
Santa María Vacations from $270
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Your Santa María Vacation
With plenty of highlights as well as some hidden gems, this city is best explored with a Santa María vacation package. Find a place to stay in El Arenal, which is good for walking, watersports and coastal beaches. If some sightseeing is on the agenda during your trip to Santa María, swing by leading attractions such as General Villamil Beach. No matter your travel plans or budget, putting together the ultimate tailored Santa María vacation is a cinch with Expedia.
The Latest Santa María vacation packages
Price found within the past 48 hours. Click for updated prices.


Hotel Rio Guayas
Las Peñas
Price was $2,743, price is now $1,250 per person
$1,250
per person
Oct 6 - Oct 12
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Guayaquil (GYE)
10/10 Exceptional! (1 review)
I absolutely loved my stay at Hotel Rio Guayas! The staff was incredibly kind, attentive, and made me feel truly welcome. One of the highlights was the stunning river view from the restaurant absolutely unforgettable. The hotel feels luxurious, with beautiful artwork and elegant decor throughout. Everything was spotless and comfortable. I highly recommend this place and would love to stay again! For Sureeee
Reviewed on Jul 30, 2025



Mansión Alcázar Boutique Hotel
Downtown Cuenca
Price was $1,223, price is now $923 per person
$923
per person
Sep 29 - Oct 4
found 9 hours ago
Roundtrip flight included
New York (NYC) to Guayaquil (GYE)
9.4/10 Exceptional! (300 reviews)
Hotel confused me for my sister who had a separate reservation. Even though I have platinum status she received the upgraded room. We had identified this at the time of checkin.
Service by hotel staff was way beyond expectations. We had two non hotel issues and hotel staff went out of their way to resolve. Can’t say enough about the staff.
Breakfast items were limited in types but items all were high quality so it balances out.
Reviewed on Jul 30, 2025
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View all tripsSanta María Hotel Deals

Hotel Presidente Beach Playas
C. 1, Playas, Guayas
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $104 total per night from Sep 17 to Sep 18
$104 total
Sep 17 - Sep 18

Karibao Resort Town
Km 7.5 Via a Playas Engabao, Gral Villamil, Playas, Guayas
$97 nightly
The price is $107 total per night from Sep 12 to Sep 13
$107 total
Sep 12 - Sep 13

Playa Paraíso
Km. 5.5 Vía a Data, General Villamil, Playas
Fully refundable
$182 nightly
The price is $200 total per night from Sep 1 to Sep 2
$200 total
Sep 1 - Sep 2
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.