Santa Regina Vacations from $403

Book a Hotel + Flight or Car together to unlock savings

Your Santa Regina Vacation

Book a Santa Regina vacation package and discover the way of life and vibe of this vibrant neighborhood. With all your travel plans worked out, the only thing you need to focus on here is having a good time. When it's time for some sightseeing, no trip to Santa Regina is complete without visiting nearby Raimundo Goncalez Malta Nature Park. No matter your travel plans or the size of your budget, booking a perfect Santa Regina vacation is quick and easy with Expedia.

The Latest Santa Regina Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Sua estadia próxima da Praia Brava - BSO
Hotel Ilha da Madeira
The Spot One by Viva - Luxo e acesso direto ao Balneário Shopping
Hotel Pires
Rizzu Marina Hotel

Black Friday Sale

Limited-time deals: Save up to 50% on select hotels.

Where to stay in Santa Regina

Find the best Santa Regina areas and neighborhoods for the activities you enjoy most. Learn more about Santa Regina

Santa Regina Hotel Deals

Tri Hotel Premium Itapema

Tri Hotel Premium Itapema

3.5 out of 5
R. 256, 1035 - Meia Praia, Itapema Itapema SC
Fully refundableReserve now, pay when you stay
$65 nightly
The price is $67 total per night from Nov 30 to Dec 1
$67 total
Nov 30 - Dec 1
Total with taxes and fees
9/10 Wonderful! (508 reviews)
Service was great

Reviewed on Nov 2, 2025

Tri Hotel Premium Itapema
Hotel Marimar The Place

Hotel Marimar The Place

3.5 out of 5
Av. Brasil 1091 - Centro Balneário Camboriú SC
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $74 total per night from Nov 30 to Dec 1
$74 total
Nov 30 - Dec 1
Total with taxes and fees
9/10 Wonderful! (1,011 reviews)
Hotel staff was great. Management and front desk made us feel welcome. They were ready to help. Expedia made a mistake by selling us a room that was not available. The hotel made it seem like it's not a problem and we got an upgrade and they made it easy and stress free.

Reviewed on Dec 19, 2024

Hotel Marimar The Place
Mercure Itajaí Navegantes

Mercure Itajaí Navegantes

3.5 out of 5
Rua PEDRO FERREIRA, 363 Itajai
Fully refundableReserve now, pay when you stay
$74 nightly
The price is $76 total per night from Dec 21 to Dec 22
$76 total
Dec 21 - Dec 22
Total with taxes and fees
9.2/10 Wonderful! (527 reviews)
Very helpful and professional staff

Reviewed on Sep 5, 2025

Mercure Itajaí Navegantes
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Santa Regina

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.