Santa Pera Vacations from $896

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Santa Pera Vacation

Say goodbye to the stress of planning and hello to a Santa Pera vacation package. With your travel details organized before you go, you can focus on discovering the best of this city, starting with El Cangrejo, which is great for distilleries and craft breweries, bars and pubs and cafes. Metromall Panama is among the must-see attractions to check off your to-do list during a trip to Santa Pera. That dream Santa Pera vacation is just a few clicks away. Search accommodations, flights and more on Expedia for a trip that's tailored just for you.

The Latest Santa Pera vacation packages

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was $1,335, price is now $896 per person
$896
per person
Aug 13 - Aug 18
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,815 reviews)
The room was very tiny, the staff so kind

Reviewed on Jul 7, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $2,640, price is now $1,268 per person
$1,268
per person
Aug 15 - Aug 22
found 2 days ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (1,001 reviews)
All good

Reviewed on Jul 8, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Save 100% on your flight
Price was $1,970, price is now $1,152 per person
$1,152
per person
Aug 15 - Aug 22
found 2 days ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,574 reviews)
The room was clean and well stocked. The breakfast was excellent with lots of variety.

Reviewed on Jul 9, 2026

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was $1,666, price is now $1,115 per person
$1,115
per person
Aug 15 - Aug 22
found 2 days ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (5,679 reviews)
Very nice and clean

Reviewed on Jul 8, 2026

Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

4 out of 5
Casco Viejo
Price was $2,084, price is now $1,433 per person
$1,433
per person
Aug 13 - Aug 20
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.8/10 Exceptional! (27 reviews)
In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions.

Reviewed on Mar 12, 2026

Don't see what you're looking for?
See all available trips from Columbus to Santa Pera
View all trips

What to do in Santa Pera

Panama City: POIN Swing Experience

Panama City: POIN Swing Experience

$32
per adult
100% of travellers recommend
Panama City: POIN Swing Experience
Panama Canal:Monkey Island,Sloth Safari, Natural Pool & Hike

Panama Canal:Monkey Island,Sloth Safari, Natural Pool & Hike

$48
per adult
94% of travellers recommend
Panama Canal:Monkey Island,Sloth Safari, Natural Pool & Hike
Panama City: Poin Full Package Experience

Panama City: Poin Full Package Experience

$155
per adult
98% of travellers recommend
Panama City: Poin Full Package Experience
See all activities in Santa Pera

Santa Pera Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$126 nightly
The price is $139 total per night from Aug 5 to Aug 6
$139 total
Aug 5 - Aug 6
Total with taxes and fees
9/10 Wonderful! (5,710 reviews)
"Very nice and clean"

Reviewed on Jul 8, 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$137 nightly
The price is $151 total per night from Aug 6 to Aug 7
$151 total
Aug 6 - Aug 7
Total with taxes and fees
8.6/10 Excellent! (2,618 reviews)
"Todo estuvo bien"

Reviewed on Jul 8, 2026

Crowne Plaza Panama Airport by IHG
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz Veracruz Panama
Fully refundableReserve now, pay when you stay
$319 nightly
The price is $319 total per night from Jul 10 to Jul 11
$319 total
Jul 10 - Jul 11
Total with taxes and fees
7.6/10 Good! (1,029 reviews)
"Very clean spacious rooms with views of the beach and resort. Breakfast was excellent!!! Staff was pleasant and willing to help!"

Reviewed on Jul 7, 2026

Dreams Playa Bonita Panama - All Inclusive
See all 1,718 properties in Santa Pera
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Pera Vacation Packages

Santa Pera Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Santa Pera vacation package cost?
Offering excellent value package deals from $896 on Expedia, you'll be thrilled with how little a vacation to Santa Pera costs! Expedia's packages simplify travel planning and maximize your savings.
What are the cheapest months to go to Santa Pera?
January, July and December are great times to search for cheap Santa Pera vacation packages. Traveling in quieter months means you'll typically find better prices on flights and accommodations.
How many days is enough for Santa Pera?
With a well-organized itinerary, you can easily visit the most popular Santa Pera attractions in a few days. But if you prefer to venture off the beaten track or go on day trips, consider booking your Santa Pera vacation for longer.
How to find the best Santa Pera package deals?
Start your search for a Santa Pera package deal by entering your preferred trip dates and destination under our "Packages" tab. Then select some filters, like "Property type" and "Amenities," to fine-tune the results to your exact needs. You can also sort by "Package discount" and discover offers that come with irresistible savings. If you don't find the ideal Santa Pera package deal right away, just tweak your dates and search again. Keep in mind that deals are only available for a limited time, so book early and get your Santa Pera escape off to a flying start.
Is it cheaper to book a Santa Pera vacation as a package?
An Expedia vacation package could land you great savings when compared to booking stays and flights separately. Better still, you can personalize your Santa Pera getaway to fit your exact style. Choose your preferred flight time, select the hotel type and add a car rental. Browse our great deals to see how much you can save.
When to book a vacation package to Santa Pera?
Land amazing discounts by booking your flights early with Expedia. If spontaneity is more your thing, take advantage of our last-minute deals for an impromptu Santa Pera getaway.
Does Expedia offer Book Now, Pay Later Santa Pera vacation packages?
Set off on your perfect escape to Santa Pera with help from Expedia's Book Now, Pay Later vacations. There's no need to scrimp and save or hold off until your next payday — we've teamed up with online lender Affirm to offer you flexibility and choice. Our vacation packages with payment plans mean you can spread the total cost across 3, 6 or 12 months. With no late payment fees or extra charges, you can easily stick to your budget and snag great deals before they sell out.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.