Santa Lucia Vacations from $1,727

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Your Santa Lucia Vacation

Take the stress and hassle out of planning your next break by booking a Santa Lucia vacation package. Immerse yourself in the sounds and sights of this wonderful neighborhood and enjoy everything it has to offer. Your trip to Santa Lucia wouldn't be complete without seeing popular attractions nearby such as Cathedral of Syracuse, Temple of Apollo and Museo Archeologico Regionale Paolo Orsi. Don't just dream it — take action! Secure your ideal Santa Lucia vacation with Expedia and enjoy traveling your way.

The Latest Santa Lucia Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Palladio

Hotel Palladio

3 out of 5
Price was $2,478, price is now $1,727 per person
$1,727
per person
Jun 11 - Jun 17
found 10 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Catania (CTA)
9/10 Wonderful! (324 reviews)
Host was outstanding offsite parking was easily accessible only a minute from the hotel and it’s a prime location for all the sites. Wonderful stay.

Reviewed on Nov 14, 2025

Eurostars Monte Tauro

Eurostars Monte Tauro

4 out of 5
Save 100% on your flight
Price was $3,038, price is now $2,002 per person
$2,002
per person
Jun 11 - Jun 17
found 10 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Catania (CTA)
8.4/10 Very Good! (466 reviews)
Outstanding view, breakfast was fantastic, very clean, and convieniently located. Highly recommend.

Reviewed on Nov 22, 2025

Castello San Marco Charming Hotel & Spa

Castello San Marco Charming Hotel & Spa

4 out of 5
Save 100% on your flight
Price was $6,440, price is now $4,310 per person
$4,310
per person
Jun 11 - Jun 17
found 10 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Catania (CTA)
9.4/10 Exceptional! (149 reviews)
Absolutely loved our stay here! The Castello San Marco really is charming! The property is beautiful, the room was extremely spacious and comfortable, the breakfast was fantastic, and we can't say enough about how lovely the staff was! Alexandra and Flavia were so wonderful and helpful with everything we asked for. We would stay there again any time!

Reviewed on Oct 27, 2025

Panoramic Hotel

Panoramic Hotel

4 out of 5
Mazzaro
Save 100% on your flight
Price was $3,452, price is now $2,518 per person
$2,518
per person
Jun 11 - Jun 17
found 10 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Catania (CTA)
9.4/10 Exceptional! (558 reviews)
The hotel has magnificent views and terraces. Breakfast is very good and the staff is very polite and helpful. Our room was comfortable and clean. The bathroom was a little dated, but also clean.

Reviewed on Oct 10, 2025

Mazzarò Sea Palace - The Leading Hotels of the World

Mazzarò Sea Palace - The Leading Hotels of the World

5 out of 5
Mazzaro
Save 100% on your flight
Price was $6,560, price is now $5,079 per person
$5,079
per person
Jun 11 - Jun 17
found 10 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Catania (CTA)
9.6/10 Exceptional! (290 reviews)
Everything to the tiniest detail was excellent! From the manager’s welcome to Carmine our evening housekeeper, restaurant and bar staff, concierge Karina, and bell service it could not have been better. One of our best hospitality stays ever!!

Reviewed on Oct 30, 2025

Where to stay in Santa Lucia

Find the best Santa Lucia areas and neighborhoods for the activities you enjoy most. Learn more about Santa Lucia
Temple of Apollo featuring a ruin and heritage elements

Ortigia

4 out of top 10 points of interest in this area
4.5/5(147 area reviews)

The historic heart of Syracuse is dotted with churches and atmospheric piazzas, where visitors enjoy sweeping sea views while dining at gourmet restaurants.

Find hotels in Ortigia

Santa Lucia Hotel Deals

Grande Albergo Alfeo

Grande Albergo Alfeo

4 out of 5
Via Nino Bixio 5 Syracuse SR
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $105 total per night from Mar 27 to Mar 28
$105 total
Mar 27 - Mar 28
Total with taxes and fees
8.6/10 Excellent! (655 reviews)
Good front desk staff, welcoming breakfast staff, clean room and good area for walking to attractions.

Reviewed on Dec 2, 2025

Grande Albergo Alfeo
Caportigia Boutique Hotel

Caportigia Boutique Hotel

5 out of 5
Viale Montedoro 76 Syracuse SR
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $140 total per night from Mar 29 to Mar 30
$140 total
Mar 29 - Mar 30
Total with taxes and fees
9.4/10 Exceptional! (268 reviews)
Excellent modern property, staff are all amazing. Walkable to everything.

Reviewed on Mar 16, 2026

Caportigia Boutique Hotel
Piccolo Hotel Casa Mia

Piccolo Hotel Casa Mia

3 out of 5
Corso Umberto, 112 Syracuse SR
Fully refundableReserve now, pay when you stay
Get rates
Piccolo Hotel Casa Mia
See all 3,743 properties in Santa Lucia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Lucia

Porto Piccolo

Explore the waterfront in Syracuse with a trip to Porto Piccolo. Wander the seaside in this culturally rich area.

Porto Piccolo

Santa Lucia Bridge

Santa Lucia Bridge is just one of the places to see in Syracuse, so why not enjoy the other things to explore during your travels? Discover the museums and monuments in this walkable area.

Santa Lucia Bridge

Syracuse Forum Ruins

You can learn about the history of Syracuse with a trip to Syracuse Forum Ruins. Wander the beautiful beaches and seaside in this culturally rich area.

Syracuse Forum Ruins

Things to do

Siracusa: Ortygia Island Boat Tour with Grotto Visit

Siracusa: Ortygia Island Boat Tour with Grotto Visit

$29
per adult
Siracusa: Ortygia Island Boat Tour with Grotto Visit
Syracuse: Boat Tour with Captain Mirko, Snorkeling & Caves

Syracuse: Boat Tour with Captain Mirko, Snorkeling & Caves

$35
per adult
Syracuse: Boat Tour with Captain Mirko, Snorkeling & Caves
Syracuse: Pillirina, Ortigia, and Sea Caves Tour by Boat

Syracuse: Pillirina, Ortigia, and Sea Caves Tour by Boat

$47
per adult
Syracuse: Pillirina, Ortigia, and Sea Caves Tour by Boat
See all activities in Syracuse
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.