko, Snorkeling & Caves
Syracuse: Pillirina, Ortigia, and Sea Caves Tour by Boat

Syracuse: Pillirina, Ortigia, and Sea Caves Tour by Boat

$47
per adult
Syracuse: Pillirina, Ortigia, and Sea Caves Tour by Boat
Excursion around Ortigia Island and sea caves

Boat tour of Ortigia Island and sea caves

$23
per adult
80% of travellers recommend
Boat tour of Ortigia Island and sea caves
See all activities in Syracuse
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.