Santa María Vacations from $270

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Your Santa María Vacation

With plenty of highlights as well as some hidden gems, this city is best explored with a Santa María vacation package. Find a place to stay in El Arenal, which is good for walking, watersports and coastal beaches. If some sightseeing is on the agenda during your trip to Santa María, swing by leading attractions such as General Villamil Beach. No matter your travel plans or budget, putting together the ultimate tailored Santa María vacation is a cinch with Expedia.

The Latest Santa María vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Boutique Santa Lucia

Hotel Boutique Santa Lucia

4 out of 5
Downtown Cuenca
Price was $353, price is now $270 per person
$270
per person
Nov 14 - Nov 16
found 11 hours ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9.2/10 Wonderful! (351 reviews)
Hot beverages were good

Reviewed on Aug 17, 2025

Hotel Rio Guayas

Hotel Rio Guayas

2.5 out of 5
Las Peñas
Price was $2,743, price is now $1,250 per person
$1,250
per person
Oct 6 - Oct 12
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Guayaquil (GYE)
10/10 Exceptional! (1 review)
I absolutely loved my stay at Hotel Rio Guayas! The staff was incredibly kind, attentive, and made me feel truly welcome. One of the highlights was the stunning river view from the restaurant absolutely unforgettable. The hotel feels luxurious, with beautiful artwork and elegant decor throughout. Everything was spotless and comfortable. I highly recommend this place and would love to stay again! For Sureeee

Reviewed on Jul 30, 2025

Hotel Cruz del Vado

Hotel Cruz del Vado

4.5 out of 5
Save 100% on your flight
Price was $574, price is now $400 per person
$400
per person
Nov 14 - Nov 16
found 11 hours ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9.4/10 Exceptional! (38 reviews)
Beautiful! Great service

Reviewed on Aug 12, 2025

Hotel El Conquistador

Hotel El Conquistador

4 out of 5
Downtown Cuenca
Price was $687, price is now $509 per person
$509
per person
Oct 8 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Guayaquil (GYE)
7.8/10 Good! (128 reviews)
Right in the heart of the historic district

Reviewed on Apr 29, 2024

Mansión Alcázar Boutique Hotel

Mansión Alcázar Boutique Hotel

4 out of 5
Downtown Cuenca
Price was $1,223, price is now $923 per person
$923
per person
Sep 29 - Oct 4
found 9 hours ago
Roundtrip flight included
New York (NYC) to Guayaquil (GYE)
9.4/10 Exceptional! (300 reviews)
Hotel confused me for my sister who had a separate reservation. Even though I have platinum status she received the upgraded room. We had identified this at the time of checkin. Service by hotel staff was way beyond expectations. We had two non hotel issues and hotel staff went out of their way to resolve. Can’t say enough about the staff. Breakfast items were limited in types but items all were high quality so it balances out.

Reviewed on Jul 30, 2025

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Santa María Hotel Deals

Hotel Presidente Beach Playas

Hotel Presidente Beach Playas

3 out of 5
C. 1, Playas, Guayas
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $104 total per night from Sep 17 to Sep 18
$104 total
Sep 17 - Sep 18
Hotel Presidente Beach Playas
Karibao Resort Town

Karibao Resort Town

4 out of 5
Km 7.5 Via a Playas Engabao, Gral Villamil, Playas, Guayas
$97 nightly
The price is $107 total per night from Sep 12 to Sep 13
$107 total
Sep 12 - Sep 13
Karibao Resort Town
Playa Paraíso

Playa Paraíso

4 out of 5
Km. 5.5 Vía a Data, General Villamil, Playas
Fully refundable
$182 nightly
The price is $200 total per night from Sep 1 to Sep 2
$200 total
Sep 1 - Sep 2
Playa Paraíso
See all 51 properties in Santa María
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does a Santa María vacation package cost?
You'll find cheap prices from $270 on Expedia for your Santa Marían escape. However, a range of factors like the length of stay, hotel choice and season will determine how much your vacation to Santa María costs.
What are the cheapest months to go to Santa María?
If you're hoping to score a cheap Santa María vacation package, consider traveling in December, January and February. You'll typically find better prices on hotels and airfares during these months — ideal for a budget-friendly getaway.
How many days is enough for Santa María?
With a well-organized travel plan, you can easily tick off the main Santa Marían attractions in a few days. But if you want to explore off the beaten track or go on day tours, think about booking your Santa María vacation for longer.
How to find the best Santa María package deals?
Use Expedia's filter tool to help you find some unbeatable Santa María package deals. When you start your search, simply set your maximum budget and then sort the results by "Price: low to high." If you want to save, plan your trip for midweek, or look for Santa María package deals in the off-season. Play around with your travel dates and you may land even bigger discounts. As a rule of thumb, it's usually best to book your vacation package as early as possible.
Is it cheaper to book a Santa María vacation as a package?
An Expedia vacation package could score you significant savings when compared to booking hotels and flights individually. Better still, you can customize your Santa Marían escape to fit your exact style. Choose your preferred flight time, select the hotel type and add a rental car. Explore our bundles to see how much you can save.
When to book a vacation package to Santa María?
If you've got your Santa María vacation dates finalized, book as soon as you can to snap up some awesome deals. With Expedia, you can often reserve some flights up to one year in advance. Prefer spontaneous trips? Our last-minute deals are perfect for jetting off on a whim.
Does Expedia offer Book Now, Pay Later Santa María vacation packages?
Your Santa María getaway should be an escape from your daily routine, not a reason for money-related stress. So to give you more flexibility, we've teamed up with online lender Affirm to offer you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and break down the cost over 3, 6 or 12 months. Plus, there aren't any hidden or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.